Background: COVID-19, caused by SARS-CoV-2, has impacted the world in an unprecedented way since ... more Background: COVID-19, caused by SARS-CoV-2, has impacted the world in an unprecedented way since December 2019. SARS-CoV-2 was found in the saliva of patients, and entry points for the virus may have been through the numerous angiotensin-converting enzyme 2 receptors in the oral cavity. Oral manifestations of COVID-19 could contribute to the burden of oral disease. Objective: To determine the prevalence of oral manifestations of COVID-19 in patients and their association with disease severity. Methods: Interviews were conducted with adult participants diagnosed with COVID-19 between October 2021 and March 2022 to document their demographic and health status data, symptoms, and the presence of oral manifestations of COVID-19. Chi-square and the Fisher’s exact test were used to compare data on the presence or absence of oral manifestations of COVID-19. Results: Of 195 participants interviewed, 33% were 18 to 24 years old, 33% were 25 to 34 years old, and 75% were female. A total of 57...
No consensus has yet been reached to associate oral bacteria conclusively with the etio-pathogene... more No consensus has yet been reached to associate oral bacteria conclusively with the etio-pathogenesis of bisphosphonate-induced osteonecrosis of the jaw (BONJ). Therefore, the present study examined the effects of oral bacteria on the development of BONJ-like lesions in a mouse model. In the pamidronate (Pam)-treated mice, but not control non-drug-treated mice, tooth extraction followed by oral infection with Fusobacterium nucleatum caused BONJ-like lesions and delayed epithelial healing, both of which were completely suppressed by a broad-spectrum antibiotic cocktail. Furthermore, in both in vitro and in vivo experiments, the combination of Pam and Fusobacterium nucleatum caused the death of gingival fibroblasts (GFs) and down-regulated their production of keratinocyte growth factor (KGF), which induces epithelial cell growth and migration. Therefore, in periodontal tissues pre-exposed to bisphosphonate, bacterial infection at tooth extraction sites caused diminished KGF expression ...
Background Conventional classroom lectures continue to represent a major component of the dental ... more Background Conventional classroom lectures continue to represent a major component of the dental education system to ensure optimum delivery of knowledge. Certain number of students are less compliant and likely to skip classes which may impact the overall academic performance. The aim of this study was to investigate dental students’ attitude towards classroom attendance and potential reasons for absenteeism at King Abdulaziz University-Faculty of Dentistry (KAU-FD). Methods This was a cross-sectional survey of all dental students actively enrolled at KAU-FD from January to June 2019. The survey included questions on demographics, average travel time to school, current dental year, most recent GPA, student’s perspective toward classroom lectures. The survey was validated and distributed to all students at a pre-selected time frame. Data were analysed and presented as frequencies and percentages; chi-square test was used to explore parameters association. Results A total of 678 stud...
Purpose: The necessity to attend classroom lectures is a disputable topic among dental schools gl... more Purpose: The necessity to attend classroom lectures is a disputable topic among dental schools globally. Since there is an ongoing debate on different aspects of this problem in literature, the purpose of this study was to compare students’ attitudes toward classroom attendance and investigate if stricter attendance tracking methods could lead to better classroom attendance at two dental schools utilising different modes of tracking students’ attendance. Method: This was an observational, cross-sectional survey distributed among dental students enrolled at King Abdul-Aziz University (KAU) and King Saud University (KSU) in Saudi Arabia. The survey included questions on demographics, average travel time, student's attitudes toward classroom lectures and common reasons for absenteeism. Collected data were analysed and summarised as frequencies and percentages and then compared using the Chi-square test for statistical significance. Findings: The study involved 678 participants fro...
Introduction: Lichen planus (LP) is a common chronic, mucocutaneous inflammatory disorder with un... more Introduction: Lichen planus (LP) is a common chronic, mucocutaneous inflammatory disorder with unclear pathophysiology. The aim was to describe the epidemiology and clinicopathological characteristics of oral lichen planus (OLP) patients at King Abdulaziz University Dental Hospital (KAUDH) in Jeddah. Materials and Methods: This was a retrospective, chart-review study which included OLP patients previously seen at KAUDH from June 2012 to June 2018. Demographic data, clinical features, management, and outcome were collected and analyzed. Diagnosis of LP was done using clinical criteria with or without histopathologic diagnosis, and the scoring system by Escudier et al. was used. Results: Fifty patients with a mean age of 48 years (range: 21–71) and 2.5:1 female-to-male ratio were included in this study. The most concomitant systemic diseases were diabetes mellitus (30%) and hypertension (26%). Reticular OLP was the most common form (98%), followed by erythematous (66%), ulcerative (26%), and plaque-like type (8%). More than half of the patients were asymptomatic (64%), whereas twenty-two symptomatic patients were managed with either topical steroids, a combination of topical and systemic steroids, and/or intralesional steroid injections with 68% improvement. Conclusion: Based on the current data, clinical features at KAUDH matched what has been previously reported in the literature. In addition, the response to different treatment modalities varied between patients which could be linked to factors such as disease extension and severity.
Background: COVID-19, caused by SARS-CoV-2, has impacted the world in an unprecedented way since ... more Background: COVID-19, caused by SARS-CoV-2, has impacted the world in an unprecedented way since December 2019. SARS-CoV-2 was found in the saliva of patients, and entry points for the virus may have been through the numerous angiotensin-converting enzyme 2 receptors in the oral cavity. Oral manifestations of COVID-19 could contribute to the burden of oral disease. Objective: To determine the prevalence of oral manifestations of COVID-19 in patients and their association with disease severity. Methods: Interviews were conducted with adult participants diagnosed with COVID-19 between October 2021 and March 2022 to document their demographic and health status data, symptoms, and the presence of oral manifestations of COVID-19. Chi-square and the Fisher’s exact test were used to compare data on the presence or absence of oral manifestations of COVID-19. Results: Of 195 participants interviewed, 33% were 18 to 24 years old, 33% were 25 to 34 years old, and 75% were female. A total of 57...
No consensus has yet been reached to associate oral bacteria conclusively with the etio-pathogene... more No consensus has yet been reached to associate oral bacteria conclusively with the etio-pathogenesis of bisphosphonate-induced osteonecrosis of the jaw (BONJ). Therefore, the present study examined the effects of oral bacteria on the development of BONJ-like lesions in a mouse model. In the pamidronate (Pam)-treated mice, but not control non-drug-treated mice, tooth extraction followed by oral infection with Fusobacterium nucleatum caused BONJ-like lesions and delayed epithelial healing, both of which were completely suppressed by a broad-spectrum antibiotic cocktail. Furthermore, in both in vitro and in vivo experiments, the combination of Pam and Fusobacterium nucleatum caused the death of gingival fibroblasts (GFs) and down-regulated their production of keratinocyte growth factor (KGF), which induces epithelial cell growth and migration. Therefore, in periodontal tissues pre-exposed to bisphosphonate, bacterial infection at tooth extraction sites caused diminished KGF expression ...
Background Conventional classroom lectures continue to represent a major component of the dental ... more Background Conventional classroom lectures continue to represent a major component of the dental education system to ensure optimum delivery of knowledge. Certain number of students are less compliant and likely to skip classes which may impact the overall academic performance. The aim of this study was to investigate dental students’ attitude towards classroom attendance and potential reasons for absenteeism at King Abdulaziz University-Faculty of Dentistry (KAU-FD). Methods This was a cross-sectional survey of all dental students actively enrolled at KAU-FD from January to June 2019. The survey included questions on demographics, average travel time to school, current dental year, most recent GPA, student’s perspective toward classroom lectures. The survey was validated and distributed to all students at a pre-selected time frame. Data were analysed and presented as frequencies and percentages; chi-square test was used to explore parameters association. Results A total of 678 stud...
Purpose: The necessity to attend classroom lectures is a disputable topic among dental schools gl... more Purpose: The necessity to attend classroom lectures is a disputable topic among dental schools globally. Since there is an ongoing debate on different aspects of this problem in literature, the purpose of this study was to compare students’ attitudes toward classroom attendance and investigate if stricter attendance tracking methods could lead to better classroom attendance at two dental schools utilising different modes of tracking students’ attendance. Method: This was an observational, cross-sectional survey distributed among dental students enrolled at King Abdul-Aziz University (KAU) and King Saud University (KSU) in Saudi Arabia. The survey included questions on demographics, average travel time, student's attitudes toward classroom lectures and common reasons for absenteeism. Collected data were analysed and summarised as frequencies and percentages and then compared using the Chi-square test for statistical significance. Findings: The study involved 678 participants fro...
Introduction: Lichen planus (LP) is a common chronic, mucocutaneous inflammatory disorder with un... more Introduction: Lichen planus (LP) is a common chronic, mucocutaneous inflammatory disorder with unclear pathophysiology. The aim was to describe the epidemiology and clinicopathological characteristics of oral lichen planus (OLP) patients at King Abdulaziz University Dental Hospital (KAUDH) in Jeddah. Materials and Methods: This was a retrospective, chart-review study which included OLP patients previously seen at KAUDH from June 2012 to June 2018. Demographic data, clinical features, management, and outcome were collected and analyzed. Diagnosis of LP was done using clinical criteria with or without histopathologic diagnosis, and the scoring system by Escudier et al. was used. Results: Fifty patients with a mean age of 48 years (range: 21–71) and 2.5:1 female-to-male ratio were included in this study. The most concomitant systemic diseases were diabetes mellitus (30%) and hypertension (26%). Reticular OLP was the most common form (98%), followed by erythematous (66%), ulcerative (26%), and plaque-like type (8%). More than half of the patients were asymptomatic (64%), whereas twenty-two symptomatic patients were managed with either topical steroids, a combination of topical and systemic steroids, and/or intralesional steroid injections with 68% improvement. Conclusion: Based on the current data, clinical features at KAUDH matched what has been previously reported in the literature. In addition, the response to different treatment modalities varied between patients which could be linked to factors such as disease extension and severity.
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