Aim. To study the prevalence of atrial fibrillation (AF) in the Russian urban population cohort a... more Aim. To study the prevalence of atrial fibrillation (AF) in the Russian urban population cohort aged 45-69 years and its changes over 13-year follow-up during aging.Material and methods. This cross-sectional long-term prospective study included random population sample of men and women 45-69 years (n=9360, HAPIEE project, Novosibirsk), which was examined in 2003-2005 and was re-examined twice and followed up for about 13±1,00 years in men and 13,1±2,17 years in women. The incidence of AF was assessed for individuals without AF or cardiovascular disease (CVD) at the baseline examination. Statistical analysis was performed using the SPSS software package (v.13.0).Results. In a population sample over a 13-year follow-up, AF prevalence increased from 1,6% (1,1% among women and 2,1% among men) at the age of 45-69 years to 4,2% (3,0% among women and 6,1% among men) aged 55-84 years according to screening rest ECG examinations. The prevalence of new AF cases over a 13-year followup in the ...
Исследована ассоциация между относительной длиной теломер лейкоцитов (ДТЛ), количеством копий мит... more Исследована ассоциация между относительной длиной теломер лейкоцитов (ДТЛ), количеством копий митохондриальной ДНК (ККмтДНК) лейкоцитов и развитием острого коронарного синдрома в 15-летнем наблюдении. Случайная популяционная выборка была исходно обследована в 2003-2005 гг. ( n =9 360, мужчины и женщины 45-69 лет, Новосибирск, проект HAPIEE) и наблюдалась в среднем в течение 15 лет. В настоящем анализе были сформированы группы по дизайну гнездовой случай-контроль; случай - новый (Incident) инфаркт миокарда/острый коронарный синдром (ИМ/ОКС) без предшествующей истории сердечно-сосудистых заболеваний (ССЗ) - ИМ, ОКС, инсульт ( n =256), и стратифицированная по полу и возрасту контрольная группа без предшествующей истории ССЗ, рака и без фатальных исходов на период окончания наблюдения ( n =799). С помощью количественной ПЦР в реальном времени был выполнен анализ относительной ДТЛ и ККмтДНК. Носители коротких теломер имели повышенный риск развития ИМ/ОКС в течение последующих 15 лет (ОР=...
Aim. To study the contribution of behavioral and social risk factors to the development of metabo... more Aim. To study the contribution of behavioral and social risk factors to the development of metabolically unhealthy obesity (MUO) according to a prospective study in the Russian population.Material and methods. From the HAPPIE project, 3197 people aged 45-69 years with a body mass index ≥30 kg/m2 were selected, who had all the necessary parameters for obesity phenotype determination. The prospective analysis included the first (2003-2005) and third screenings (2015-2017). A subsample was formed (n=1275; 276 men — 22%, 999 women — 78%). The mean follow-up period was 12,4 years. IDF criteria (2005) were taken for analysis.Results. Men with a metabolically healthy obesity (MHO) phenotype most often have a secondary and higher education, while women with MHO — vocational and secondary education. In women, secondary education was most often noted. Among persons with obesity, both men and women are more often not single, while having MUO as follows: 56,8% and 34,2%, respectively. Men and w...
Aim. To evaluate the occurrence of cholelithiasis (CL) diagnosed by routine autopsy and to compar... more Aim. To evaluate the occurrence of cholelithiasis (CL) diagnosed by routine autopsy and to compare these data with the results of ultrasonographic examination of the general population. Material and methods. Autopsy protocols (n = 1124) from a large general hospital were analysed, and a representative sample of Novosibirsk population (1678 examinees aged 25-64 years) was examined by ultrasonography. Results. Prevalence of CL increased with age and was five-fold higher in females than in males. Both methods showed good concordance. The age-adjusted CL prevalence rates in 25-64 year-old groups was 1.94% in males and 9.53% in females in autopsy series, and 2.16% and 11.16%, respectively, in ultrasonographic study. Conclusion. Routine autopsy may serve as a reliable tool in evaluating prevalence of CL among the population provided the values are gender- and age-standardized.
The aim of the study was to evaluate the association of methylation of the F2RL3, CDKN2A gene wit... more The aim of the study was to evaluate the association of methylation of the F2RL3, CDKN2A gene with sudden cardiac death (SCD). Material and methods. Case-control study design. The SCD group included 150 deceased men (mean age 46.7 ± 9.2 years) with the main pathological diagnoses of acute circulatory failure, acute coronary insufficiency, which meets the SCD criteria of the European Society of Cardiology. The control group included 150 men who died suddenly, but not due to cardiovascular pathology (mean age 42.6 ± 1.2 years). DNA was isolated by phenol-chloroform extraction from myocardial tissue in both groups. The methylation status of the F2RL3 gene (19: 16890405-16890606, GRCh38.p13) and the CDKN2A gene (9: 21974726-21974877, GRCh38.p13) was assessed by methyl-specific polymerase chain reaction. Results. In the SCD group, 17.3 % (26/150) had the F2RL3 gene completely methylated (MM); in 6.0 % (9/150) it is completely unmethylated (UU); 76.7 % (115/150) had both methylated and un...
This presentation uses only data from the Czech, Russia and Poland because detailed FFQ was not i... more This presentation uses only data from the Czech, Russia and Poland because detailed FFQ was not included in Lithuanian part of the study. Figure 1. Life expectancy at age 15, men, 1970-2007 Dietary patterns and nutrient intake have been previously shown to be related to range of diseases and health outcomes such as cardiovascular disease (CVD). It has been speculated that poor diet and low levels of related biomarkers (such as folate or antioxidant vitamins) may be partly responsible for high rates of CVD and all-cause mortality in Central and Eastern Europe (CEE) and the former Soviet Union (FSU) as well as social patterning of CVD and all-cause mortality in the region.
Advances in gerontology = Uspekhi gerontologii, 2016
The purpose of the research was studying of leukocyte telomere length association with age, sex, ... more The purpose of the research was studying of leukocyte telomere length association with age, sex, risk factors for age-related diseases in Russian people of pre-retirement and retirement age. By quantitative real-time PCR method we studied the leukocyte telomere length in 398 men (56,3±7,2 years) and 365 women (56,6±7,1 years) selected from a population sample of 45-69 year-old residents of the Oktyabrsky and Kirovsky districts of Novosibirsk (9 400 people). The selection was formed in the course of work on the international project HAPIEE. As a result, an inverse correlation of telomere length with age (r=-0,159, р<0,001), with the ratio waist / hips (r=-0,107, p=0,003) was found out. The average length of telomeres in women significantly more than in men, p=0,031.The correlation of telomere length in males with weight (r=0,140, p=0,005), waist size (r=0,111, p=0,027) was found out. In women, there is an inverse correlation of telomere length with a waist size (r=-0,127, p=0,015)...
BACKGROUND: The attention to the forearm fractures, as to osteoporotic fractures, is important fo... more BACKGROUND: The attention to the forearm fractures, as to osteoporotic fractures, is important for ensuring early detection of individuals at increased risk of future fractures and taking preventive measures. AIMS: To determine the frequency of a history of forearm fractures in patients with type 2 diabetes mellitus (DM2) and without diabetes, and their association with risk factors for chronic non-communicable diseases (NCD). MATERIAL AND METHODS: In 20152017, in Novosibirsk, a random urban population sample of males and females, 5884 years old (n=3878), was surveyed. The study included persons who signed the informed consent to conduct the study, excluded individuals who wrote a waiver of taking blood to determine biochemical parameters. In total, the analysis included n=3393 people, 718 of them with DM2 (21.2%). Work design is cross-sectional research. The collection of information on fractures during for the last 3 years, the registration of socio-demographic data; and risk fact...
Aim. To study the prevalence of atrial fibrillation (AF) in the Russian urban population cohort a... more Aim. To study the prevalence of atrial fibrillation (AF) in the Russian urban population cohort aged 45-69 years and its changes over 13-year follow-up during aging.Material and methods. This cross-sectional long-term prospective study included random population sample of men and women 45-69 years (n=9360, HAPIEE project, Novosibirsk), which was examined in 2003-2005 and was re-examined twice and followed up for about 13±1,00 years in men and 13,1±2,17 years in women. The incidence of AF was assessed for individuals without AF or cardiovascular disease (CVD) at the baseline examination. Statistical analysis was performed using the SPSS software package (v.13.0).Results. In a population sample over a 13-year follow-up, AF prevalence increased from 1,6% (1,1% among women and 2,1% among men) at the age of 45-69 years to 4,2% (3,0% among women and 6,1% among men) aged 55-84 years according to screening rest ECG examinations. The prevalence of new AF cases over a 13-year followup in the ...
Исследована ассоциация между относительной длиной теломер лейкоцитов (ДТЛ), количеством копий мит... more Исследована ассоциация между относительной длиной теломер лейкоцитов (ДТЛ), количеством копий митохондриальной ДНК (ККмтДНК) лейкоцитов и развитием острого коронарного синдрома в 15-летнем наблюдении. Случайная популяционная выборка была исходно обследована в 2003-2005 гг. ( n =9 360, мужчины и женщины 45-69 лет, Новосибирск, проект HAPIEE) и наблюдалась в среднем в течение 15 лет. В настоящем анализе были сформированы группы по дизайну гнездовой случай-контроль; случай - новый (Incident) инфаркт миокарда/острый коронарный синдром (ИМ/ОКС) без предшествующей истории сердечно-сосудистых заболеваний (ССЗ) - ИМ, ОКС, инсульт ( n =256), и стратифицированная по полу и возрасту контрольная группа без предшествующей истории ССЗ, рака и без фатальных исходов на период окончания наблюдения ( n =799). С помощью количественной ПЦР в реальном времени был выполнен анализ относительной ДТЛ и ККмтДНК. Носители коротких теломер имели повышенный риск развития ИМ/ОКС в течение последующих 15 лет (ОР=...
Aim. To study the contribution of behavioral and social risk factors to the development of metabo... more Aim. To study the contribution of behavioral and social risk factors to the development of metabolically unhealthy obesity (MUO) according to a prospective study in the Russian population.Material and methods. From the HAPPIE project, 3197 people aged 45-69 years with a body mass index ≥30 kg/m2 were selected, who had all the necessary parameters for obesity phenotype determination. The prospective analysis included the first (2003-2005) and third screenings (2015-2017). A subsample was formed (n=1275; 276 men — 22%, 999 women — 78%). The mean follow-up period was 12,4 years. IDF criteria (2005) were taken for analysis.Results. Men with a metabolically healthy obesity (MHO) phenotype most often have a secondary and higher education, while women with MHO — vocational and secondary education. In women, secondary education was most often noted. Among persons with obesity, both men and women are more often not single, while having MUO as follows: 56,8% and 34,2%, respectively. Men and w...
Aim. To evaluate the occurrence of cholelithiasis (CL) diagnosed by routine autopsy and to compar... more Aim. To evaluate the occurrence of cholelithiasis (CL) diagnosed by routine autopsy and to compare these data with the results of ultrasonographic examination of the general population. Material and methods. Autopsy protocols (n = 1124) from a large general hospital were analysed, and a representative sample of Novosibirsk population (1678 examinees aged 25-64 years) was examined by ultrasonography. Results. Prevalence of CL increased with age and was five-fold higher in females than in males. Both methods showed good concordance. The age-adjusted CL prevalence rates in 25-64 year-old groups was 1.94% in males and 9.53% in females in autopsy series, and 2.16% and 11.16%, respectively, in ultrasonographic study. Conclusion. Routine autopsy may serve as a reliable tool in evaluating prevalence of CL among the population provided the values are gender- and age-standardized.
The aim of the study was to evaluate the association of methylation of the F2RL3, CDKN2A gene wit... more The aim of the study was to evaluate the association of methylation of the F2RL3, CDKN2A gene with sudden cardiac death (SCD). Material and methods. Case-control study design. The SCD group included 150 deceased men (mean age 46.7 ± 9.2 years) with the main pathological diagnoses of acute circulatory failure, acute coronary insufficiency, which meets the SCD criteria of the European Society of Cardiology. The control group included 150 men who died suddenly, but not due to cardiovascular pathology (mean age 42.6 ± 1.2 years). DNA was isolated by phenol-chloroform extraction from myocardial tissue in both groups. The methylation status of the F2RL3 gene (19: 16890405-16890606, GRCh38.p13) and the CDKN2A gene (9: 21974726-21974877, GRCh38.p13) was assessed by methyl-specific polymerase chain reaction. Results. In the SCD group, 17.3 % (26/150) had the F2RL3 gene completely methylated (MM); in 6.0 % (9/150) it is completely unmethylated (UU); 76.7 % (115/150) had both methylated and un...
This presentation uses only data from the Czech, Russia and Poland because detailed FFQ was not i... more This presentation uses only data from the Czech, Russia and Poland because detailed FFQ was not included in Lithuanian part of the study. Figure 1. Life expectancy at age 15, men, 1970-2007 Dietary patterns and nutrient intake have been previously shown to be related to range of diseases and health outcomes such as cardiovascular disease (CVD). It has been speculated that poor diet and low levels of related biomarkers (such as folate or antioxidant vitamins) may be partly responsible for high rates of CVD and all-cause mortality in Central and Eastern Europe (CEE) and the former Soviet Union (FSU) as well as social patterning of CVD and all-cause mortality in the region.
Advances in gerontology = Uspekhi gerontologii, 2016
The purpose of the research was studying of leukocyte telomere length association with age, sex, ... more The purpose of the research was studying of leukocyte telomere length association with age, sex, risk factors for age-related diseases in Russian people of pre-retirement and retirement age. By quantitative real-time PCR method we studied the leukocyte telomere length in 398 men (56,3±7,2 years) and 365 women (56,6±7,1 years) selected from a population sample of 45-69 year-old residents of the Oktyabrsky and Kirovsky districts of Novosibirsk (9 400 people). The selection was formed in the course of work on the international project HAPIEE. As a result, an inverse correlation of telomere length with age (r=-0,159, р<0,001), with the ratio waist / hips (r=-0,107, p=0,003) was found out. The average length of telomeres in women significantly more than in men, p=0,031.The correlation of telomere length in males with weight (r=0,140, p=0,005), waist size (r=0,111, p=0,027) was found out. In women, there is an inverse correlation of telomere length with a waist size (r=-0,127, p=0,015)...
BACKGROUND: The attention to the forearm fractures, as to osteoporotic fractures, is important fo... more BACKGROUND: The attention to the forearm fractures, as to osteoporotic fractures, is important for ensuring early detection of individuals at increased risk of future fractures and taking preventive measures. AIMS: To determine the frequency of a history of forearm fractures in patients with type 2 diabetes mellitus (DM2) and without diabetes, and their association with risk factors for chronic non-communicable diseases (NCD). MATERIAL AND METHODS: In 20152017, in Novosibirsk, a random urban population sample of males and females, 5884 years old (n=3878), was surveyed. The study included persons who signed the informed consent to conduct the study, excluded individuals who wrote a waiver of taking blood to determine biochemical parameters. In total, the analysis included n=3393 people, 718 of them with DM2 (21.2%). Work design is cross-sectional research. The collection of information on fractures during for the last 3 years, the registration of socio-demographic data; and risk fact...
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