The effect upon the neonate of a short period of maternal hypotension sustained during the initia... more The effect upon the neonate of a short period of maternal hypotension sustained during the initiation of spinal analgesia for Caesarean section was studied. Babies born to mothers with hypotension were significantly more acidotic than controls although acid‐base levels were still within normal limits. Neuro‐behavioural studies were found to be normal in both groups at 4 and 24 hours. It was concluded that a short period (<2 minutes) of hypotension was not harmful to the neonate.
2008 51st Midwest Symposium on Circuits and Systems, 2008
This paper presents a low-power sensor read-out circuit with FSK telemetry option. The proposed s... more This paper presents a low-power sensor read-out circuit with FSK telemetry option. The proposed system consists of a data generator block and a FSK generator block. The data generator block converts a sensor current to a square wave data signal whereas the FSK generator block produces two different frequencies depending upon the value of the data signal. The relatively simple architecture of the proposed system facilitates the low-voltage and low-power operation. The system has been designed using AMI 0.5 mum CMOS process. Simulation results show that the proposed system can detect a sensor current in the range of 50 nA to 5 muA and the total power consumption is 431 muW with a 3.3 V supply. The circuit is ready to be submitted for monolithic integration.
2010 IEEE Computer Society Annual Symposium on VLSI, 2010
Abstract Reconfigurable analog-to-digital converters (ADC) have been receiving increased attenti... more Abstract Reconfigurable analog-to-digital converters (ADC) have been receiving increased attention in the research community for the capability to adapt to continuously varying signal processing requirements. The reconfigurable ADC is particularly advantageous in ...
2009 International Semiconductor Device Research Symposium, 2009
Photosystem reaction centers are special biomolecules found in oxygenic plants that absorb photon... more Photosystem reaction centers are special biomolecules found in oxygenic plants that absorb photons with high quantum efficiency, resulting in a separation of charges and the development of electrostatic potential across the reaction centers. This paper reports the performance of AlGaN/GaN ChemFETs configured as a floating gate transistor to characterize Photosystem I (PSI) reaction centers and presents a physical model to
International Conference on Electrical & Computer Engineering (ICECE 2010), 2010
Healthcare providers are depending on remote patient monitoring system more and more to treat a p... more Healthcare providers are depending on remote patient monitoring system more and more to treat a patient before the conditions become acute. Low-power electronics is an integral part of the remote patient monitoring system which is required for data acquisition, signal processing and data transmission. This work reports a low-power digitally controllable current readout circuit and a modulator unit designed for
ABSTRACTA self resonating bimorph cantilever structure for fast temperature cycling in a pyroelec... more ABSTRACTA self resonating bimorph cantilever structure for fast temperature cycling in a pyroelectric energy harvester has been modeled using finite element method. Effect of constituting material properties and system parameters on the frequency and magnitude of temperature cycling and the efficiency of energy recycling using the proposed structure has been investigated. Results show that thermal contact conductance and heat source temperature play a key role in dominating the cycling frequency and efficiency of energy recycling. Studying the performance trend with various parameters such as thermal contact conductance, heat source temperature, device aspect ratio and constituent material of varying thermal conductivity and expansion coefficient, an optimal solution for most efficient energy scavenging process has been sought.
International Conference on Electrical & Computer Engineering (ICECE 2010), 2010
This paper demonstrates a novel way of using a single type of high electron mobility transistor (... more This paper demonstrates a novel way of using a single type of high electron mobility transistor (HEMT) device for detecting two kinds of biomolecules (Photosystem I and recombinant human monokine induced by interferon gamma, MIG). MIG was successfully detected in 150 mM concentration of phosphate buffer solution (PBS). Floating gate configuration used for biomolecule detection eliminates the need of external
2011 International Semiconductor Device Research Symposium (ISDRS), 2011
Abstract The paper demonstrates a novel way of detecting Monokine induced by interferon gamma (MI... more Abstract The paper demonstrates a novel way of detecting Monokine induced by interferon gamma (MIG) in physiological condition (150mM phosphate buffer solution) using a two terminal device. To provide specific MIG detection capability, anti-MIG IgG molecular ...
ABSTRACT Implantable biomedical sensors and continuous real time in vivo monitoring of various ph... more ABSTRACT Implantable biomedical sensors and continuous real time in vivo monitoring of various physiological parameters requires low-power sensor electronics and wireless telemetry for transmission of sensor data. In this article, generic blocks required for such systems have been demonstrated with design examples. Ideally neural or electro-chemical sensor signal monitoring units comprise of low noise amplifiers, current or voltage mode analog to digital domain data conversion circuits and wireless telemetry circuits. The low-noise amplifier described here has a novel open loop amplifier scheme used for neural signal recording systems. The design has been implemented using 0.5-μm SOIBiCMOS process. The fabricated chip can work with 1 V supply and consumes 805 nA. The current mode analog to digital conversion signal processing circuitry takes the current signal as an input and generates a pulse-width modulated data signal. The data signal is then modulated with a high frequency carrier signal to generate FSK data for wireless transmission. The design is fabricated in 0.5-μm standard CMOS process and consumes 1.1 mW of power with 3.5 V supply.
International Conference on Electrical & Computer Engineering (ICECE 2010), 2010
... REFERENCES [1] UK Mishra, PP Parikh, and YF Wu, AlGaN/GaN HEMTsAn Overview of Device Operat... more ... REFERENCES [1] UK Mishra, PP Parikh, and YF Wu, AlGaN/GaN HEMTsAn Overview of Device Operation and Applications, Proceedings of the IEEE, vol. ... 33, no. 9, pp. 999 1001, 1999. [3] SA Eliza, SK Islam, I. Lee, E. Greenbaum, MA Khan, and MN Ericson, Detection of ...
Monokine induced by interferon gamma (MIG/CXCL9) is used as an immune biomarker for early monitor... more Monokine induced by interferon gamma (MIG/CXCL9) is used as an immune biomarker for early monitoring of transplant or allograft rejection. This paper demonstrates a direct electrical, label-free detection method of recombinant human MIG with anti-MIG IgG molecules in physiologically relevant buffer environment. The sensor platform used is a biologically modified GaN-based high electron mobility transistor (HEMT) device. Biomolecular recognition capability was provided by using high affinity anti-MIG monoclonal antibody to form molecular affinity interface receptors on short N-hydroxysuccinimide-ester functionalized disulphide (DSP) self-assembled monolayers (SAMs) on the gold sensing gate of the HEMT device. A floating gate configuration has been adopted to eliminate the influences of external gate voltage. Preliminary test results with the proposed chemically treated GaN HEMT biosensor show that MIG can be detected for a wide range of concentration varying from 5 ng/mL to 500 ng/mL.
In oxygenic plants, photons are captured with high quantum efficiency by two specialized reaction... more In oxygenic plants, photons are captured with high quantum efficiency by two specialized reaction centers (RC) called Photosystem I (PS I) and Photosystem II (PS II). The captured photon triggers rapid charge separation and the photon energy is converted into an electrostatic potential across the nanometer-scale (~6 nm) reaction centers. The exogenous photovoltages from a single PS I RC have been previously measured using the technique of Kelvin force probe microscopy (KFM). However, biomolecular photovoltaic applications require two-terminal devices. This paper presents for the first time, a micro-device for detection and characterization of isolated PS I RCs. The device is based on an AlGaN/GaN high electron mobility transistor (HEMT) structure. AlGaN/GaN HEMTs show high current throughputs and greater sensitivity to surface charges compared to other field-effect devices. PS I complexes immobilized on the floating gate of AlGaN/GaN HEMTs resulted in significant changes in the device characteristics under illumination. An analytical model has been developed to estimate the RCs of a major orientation on the functionalized gate surface of the HEMTs.
AbstractAn analog signal processing integrated circuit for microcantilever array has been design... more AbstractAn analog signal processing integrated circuit for microcantilever array has been designed for pressure measure-ment in biomedical applications. The chip consists of analog multiplexer, instrumentation amplifier, sample-and-hold circuit, on-chip voltage and ...
AbstractIn this work, MOSFET-embedded cantilevers are configured as microbial sensors for detect... more AbstractIn this work, MOSFET-embedded cantilevers are configured as microbial sensors for detection of anthrax simu-lants, Bacillus thuringiensis. Anthrax simulants attached to the chemically treated gold-coated cantilever cause changes in the MOSFET drain current due to the ...
The effect upon the neonate of a short period of maternal hypotension sustained during the initia... more The effect upon the neonate of a short period of maternal hypotension sustained during the initiation of spinal analgesia for Caesarean section was studied. Babies born to mothers with hypotension were significantly more acidotic than controls although acid‐base levels were still within normal limits. Neuro‐behavioural studies were found to be normal in both groups at 4 and 24 hours. It was concluded that a short period (<2 minutes) of hypotension was not harmful to the neonate.
2008 51st Midwest Symposium on Circuits and Systems, 2008
This paper presents a low-power sensor read-out circuit with FSK telemetry option. The proposed s... more This paper presents a low-power sensor read-out circuit with FSK telemetry option. The proposed system consists of a data generator block and a FSK generator block. The data generator block converts a sensor current to a square wave data signal whereas the FSK generator block produces two different frequencies depending upon the value of the data signal. The relatively simple architecture of the proposed system facilitates the low-voltage and low-power operation. The system has been designed using AMI 0.5 mum CMOS process. Simulation results show that the proposed system can detect a sensor current in the range of 50 nA to 5 muA and the total power consumption is 431 muW with a 3.3 V supply. The circuit is ready to be submitted for monolithic integration.
2010 IEEE Computer Society Annual Symposium on VLSI, 2010
Abstract Reconfigurable analog-to-digital converters (ADC) have been receiving increased attenti... more Abstract Reconfigurable analog-to-digital converters (ADC) have been receiving increased attention in the research community for the capability to adapt to continuously varying signal processing requirements. The reconfigurable ADC is particularly advantageous in ...
2009 International Semiconductor Device Research Symposium, 2009
Photosystem reaction centers are special biomolecules found in oxygenic plants that absorb photon... more Photosystem reaction centers are special biomolecules found in oxygenic plants that absorb photons with high quantum efficiency, resulting in a separation of charges and the development of electrostatic potential across the reaction centers. This paper reports the performance of AlGaN/GaN ChemFETs configured as a floating gate transistor to characterize Photosystem I (PSI) reaction centers and presents a physical model to
International Conference on Electrical & Computer Engineering (ICECE 2010), 2010
Healthcare providers are depending on remote patient monitoring system more and more to treat a p... more Healthcare providers are depending on remote patient monitoring system more and more to treat a patient before the conditions become acute. Low-power electronics is an integral part of the remote patient monitoring system which is required for data acquisition, signal processing and data transmission. This work reports a low-power digitally controllable current readout circuit and a modulator unit designed for
ABSTRACTA self resonating bimorph cantilever structure for fast temperature cycling in a pyroelec... more ABSTRACTA self resonating bimorph cantilever structure for fast temperature cycling in a pyroelectric energy harvester has been modeled using finite element method. Effect of constituting material properties and system parameters on the frequency and magnitude of temperature cycling and the efficiency of energy recycling using the proposed structure has been investigated. Results show that thermal contact conductance and heat source temperature play a key role in dominating the cycling frequency and efficiency of energy recycling. Studying the performance trend with various parameters such as thermal contact conductance, heat source temperature, device aspect ratio and constituent material of varying thermal conductivity and expansion coefficient, an optimal solution for most efficient energy scavenging process has been sought.
International Conference on Electrical & Computer Engineering (ICECE 2010), 2010
This paper demonstrates a novel way of using a single type of high electron mobility transistor (... more This paper demonstrates a novel way of using a single type of high electron mobility transistor (HEMT) device for detecting two kinds of biomolecules (Photosystem I and recombinant human monokine induced by interferon gamma, MIG). MIG was successfully detected in 150 mM concentration of phosphate buffer solution (PBS). Floating gate configuration used for biomolecule detection eliminates the need of external
2011 International Semiconductor Device Research Symposium (ISDRS), 2011
Abstract The paper demonstrates a novel way of detecting Monokine induced by interferon gamma (MI... more Abstract The paper demonstrates a novel way of detecting Monokine induced by interferon gamma (MIG) in physiological condition (150mM phosphate buffer solution) using a two terminal device. To provide specific MIG detection capability, anti-MIG IgG molecular ...
ABSTRACT Implantable biomedical sensors and continuous real time in vivo monitoring of various ph... more ABSTRACT Implantable biomedical sensors and continuous real time in vivo monitoring of various physiological parameters requires low-power sensor electronics and wireless telemetry for transmission of sensor data. In this article, generic blocks required for such systems have been demonstrated with design examples. Ideally neural or electro-chemical sensor signal monitoring units comprise of low noise amplifiers, current or voltage mode analog to digital domain data conversion circuits and wireless telemetry circuits. The low-noise amplifier described here has a novel open loop amplifier scheme used for neural signal recording systems. The design has been implemented using 0.5-μm SOIBiCMOS process. The fabricated chip can work with 1 V supply and consumes 805 nA. The current mode analog to digital conversion signal processing circuitry takes the current signal as an input and generates a pulse-width modulated data signal. The data signal is then modulated with a high frequency carrier signal to generate FSK data for wireless transmission. The design is fabricated in 0.5-μm standard CMOS process and consumes 1.1 mW of power with 3.5 V supply.
International Conference on Electrical & Computer Engineering (ICECE 2010), 2010
... REFERENCES [1] UK Mishra, PP Parikh, and YF Wu, AlGaN/GaN HEMTsAn Overview of Device Operat... more ... REFERENCES [1] UK Mishra, PP Parikh, and YF Wu, AlGaN/GaN HEMTsAn Overview of Device Operation and Applications, Proceedings of the IEEE, vol. ... 33, no. 9, pp. 999 1001, 1999. [3] SA Eliza, SK Islam, I. Lee, E. Greenbaum, MA Khan, and MN Ericson, Detection of ...
Monokine induced by interferon gamma (MIG/CXCL9) is used as an immune biomarker for early monitor... more Monokine induced by interferon gamma (MIG/CXCL9) is used as an immune biomarker for early monitoring of transplant or allograft rejection. This paper demonstrates a direct electrical, label-free detection method of recombinant human MIG with anti-MIG IgG molecules in physiologically relevant buffer environment. The sensor platform used is a biologically modified GaN-based high electron mobility transistor (HEMT) device. Biomolecular recognition capability was provided by using high affinity anti-MIG monoclonal antibody to form molecular affinity interface receptors on short N-hydroxysuccinimide-ester functionalized disulphide (DSP) self-assembled monolayers (SAMs) on the gold sensing gate of the HEMT device. A floating gate configuration has been adopted to eliminate the influences of external gate voltage. Preliminary test results with the proposed chemically treated GaN HEMT biosensor show that MIG can be detected for a wide range of concentration varying from 5 ng/mL to 500 ng/mL.
In oxygenic plants, photons are captured with high quantum efficiency by two specialized reaction... more In oxygenic plants, photons are captured with high quantum efficiency by two specialized reaction centers (RC) called Photosystem I (PS I) and Photosystem II (PS II). The captured photon triggers rapid charge separation and the photon energy is converted into an electrostatic potential across the nanometer-scale (~6 nm) reaction centers. The exogenous photovoltages from a single PS I RC have been previously measured using the technique of Kelvin force probe microscopy (KFM). However, biomolecular photovoltaic applications require two-terminal devices. This paper presents for the first time, a micro-device for detection and characterization of isolated PS I RCs. The device is based on an AlGaN/GaN high electron mobility transistor (HEMT) structure. AlGaN/GaN HEMTs show high current throughputs and greater sensitivity to surface charges compared to other field-effect devices. PS I complexes immobilized on the floating gate of AlGaN/GaN HEMTs resulted in significant changes in the device characteristics under illumination. An analytical model has been developed to estimate the RCs of a major orientation on the functionalized gate surface of the HEMTs.
AbstractAn analog signal processing integrated circuit for microcantilever array has been design... more AbstractAn analog signal processing integrated circuit for microcantilever array has been designed for pressure measure-ment in biomedical applications. The chip consists of analog multiplexer, instrumentation amplifier, sample-and-hold circuit, on-chip voltage and ...
AbstractIn this work, MOSFET-embedded cantilevers are configured as microbial sensors for detect... more AbstractIn this work, MOSFET-embedded cantilevers are configured as microbial sensors for detection of anthrax simu-lants, Bacillus thuringiensis. Anthrax simulants attached to the chemically treated gold-coated cantilever cause changes in the MOSFET drain current due to the ...
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Papers by Salwa Mostafa