We introduce the Korea Institute of Science and Technology-Novel Materials Discovery (KISTNOMAD) ... more We introduce the Korea Institute of Science and Technology-Novel Materials Discovery (KISTNOMAD) platform, a materials data repository. We describe its functionality and novel features from an academic viewpoint. It is a data repository designed for computational material science, especially focusing on managing and sharing the results of molecular dynamics simulation results as well as quantum mechanical computations. It consists of three main components: a database, file storage, and web-based front end. The database hosts material properties, which are extracted from the computational results. The front end has a graphical user interface and an open application programming interface, which allow researchers to interact with the system more easily. KIST-NOMAD’s panel displays the searched results on a well-organized and research-oriented web page. All the open access data and files are available for downloading in comma-separated value format as well as zipped archives. This autom...
Soil moisture content is one of the factors that controls the infiltration capacity of soils. Pre... more Soil moisture content is one of the factors that controls the infiltration capacity of soils. Precipitation and irrigation increase soil moisture which in turn reduces infiltration capacity. This results in increased runoff during subsequent storm events. Increased stormwater runoff may cause adverse environmental problems such as increased soil erosion, increased bed and suspended loads in streams, and increased non-point source
A two‐dimensional probabilistic transport model is developed‐by coupling a reliability algorithm ... more A two‐dimensional probabilistic transport model is developed‐by coupling a reliability algorithm to a two‐dimensional unsaturated flow and transport model. The goal is to determine the significance of the uncertainty of each variable to the probability outcome. Model input includes the mean, standard deviation, and probability distribution of each uncertain variable. The uncertain variables are assumed to be uncorrelated to each other. The uncertain variables are saturated water content, residual water content, van Genuchten model parameters alpha (α) and n, saturated hydraulic conductivity, bulk density, coefficient of distribution, molecular diffusion coefficient, and dispersivity. Coefficient of variation is used as the measure of uncertainty for each uncertain variable. Three soil samples are considered for model simulations. One half of the flow surface area is the source of a generic contaminant spill. The reliability analysis determines the probability of exceeding a specific...
Biochemical and Biophysical Research Communications, 1997
The activity of the sarcoplasmic reticulum (SR) CaATPase in cardiac muscle is regulated by phosph... more The activity of the sarcoplasmic reticulum (SR) CaATPase in cardiac muscle is regulated by phospholamban via its ability to be phosphorylated. It is unclear what role phospholamban phosphorylation plays in cardiac adaptation and disease. The study of the native phospholamban phosphorylation in tissue has been technically difficult because of the presence of endogenous enzymes. Using mobility shifts on SDS PAGE gels we have demonstrated that significant dephosphorylation of phospholamban occurs during tissue homogenisation in the absence of phosphatase inhibitors. Endogenous kinases do not appear to alter phospholamban phosphorylation. When 10 mM NaF (a phosphatase inhibitor) was used in the preparation of crude SR homogenates, CaATPase activity (measured by oxalate stimulated calcium uptake) was stimulated almost 2 fold, p < 0.01. Increased CaATPase activity in NaF was associated with increased phospholamban phosphorylation. Phosphatase inhibitors were used in tissue homogenisation to determine phospholamban phosphorylation in normal hearts and in cardiac hypertrophy induced by abdominal aortic constriction. In 50 mM NaF which completely inhibits endogenous phosphatases, phospholamban from hypertrophied hearts had a slower mobility compared with normal hearts. This suggests that phospholamban was more highly phosphorylated in cardiac hypertrophy. Increased phospholamban phosphorylation following cardiac hypertrophy may enable the myocardium to compensate functionally in the early stages of adaptation.
We introduce the Korea Institute of Science and Technology-Novel Materials Discovery (KISTNOMAD) ... more We introduce the Korea Institute of Science and Technology-Novel Materials Discovery (KISTNOMAD) platform, a materials data repository. We describe its functionality and novel features from an academic viewpoint. It is a data repository designed for computational material science, especially focusing on managing and sharing the results of molecular dynamics simulation results as well as quantum mechanical computations. It consists of three main components: a database, file storage, and web-based front end. The database hosts material properties, which are extracted from the computational results. The front end has a graphical user interface and an open application programming interface, which allow researchers to interact with the system more easily. KIST-NOMAD’s panel displays the searched results on a well-organized and research-oriented web page. All the open access data and files are available for downloading in comma-separated value format as well as zipped archives. This autom...
Soil moisture content is one of the factors that controls the infiltration capacity of soils. Pre... more Soil moisture content is one of the factors that controls the infiltration capacity of soils. Precipitation and irrigation increase soil moisture which in turn reduces infiltration capacity. This results in increased runoff during subsequent storm events. Increased stormwater runoff may cause adverse environmental problems such as increased soil erosion, increased bed and suspended loads in streams, and increased non-point source
A two‐dimensional probabilistic transport model is developed‐by coupling a reliability algorithm ... more A two‐dimensional probabilistic transport model is developed‐by coupling a reliability algorithm to a two‐dimensional unsaturated flow and transport model. The goal is to determine the significance of the uncertainty of each variable to the probability outcome. Model input includes the mean, standard deviation, and probability distribution of each uncertain variable. The uncertain variables are assumed to be uncorrelated to each other. The uncertain variables are saturated water content, residual water content, van Genuchten model parameters alpha (α) and n, saturated hydraulic conductivity, bulk density, coefficient of distribution, molecular diffusion coefficient, and dispersivity. Coefficient of variation is used as the measure of uncertainty for each uncertain variable. Three soil samples are considered for model simulations. One half of the flow surface area is the source of a generic contaminant spill. The reliability analysis determines the probability of exceeding a specific...
Biochemical and Biophysical Research Communications, 1997
The activity of the sarcoplasmic reticulum (SR) CaATPase in cardiac muscle is regulated by phosph... more The activity of the sarcoplasmic reticulum (SR) CaATPase in cardiac muscle is regulated by phospholamban via its ability to be phosphorylated. It is unclear what role phospholamban phosphorylation plays in cardiac adaptation and disease. The study of the native phospholamban phosphorylation in tissue has been technically difficult because of the presence of endogenous enzymes. Using mobility shifts on SDS PAGE gels we have demonstrated that significant dephosphorylation of phospholamban occurs during tissue homogenisation in the absence of phosphatase inhibitors. Endogenous kinases do not appear to alter phospholamban phosphorylation. When 10 mM NaF (a phosphatase inhibitor) was used in the preparation of crude SR homogenates, CaATPase activity (measured by oxalate stimulated calcium uptake) was stimulated almost 2 fold, p < 0.01. Increased CaATPase activity in NaF was associated with increased phospholamban phosphorylation. Phosphatase inhibitors were used in tissue homogenisation to determine phospholamban phosphorylation in normal hearts and in cardiac hypertrophy induced by abdominal aortic constriction. In 50 mM NaF which completely inhibits endogenous phosphatases, phospholamban from hypertrophied hearts had a slower mobility compared with normal hearts. This suggests that phospholamban was more highly phosphorylated in cardiac hypertrophy. Increased phospholamban phosphorylation following cardiac hypertrophy may enable the myocardium to compensate functionally in the early stages of adaptation.
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