Fluoride impurities were determined in technical samples of Leuprolide (anti-cancer drug for pros... more Fluoride impurities were determined in technical samples of Leuprolide (anti-cancer drug for prosthetic cancer) using reverse-phase liquid chromatography and derivative spectrophotometry. The chromatographic method was based on the ternary fluoride complex with zirconium(IV) and 2-(5-bromo-2-pyridylazo)-5-diethylaminophenol (5-Br-PADAP). The analysis was performed on a Nucleosil C18 column with LiChrosphere RP-100 end-capped phase, using as eluent acetonitrile (85%v/v) water mixture at pH 4.1±0.2.
Visible absorption spectra are reported for a series of anion radicals of diaryl carbonyl compoun... more Visible absorption spectra are reported for a series of anion radicals of diaryl carbonyl compounds. The radicals were generated by electrolytic reduction of benzophenone,p-phenylbenzophenone, and 1-naphthylphenyl and 2-naphthylphenyl ketones as well as di-1-naphthyl and di-2-naphthyl ketones inN,N-dimethylformamide solutions. It has been found that the Hammett–Streitwieser equation describes the wave number (ν̃max) of the first intense bands in terms of the position constant (σr+) appropriate for the aryl skeleton attached in its r position to the carbonyl group. A satisfactory linear correlation in the formν̃max;eq (−1.68 ± 0.96) × 103Σσr+ (13.48 ± 0.39) × 103exists for the members of the reaction series.
The ternary titanium(IV), vanadium(V) and molybdenum(VI) complexes with H2O2 and 5-Br-PADAP were ... more The ternary titanium(IV), vanadium(V) and molybdenum(VI) complexes with H2O2 and 5-Br-PADAP were investigated by spectrophotometry (Vis) and chromatography (LC). Occurrence of two different ternary titanium(IV) complexes with hydrogen peroxide and 5-Br-PADAP (limited by concentration of methanol in the sample) was established. Stability of Ti(IV) and V(V) ternary complexes under spectrophotometric and chromatographic conditions was discussed. Two liquid chromatographic methods for
Fluoride impurities were determined in technical samples of Leuprolide (anti-cancer drug for pros... more Fluoride impurities were determined in technical samples of Leuprolide (anti-cancer drug for prosthetic cancer) using reverse-phase liquid chromatography and derivative spectrophotometry. The chromatographic method was based on the ternary fluoride complex with zirconium(IV) and 2-(5-bromo-2-pyridylazo)-5-diethylaminophenol (5-Br-PADAP). The analysis was performed on a Nucleosil C18 column with LiChrosphere RP-100 end-capped phase, using as eluent acetonitrile (85%v/v) water mixture at pH 4.1±0.2.
Visible absorption spectra are reported for a series of anion radicals of diaryl carbonyl compoun... more Visible absorption spectra are reported for a series of anion radicals of diaryl carbonyl compounds. The radicals were generated by electrolytic reduction of benzophenone,p-phenylbenzophenone, and 1-naphthylphenyl and 2-naphthylphenyl ketones as well as di-1-naphthyl and di-2-naphthyl ketones inN,N-dimethylformamide solutions. It has been found that the Hammett–Streitwieser equation describes the wave number (ν̃max) of the first intense bands in terms of the position constant (σr+) appropriate for the aryl skeleton attached in its r position to the carbonyl group. A satisfactory linear correlation in the formν̃max;eq (−1.68 ± 0.96) × 103Σσr+ (13.48 ± 0.39) × 103exists for the members of the reaction series.
The ternary titanium(IV), vanadium(V) and molybdenum(VI) complexes with H2O2 and 5-Br-PADAP were ... more The ternary titanium(IV), vanadium(V) and molybdenum(VI) complexes with H2O2 and 5-Br-PADAP were investigated by spectrophotometry (Vis) and chromatography (LC). Occurrence of two different ternary titanium(IV) complexes with hydrogen peroxide and 5-Br-PADAP (limited by concentration of methanol in the sample) was established. Stability of Ti(IV) and V(V) ternary complexes under spectrophotometric and chromatographic conditions was discussed. Two liquid chromatographic methods for
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