We have designed and developed a data integration and visualization platform that provides eviden... more We have designed and developed a data integration and visualization platform that provides evidence about the association of known and potential drug targets with diseases. The platform is designed to support identification and prioritization of biological targets for follow-up. Each drug target is linked to a disease using integrated genome-wide data from a broad range of data sources. The platform provides either a target-centric workflow to identify diseases that may be associated with a specific target, or a disease-centric workflow to identify targets that may be associated with a specific disease. Users can easily transition between these target- and disease-centric workflows. The Open Targets Validation Platform is accessible at https://www.targetvalidation.org.
Natural hazards such as floods, bushfires, cyclones or hurricanes, can cause significant damage t... more Natural hazards such as floods, bushfires, cyclones or hurricanes, can cause significant damage that disrupts our infrastructure systems. Climate change is making such extreme events more frequent and more severe. In addition, infrastructure systems have become more interconnected and interdependent. By interconnected, we mean that infrastructure systems use each other's output and operate together to provide joint services. The interdependence of two systems or components, on the other hand, refers to the effect of a decline of the performance of one system or component on another. Hence, a disruption to one infrastructure system may propagate into others and eventually affect various services that are critical for the well-being of communities. In recent years, cascading failures of infrastructure systems at a national scale have attracted significant attention. However, our understanding of these failures at a local scale remains limited. During major disasters, communities f...
Background Related species, such as humans and chimpanzees, often experience the same disease wit... more Background Related species, such as humans and chimpanzees, often experience the same disease with varying degrees of pathology, as seen in the cases of Alzheimer's disease, or differing symptomatology as in AIDS. Furthermore, certain diseases such as schizophrenia, epithelial cancers and autoimmune disorders are far more frequent in humans than in other species for reasons not associated with lifestyle. Genes that have undergone positive selection during species evolution are indicative of functional adaptations that drive species differences. Thus we investigate whether biomedical disease differences between species can be attributed to positively selected genes. Results We identified genes that putatively underwent positive selection during the evolution of humans and four mammals which are often used to model human diseases (mouse, rat, chimpanzee and dog). We show that genes predicted to have been subject to positive selection pressure during human evolution are implicated...
Hurricanes are costly natural disasters periodically faced by households in coastal and, to some ... more Hurricanes are costly natural disasters periodically faced by households in coastal and, to some extent, inland areas. Public agencies must understand household behavior in order to develop evacuation plans than align with evacuee choices and behavior. This paper presents a household-level hurricane evacuation destination type choice model never presented before. The discrete choice of destination type is modeled using a Nested Logit model. While previous literature considers only houses of friends and relatives and hotels ...
Transportation Research Record: Journal of the Transportation Research Board, Dec 1, 2011
An econometric framework was developed to combine data from various sources to identify the key f... more An econometric framework was developed to combine data from various sources to identify the key factors contributing to travel time variations in Central London. Nonlinear latent variable regression models that explicitly accounted for measurement errors in the data were developed to combine data extracted from automatic number plate recognition cameras and automatic traffic counters. This procedure significantly differed from previous research in this area that was based primarily on traffic flow data and ignored ...
Transportation Research Record: Journal of the Transportation Research Board, Dec 1, 2011
Pedestrian safety has been a major concern for megacities such as New York City. Although pedestr... more Pedestrian safety has been a major concern for megacities such as New York City. Although pedestrian fatalities show a downward trend, these fatalities constitute a high percentage of overall traffic fatalities in the city. Data from New York City were used to study the factors that influence the frequency of pedestrian crashes. Specifically, a random parameter, negative binomial model was developed for predicting pedestrian crash frequencies at the census tract level. This approach allows the incorporation of unobserved heterogeneity across the ...
We have designed and developed a data integration and visualization platform that provides eviden... more We have designed and developed a data integration and visualization platform that provides evidence about the association of known and potential drug targets with diseases. The platform is designed to support identification and prioritization of biological targets for follow-up. Each drug target is linked to a disease using integrated genome-wide data from a broad range of data sources. The platform provides either a target-centric workflow to identify diseases that may be associated with a specific target, or a disease-centric workflow to identify targets that may be associated with a specific disease. Users can easily transition between these target- and disease-centric workflows. The Open Targets Validation Platform is accessible at https://www.targetvalidation.org.
Natural hazards such as floods, bushfires, cyclones or hurricanes, can cause significant damage t... more Natural hazards such as floods, bushfires, cyclones or hurricanes, can cause significant damage that disrupts our infrastructure systems. Climate change is making such extreme events more frequent and more severe. In addition, infrastructure systems have become more interconnected and interdependent. By interconnected, we mean that infrastructure systems use each other's output and operate together to provide joint services. The interdependence of two systems or components, on the other hand, refers to the effect of a decline of the performance of one system or component on another. Hence, a disruption to one infrastructure system may propagate into others and eventually affect various services that are critical for the well-being of communities. In recent years, cascading failures of infrastructure systems at a national scale have attracted significant attention. However, our understanding of these failures at a local scale remains limited. During major disasters, communities f...
Background Related species, such as humans and chimpanzees, often experience the same disease wit... more Background Related species, such as humans and chimpanzees, often experience the same disease with varying degrees of pathology, as seen in the cases of Alzheimer's disease, or differing symptomatology as in AIDS. Furthermore, certain diseases such as schizophrenia, epithelial cancers and autoimmune disorders are far more frequent in humans than in other species for reasons not associated with lifestyle. Genes that have undergone positive selection during species evolution are indicative of functional adaptations that drive species differences. Thus we investigate whether biomedical disease differences between species can be attributed to positively selected genes. Results We identified genes that putatively underwent positive selection during the evolution of humans and four mammals which are often used to model human diseases (mouse, rat, chimpanzee and dog). We show that genes predicted to have been subject to positive selection pressure during human evolution are implicated...
Hurricanes are costly natural disasters periodically faced by households in coastal and, to some ... more Hurricanes are costly natural disasters periodically faced by households in coastal and, to some extent, inland areas. Public agencies must understand household behavior in order to develop evacuation plans than align with evacuee choices and behavior. This paper presents a household-level hurricane evacuation destination type choice model never presented before. The discrete choice of destination type is modeled using a Nested Logit model. While previous literature considers only houses of friends and relatives and hotels ...
Transportation Research Record: Journal of the Transportation Research Board, Dec 1, 2011
An econometric framework was developed to combine data from various sources to identify the key f... more An econometric framework was developed to combine data from various sources to identify the key factors contributing to travel time variations in Central London. Nonlinear latent variable regression models that explicitly accounted for measurement errors in the data were developed to combine data extracted from automatic number plate recognition cameras and automatic traffic counters. This procedure significantly differed from previous research in this area that was based primarily on traffic flow data and ignored ...
Transportation Research Record: Journal of the Transportation Research Board, Dec 1, 2011
Pedestrian safety has been a major concern for megacities such as New York City. Although pedestr... more Pedestrian safety has been a major concern for megacities such as New York City. Although pedestrian fatalities show a downward trend, these fatalities constitute a high percentage of overall traffic fatalities in the city. Data from New York City were used to study the factors that influence the frequency of pedestrian crashes. Specifically, a random parameter, negative binomial model was developed for predicting pedestrian crash frequencies at the census tract level. This approach allows the incorporation of unobserved heterogeneity across the ...
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Papers by Samiul Hasan