Regional Anesthesia and Pain Medicine, Sep 1, 2008
ethods: Sixty patients scheduled for elective hand surgery paricipated in this prospective random... more ethods: Sixty patients scheduled for elective hand surgery paricipated in this prospective randomized double-blind study. The VRA was achieved using 3 mg kg (-1) lidocaine diluted with saline o a total volume of 40 mL in the control group (group C) or 1 icrog kg(-1) of dexmedetomidine 3 mg kg(-1) lidocaine or 0.5 g neostigmine 3 mg kg(-1) lidocaine diluted with saline to a otal volume of 40 mL in Group D or Group N. Sensory and motor lock onset and recovery times, pain, sedation score, and hemodyamic parameters were assessed. Visual analog scale pain scores 0-10) were recorded, and patients received diclofenac, 75 mg IM, f their pain score was 4. The tourniquet deflation and first equest of analgesic was accepted as analgesia period.
Background Ischemia occurs when blood supply to tissues is limited, resulting in cellular dysfunc... more Background Ischemia occurs when blood supply to tissues is limited, resulting in cellular dysfunction and necrosis. Reperfusion, or the process of restoring blood flow, can result in an overabundance of reactive oxygen species (ROS) and toxic byproducts. The I/R (Ischemia / Reperfusion) technique used in liver resection and transplantation has been linked to liver damage. Molnupiravir, a non-hepatotoxic oral medicine, is converted into N-hydroxycytidine (NHC). The purpose of this study is to see how molnupiravir affects I/R-induced damage of liver in rats. Methods We divided the rats into three groups: Sham operation (SG) (n = 6), Liver I/R (LIR) (n = 6), and Molnupiravir + Liver I/R (MIR) (n = 6) groups. The MIR group (n = 6) received 40 mg/kg of molnupiravir. All animals were subjected to laparotomy, hepatic ischemia (1 hour), and reperfusion (6 hours). At the end of the trial, liver tissue samples were tested for IL-1β, tGSH, NF-κB, MDA, and TNF-α levels, as well as histopatholog...
Regional Anesthesia and Pain Medicine, Sep 1, 2008
ethods: Sixty patients scheduled for elective hand surgery paricipated in this prospective random... more ethods: Sixty patients scheduled for elective hand surgery paricipated in this prospective randomized double-blind study. The VRA was achieved using 3 mg kg (-1) lidocaine diluted with saline o a total volume of 40 mL in the control group (group C) or 1 icrog kg(-1) of dexmedetomidine 3 mg kg(-1) lidocaine or 0.5 g neostigmine 3 mg kg(-1) lidocaine diluted with saline to a otal volume of 40 mL in Group D or Group N. Sensory and motor lock onset and recovery times, pain, sedation score, and hemodyamic parameters were assessed. Visual analog scale pain scores 0-10) were recorded, and patients received diclofenac, 75 mg IM, f their pain score was 4. The tourniquet deflation and first equest of analgesic was accepted as analgesia period.
Background Ischemia occurs when blood supply to tissues is limited, resulting in cellular dysfunc... more Background Ischemia occurs when blood supply to tissues is limited, resulting in cellular dysfunction and necrosis. Reperfusion, or the process of restoring blood flow, can result in an overabundance of reactive oxygen species (ROS) and toxic byproducts. The I/R (Ischemia / Reperfusion) technique used in liver resection and transplantation has been linked to liver damage. Molnupiravir, a non-hepatotoxic oral medicine, is converted into N-hydroxycytidine (NHC). The purpose of this study is to see how molnupiravir affects I/R-induced damage of liver in rats. Methods We divided the rats into three groups: Sham operation (SG) (n = 6), Liver I/R (LIR) (n = 6), and Molnupiravir + Liver I/R (MIR) (n = 6) groups. The MIR group (n = 6) received 40 mg/kg of molnupiravir. All animals were subjected to laparotomy, hepatic ischemia (1 hour), and reperfusion (6 hours). At the end of the trial, liver tissue samples were tested for IL-1β, tGSH, NF-κB, MDA, and TNF-α levels, as well as histopatholog...
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