Journal of KIISE:Computing Practices and Letters, 2011
To provide users location-based services in a safe way, a scheme for user location protection is ... more To provide users location-based services in a safe way, a scheme for user location protection is required. But existing work has a problem of disclosing users' locations in case of continuous query processing. To solve the problem, we, in this paper, propose a new location anonymization scheme to support continuous query processing in road network. For this, we define the level of privacy protection in order to reduce the probability of user location disclosure for continuous query processing. By using it, we can support privacy protection to a higher level than threshold. Finally, we show from a performance analysis that our scheme outperforms existing work in terms of cloaking area creation time and the number of its successes.
2019 26th International Workshop on Active-Matrix Flatpanel Displays and Devices (AM-FPD), 2019
The device characteristics and reliability of the In-Ga-Zn-O (IGZO) TFTs employing the HfO2 gate ... more The device characteristics and reliability of the In-Ga-Zn-O (IGZO) TFTs employing the HfO2 gate insulator prepared by atomic-layer deposition (ALD) at a temperature as low as 150°C were investigated. The leakage current density and the dielectric constant for this HfO2 thin film were obtained to be 3.8×10−7 A/cm2 and 22, respectively. The IGZO TFT showed a saturation mobility of 6.8 cm2/Vs and a subthreshold swing of 0.26 V/dec. Under the positive bias stress condition, the threshold voltage shift was evaluated to be less than −0.19 V.
Oxide thin films transistors (TFTs) with Hf and Al co-incorporated ZnO active channels prepared b... more Oxide thin films transistors (TFTs) with Hf and Al co-incorporated ZnO active channels prepared by atomic-layer deposition are presented.
Clinical and experimental rheumatology, Jan 18, 2016
The goal of this study was to investigate whether microRNA-155 might be a potential therapeutic t... more The goal of this study was to investigate whether microRNA-155 might be a potential therapeutic target for Behçet's disease (BD). Expression levels of miR-155 were quantified using TaqMan microRNA assays in peripheral blood mononuclear cells and in isolated CD4+ T cells from BD patients and healthy controls. To identify targets of miR-155, luciferase reporter assays and western blotting were performed. The effect of miR-155 on Th17 polarisation was analysed in patients with active BD by using flow cytometry and enzyme-linked immunosorbent assay. The expression of miR-155 and IL-17 was significantly increased in CD4+ T cells of patients with active BD. A luciferase reporter assay and western blot showed that Ets-1 expression was reduced by miR-155 mimics. Furthermore, the expression of Ets-1 was significantly decreased in patients with active BD compared to healthy controls. More importantly, repression of miR-155 in CD4+ T cells from active BD patients increased Ets-1 expression...
Journal of pediatric gastroenterology and nutrition, 2015
To investigate the genetic polymorphisms of the autophagy associated genes ATG16L1, IRGM, ULK1, a... more To investigate the genetic polymorphisms of the autophagy associated genes ATG16L1, IRGM, ULK1, and NOD2 with respect to early-onset Crohn disease (CD) among Korean children. Sixty-five CD patients from Seoul National University Children's Hospital, from January 2000 to May 2012, and 72 unaffected controls were selected. Twelve different single nucleotide polymorphisms (SNPs) were analyzed [Taqman assay: ATG16L1 rs2241880, IRGM SNPs (rs13361189, rs4958847, rs1000113, rs10065172, rs72553867), ULK1 SNPs (rs12303764, rs10902469, rs7488085), NOD2 SNPs (Arg702Trp, Gly908Arg); direct sequencing: NOD2 leu1007fsinsC]. The onset age of patients was 8.6 ± 4.7 years. Twelve patients (18.5%) had an onset age of <1 year. Two of the 12 SNPs showed significant results. IRGM rs1000113 exhibited an association with CD with respect to its minor allele frequency (OR 1.71, 95% CI 1.05-2.79, p = 0.03) and genotype distribution (dominant model: OR 2.17, 95% CI 1.07-4.39, p = 0.03). IRGM rs72553867...
Eccrine angiomatous hamartoma (EAH) is a rare benign disease that is characterized by an abnormal... more Eccrine angiomatous hamartoma (EAH) is a rare benign disease that is characterized by an abnormal proliferation of eccrine glands and vascular elements. It is generally congenital, but it can appear before puberty. It usually presents as a single plaque or nodule, but multiple patch-like lesions are also possible. EAH is mostly asymptomatic, but it is sometimes associated with pain or hyperhidrosis. It generally does not require aggressive treatment, but the lesion can be excised due to pain, enlargement and cosmetic reasons. A 3-week-old Korean female presented with a hemorrhagic skin lesion on the right foot since birth. There was no specific birth history. The lesion first appeared on the third toe of the right foot and quickly spread to almost half of the right foot. Histopathology examination revealed acanthosis in the epidermis and a proliferation of eccrine ducts, glands and capillaries. The eccrine glands were immunohistochemically-positive for carcinoembryonic antigen.
Blue nevi are characterized by a collection of pigment-producing melanocytes in the dermis. These... more Blue nevi are characterized by a collection of pigment-producing melanocytes in the dermis. These lesions clinically present as well demarcated cerulean-blue or bluish black colored papules or plaques that usually measure less than 1 cm in diameter. They are typically found on the dorsal surface of the hands and feet or in the head and neck region; however, they are rarely found in the oral cavity. These lesions are usually benign and stable over time. However, malignant melanomas developing in or associated with a blue nevus (which is also called malignant blue nevus) have been only rarely reported. A malignant blue nevus might develop in a common blue or cellular blue nevus, a giant congenital nevus or in a nevus of Ota, or it may be malignant from the start. Malignant blue nevi most commonly are found on the scalp. A malignant blue nevus of the lip has not been previously reported in the medical literature. We report here on a patient with a malignant melanoma associated with a b...
The IL-23/IL-17 pathway is implicated in the development of certain inflammatory diseases. The ai... more The IL-23/IL-17 pathway is implicated in the development of certain inflammatory diseases. The aim of the present study was to investigate the expression of Th17 and related cytokines according to clinical activity in Behçet's disease (BD). Peripheral blood mononuclear cells (PBMCs) from eleven patients with active BD, eleven patients with inactive BD, ten patients with recurrent aphthous ulcers, and ten healthy controls were cultured and stained with the appropriate fluorescent antibodies for analysis by flow cytometry. ELISA assays were utilized to determine the concentrations of IL-17, IFN-γ, IL-23, and IL-12/23p40 in serum and culture supernatants. IL-12p35, IL-12/23p40, and IL-23p19 transcript levels in PBMCs were measured by real-time PCR. Significantly higher frequencies of IL-17 and IFN-γ expressing CD4(+) T cells were observed in patients with active BD compared with control groups. Similarly, levels of IL-17, IL-23, IL-12/23p40, and IFN-γ in serum and supernatants were...
Journal of KIISE:Computing Practices and Letters, 2011
To provide users location-based services in a safe way, a scheme for user location protection is ... more To provide users location-based services in a safe way, a scheme for user location protection is required. But existing work has a problem of disclosing users' locations in case of continuous query processing. To solve the problem, we, in this paper, propose a new location anonymization scheme to support continuous query processing in road network. For this, we define the level of privacy protection in order to reduce the probability of user location disclosure for continuous query processing. By using it, we can support privacy protection to a higher level than threshold. Finally, we show from a performance analysis that our scheme outperforms existing work in terms of cloaking area creation time and the number of its successes.
2019 26th International Workshop on Active-Matrix Flatpanel Displays and Devices (AM-FPD), 2019
The device characteristics and reliability of the In-Ga-Zn-O (IGZO) TFTs employing the HfO2 gate ... more The device characteristics and reliability of the In-Ga-Zn-O (IGZO) TFTs employing the HfO2 gate insulator prepared by atomic-layer deposition (ALD) at a temperature as low as 150°C were investigated. The leakage current density and the dielectric constant for this HfO2 thin film were obtained to be 3.8×10−7 A/cm2 and 22, respectively. The IGZO TFT showed a saturation mobility of 6.8 cm2/Vs and a subthreshold swing of 0.26 V/dec. Under the positive bias stress condition, the threshold voltage shift was evaluated to be less than −0.19 V.
Oxide thin films transistors (TFTs) with Hf and Al co-incorporated ZnO active channels prepared b... more Oxide thin films transistors (TFTs) with Hf and Al co-incorporated ZnO active channels prepared by atomic-layer deposition are presented.
Clinical and experimental rheumatology, Jan 18, 2016
The goal of this study was to investigate whether microRNA-155 might be a potential therapeutic t... more The goal of this study was to investigate whether microRNA-155 might be a potential therapeutic target for Behçet's disease (BD). Expression levels of miR-155 were quantified using TaqMan microRNA assays in peripheral blood mononuclear cells and in isolated CD4+ T cells from BD patients and healthy controls. To identify targets of miR-155, luciferase reporter assays and western blotting were performed. The effect of miR-155 on Th17 polarisation was analysed in patients with active BD by using flow cytometry and enzyme-linked immunosorbent assay. The expression of miR-155 and IL-17 was significantly increased in CD4+ T cells of patients with active BD. A luciferase reporter assay and western blot showed that Ets-1 expression was reduced by miR-155 mimics. Furthermore, the expression of Ets-1 was significantly decreased in patients with active BD compared to healthy controls. More importantly, repression of miR-155 in CD4+ T cells from active BD patients increased Ets-1 expression...
Journal of pediatric gastroenterology and nutrition, 2015
To investigate the genetic polymorphisms of the autophagy associated genes ATG16L1, IRGM, ULK1, a... more To investigate the genetic polymorphisms of the autophagy associated genes ATG16L1, IRGM, ULK1, and NOD2 with respect to early-onset Crohn disease (CD) among Korean children. Sixty-five CD patients from Seoul National University Children's Hospital, from January 2000 to May 2012, and 72 unaffected controls were selected. Twelve different single nucleotide polymorphisms (SNPs) were analyzed [Taqman assay: ATG16L1 rs2241880, IRGM SNPs (rs13361189, rs4958847, rs1000113, rs10065172, rs72553867), ULK1 SNPs (rs12303764, rs10902469, rs7488085), NOD2 SNPs (Arg702Trp, Gly908Arg); direct sequencing: NOD2 leu1007fsinsC]. The onset age of patients was 8.6 ± 4.7 years. Twelve patients (18.5%) had an onset age of <1 year. Two of the 12 SNPs showed significant results. IRGM rs1000113 exhibited an association with CD with respect to its minor allele frequency (OR 1.71, 95% CI 1.05-2.79, p = 0.03) and genotype distribution (dominant model: OR 2.17, 95% CI 1.07-4.39, p = 0.03). IRGM rs72553867...
Eccrine angiomatous hamartoma (EAH) is a rare benign disease that is characterized by an abnormal... more Eccrine angiomatous hamartoma (EAH) is a rare benign disease that is characterized by an abnormal proliferation of eccrine glands and vascular elements. It is generally congenital, but it can appear before puberty. It usually presents as a single plaque or nodule, but multiple patch-like lesions are also possible. EAH is mostly asymptomatic, but it is sometimes associated with pain or hyperhidrosis. It generally does not require aggressive treatment, but the lesion can be excised due to pain, enlargement and cosmetic reasons. A 3-week-old Korean female presented with a hemorrhagic skin lesion on the right foot since birth. There was no specific birth history. The lesion first appeared on the third toe of the right foot and quickly spread to almost half of the right foot. Histopathology examination revealed acanthosis in the epidermis and a proliferation of eccrine ducts, glands and capillaries. The eccrine glands were immunohistochemically-positive for carcinoembryonic antigen.
Blue nevi are characterized by a collection of pigment-producing melanocytes in the dermis. These... more Blue nevi are characterized by a collection of pigment-producing melanocytes in the dermis. These lesions clinically present as well demarcated cerulean-blue or bluish black colored papules or plaques that usually measure less than 1 cm in diameter. They are typically found on the dorsal surface of the hands and feet or in the head and neck region; however, they are rarely found in the oral cavity. These lesions are usually benign and stable over time. However, malignant melanomas developing in or associated with a blue nevus (which is also called malignant blue nevus) have been only rarely reported. A malignant blue nevus might develop in a common blue or cellular blue nevus, a giant congenital nevus or in a nevus of Ota, or it may be malignant from the start. Malignant blue nevi most commonly are found on the scalp. A malignant blue nevus of the lip has not been previously reported in the medical literature. We report here on a patient with a malignant melanoma associated with a b...
The IL-23/IL-17 pathway is implicated in the development of certain inflammatory diseases. The ai... more The IL-23/IL-17 pathway is implicated in the development of certain inflammatory diseases. The aim of the present study was to investigate the expression of Th17 and related cytokines according to clinical activity in Behçet's disease (BD). Peripheral blood mononuclear cells (PBMCs) from eleven patients with active BD, eleven patients with inactive BD, ten patients with recurrent aphthous ulcers, and ten healthy controls were cultured and stained with the appropriate fluorescent antibodies for analysis by flow cytometry. ELISA assays were utilized to determine the concentrations of IL-17, IFN-γ, IL-23, and IL-12/23p40 in serum and culture supernatants. IL-12p35, IL-12/23p40, and IL-23p19 transcript levels in PBMCs were measured by real-time PCR. Significantly higher frequencies of IL-17 and IFN-γ expressing CD4(+) T cells were observed in patients with active BD compared with control groups. Similarly, levels of IL-17, IL-23, IL-12/23p40, and IFN-γ in serum and supernatants were...
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