International Journal of Corrosion and Scale Inhibition
In this work, two epoxy compounds, namely: diglycidyl ether ethylene (DGEE) and diglycidyl ether ... more In this work, two epoxy compounds, namely: diglycidyl ether ethylene (DGEE) and diglycidyl ether benzene (DGEB) were evaluated as corrosion inhibitors for C38 steel in 1 M HCl medium. This assessment was performed using electrochemical stationary and transiency, density functional theory (DFT) methods, Monte Carlo, and molecular dynamic simulations. Moreover, the surface of the C38 steel before and after the corrosion test was examined using scanning electron microscopy (SEM). The inhibitory performance of both compounds is enhanced by increasing the concentration of the inhibitors tested, we obtained the most efficiency with an optimal concentration of 5 mM of the inhibitors used. This study permitted to survey the evolution of the inhibitory effect of the two epoxy compounds and show that these inhibitors act as mixed-type inhibitors delaying the rate of anodic and cathodic reactions. Their adsorption isotherms are Langmuir type and primary mechanisms involve physical adsorption. Also, the SEM study confirmed that corrosion inhibition of C38 steel occurs by adsorption of inhibiting molecules on the metal surface, which makes a barrier against corrosion of the latter. The Quantum chemical calculations confirmed the obtained experimental results.
In this work, the effect of a synthesised organic molecule containing heteroatoms such as nitroge... more In this work, the effect of a synthesised organic molecule containing heteroatoms such as nitrogen and sulphur on the corrosion behaviour of iron was investigated. Electrochemical studies of the iron samples were performed in an aerated solution of 1M HCl by means of electrochemical impedance spectroscopy as well as polarisation curves.The recorded electrochemical data showed that the corrosion resistance was
Simple, fast, and inexpensive electroanalytical procedures were developed for the determination o... more Simple, fast, and inexpensive electroanalytical procedures were developed for the determination of codeine (COD) solely and paracetamol (PCT) and COD simultaneously in pharmaceutical formulations and human body fluids. The methods involve the combination of square-wave voltammetry (SWV) with a cathodically pretreated boron-doped diamond electrode and a 0.2 mol L -1 acetate buffer (pH 4.0) solution as the supporting electrolyte. Significantly low limits of detection were obtained for COD solely or PCT and COD simultaneously: 1.19 or 18 and 14 nmol L -1 , respectively. The proposed SWV method was successfully applied in the simultaneous determination of PCT and COD in four samples of pharmaceutical tablets, with results similar (at 98% confidence level) to those obtained using a reference high-performance liquid chromatography (HPLC) method. Additionally, adequate results were obtained when concentrations of PCT and COD were determined in human urine or serum samples by addition-recovery. Clearly, the proposed method is an excellent option for the determination of COD solely or PCT and COD simultaneously.
L'objet de ce travail est d'etudier l'effet des ions sulfures sur la resistance a la ... more L'objet de ce travail est d'etudier l'effet des ions sulfures sur la resistance a la corrosion d'aciers inoxydables speciaux (z2 cndu 25-25, z2 ncdu 25-20, z2 cndu 25-6, z1 cn 25-20 et z1 cd 29-4) en milieux phosphoriques proche des milieux industriels et preciser le role des differents elements d'alliages. Les resultats obtenus montre que l'addition des ions sulfures se manifeste par une augmentation de la vitesse de corrosion des alliages etudies sauf dans le cas de l'acier sans nickel z1 cd 29-4 pour lequel ce phenomene n'a pas ete observe. Pour des concentrations assez elevees, les sulfures empechent l'etablissement de la passivite. La presence simultanee des ions sulfures et d'autres impuretes (c1#-, f#-) accentue d'une facon important l'attaque du materiau. Cette agressivite est diminuee par la presence des ions oxydants. En ce qui concerne les mecanismes reactionnels, les diagrammes d'impedance electrochimique ont permis de mettre en evidence la presence d'un phenomene de diffusion probablement a travers les pores de la couche des produits de corrosion. Des analyses de surface (esca, ir, sims, eds) montrent que les films formes en presence des sulfures contiennent des sulfures metalliques en fortes proportions et des oxy-hydroxydes de fer et de chrome. En milieu pollue par des sulfures, le role protecteur des couches est altere par la presence des sulfures metalliques, et notamment des sulfures de nickel. Contrairement au nickel, la presence de chrome et de molybdene en fortes proportions est essentielle pour augmenter la resistance a la corrosion des aciers inoxydables dans ces milieux
e rapid growth of anthropogenic activities in recent decades has resulted in the appearance of nu... more e rapid growth of anthropogenic activities in recent decades has resulted in the appearance of numerous new chemical compounds in the environment, known as "emerging pollutants" (EPs) or "contaminants of emerging concern" (CECs). Although partially or not yet regulated or monitored, there is growing research interest in these EPs among the scientific community because of their bioaccumulation, persistence, and adverse effects. Among these, endocrine disruptors, pesticides, and pharmaceuticals can have harmful impacts on human health and the ecosystem. Conventional wastewater treatment technologies are not effective in removing these contaminants, allowing them to be released into the receiving environment. In order to improve the understanding of emerging pollutants, this review discusses the source, occurrence, and impacts of bisphenol A, atrazine, amoxicillin, and paracetamol as model molecules of emerging environmental pollutants, an issue that remains underrepresented in Morocco. en, treatment methods for EPs are reviewed, including adsorption, advanced oxidation processes, biodegradation, and hybrid treatment. It is proposed that adsorption and photocatalysis can be used as simple, effective, and environmentally friendly technologies for their removal. us, we summarize some of the adsorbent and photocatalyst materials applied in recent work to control these pollutants. Towards the end of this paper, the development of inexpensive and locally available (Morocco) materials to remove these compounds from wastewater is considered.
The Journal of Microbiology, Biotechnology and Food Sciences, Jun 2, 2022
This work aims to determine the antioxidant, antibacterial properties and chemical profile of the... more This work aims to determine the antioxidant, antibacterial properties and chemical profile of the essential oil (EO) of Lavandula multifida (LM) at the flowering stage collected in northwestern Morocco. So far, information on essential oils of L. multifida remains limited. The extraction yield of the essential oil was 0.46%. The composition was determined by GC-MS-FID. Twenty compounds were identified and the major phytochemicals were carvacrol, ß-bisabolene, and careophyllene oxide (44.3%, 31.9%, and 5.8% respectively). In addition, information on the essential oil of L. multifida collected in the Rabat region is reported for the first time in this study. DPPH and FRAP tests were used to evaluate its antioxidant activity. Antibacterial activities were also studied. Indeed, the essential oil of L. multifida exhibited inhibition effects on the growth of various microorganisms, including S. aureus where the MIC and MBC were equal to 0.5 and 2μg/ml, respectively. Therefore, the use of Lavandula multifida essential oil shows great promise in various fields.
Science and Technology of Advanced Materials, 2005
Conversion coating modified by alumina has been studied as a way for improving the resistance to ... more Conversion coating modified by alumina has been studied as a way for improving the resistance to thermal oxidation of an austenitic stainless steel. Conversion coating, characterized by a particular morphology and strong interfacial adhesion with the substrate, facilitate the electrochemical deposition of ceramic layers and enhance their adhesion to the substrate. The influence of the current density and treatment time on alumina deposit was studied using statistical experimental designs like Doehlert uniform shell design. After heating, coatings present a continuous composition gradient with refractory compounds at the surface. The behavior at high temperature (1000 8C) of the alumina coating was investigated. The presence of alumina increases the oxidation resistance of an austenitic stainless steel at 1000 8C. The morphology and the chemical composition of the deposit are analyzed. Results on the thermal stability of coating on austenitic stainless steel are presented.
Abstract Emergence and spread of corona virus disease 2019 (COVID-19), caused by severe respirato... more Abstract Emergence and spread of corona virus disease 2019 (COVID-19), caused by severe respiratory syndrome coronavirus, is considered a public health emergency threatening global health systems, as of June, 2020, It caused a cumulative total of 9,033,423 confirmed cases and more than 469,539 deaths across 215 countries, person to-person transmission has being identified as the route for spreading. So far, the lack of effective vaccines for the treatment or prevention of Covid-19 has further worsened the situation. In this context, the present study aims to assess whether naturally occurring components have an antiviral effect via a computational modeling approach. Density Functional theory (DFT) was performed to estimate the kinetic parameters, frontier molecular orbitals, molecular electrostatic potential as well as chemical reactivity descriptors of various ligands. The results revealed that Crocin and Digitoxigenin exhibited a potential applicant with the lowest resistance to electronic charge transfer with a chemical hardness of 2.19eV and 2.96eV respectively, as well as the lowest HOMO-LUMO difference. In addition to the DFT calculation, a docking simulation study was conducted on the SARS-CoV-2 base protease (PDB: 6LU7) to determine the binding affinity of ligands. The findings show that Crocin exhibits the lowest binding energy of -8.1 Kcal/mol and may be a good inhibitor of CoV-2-SARS compared to hydroxychloroquine and chloroquine, which have a binding affinity of -5.4 and -4.9 Kcal/mol, respectively. The high binding affinity of L3 was assigned to the existence of 14 hydrogen bonds connecting the ligand to the critical amino acid residues of the receptor.
The removal of imazapyr pesticide from aqueous solutions, using amacroporous natural phosphate ro... more The removal of imazapyr pesticide from aqueous solutions, using amacroporous natural phosphate rock (PR)as adsorbent, is studied. The adsorption equilibrium, isotherms and kinetics for imazapyr are studied and the data was fitted into various mathematical models and Langmuir and Freundlich isotherms. Experiments performed by the batch method showed that the sorption process occurs by a monolayer deposition of imazapyr pesticide according to a second order reaction.
Bulletin de la Société royale des sciences de Liège, 2015
In this paper, we studied the effect of oxidation pre-treatment on the activation behavior of lig... more In this paper, we studied the effect of oxidation pre-treatment on the activation behavior of lignin char. We followed the evolution of mass loss, of the elemental composition, of the microstructure and dimensional variations accompanying the lignin char during activation with CO2, during pre-oxidation by air and during activation preceded by oxidation. The preoxidation is a treatment carried out in air from ambient up to 245 °C. The duration of this pretreatment is set at 6 hours. Beyond 140 °C, we have seen that there is a relationship between the mass loss and the carbon content on the one hand, and between the dimensional variations and the oxygen content on the other hand. In so far as the carbon content decreases while that of oxygen increases, the coal would undergo partial oxidation accompanied by a fixation of oxygen. At 245 °C, the carbon content decreased by 10 %, that of oxygen was increased to 45 %. Under these conditions, the sample has evolved from a thermoplastic behaviour to a thermosetting behaviour. The pre-oxidised coal reacts more than the non oxidised coal during the CO2 activation whereas the reduction in volume in the first case is smaller than in the second one. Compared to the non oxidised coal, the pre-oxidised and then activated carbon, by the microscopic characterization, shows the formation and the development of microporosity at the expense of macroporosity.
Morocco's prickly pear has high economic value. However, it’s infected by the cochineal Dacty... more Morocco's prickly pear has high economic value. However, it’s infected by the cochineal Dactylopius opuntiae, causing massive losses. Thus, the present work aims to study insecticidal effect of bioactive natural extracts. Essential oils and hydrosols of oregano (Origanum vulgare), thyme (Thymus vulgaris), pennyroyal (Mentha pulegium) and peppermint (Mentha piperita) were tested. Two concentrations were used for essential oils (1.5% and 3%) and for hydrosols (100% and 75%) with contact and fumigant application. Mortality rate was determined after 24h of treatment. Highest values were recorded at 3% E.O concentration with contact assay comparing to fumigation. As it’s EO (99.44%), O. vulgare hydrosol has significant insecticidal activity reaching 80% of mortality rate. Chemical composition of essential oils using Gas Chromatography coupled to Mass Spectrometry (GC/MS) was studied. Bioactive compounds include carvacrol and m-cymene (O. vulgare and T. vulgaris), pulegone and l-menth...
Capparis spinosa L., commonly known as the caper bush, is a spiny shrub known for its edible flow... more Capparis spinosa L., commonly known as the caper bush, is a spiny shrub known for its edible flower buds and its use as a medicinal plant in traditional medicine. While performing bio-guided isolation of active compounds from Capparis spinosa L. leaves and buds, large amounts of bis(2-ethylhexyl) terephthalate (DEHT, a.k.a. dioctyl terephthalate or DOTP) and bis(2-ethylhexyl) phthalate (DEHP) were isolated from a fraction from the leaf extract that showed antifungal activity against Cryptococcus neoformans. The structures of these two compounds were confirmed by NMR and mass spectroscopic data, which matched with those from the standards that were purchased from Sigma-Aldrich. DEHT and DEHP are phthalic and terephthalic acid esters, the main plasticizers that are used to confer elasticity and flexibility to various fiber and plastic products. This is the first time DEHT and DEHP have been isolated from the leaves of a plant that is as commonly used as Capparis spinosa L. This study ...
International Journal of Corrosion and Scale Inhibition
In this work, two epoxy compounds, namely: diglycidyl ether ethylene (DGEE) and diglycidyl ether ... more In this work, two epoxy compounds, namely: diglycidyl ether ethylene (DGEE) and diglycidyl ether benzene (DGEB) were evaluated as corrosion inhibitors for C38 steel in 1 M HCl medium. This assessment was performed using electrochemical stationary and transiency, density functional theory (DFT) methods, Monte Carlo, and molecular dynamic simulations. Moreover, the surface of the C38 steel before and after the corrosion test was examined using scanning electron microscopy (SEM). The inhibitory performance of both compounds is enhanced by increasing the concentration of the inhibitors tested, we obtained the most efficiency with an optimal concentration of 5 mM of the inhibitors used. This study permitted to survey the evolution of the inhibitory effect of the two epoxy compounds and show that these inhibitors act as mixed-type inhibitors delaying the rate of anodic and cathodic reactions. Their adsorption isotherms are Langmuir type and primary mechanisms involve physical adsorption. Also, the SEM study confirmed that corrosion inhibition of C38 steel occurs by adsorption of inhibiting molecules on the metal surface, which makes a barrier against corrosion of the latter. The Quantum chemical calculations confirmed the obtained experimental results.
In this work, the effect of a synthesised organic molecule containing heteroatoms such as nitroge... more In this work, the effect of a synthesised organic molecule containing heteroatoms such as nitrogen and sulphur on the corrosion behaviour of iron was investigated. Electrochemical studies of the iron samples were performed in an aerated solution of 1M HCl by means of electrochemical impedance spectroscopy as well as polarisation curves.The recorded electrochemical data showed that the corrosion resistance was
Simple, fast, and inexpensive electroanalytical procedures were developed for the determination o... more Simple, fast, and inexpensive electroanalytical procedures were developed for the determination of codeine (COD) solely and paracetamol (PCT) and COD simultaneously in pharmaceutical formulations and human body fluids. The methods involve the combination of square-wave voltammetry (SWV) with a cathodically pretreated boron-doped diamond electrode and a 0.2 mol L -1 acetate buffer (pH 4.0) solution as the supporting electrolyte. Significantly low limits of detection were obtained for COD solely or PCT and COD simultaneously: 1.19 or 18 and 14 nmol L -1 , respectively. The proposed SWV method was successfully applied in the simultaneous determination of PCT and COD in four samples of pharmaceutical tablets, with results similar (at 98% confidence level) to those obtained using a reference high-performance liquid chromatography (HPLC) method. Additionally, adequate results were obtained when concentrations of PCT and COD were determined in human urine or serum samples by addition-recovery. Clearly, the proposed method is an excellent option for the determination of COD solely or PCT and COD simultaneously.
L'objet de ce travail est d'etudier l'effet des ions sulfures sur la resistance a la ... more L'objet de ce travail est d'etudier l'effet des ions sulfures sur la resistance a la corrosion d'aciers inoxydables speciaux (z2 cndu 25-25, z2 ncdu 25-20, z2 cndu 25-6, z1 cn 25-20 et z1 cd 29-4) en milieux phosphoriques proche des milieux industriels et preciser le role des differents elements d'alliages. Les resultats obtenus montre que l'addition des ions sulfures se manifeste par une augmentation de la vitesse de corrosion des alliages etudies sauf dans le cas de l'acier sans nickel z1 cd 29-4 pour lequel ce phenomene n'a pas ete observe. Pour des concentrations assez elevees, les sulfures empechent l'etablissement de la passivite. La presence simultanee des ions sulfures et d'autres impuretes (c1#-, f#-) accentue d'une facon important l'attaque du materiau. Cette agressivite est diminuee par la presence des ions oxydants. En ce qui concerne les mecanismes reactionnels, les diagrammes d'impedance electrochimique ont permis de mettre en evidence la presence d'un phenomene de diffusion probablement a travers les pores de la couche des produits de corrosion. Des analyses de surface (esca, ir, sims, eds) montrent que les films formes en presence des sulfures contiennent des sulfures metalliques en fortes proportions et des oxy-hydroxydes de fer et de chrome. En milieu pollue par des sulfures, le role protecteur des couches est altere par la presence des sulfures metalliques, et notamment des sulfures de nickel. Contrairement au nickel, la presence de chrome et de molybdene en fortes proportions est essentielle pour augmenter la resistance a la corrosion des aciers inoxydables dans ces milieux
e rapid growth of anthropogenic activities in recent decades has resulted in the appearance of nu... more e rapid growth of anthropogenic activities in recent decades has resulted in the appearance of numerous new chemical compounds in the environment, known as "emerging pollutants" (EPs) or "contaminants of emerging concern" (CECs). Although partially or not yet regulated or monitored, there is growing research interest in these EPs among the scientific community because of their bioaccumulation, persistence, and adverse effects. Among these, endocrine disruptors, pesticides, and pharmaceuticals can have harmful impacts on human health and the ecosystem. Conventional wastewater treatment technologies are not effective in removing these contaminants, allowing them to be released into the receiving environment. In order to improve the understanding of emerging pollutants, this review discusses the source, occurrence, and impacts of bisphenol A, atrazine, amoxicillin, and paracetamol as model molecules of emerging environmental pollutants, an issue that remains underrepresented in Morocco. en, treatment methods for EPs are reviewed, including adsorption, advanced oxidation processes, biodegradation, and hybrid treatment. It is proposed that adsorption and photocatalysis can be used as simple, effective, and environmentally friendly technologies for their removal. us, we summarize some of the adsorbent and photocatalyst materials applied in recent work to control these pollutants. Towards the end of this paper, the development of inexpensive and locally available (Morocco) materials to remove these compounds from wastewater is considered.
The Journal of Microbiology, Biotechnology and Food Sciences, Jun 2, 2022
This work aims to determine the antioxidant, antibacterial properties and chemical profile of the... more This work aims to determine the antioxidant, antibacterial properties and chemical profile of the essential oil (EO) of Lavandula multifida (LM) at the flowering stage collected in northwestern Morocco. So far, information on essential oils of L. multifida remains limited. The extraction yield of the essential oil was 0.46%. The composition was determined by GC-MS-FID. Twenty compounds were identified and the major phytochemicals were carvacrol, ß-bisabolene, and careophyllene oxide (44.3%, 31.9%, and 5.8% respectively). In addition, information on the essential oil of L. multifida collected in the Rabat region is reported for the first time in this study. DPPH and FRAP tests were used to evaluate its antioxidant activity. Antibacterial activities were also studied. Indeed, the essential oil of L. multifida exhibited inhibition effects on the growth of various microorganisms, including S. aureus where the MIC and MBC were equal to 0.5 and 2μg/ml, respectively. Therefore, the use of Lavandula multifida essential oil shows great promise in various fields.
Science and Technology of Advanced Materials, 2005
Conversion coating modified by alumina has been studied as a way for improving the resistance to ... more Conversion coating modified by alumina has been studied as a way for improving the resistance to thermal oxidation of an austenitic stainless steel. Conversion coating, characterized by a particular morphology and strong interfacial adhesion with the substrate, facilitate the electrochemical deposition of ceramic layers and enhance their adhesion to the substrate. The influence of the current density and treatment time on alumina deposit was studied using statistical experimental designs like Doehlert uniform shell design. After heating, coatings present a continuous composition gradient with refractory compounds at the surface. The behavior at high temperature (1000 8C) of the alumina coating was investigated. The presence of alumina increases the oxidation resistance of an austenitic stainless steel at 1000 8C. The morphology and the chemical composition of the deposit are analyzed. Results on the thermal stability of coating on austenitic stainless steel are presented.
Abstract Emergence and spread of corona virus disease 2019 (COVID-19), caused by severe respirato... more Abstract Emergence and spread of corona virus disease 2019 (COVID-19), caused by severe respiratory syndrome coronavirus, is considered a public health emergency threatening global health systems, as of June, 2020, It caused a cumulative total of 9,033,423 confirmed cases and more than 469,539 deaths across 215 countries, person to-person transmission has being identified as the route for spreading. So far, the lack of effective vaccines for the treatment or prevention of Covid-19 has further worsened the situation. In this context, the present study aims to assess whether naturally occurring components have an antiviral effect via a computational modeling approach. Density Functional theory (DFT) was performed to estimate the kinetic parameters, frontier molecular orbitals, molecular electrostatic potential as well as chemical reactivity descriptors of various ligands. The results revealed that Crocin and Digitoxigenin exhibited a potential applicant with the lowest resistance to electronic charge transfer with a chemical hardness of 2.19eV and 2.96eV respectively, as well as the lowest HOMO-LUMO difference. In addition to the DFT calculation, a docking simulation study was conducted on the SARS-CoV-2 base protease (PDB: 6LU7) to determine the binding affinity of ligands. The findings show that Crocin exhibits the lowest binding energy of -8.1 Kcal/mol and may be a good inhibitor of CoV-2-SARS compared to hydroxychloroquine and chloroquine, which have a binding affinity of -5.4 and -4.9 Kcal/mol, respectively. The high binding affinity of L3 was assigned to the existence of 14 hydrogen bonds connecting the ligand to the critical amino acid residues of the receptor.
The removal of imazapyr pesticide from aqueous solutions, using amacroporous natural phosphate ro... more The removal of imazapyr pesticide from aqueous solutions, using amacroporous natural phosphate rock (PR)as adsorbent, is studied. The adsorption equilibrium, isotherms and kinetics for imazapyr are studied and the data was fitted into various mathematical models and Langmuir and Freundlich isotherms. Experiments performed by the batch method showed that the sorption process occurs by a monolayer deposition of imazapyr pesticide according to a second order reaction.
Bulletin de la Société royale des sciences de Liège, 2015
In this paper, we studied the effect of oxidation pre-treatment on the activation behavior of lig... more In this paper, we studied the effect of oxidation pre-treatment on the activation behavior of lignin char. We followed the evolution of mass loss, of the elemental composition, of the microstructure and dimensional variations accompanying the lignin char during activation with CO2, during pre-oxidation by air and during activation preceded by oxidation. The preoxidation is a treatment carried out in air from ambient up to 245 °C. The duration of this pretreatment is set at 6 hours. Beyond 140 °C, we have seen that there is a relationship between the mass loss and the carbon content on the one hand, and between the dimensional variations and the oxygen content on the other hand. In so far as the carbon content decreases while that of oxygen increases, the coal would undergo partial oxidation accompanied by a fixation of oxygen. At 245 °C, the carbon content decreased by 10 %, that of oxygen was increased to 45 %. Under these conditions, the sample has evolved from a thermoplastic behaviour to a thermosetting behaviour. The pre-oxidised coal reacts more than the non oxidised coal during the CO2 activation whereas the reduction in volume in the first case is smaller than in the second one. Compared to the non oxidised coal, the pre-oxidised and then activated carbon, by the microscopic characterization, shows the formation and the development of microporosity at the expense of macroporosity.
Morocco's prickly pear has high economic value. However, it’s infected by the cochineal Dacty... more Morocco's prickly pear has high economic value. However, it’s infected by the cochineal Dactylopius opuntiae, causing massive losses. Thus, the present work aims to study insecticidal effect of bioactive natural extracts. Essential oils and hydrosols of oregano (Origanum vulgare), thyme (Thymus vulgaris), pennyroyal (Mentha pulegium) and peppermint (Mentha piperita) were tested. Two concentrations were used for essential oils (1.5% and 3%) and for hydrosols (100% and 75%) with contact and fumigant application. Mortality rate was determined after 24h of treatment. Highest values were recorded at 3% E.O concentration with contact assay comparing to fumigation. As it’s EO (99.44%), O. vulgare hydrosol has significant insecticidal activity reaching 80% of mortality rate. Chemical composition of essential oils using Gas Chromatography coupled to Mass Spectrometry (GC/MS) was studied. Bioactive compounds include carvacrol and m-cymene (O. vulgare and T. vulgaris), pulegone and l-menth...
Capparis spinosa L., commonly known as the caper bush, is a spiny shrub known for its edible flow... more Capparis spinosa L., commonly known as the caper bush, is a spiny shrub known for its edible flower buds and its use as a medicinal plant in traditional medicine. While performing bio-guided isolation of active compounds from Capparis spinosa L. leaves and buds, large amounts of bis(2-ethylhexyl) terephthalate (DEHT, a.k.a. dioctyl terephthalate or DOTP) and bis(2-ethylhexyl) phthalate (DEHP) were isolated from a fraction from the leaf extract that showed antifungal activity against Cryptococcus neoformans. The structures of these two compounds were confirmed by NMR and mass spectroscopic data, which matched with those from the standards that were purchased from Sigma-Aldrich. DEHT and DEHP are phthalic and terephthalic acid esters, the main plasticizers that are used to confer elasticity and flexibility to various fiber and plastic products. This is the first time DEHT and DEHP have been isolated from the leaves of a plant that is as commonly used as Capparis spinosa L. This study ...
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