Patient populations, including those with hematological malignancies, have different responses to... more Patient populations, including those with hematological malignancies, have different responses to COVID-19 vaccines. This study aimed to quantitatively analyze the efficacy and safety of COVID-19 mRNA vaccines in patients with hematological malignancies. Studies reporting on the efficacy and safety of COVID-19 mRNA vaccines in cohorts with hematological malignancies compared to healthy controls were systematically searched in four databases. Meta-analysis and subgroup analyses were performed to generate quantitative synthesis. Fifteen studies with 2,055 cohorts with hematological malignancies and 1,105 healthy subjects as control were included. After two doses of COVID-19 vaccination, only 60% of cohorts with hematological malignancies were seroconverted compared to healthy controls (RR 0.60; 95%CI 0.50–0.71). A single dose of the vaccine resulted in a significantly lower seroconversion rate (RR 0.30; 95%CI 0.16–0.54). Non-Hodgkin lymphoma cohorts had the lowest rate of seroconversi...
Journal of International Dental and Medical Research, 2019
Doxorubicin (DOX) is a chemotherapeutic agent widely used against various cancers. However, its u... more Doxorubicin (DOX) is a chemotherapeutic agent widely used against various cancers. However, its usage is linked to cardiotoxicity side effects via production of reactive oxygen species, causing oxidative stress and cardiac myocyte death. L-Citrulline (CIT) is a potent anti-oxidant agent with potential to prevent DOX-induced cardiotoxicity. This study analyzed the effect of CIT against DOXinduced cardiotoxicity using oxidative stress biomarkers. Administration of DOX (intraperitoneal injection) was performed to induce cardiotoxicity in 20 Wistar rats, divided into 4 groups. Two doses (300 and 600 mg/kg of body weight) of CIT were administered via gavage prior to, during, and after DOX injection. Serum levels of glutathione (GSH) and malondialdehyde (MDA) were measured using colorimetric analysis. Both doses of CIT increase slightly the concentration of GSH (P=.063 vs. control). The concentration of MDA was also increased in the low-dose (P=0.103), and highdose groups (P<0.001). Th...
Proposal Skripsi Berbasis Karya yang berjudul “Eksplorasi 360 Derajat Jakarta dan Palembang dalam... more Proposal Skripsi Berbasis Karya yang berjudul “Eksplorasi 360 Derajat Jakarta dan Palembang dalam Asian Games 2018” ini merupakan hasil riset yang telah dilakukan oleh penulis pada saat menjadi bagian dalam ajang olahraga Asian Games 2018. Terdapat beberapa teori yang berkaitan seperti Teori Interaktivitas, Teori Interactive Multimedia Storytelling, Media Online, Mobile Website, Teori Immersive , Teori Kamera 360, dan Teori Drone. Penggunaan kamera 360 derajat dapat menjadi inovasi dan bentuk baru bagi produk jurnalistik yang masih belum populer di Indonesia. Immersive jurnaslime dapat memberikan pengalaman pengguna untuk merasakan seakan-akan berada di tengah venue Asian Games. Dalam proposal ini, nantinya akan dijelaskan bagiaman proses produksi konten untuk Interactive Multimedia Story-telling dan apa saja halangan yang dirasakan oleh penulis selama proses produksi berlangsung.
Dalam sistem pemerintahan presidensial tidak mengenal pemisahan antara kepala negara dengan kepal... more Dalam sistem pemerintahan presidensial tidak mengenal pemisahan antara kepala negara dengan kepala pemerintahan. Hal ini menjadikan kedudukan Presiden sangat sentral dan kuat. Mahkamah Konstitusi menjadikan dasar ini untuk memberikan kewenangan kepada Presiden terkait izin atau persetujuan tertulisnya kepada DPR yang diduga melakukan tindak pidana. Selanjutnya Pertama, perlu dikaji pertimbangan Mahkamah Konsitusi apakah sudah tepat untuk memberikan kewenangan kepada Presiden terkait izin atau persetujuannya kepada anggota DPR yang diduga melakukan tindak pidana. Kedua, bagaimanakah Presiden dapat mengobjektifikasikan kewenangannya dalam meneribitkan izin atau persetujuannya.
International Journal of Applied Pharmaceutics, 2019
Objective: Alcohol accumulation in the liver can cause pathological disorders such as liver fibro... more Objective: Alcohol accumulation in the liver can cause pathological disorders such as liver fibrosis that can develop into hepatocellular carcinoma,one of the main causes of mortality associated with liver disease. The previous studies have shown that a plant compound, alpha-mangostin, has anantioxidant effect in the inhibition of pancreatic tumor growth in vitro. This study aimed to analyze the antioxidative properties of alpha-mangostin inacetaldehyde-induced liver fibrosis in vitro.Methods: Immortalized hepatic stellate cells (HSCs), of the LX-2 cell line, were incubated with acetaldehyde in the presence or absence of alphamangostin(10 and 20 μM). The cells were then counted and lysed, and LX-2 cell viability was determined with the trypan blue exclusion method. Themalondialdehyde levels, superoxide dismutase activity, and glutathione (GSH) levels were also determined using the cell lysates.Results: Acetaldehyde treatment resulted in a significant increase in HSC cell viability a...
... PT Sarang Imitasi bergerak di bidang supplier aksesoris mainan untuk produk snack (sebagai fo... more ... PT Sarang Imitasi bergerak di bidang supplier aksesoris mainan untuk produk snack (sebagai fokus utama), stationery (alat-alat tulis, tas sekolah, dan sebagainya), produk elektronik (jamtangan, radio mini, dan ... Pelanggan dapat memperoleh informasi dan harga produk dari ...
Patient populations, including those with hematological malignancies, have different responses to... more Patient populations, including those with hematological malignancies, have different responses to COVID-19 vaccines. This study aimed to quantitatively analyze the efficacy and safety of COVID-19 mRNA vaccines in patients with hematological malignancies. Studies reporting on the efficacy and safety of COVID-19 mRNA vaccines in cohorts with hematological malignancies compared to healthy controls were systematically searched in four databases. Meta-analysis and subgroup analyses were performed to generate quantitative synthesis. Fifteen studies with 2,055 cohorts with hematological malignancies and 1,105 healthy subjects as control were included. After two doses of COVID-19 vaccination, only 60% of cohorts with hematological malignancies were seroconverted compared to healthy controls (RR 0.60; 95%CI 0.50–0.71). A single dose of the vaccine resulted in a significantly lower seroconversion rate (RR 0.30; 95%CI 0.16–0.54). Non-Hodgkin lymphoma cohorts had the lowest rate of seroconversi...
Journal of International Dental and Medical Research, 2019
Doxorubicin (DOX) is a chemotherapeutic agent widely used against various cancers. However, its u... more Doxorubicin (DOX) is a chemotherapeutic agent widely used against various cancers. However, its usage is linked to cardiotoxicity side effects via production of reactive oxygen species, causing oxidative stress and cardiac myocyte death. L-Citrulline (CIT) is a potent anti-oxidant agent with potential to prevent DOX-induced cardiotoxicity. This study analyzed the effect of CIT against DOXinduced cardiotoxicity using oxidative stress biomarkers. Administration of DOX (intraperitoneal injection) was performed to induce cardiotoxicity in 20 Wistar rats, divided into 4 groups. Two doses (300 and 600 mg/kg of body weight) of CIT were administered via gavage prior to, during, and after DOX injection. Serum levels of glutathione (GSH) and malondialdehyde (MDA) were measured using colorimetric analysis. Both doses of CIT increase slightly the concentration of GSH (P=.063 vs. control). The concentration of MDA was also increased in the low-dose (P=0.103), and highdose groups (P<0.001). Th...
Proposal Skripsi Berbasis Karya yang berjudul “Eksplorasi 360 Derajat Jakarta dan Palembang dalam... more Proposal Skripsi Berbasis Karya yang berjudul “Eksplorasi 360 Derajat Jakarta dan Palembang dalam Asian Games 2018” ini merupakan hasil riset yang telah dilakukan oleh penulis pada saat menjadi bagian dalam ajang olahraga Asian Games 2018. Terdapat beberapa teori yang berkaitan seperti Teori Interaktivitas, Teori Interactive Multimedia Storytelling, Media Online, Mobile Website, Teori Immersive , Teori Kamera 360, dan Teori Drone. Penggunaan kamera 360 derajat dapat menjadi inovasi dan bentuk baru bagi produk jurnalistik yang masih belum populer di Indonesia. Immersive jurnaslime dapat memberikan pengalaman pengguna untuk merasakan seakan-akan berada di tengah venue Asian Games. Dalam proposal ini, nantinya akan dijelaskan bagiaman proses produksi konten untuk Interactive Multimedia Story-telling dan apa saja halangan yang dirasakan oleh penulis selama proses produksi berlangsung.
Dalam sistem pemerintahan presidensial tidak mengenal pemisahan antara kepala negara dengan kepal... more Dalam sistem pemerintahan presidensial tidak mengenal pemisahan antara kepala negara dengan kepala pemerintahan. Hal ini menjadikan kedudukan Presiden sangat sentral dan kuat. Mahkamah Konstitusi menjadikan dasar ini untuk memberikan kewenangan kepada Presiden terkait izin atau persetujuan tertulisnya kepada DPR yang diduga melakukan tindak pidana. Selanjutnya Pertama, perlu dikaji pertimbangan Mahkamah Konsitusi apakah sudah tepat untuk memberikan kewenangan kepada Presiden terkait izin atau persetujuannya kepada anggota DPR yang diduga melakukan tindak pidana. Kedua, bagaimanakah Presiden dapat mengobjektifikasikan kewenangannya dalam meneribitkan izin atau persetujuannya.
International Journal of Applied Pharmaceutics, 2019
Objective: Alcohol accumulation in the liver can cause pathological disorders such as liver fibro... more Objective: Alcohol accumulation in the liver can cause pathological disorders such as liver fibrosis that can develop into hepatocellular carcinoma,one of the main causes of mortality associated with liver disease. The previous studies have shown that a plant compound, alpha-mangostin, has anantioxidant effect in the inhibition of pancreatic tumor growth in vitro. This study aimed to analyze the antioxidative properties of alpha-mangostin inacetaldehyde-induced liver fibrosis in vitro.Methods: Immortalized hepatic stellate cells (HSCs), of the LX-2 cell line, were incubated with acetaldehyde in the presence or absence of alphamangostin(10 and 20 μM). The cells were then counted and lysed, and LX-2 cell viability was determined with the trypan blue exclusion method. Themalondialdehyde levels, superoxide dismutase activity, and glutathione (GSH) levels were also determined using the cell lysates.Results: Acetaldehyde treatment resulted in a significant increase in HSC cell viability a...
... PT Sarang Imitasi bergerak di bidang supplier aksesoris mainan untuk produk snack (sebagai fo... more ... PT Sarang Imitasi bergerak di bidang supplier aksesoris mainan untuk produk snack (sebagai fokus utama), stationery (alat-alat tulis, tas sekolah, dan sebagainya), produk elektronik (jamtangan, radio mini, dan ... Pelanggan dapat memperoleh informasi dan harga produk dari ...
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