2007;132;1093-1094; Chest Carolyn S. Calfee and Michael A. Matthay G. Umberto Meduri, Paul E. Mar... more 2007;132;1093-1094; Chest Carolyn S. Calfee and Michael A. Matthay G. Umberto Meduri, Paul E. Marik, Stephen M. Pastores, Djillali Annane, Corticosteroids in ARDS: A Counterpoint http://chestjournal.org and services can be found online on the World Wide Web at: The online version of this article, along with updated information ). ISSN: 0012-3692. http://www.chestjournal.org/misc/reprints.shtml ( of the copyright holder may be reproduced or distributed without the prior written permission Northbrook IL 60062. All rights reserved. No part of this article or PDF by the American College of Chest Physicians, 3300 Dundee Road, 2007 Physicians. It has been published monthly since 1935. Copyright CHEST is the official journal of the American College of Chest
SESSION TITLE: Lessons from the ICU: What have We Learned about the Management of COVID-19 SESSIO... more SESSION TITLE: Lessons from the ICU: What have We Learned about the Management of COVID-19 SESSION TYPE: Original Investigations PRESENTED ON: October 18-21, 2020 PURPOSE: The purpose of this study is to describe the characteristics and outcomes of critically ill patients with cancer and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection METHODS: We reviewed the clinical characteristics and outcomes of adult patients (> 18 yrs) with active or recent history of cancer and confirmed COVID-19 who developed acute hypoxemic respiratory insufficiency/failure with radiographic opacities and were consecutively admitted to two intensive care units (ICU) at Memorial Sloan Kettering Cancer Center between March 16 and May 27, 2020 The hospital adopted an early-intubation strategy during the first 4 weeks and a waiting period of 4 weeks before considering a tracheostomy Pressure control ventilation and targeted tidal volume of 6 ml/kg predicted body weight and moderate to ...
Chimeric antigen receptor T-cell therapy, a type of immune effector therapy for cancer, has demon... more Chimeric antigen receptor T-cell therapy, a type of immune effector therapy for cancer, has demonstrated encouraging results in clinical trials for the treatment of patients with refractory hematologic malignancies. Nevertheless, there are toxicities specific to these treatments that, if not recognized and treated appropriately, can lead to multiple organ failure and death. This article is a comprehensive review of the available literature and provides, from a critical care perspective, recommendations by experienced intensivists in the care of critically ill adult chimeric antigen receptor T-cell patients. PubMed and Medline search of articles published from 2006 to date. Clinical studies, reviews, or guidelines were selected and reviewed by the authors. Not available . Not available. Until modifications in chimeric antigen receptor T-cell therapy decrease their toxicities, the intensivist will play a leading role in the management of critically ill chimeric antigen receptor T-cell...
To update the 2008 consensus statements for the diagnosis and management of critical illness-rela... more To update the 2008 consensus statements for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in adult and pediatric patients. A multispecialty task force of 16 international experts in critical care medicine, endocrinology, and guideline methods, all of them members of the Society of Critical Care Medicine and/or the European Society of Intensive Care Medicine. The recommendations were based on the summarized evidence from the 2008 document in addition to more recent findings from an updated systematic review of relevant studies from 2008 to 2017 and were formulated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. The strength of each recommendation was classified as strong or conditional, and the quality of evidence was rated from high to very low based on factors including the individual study design, the risk of bias, the consistency of the results, and the directness and precision of th...
2007;132;1093-1094; Chest Carolyn S. Calfee and Michael A. Matthay G. Umberto Meduri, Paul E. Mar... more 2007;132;1093-1094; Chest Carolyn S. Calfee and Michael A. Matthay G. Umberto Meduri, Paul E. Marik, Stephen M. Pastores, Djillali Annane, Corticosteroids in ARDS: A Counterpoint http://chestjournal.org and services can be found online on the World Wide Web at: The online version of this article, along with updated information ). ISSN: 0012-3692. http://www.chestjournal.org/misc/reprints.shtml ( of the copyright holder may be reproduced or distributed without the prior written permission Northbrook IL 60062. All rights reserved. No part of this article or PDF by the American College of Chest Physicians, 3300 Dundee Road, 2007 Physicians. It has been published monthly since 1935. Copyright CHEST is the official journal of the American College of Chest
SESSION TITLE: Lessons from the ICU: What have We Learned about the Management of COVID-19 SESSIO... more SESSION TITLE: Lessons from the ICU: What have We Learned about the Management of COVID-19 SESSION TYPE: Original Investigations PRESENTED ON: October 18-21, 2020 PURPOSE: The purpose of this study is to describe the characteristics and outcomes of critically ill patients with cancer and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection METHODS: We reviewed the clinical characteristics and outcomes of adult patients (> 18 yrs) with active or recent history of cancer and confirmed COVID-19 who developed acute hypoxemic respiratory insufficiency/failure with radiographic opacities and were consecutively admitted to two intensive care units (ICU) at Memorial Sloan Kettering Cancer Center between March 16 and May 27, 2020 The hospital adopted an early-intubation strategy during the first 4 weeks and a waiting period of 4 weeks before considering a tracheostomy Pressure control ventilation and targeted tidal volume of 6 ml/kg predicted body weight and moderate to ...
Chimeric antigen receptor T-cell therapy, a type of immune effector therapy for cancer, has demon... more Chimeric antigen receptor T-cell therapy, a type of immune effector therapy for cancer, has demonstrated encouraging results in clinical trials for the treatment of patients with refractory hematologic malignancies. Nevertheless, there are toxicities specific to these treatments that, if not recognized and treated appropriately, can lead to multiple organ failure and death. This article is a comprehensive review of the available literature and provides, from a critical care perspective, recommendations by experienced intensivists in the care of critically ill adult chimeric antigen receptor T-cell patients. PubMed and Medline search of articles published from 2006 to date. Clinical studies, reviews, or guidelines were selected and reviewed by the authors. Not available . Not available. Until modifications in chimeric antigen receptor T-cell therapy decrease their toxicities, the intensivist will play a leading role in the management of critically ill chimeric antigen receptor T-cell...
To update the 2008 consensus statements for the diagnosis and management of critical illness-rela... more To update the 2008 consensus statements for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in adult and pediatric patients. A multispecialty task force of 16 international experts in critical care medicine, endocrinology, and guideline methods, all of them members of the Society of Critical Care Medicine and/or the European Society of Intensive Care Medicine. The recommendations were based on the summarized evidence from the 2008 document in addition to more recent findings from an updated systematic review of relevant studies from 2008 to 2017 and were formulated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. The strength of each recommendation was classified as strong or conditional, and the quality of evidence was rated from high to very low based on factors including the individual study design, the risk of bias, the consistency of the results, and the directness and precision of th...
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Papers by Stephen Pastores