Transportation Research Record: Journal of the Transportation Research Board
This study investigated the operational impact of heavy commercial vehicle (HCV) platooning on ur... more This study investigated the operational impact of heavy commercial vehicle (HCV) platooning on urban arterials. HCV platooning is an important application of vehicle-to-vehicle (V2V) technology, with urban arterials facilitating an essential component of HCV movements when picking up and delivering goods. HCV platooning has the potential to reduce fuel consumption and emissions. Moreover, the increasing HCV driver shortage problem can be alleviated if the vehicle following behind a lead vehicle can function without a driver by using autonomous technology enabling Society of Automotive Engineers Level 4 or higher. PTV VISSIM was used to develop a set of micro-simulation models that investigated the impact of traffic signal priority (TSP) and low levels (0%, 5%, and 10%) of HCV platooning. The performance measures include travel time and the number of stops. With the existing traffic control system, HCV platooning increased travel time and increased the number of stops for all vehicle...
The length of an acceleration lane is one of the dominant freeway geometric design parameters. Th... more The length of an acceleration lane is one of the dominant freeway geometric design parameters. This length requires new analyses to anticipate the needs of heavy commercial vehicle (HCV) platooning. We evaluated the safety and operational impact of HCV platooning on acceleration lane length for a freeway ramp in Ontario, Canada. This study modified the 2018 AASHTO’s acceleration lane length estimation analytical model. Furthermore, this study used a VISSIM micro-simulation model and surrogated safety assessment model (SSAM) to examine the safety and operational impact on the real-world circumstances of HCV platooning at 0.6 s and 1.2 s headways and different market penetration rates of 0%, 5%, and 10%. The results suggest a minimum acceleration lane length of 600 m for platooned HCVs, which is inadequate compared to American and Canadian design guidelines. An extended acceleration lane length (600 m) will improve safety by reducing conflict by 19.2% and operational performance by re...
The existing study was made to investigate the thrombolytic exercise and cytotoxic potential with... more The existing study was made to investigate the thrombolytic exercise and cytotoxic potential with the methanol extract of Syzygium operculatum leaves. The cytotoxicity had been assessed while using brine shrimp lethality bioassay and also thrombolytic impact with individual blood. The brine shrimp lethality bioassay was employed to evaluate cytotoxicity (LC50=272.82μg/ml) compared to vincristine associated with sulphate (LC50=0.512μg/ml). It had been also assessed as thrombolytic agent compared to streptokinase. It's got Significant thrombolytic exercise (36. 28%) compared to standard streptokinase (75.09%).
The safety of pedestrians, such as workers who largely walk to and from work, has not been given ... more The safety of pedestrians, such as workers who largely walk to and from work, has not been given sufficient attention, especially in the area of traffic safety in developing countries, including Bangladesh. Although the National Road Safety Strategy has a very strong emphasis on road safety education and publicity campaigns, the road safety knowledge may not have reached these vulnerable road users who most needed them. Moreover, little is known about the penetration rate of these campaigns and who have benefited or not benefited from them. On the other hand, the developing country, like Bangladesh, is heavily dependent on its Readymade Garment (RMG) workers for earning foreign currency, and walking is one of the major mode of transports of those workers. The objective of this study is to identify those who are not reach by the safety education. Results from a survey of 1020 RMG workers around Dhaka identified several socioeconomic, demographic, travel characteristics and accident e...
Journal of Chittagong Medical College Teachers' Association
Midgut volvulus with gangrene is not a rare event. With normal rotation, the mesentery is broad a... more Midgut volvulus with gangrene is not a rare event. With normal rotation, the mesentery is broad and fixed, but the narrow pedicle formed by the base of the mesentery in malrotation of the gut predisposes the midgut to clockwise twisting from the duodenum to the transverse colon. Excessive length of the mesentery, or a point of adhesion at the convexity of the loop may act as an axis for the loop .The actual inciting mechanism is unknown but various possibilities, including unusual movement of the torso, abnormal intestinal peristalsis, or segmental bowel distention, have been suggested. This is a grave surgical emergency to save the life of the patient. We are reporting a case of midgut volvulus with herniation of the ileum into the right paraduodenal recess after blunt abdominal trauma (BAT). A 8 years old boy complaints of abdominal pain, vomiting, and distension of the abdomen following diving to a pond. Abdominal x-ray and USG, CBC, Serum Electrolyte were carried out to evaluate...
Journal of Chittagong Medical College Teachers' Association
Identification and management of serious intra abdominal and associated injuries due to blunt mec... more Identification and management of serious intra abdominal and associated injuries due to blunt mechanisms are challenging. This study aims to evaluate current approach to manage such patients in a leading teaching hospital of a low income country. Methods: This prospective study was carried out in the departments of General surgery and Paediatric surgery, Chittagong Medical College and Hospital; Chittagong; Bangladesh from July, 2001- June, 2002. Total 132 patients suffering from blunt abdominal trauma (BAT) were evaluated. Results: The majority of the trauma victims aged 30 years and below with male predominance. Road traffic accident (RTA) was the leading cause (57.57%). Sixty eight percent (68%) patients were brought to the hospital within 24 hours of injury. Abdominal pain was the commonest mode of presentation (83.33%). External signs of injury in abdomen were noticed in only 39% patients. The most important abdominal finding was features of peritonitis (generalized muscle guard...
Different brands available for atorvastatin calcium, is a most prescribed oral 3-hydroxy-3- methy... more Different brands available for atorvastatin calcium, is a most prescribed oral 3-hydroxy-3- methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors that is mainly used to treat primary hyperlipidemia. The objective of this study was to develop the degradation studies of five different brands of Atorvastatin 10 mg tablets. This drug was subjected to different stress conditions as per International Conference on Harmonization guidelines (ICH). An ultraviolet UV spectroscopic method was developed for analysis of the drug in the presence of the degradation products. Methanol was used as a solvent. The amount of degraded drugs was calculated by taking the absorbance at 244nm. According to the assay specified limit of USP that the content should not be less than 95% and not more than 105% of labelled amount. All brands were degraded by after the heat exposure. In addition to basic pH and acidic pH, all brands also degraded. The method was found to be simple and less time consuming and co...
This study was subjected to investigate thrombolytic and cytotoxic properties of Commelina bengha... more This study was subjected to investigate thrombolytic and cytotoxic properties of Commelina benghalensis methanol extract. The cytotoxicity had been assessed while using brine shrimp lethality bioassay and also thrombolytic impact with individual blood. The brine shrimp lethality bioassay result was (LC50= 278.69 µg/ml) compared with standard vincristine sulphate (LC50=0.512 µg/ml). It has significant thrombolytic activity (40.94%) compared with standard streptokinase (75%).
Journal of Chittagong Medical College Teachers' Association, 2011
Introduction : Malrotation is a common anomaly in the pediatric age group which includes a wide ... more Introduction : Malrotation is a common anomaly in the pediatric age group which includes a wide spectrum of anomalies of Rotation. Both acute and chronic presentations are common. Atypical malrotation not having all the features of classic mal Rotation is frequently found which a diagnostic dilemma and the management varies from centre to centre. Materials and Methods : The medical records of all patients with symptomatic malrotation, who underwent surgery between July 2001 to June 2011, were retrospectively reviewed. Patients’ presentation, management, operative findings and complications were evaluated. Results : 68 patients underwent surgery for malrotation at a median age of 2 years. Male to female ratio was 2:1. 28(41%) presented with acute symptoms and 40(59%) with chronic symptoms. 54(79%) patients had vomiting, 36 (%3%) presented with abdominal distension, 19(28%) had recurrent abdominal pain. Diagnostic laparoscopy was done in 7(10%) patients. Ladd’s band was found in 16(2...
The present work describes a conceptual study of Staggered Cylinders of Square Cross Section by u... more The present work describes a conceptual study of Staggered Cylinders of Square Cross Section by using Computational Fluid Dynamics. The overall pressure distribution over the cylinders were analyzed. The static pressure distributions on the group of cylinders with square cross sections in a uniform flow velocity of 13.5 m/s at a Reynolds number 4.13 × 104 is presented here. The group consists of three square cylinders of identical dimension. One square cylinder is placed centrally in the upstream side and the other two square cylinders are placed symmetrically in the downstream side. Surface pressure distributions on the cylinders are measured and compared for various longitudinal as well as transverse spacing of the cylinders. Wind loads are obtained in terms of drag coefficients, lift coefficients and total pressure coefficients. The outcome of this investigation was shown and computed by using ANSYS Fluent 16.The present work describes a conceptual study of Staggered Cylinders of Square Cross Section by using Computational Fluid Dynamics. The overall pressure distribution over the cylinders were analyzed. The static pressure distributions on the group of cylinders with square cross sections in a uniform flow velocity of 13.5 m/s at a Reynolds number 4.13 × 104 is presented here. The group consists of three square cylinders of identical dimension. One square cylinder is placed centrally in the upstream side and the other two square cylinders are placed symmetrically in the downstream side. Surface pressure distributions on the cylinders are measured and compared for various longitudinal as well as transverse spacing of the cylinders. Wind loads are obtained in terms of drag coefficients, lift coefficients and total pressure coefficients. The outcome of this investigation was shown and computed by using ANSYS Fluent 16.
The present study aims to investigate the thrombolytic effect of some antidiabetic drugs by in vi... more The present study aims to investigate the thrombolytic effect of some antidiabetic drugs by in vitro clot lysis method and in silico molecular docking used to identify whether these drugs interact with the responsible protein (tissue-type plasminogen activator). In vitro clot lysis model was used to observe the thrombolytic effect of Glibenclamide, Metformin hydrochloride, Sitagliptin phosphate and Vildagliptin drugs, where they exhibited 46.61 ± 2.84%, 43.89 ± 3.41%, 24.45 ± 2.62 % and 35.89 ± 3.57 % clot lysis, respectively. Reference drug streptokinase exhibited 78.70±0.92% clot lysis. A wide range of docking score found during molecular docking by CPI server. Glibenclamide, Metformin hydrochloride, Sitagliptin phosphate and Vildagliptin drugs showed the docking score -8.6, -4.9, -3.8 and -7.3, respectively. Glibenclamide possessed highest clot lysis effect and also showed best docking score among the antidiabetic drugs, where Sitagliptin phosphate exhibited the opposite. But res...
Objective: The present study was to evaluate the anti-compulsive effect of ethanol extract of Ste... more Objective: The present study was to evaluate the anti-compulsive effect of ethanol extract of Steudnera colocasiifolia K. Koch leaves. Methods: The experiment was conducted in specific animal models of Swiss albino mice to evaluate marble-burying behavior. Results: Oral administration of 100 and 200 mg/kg of ethanol extract of S. colocasiifolia (EESC) significantly (P<0.01-0.05) decreased the total number of buried marbles. The effect was comparable to that of the Imipramine hydrochloride (10 mg/kg). Imipramine hydrochloride and EESC do not produce any overt motor dysfunction. Conclusions: The results of the study for the first time show that the plant possesses anticompulsive activity. Future research should focus on the identification and the mechanism of action of the constituents from this plant.
Hypertension is a common medical condition and is a significant risk factor for heart attack, str... more Hypertension is a common medical condition and is a significant risk factor for heart attack, stroke, kidney disease, and mortality. Developing a risk prediction model for hypertension incidence incorporating its risk factors can help identify high-risk individuals who should be targeted for healthy behavioral changes or medical treatment to prevent hypertension onset. This research aims to develop a robust hypertension prediction model for the general population. More specifically, we aimed to 1) conduct a comprehensive systematic review to identify risk factors and prediction models for hypertension incidence and perform a meta-analysis to evaluate the current model's predictive performance. 2) develop a risk prediction model for incident hypertension in a Canadian cohort using a traditional modeling approach. 3) develop machine learning algorithms to predict hypertension incidence and compare their predictive performance with a traditional statistical model. We systematically searched MEDLINE, EMBASE, Web of Science, Scopus, and the grey literature for studies predicting the risk of hypertension among the general adult population. We identified 52 studies that presented 117 models, of which 75 were developed using traditional regression-based modeling and 42 using machine learning algorithms. No studies were from Canada where a hypertension prediction model was developed or validated. Meta-analysis showed the overall pooled C-statistics 0.75 [0.73 – 0.77] for the traditional regression-based models and 0.76 [0.72 – 0.79] for the machine learning-based models. The lack of a hypertension prediction model in a Canadian context motivated us to develop a new model. We used the data of 18,322 participants on 29 candidate variables from the large Alberta's Tomorrow Project (ATP) to develop traditional Cox proportional hazards (PH) model. Age, sex, body mass index (BMI), systolic blood pressure (SBP), diabetes, total physical activity time, and cardiovascular disease were used as significant risk factors in the model. [...]
This study aims to predict whether Podocarpusflavone A (isolated from Podocarpus imbricatus), Pod... more This study aims to predict whether Podocarpusflavone A (isolated from Podocarpus imbricatus), Podocarpusflavone B (isolated from Psilotum nudum), Robustaflavone (isolated from Selaginella sellowii), Robustaflavone-7-methyl ether (isolated from Podocarpus imbricatus), Sciadopitysin (isolated from Taxus cuspidata) and β-sitosterol (isolated from Rubus suavissimus) have thrombolytic effects, which were done by using two in silico tools PASS prediction and Molecular docking. These six were analyzed by the PASS prediction for their thrombolytic activity and found wide range of activity. Podocarpusflavone A and Podocarpusflavone B was the best compound for thrombolytic effect from all the compounds, though it had much bigger Pa value (0.256) than Pi value (0.022). As a result, Podocarpusflavone A and Podocarpusflavone B both had 11.64 ratio (Pa : Pi) value. A wide range of docking score found during molecular docking by CPI server. Podocarpusflavone A, Podocarpusflavone B, Robustaflavone,...
Transportation Research Record: Journal of the Transportation Research Board
This study investigated the operational impact of heavy commercial vehicle (HCV) platooning on ur... more This study investigated the operational impact of heavy commercial vehicle (HCV) platooning on urban arterials. HCV platooning is an important application of vehicle-to-vehicle (V2V) technology, with urban arterials facilitating an essential component of HCV movements when picking up and delivering goods. HCV platooning has the potential to reduce fuel consumption and emissions. Moreover, the increasing HCV driver shortage problem can be alleviated if the vehicle following behind a lead vehicle can function without a driver by using autonomous technology enabling Society of Automotive Engineers Level 4 or higher. PTV VISSIM was used to develop a set of micro-simulation models that investigated the impact of traffic signal priority (TSP) and low levels (0%, 5%, and 10%) of HCV platooning. The performance measures include travel time and the number of stops. With the existing traffic control system, HCV platooning increased travel time and increased the number of stops for all vehicle...
The length of an acceleration lane is one of the dominant freeway geometric design parameters. Th... more The length of an acceleration lane is one of the dominant freeway geometric design parameters. This length requires new analyses to anticipate the needs of heavy commercial vehicle (HCV) platooning. We evaluated the safety and operational impact of HCV platooning on acceleration lane length for a freeway ramp in Ontario, Canada. This study modified the 2018 AASHTO’s acceleration lane length estimation analytical model. Furthermore, this study used a VISSIM micro-simulation model and surrogated safety assessment model (SSAM) to examine the safety and operational impact on the real-world circumstances of HCV platooning at 0.6 s and 1.2 s headways and different market penetration rates of 0%, 5%, and 10%. The results suggest a minimum acceleration lane length of 600 m for platooned HCVs, which is inadequate compared to American and Canadian design guidelines. An extended acceleration lane length (600 m) will improve safety by reducing conflict by 19.2% and operational performance by re...
The existing study was made to investigate the thrombolytic exercise and cytotoxic potential with... more The existing study was made to investigate the thrombolytic exercise and cytotoxic potential with the methanol extract of Syzygium operculatum leaves. The cytotoxicity had been assessed while using brine shrimp lethality bioassay and also thrombolytic impact with individual blood. The brine shrimp lethality bioassay was employed to evaluate cytotoxicity (LC50=272.82μg/ml) compared to vincristine associated with sulphate (LC50=0.512μg/ml). It had been also assessed as thrombolytic agent compared to streptokinase. It's got Significant thrombolytic exercise (36. 28%) compared to standard streptokinase (75.09%).
The safety of pedestrians, such as workers who largely walk to and from work, has not been given ... more The safety of pedestrians, such as workers who largely walk to and from work, has not been given sufficient attention, especially in the area of traffic safety in developing countries, including Bangladesh. Although the National Road Safety Strategy has a very strong emphasis on road safety education and publicity campaigns, the road safety knowledge may not have reached these vulnerable road users who most needed them. Moreover, little is known about the penetration rate of these campaigns and who have benefited or not benefited from them. On the other hand, the developing country, like Bangladesh, is heavily dependent on its Readymade Garment (RMG) workers for earning foreign currency, and walking is one of the major mode of transports of those workers. The objective of this study is to identify those who are not reach by the safety education. Results from a survey of 1020 RMG workers around Dhaka identified several socioeconomic, demographic, travel characteristics and accident e...
Journal of Chittagong Medical College Teachers' Association
Midgut volvulus with gangrene is not a rare event. With normal rotation, the mesentery is broad a... more Midgut volvulus with gangrene is not a rare event. With normal rotation, the mesentery is broad and fixed, but the narrow pedicle formed by the base of the mesentery in malrotation of the gut predisposes the midgut to clockwise twisting from the duodenum to the transverse colon. Excessive length of the mesentery, or a point of adhesion at the convexity of the loop may act as an axis for the loop .The actual inciting mechanism is unknown but various possibilities, including unusual movement of the torso, abnormal intestinal peristalsis, or segmental bowel distention, have been suggested. This is a grave surgical emergency to save the life of the patient. We are reporting a case of midgut volvulus with herniation of the ileum into the right paraduodenal recess after blunt abdominal trauma (BAT). A 8 years old boy complaints of abdominal pain, vomiting, and distension of the abdomen following diving to a pond. Abdominal x-ray and USG, CBC, Serum Electrolyte were carried out to evaluate...
Journal of Chittagong Medical College Teachers' Association
Identification and management of serious intra abdominal and associated injuries due to blunt mec... more Identification and management of serious intra abdominal and associated injuries due to blunt mechanisms are challenging. This study aims to evaluate current approach to manage such patients in a leading teaching hospital of a low income country. Methods: This prospective study was carried out in the departments of General surgery and Paediatric surgery, Chittagong Medical College and Hospital; Chittagong; Bangladesh from July, 2001- June, 2002. Total 132 patients suffering from blunt abdominal trauma (BAT) were evaluated. Results: The majority of the trauma victims aged 30 years and below with male predominance. Road traffic accident (RTA) was the leading cause (57.57%). Sixty eight percent (68%) patients were brought to the hospital within 24 hours of injury. Abdominal pain was the commonest mode of presentation (83.33%). External signs of injury in abdomen were noticed in only 39% patients. The most important abdominal finding was features of peritonitis (generalized muscle guard...
Different brands available for atorvastatin calcium, is a most prescribed oral 3-hydroxy-3- methy... more Different brands available for atorvastatin calcium, is a most prescribed oral 3-hydroxy-3- methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors that is mainly used to treat primary hyperlipidemia. The objective of this study was to develop the degradation studies of five different brands of Atorvastatin 10 mg tablets. This drug was subjected to different stress conditions as per International Conference on Harmonization guidelines (ICH). An ultraviolet UV spectroscopic method was developed for analysis of the drug in the presence of the degradation products. Methanol was used as a solvent. The amount of degraded drugs was calculated by taking the absorbance at 244nm. According to the assay specified limit of USP that the content should not be less than 95% and not more than 105% of labelled amount. All brands were degraded by after the heat exposure. In addition to basic pH and acidic pH, all brands also degraded. The method was found to be simple and less time consuming and co...
This study was subjected to investigate thrombolytic and cytotoxic properties of Commelina bengha... more This study was subjected to investigate thrombolytic and cytotoxic properties of Commelina benghalensis methanol extract. The cytotoxicity had been assessed while using brine shrimp lethality bioassay and also thrombolytic impact with individual blood. The brine shrimp lethality bioassay result was (LC50= 278.69 µg/ml) compared with standard vincristine sulphate (LC50=0.512 µg/ml). It has significant thrombolytic activity (40.94%) compared with standard streptokinase (75%).
Journal of Chittagong Medical College Teachers' Association, 2011
Introduction : Malrotation is a common anomaly in the pediatric age group which includes a wide ... more Introduction : Malrotation is a common anomaly in the pediatric age group which includes a wide spectrum of anomalies of Rotation. Both acute and chronic presentations are common. Atypical malrotation not having all the features of classic mal Rotation is frequently found which a diagnostic dilemma and the management varies from centre to centre. Materials and Methods : The medical records of all patients with symptomatic malrotation, who underwent surgery between July 2001 to June 2011, were retrospectively reviewed. Patients’ presentation, management, operative findings and complications were evaluated. Results : 68 patients underwent surgery for malrotation at a median age of 2 years. Male to female ratio was 2:1. 28(41%) presented with acute symptoms and 40(59%) with chronic symptoms. 54(79%) patients had vomiting, 36 (%3%) presented with abdominal distension, 19(28%) had recurrent abdominal pain. Diagnostic laparoscopy was done in 7(10%) patients. Ladd’s band was found in 16(2...
The present work describes a conceptual study of Staggered Cylinders of Square Cross Section by u... more The present work describes a conceptual study of Staggered Cylinders of Square Cross Section by using Computational Fluid Dynamics. The overall pressure distribution over the cylinders were analyzed. The static pressure distributions on the group of cylinders with square cross sections in a uniform flow velocity of 13.5 m/s at a Reynolds number 4.13 × 104 is presented here. The group consists of three square cylinders of identical dimension. One square cylinder is placed centrally in the upstream side and the other two square cylinders are placed symmetrically in the downstream side. Surface pressure distributions on the cylinders are measured and compared for various longitudinal as well as transverse spacing of the cylinders. Wind loads are obtained in terms of drag coefficients, lift coefficients and total pressure coefficients. The outcome of this investigation was shown and computed by using ANSYS Fluent 16.The present work describes a conceptual study of Staggered Cylinders of Square Cross Section by using Computational Fluid Dynamics. The overall pressure distribution over the cylinders were analyzed. The static pressure distributions on the group of cylinders with square cross sections in a uniform flow velocity of 13.5 m/s at a Reynolds number 4.13 × 104 is presented here. The group consists of three square cylinders of identical dimension. One square cylinder is placed centrally in the upstream side and the other two square cylinders are placed symmetrically in the downstream side. Surface pressure distributions on the cylinders are measured and compared for various longitudinal as well as transverse spacing of the cylinders. Wind loads are obtained in terms of drag coefficients, lift coefficients and total pressure coefficients. The outcome of this investigation was shown and computed by using ANSYS Fluent 16.
The present study aims to investigate the thrombolytic effect of some antidiabetic drugs by in vi... more The present study aims to investigate the thrombolytic effect of some antidiabetic drugs by in vitro clot lysis method and in silico molecular docking used to identify whether these drugs interact with the responsible protein (tissue-type plasminogen activator). In vitro clot lysis model was used to observe the thrombolytic effect of Glibenclamide, Metformin hydrochloride, Sitagliptin phosphate and Vildagliptin drugs, where they exhibited 46.61 ± 2.84%, 43.89 ± 3.41%, 24.45 ± 2.62 % and 35.89 ± 3.57 % clot lysis, respectively. Reference drug streptokinase exhibited 78.70±0.92% clot lysis. A wide range of docking score found during molecular docking by CPI server. Glibenclamide, Metformin hydrochloride, Sitagliptin phosphate and Vildagliptin drugs showed the docking score -8.6, -4.9, -3.8 and -7.3, respectively. Glibenclamide possessed highest clot lysis effect and also showed best docking score among the antidiabetic drugs, where Sitagliptin phosphate exhibited the opposite. But res...
Objective: The present study was to evaluate the anti-compulsive effect of ethanol extract of Ste... more Objective: The present study was to evaluate the anti-compulsive effect of ethanol extract of Steudnera colocasiifolia K. Koch leaves. Methods: The experiment was conducted in specific animal models of Swiss albino mice to evaluate marble-burying behavior. Results: Oral administration of 100 and 200 mg/kg of ethanol extract of S. colocasiifolia (EESC) significantly (P<0.01-0.05) decreased the total number of buried marbles. The effect was comparable to that of the Imipramine hydrochloride (10 mg/kg). Imipramine hydrochloride and EESC do not produce any overt motor dysfunction. Conclusions: The results of the study for the first time show that the plant possesses anticompulsive activity. Future research should focus on the identification and the mechanism of action of the constituents from this plant.
Hypertension is a common medical condition and is a significant risk factor for heart attack, str... more Hypertension is a common medical condition and is a significant risk factor for heart attack, stroke, kidney disease, and mortality. Developing a risk prediction model for hypertension incidence incorporating its risk factors can help identify high-risk individuals who should be targeted for healthy behavioral changes or medical treatment to prevent hypertension onset. This research aims to develop a robust hypertension prediction model for the general population. More specifically, we aimed to 1) conduct a comprehensive systematic review to identify risk factors and prediction models for hypertension incidence and perform a meta-analysis to evaluate the current model's predictive performance. 2) develop a risk prediction model for incident hypertension in a Canadian cohort using a traditional modeling approach. 3) develop machine learning algorithms to predict hypertension incidence and compare their predictive performance with a traditional statistical model. We systematically searched MEDLINE, EMBASE, Web of Science, Scopus, and the grey literature for studies predicting the risk of hypertension among the general adult population. We identified 52 studies that presented 117 models, of which 75 were developed using traditional regression-based modeling and 42 using machine learning algorithms. No studies were from Canada where a hypertension prediction model was developed or validated. Meta-analysis showed the overall pooled C-statistics 0.75 [0.73 – 0.77] for the traditional regression-based models and 0.76 [0.72 – 0.79] for the machine learning-based models. The lack of a hypertension prediction model in a Canadian context motivated us to develop a new model. We used the data of 18,322 participants on 29 candidate variables from the large Alberta's Tomorrow Project (ATP) to develop traditional Cox proportional hazards (PH) model. Age, sex, body mass index (BMI), systolic blood pressure (SBP), diabetes, total physical activity time, and cardiovascular disease were used as significant risk factors in the model. [...]
This study aims to predict whether Podocarpusflavone A (isolated from Podocarpus imbricatus), Pod... more This study aims to predict whether Podocarpusflavone A (isolated from Podocarpus imbricatus), Podocarpusflavone B (isolated from Psilotum nudum), Robustaflavone (isolated from Selaginella sellowii), Robustaflavone-7-methyl ether (isolated from Podocarpus imbricatus), Sciadopitysin (isolated from Taxus cuspidata) and β-sitosterol (isolated from Rubus suavissimus) have thrombolytic effects, which were done by using two in silico tools PASS prediction and Molecular docking. These six were analyzed by the PASS prediction for their thrombolytic activity and found wide range of activity. Podocarpusflavone A and Podocarpusflavone B was the best compound for thrombolytic effect from all the compounds, though it had much bigger Pa value (0.256) than Pi value (0.022). As a result, Podocarpusflavone A and Podocarpusflavone B both had 11.64 ratio (Pa : Pi) value. A wide range of docking score found during molecular docking by CPI server. Podocarpusflavone A, Podocarpusflavone B, Robustaflavone,...
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Papers by Tanvir Chowdhury