ABSTRACT Considering that nitric oxide (NO) plays an important role on cutaneous wound repair, bu... more ABSTRACT Considering that nitric oxide (NO) plays an important role on cutaneous wound repair, but its effects have not been defined, an inhibitor of NO synthesis (LNAME) was used. Control group received free water and LNAME group received LNAME (20 mg/kg/day) in drinking water. A full‐thickness excisional wound was performed (0d), and the animals were sacrificed 7, 14, and 21 days later. Wound contraction was evaluated by lesion surface measurement at 0d, 7d, 14d, and 21d. The blood pressure of all rats was measured in the beginning and at the each time point of the experiment with a plethysmography method. The wound and normal skin surrounding was formol fixed and paraffin embedded. To evaluate the vessels, an immunohistochemistry for α‐smooth muscle actin was done and stereological parameters were estimated in superficial and deep dermis. At 7d, 14d, and 21d the blood pressure of LNAME group was higher compared with control group (p Document Type: Abstract DOI: http://dx.doi.org/10.1111/j.1067-1927.2005.130117f.x Affiliations: 1: Histology and Embryology Department, State University of Rio de Janeiro, RJ, Brazil, 2: INSERM E0362, Université Victor Segalen, Bordeaux, France Publication date: January 1, 2005 $(document).ready(function() { var shortdescription = $(".originaldescription").text().replace(/\\&/g, '&').replace(/\\, '<').replace(/\\>/g, '>').replace(/\\t/g, ' ').replace(/\\n/g, ''); if (shortdescription.length > 350){ shortdescription = "" + shortdescription.substring(0,250) + "... more"; } $(".descriptionitem").prepend(shortdescription); $(".shortdescription a").click(function() { $(".shortdescription").hide(); $(".originaldescription").slideDown(); return false; }); }); Related content In this: publication By this: publisher In this Subject: Surgery By this author: Amadeu, TP ; Desmoulière, A ; Costa, AMA GA_googleFillSlot("Horizontal_banner_bottom");
Background Combined pulmonary fibrosis and emphysema (CPFE) is an entity characterized by the pre... more Background Combined pulmonary fibrosis and emphysema (CPFE) is an entity characterized by the presence of emphysema in upper lobes and fibrosis in lower lobes. Due to the presence of the two diseases concomitantly, it may be difficult to diagnose. This study aims at a better understanding of this entity and proposes biological markers (functional and biochemical) that help in this characterization. Methods A prospective, observational, cross-sectional study was carried out at a reference center. Pulmonary function tests (spirometry, CO-diffusion capacity, plethysmography and single-maneuver nitrogen washout test - SBWN 2 ) and biochemical markers (periostin, mucin-16, PDGF-BB and TGF-β 1 ) were measured in groups of patients: idiopathic pulmonary fibrosis, CPFE and chronic obstructive pulmonary disease (COPD). Results Variables derived from SBWN 2 - closing volume (CV) / vital capacity (VC) (%) and closing capacity (CC) / total lung capacity (TLC) (%) - were found to be higher in th...
Autoeficácia para atividades físicas (AEAF) é a crença que um indivíduo tem na capacidade de real... more Autoeficácia para atividades físicas (AEAF) é a crença que um indivíduo tem na capacidade de realizá-las com determinado desempenho, envolvendo um componente cognitivo e um poder de escolha. Objetivou-se, nesta revisão integrativa, identificar estudos sobre AEAF em adolescentes, produzidos no contexto da Educação Física Escolar brasileira ou estrangeira, para conhecer suas metodologias e principais resultados. Foram sumarizados, qualitativamente, 15 artigos, publicados entre 2008 e 2018 nas línguas portuguesa e inglesa, selecionados nas bases de dados: Google Acadêmico; BIREME/BVS; PUBMED; SCOPUS; e WEB OF SCIENCE, utilizando o termo autoeficácia e as palavras-chave Educação Física, saúde e ensino. Os estudos, majoritariamente em língua inglesa, sendo apenas dois em língua portuguesa, enfatizam os domínios autoeficácia para a tarefa, autoeficácia para superar barreiras e modelo tripartite. Esses domínios são capazes de explicar mudanças de comportamento em relação à prática de ativi...
Pleural tuberculosis (PlTB), a common form of extrapulmonary TB, remains as a challenge in the di... more Pleural tuberculosis (PlTB), a common form of extrapulmonary TB, remains as a challenge in the diagnosis among many causes of pleural effusion. We recently reported that the combinatorial analysis of interferon-gamma (IFN-γ), IFN-γ-inducible protein 10 (IP-10), and adenosine deaminase (ADA) from the pleural microenvironment was useful to distinguish pleural effusion caused by TB (microbiologically or not confirmed cases) among other etiologies. In this cross-sectional cohort study, a set of inflammatory mediators was quantified in blood and pleural fluid (PF) from exudative pleural effusion cases, including PlTB (n = 27) and non-PlTB (nTB; n = 25) patients. The levels of IL-2, IL-4, IL-6, IL-10, IL-17A, IFN-γ, TNF, IP-10, TGF-β1, and ADA were determined using cytometric bead assay, ELISA or biochemical tests. IFN-γ, IP-10, TNF, TGF-β, and ADA quantified in PF showed significantly higher concentrations in PlTB patients when compared to nTB. When blood and PF were compared, we have id...
Pleural tuberculosis (PlTB), a form of extrapulmonary TB, remains as a challenge in the diagnosis... more Pleural tuberculosis (PlTB), a form of extrapulmonary TB, remains as a challenge in the diagnosis among many causes of pleural effusion. We recently reported that the combinatorial analysis of interferon-gamma (IFN-γ), IFN-γ-inducible protein 10 (IP-10), and adenosine deaminase (ADA) from the pleural microenvironment was useful to distinguish pleural effusion caused by TB (microbiologically or not confirmed cases) among other etiologies. In this prospective cohort study, a set of inflammatory mediators was quantified in blood and pleural fluid (PF) from exudative pleural effusion cases, including PlTB (n = 22) and non-PlTB (NTB; n = 17) patients. The levels of IL-2, IL-4, IL-6, IL-10, IL-17A, IFN-γ, TNF, IP-10, TGF-β1, and ADA were measured and a principal component analysis was applied in order to identify the mediators who contributed most for the variance in data. IFN-γ, IP-10, TNF, TGF-β, and ADA quantified in PF showed significantly higher concentrations in PlTB patients when c...
ABSTRACT The chronic course of leprosy is aggravated by the emergence of reactional states such a... more ABSTRACT The chronic course of leprosy is aggravated by the emergence of reactional states such as type 1 reaction (T1R). The occurrence of T1R is deemed to be a sudden and heightened inflammatory response that eventually compromises the skin and peripheral nerves 1. T1R occurs more frequently among the unstable borderline forms (BT, BB and BL) but has also been known to occur in lepromatous patients (LL)2This article is protected by copyright. All rights reserved.
ABSTRACT Considering that nitric oxide (NO) plays an important role on cutaneous wound repair, bu... more ABSTRACT Considering that nitric oxide (NO) plays an important role on cutaneous wound repair, but its effects have not been defined, an inhibitor of NO synthesis (LNAME) was used. Control group received free water and LNAME group received LNAME (20 mg/kg/day) in drinking water. A full‐thickness excisional wound was performed (0d), and the animals were sacrificed 7, 14, and 21 days later. Wound contraction was evaluated by lesion surface measurement at 0d, 7d, 14d, and 21d. The blood pressure of all rats was measured in the beginning and at the each time point of the experiment with a plethysmography method. The wound and normal skin surrounding was formol fixed and paraffin embedded. To evaluate the vessels, an immunohistochemistry for α‐smooth muscle actin was done and stereological parameters were estimated in superficial and deep dermis. At 7d, 14d, and 21d the blood pressure of LNAME group was higher compared with control group (p Document Type: Abstract DOI: http://dx.doi.org/10.1111/j.1067-1927.2005.130117f.x Affiliations: 1: Histology and Embryology Department, State University of Rio de Janeiro, RJ, Brazil, 2: INSERM E0362, Université Victor Segalen, Bordeaux, France Publication date: January 1, 2005 $(document).ready(function() { var shortdescription = $(".originaldescription").text().replace(/\\&/g, '&').replace(/\\, '<').replace(/\\>/g, '>').replace(/\\t/g, ' ').replace(/\\n/g, ''); if (shortdescription.length > 350){ shortdescription = "" + shortdescription.substring(0,250) + "... more"; } $(".descriptionitem").prepend(shortdescription); $(".shortdescription a").click(function() { $(".shortdescription").hide(); $(".originaldescription").slideDown(); return false; }); }); Related content In this: publication By this: publisher In this Subject: Surgery By this author: Amadeu, TP ; Desmoulière, A ; Costa, AMA GA_googleFillSlot("Horizontal_banner_bottom");
Background Combined pulmonary fibrosis and emphysema (CPFE) is an entity characterized by the pre... more Background Combined pulmonary fibrosis and emphysema (CPFE) is an entity characterized by the presence of emphysema in upper lobes and fibrosis in lower lobes. Due to the presence of the two diseases concomitantly, it may be difficult to diagnose. This study aims at a better understanding of this entity and proposes biological markers (functional and biochemical) that help in this characterization. Methods A prospective, observational, cross-sectional study was carried out at a reference center. Pulmonary function tests (spirometry, CO-diffusion capacity, plethysmography and single-maneuver nitrogen washout test - SBWN 2 ) and biochemical markers (periostin, mucin-16, PDGF-BB and TGF-β 1 ) were measured in groups of patients: idiopathic pulmonary fibrosis, CPFE and chronic obstructive pulmonary disease (COPD). Results Variables derived from SBWN 2 - closing volume (CV) / vital capacity (VC) (%) and closing capacity (CC) / total lung capacity (TLC) (%) - were found to be higher in th...
Autoeficácia para atividades físicas (AEAF) é a crença que um indivíduo tem na capacidade de real... more Autoeficácia para atividades físicas (AEAF) é a crença que um indivíduo tem na capacidade de realizá-las com determinado desempenho, envolvendo um componente cognitivo e um poder de escolha. Objetivou-se, nesta revisão integrativa, identificar estudos sobre AEAF em adolescentes, produzidos no contexto da Educação Física Escolar brasileira ou estrangeira, para conhecer suas metodologias e principais resultados. Foram sumarizados, qualitativamente, 15 artigos, publicados entre 2008 e 2018 nas línguas portuguesa e inglesa, selecionados nas bases de dados: Google Acadêmico; BIREME/BVS; PUBMED; SCOPUS; e WEB OF SCIENCE, utilizando o termo autoeficácia e as palavras-chave Educação Física, saúde e ensino. Os estudos, majoritariamente em língua inglesa, sendo apenas dois em língua portuguesa, enfatizam os domínios autoeficácia para a tarefa, autoeficácia para superar barreiras e modelo tripartite. Esses domínios são capazes de explicar mudanças de comportamento em relação à prática de ativi...
Pleural tuberculosis (PlTB), a common form of extrapulmonary TB, remains as a challenge in the di... more Pleural tuberculosis (PlTB), a common form of extrapulmonary TB, remains as a challenge in the diagnosis among many causes of pleural effusion. We recently reported that the combinatorial analysis of interferon-gamma (IFN-γ), IFN-γ-inducible protein 10 (IP-10), and adenosine deaminase (ADA) from the pleural microenvironment was useful to distinguish pleural effusion caused by TB (microbiologically or not confirmed cases) among other etiologies. In this cross-sectional cohort study, a set of inflammatory mediators was quantified in blood and pleural fluid (PF) from exudative pleural effusion cases, including PlTB (n = 27) and non-PlTB (nTB; n = 25) patients. The levels of IL-2, IL-4, IL-6, IL-10, IL-17A, IFN-γ, TNF, IP-10, TGF-β1, and ADA were determined using cytometric bead assay, ELISA or biochemical tests. IFN-γ, IP-10, TNF, TGF-β, and ADA quantified in PF showed significantly higher concentrations in PlTB patients when compared to nTB. When blood and PF were compared, we have id...
Pleural tuberculosis (PlTB), a form of extrapulmonary TB, remains as a challenge in the diagnosis... more Pleural tuberculosis (PlTB), a form of extrapulmonary TB, remains as a challenge in the diagnosis among many causes of pleural effusion. We recently reported that the combinatorial analysis of interferon-gamma (IFN-γ), IFN-γ-inducible protein 10 (IP-10), and adenosine deaminase (ADA) from the pleural microenvironment was useful to distinguish pleural effusion caused by TB (microbiologically or not confirmed cases) among other etiologies. In this prospective cohort study, a set of inflammatory mediators was quantified in blood and pleural fluid (PF) from exudative pleural effusion cases, including PlTB (n = 22) and non-PlTB (NTB; n = 17) patients. The levels of IL-2, IL-4, IL-6, IL-10, IL-17A, IFN-γ, TNF, IP-10, TGF-β1, and ADA were measured and a principal component analysis was applied in order to identify the mediators who contributed most for the variance in data. IFN-γ, IP-10, TNF, TGF-β, and ADA quantified in PF showed significantly higher concentrations in PlTB patients when c...
ABSTRACT The chronic course of leprosy is aggravated by the emergence of reactional states such a... more ABSTRACT The chronic course of leprosy is aggravated by the emergence of reactional states such as type 1 reaction (T1R). The occurrence of T1R is deemed to be a sudden and heightened inflammatory response that eventually compromises the skin and peripheral nerves 1. T1R occurs more frequently among the unstable borderline forms (BT, BB and BL) but has also been known to occur in lepromatous patients (LL)2This article is protected by copyright. All rights reserved.
Uploads