Short-term mutagenicity tests on Salmonella typhimurium : studies on vinyl chloride, ethylene dic... more Short-term mutagenicity tests on Salmonella typhimurium : studies on vinyl chloride, ethylene dichloride and other compounds related to the vinyl chloride industry
Ten different diesel fuels were tested for 26 physical and 45 chemical parameters. Principal comp... more Ten different diesel fuels were tested for 26 physical and 45 chemical parameters. Principal components analysis (PCA) was used for statistical analysis of the physical and chemical data separately and combined. Physically, these and similar fuels may be described in a few general ...
PLE quicker and more convenient alternative than EPA Soxhlet method TO-13A for extraction of PAHs... more PLE quicker and more convenient alternative than EPA Soxhlet method TO-13A for extraction of PAHs from atmospheric PUF samples.
It is well known that the use of a biofuel as an automotive fuel, such as the use of ethanol prod... more It is well known that the use of a biofuel as an automotive fuel, such as the use of ethanol produced from lignocellulosics, is an efficient way of reducing the net emission of carbon dioxide. The question raised is what happens to the emission of components which are related to health risks? This question is one of the key questions to be answered by the investigations included in a project which has been sponsored by the Swedish government with the object of bringing about a reduction in the emissions from buses and heavy duty trucks which are operated in urban areas. This presentation discusses the importance of the characterization of the emissions as an aid to the development of an ethanol fueled bus engine, an exhaust control system and to some extent the question of how to specify the ethanol fuel to be used. The characterization of the emissions was carried out both on an engine on test and on vehicles driven on a chassis dynamometer. The emissions measured were the regulated emissions including NO2 and the unregulated emissions such as CO2, aldehydes, olefins and polycyclic aromatic compounds (PAC). In addition the biological activity of the exhaust was tested with respect to mutagenicity according to Ames, and with a TCDD receptor affinity test system. (A) For the covering abstract see IRRD 875003.
... Sta-tistical analysis was performed by x2 test of independent distribution of number of inges... more ... Sta-tistical analysis was performed by x2 test of independent distribution of number of ingested particles per ... proposed compound methylnaphthalenecarboxaldehydec fluoren-9-one" methylfluoren-9-onec*eg unknownh dibenzofurancarboxaldehyde methylfluoren-9-oneC@-g ...
... Arrhenius Laboratory, Department of Analytical Chemistry, University of Stockholm, 106 9 1 St... more ... Arrhenius Laboratory, Department of Analytical Chemistry, University of Stockholm, 106 9 1 Stockholm, Sweden Ulf Rannug and Lars Winquist Wallenberg Laboratory, Department of Genetic and Cellular Toxicology, University of Stockholm, 106 9 1 Stockholm, Sweden ...
Abstract The impact on exhaust emissions of diesel fuel composition was studied by a comprehensiv... more Abstract The impact on exhaust emissions of diesel fuel composition was studied by a comprehensive program compiled after discussions with the oil industry, the motor vehicle manufacturers and the Swedish Environmental Protection Agency. In order to reduce the emissions from diesel fueled vehicles different possibilities have to be taken into consideration such as improvement of the engine, use of exhaust purification devices and use of diesel fuels of improved quality. The aim of this investigation was to study the connection between certain fuel parameters and exhaust emissions. Eight different diesel fuels were used in the investigation and the emission tests were carried out using a city bus and a truck, driven on a chassis dynamometer. Both regulated andunregulated emissions were measured. In addition to the emission measurements samples were taken and prepared for biological testing. The investigation showed that there is a clear correlation between certain fuel parameters and the emissions and biological activity of the exhaust. Multivariate analysis was undertaken on groups of data derived from the eight blends of fuels in order to study the correlation between the fuel and emission parameters. A least square regression analysis of the correlation between 23 fuel parameters and 43 exhaust emission parameters resulted in correlation coefficients, which were higher than 0.95 for the two vehicles tested. It was confirmed that the most important fuel parameters to be controlled are the density, boiling point range, the content of aromatics and cetane index. In addition to these parameters the content of polycyclic aromatic hydrocarbons should be controlled and limited. Sulfur is also an important parameter to be controlled especially when the fuel is going to be used for vehicles equipped with catalysts or catalytically activated particulate filters.
Proceedings of the National Academy of Sciences of the United States of America, Jan 20, 2012
Altered systemic levels of 6-formylindolo[3,2-b]carbazole (FICZ), an enigmatic endogenous ligand ... more Altered systemic levels of 6-formylindolo[3,2-b]carbazole (FICZ), an enigmatic endogenous ligand for the aryl hydrocarbon receptor (AHR), may explain adverse physiological responses evoked by small natural and anthropogenic molecules as well as by oxidative stress and light. We demonstrate here that several different chemical compounds can inhibit the metabolism of FICZ, thereby disrupting the autoregulatory feedback control of cytochrome P4501 systems and other proteins whose expression is regulated by AHR. FICZ is both the most tightly bound endogenous agonist for the AHR and an ideal substrate for cytochrome CYP1A1/1A2 and 1B1, thereby also participating in an autoregulatory loop that keeps its own steady-state concentration low. At very low concentrations FICZ influences circadian rhythms, responses to UV light, homeostasis associated with pro- and anti-inflammatory processes, and genomic stability. Here, we demonstrate that, if its metabolic clearance is compromised, femtomolar...
Short-term mutagenicity tests on Salmonella typhimurium : studies on vinyl chloride, ethylene dic... more Short-term mutagenicity tests on Salmonella typhimurium : studies on vinyl chloride, ethylene dichloride and other compounds related to the vinyl chloride industry
Ten different diesel fuels were tested for 26 physical and 45 chemical parameters. Principal comp... more Ten different diesel fuels were tested for 26 physical and 45 chemical parameters. Principal components analysis (PCA) was used for statistical analysis of the physical and chemical data separately and combined. Physically, these and similar fuels may be described in a few general ...
PLE quicker and more convenient alternative than EPA Soxhlet method TO-13A for extraction of PAHs... more PLE quicker and more convenient alternative than EPA Soxhlet method TO-13A for extraction of PAHs from atmospheric PUF samples.
It is well known that the use of a biofuel as an automotive fuel, such as the use of ethanol prod... more It is well known that the use of a biofuel as an automotive fuel, such as the use of ethanol produced from lignocellulosics, is an efficient way of reducing the net emission of carbon dioxide. The question raised is what happens to the emission of components which are related to health risks? This question is one of the key questions to be answered by the investigations included in a project which has been sponsored by the Swedish government with the object of bringing about a reduction in the emissions from buses and heavy duty trucks which are operated in urban areas. This presentation discusses the importance of the characterization of the emissions as an aid to the development of an ethanol fueled bus engine, an exhaust control system and to some extent the question of how to specify the ethanol fuel to be used. The characterization of the emissions was carried out both on an engine on test and on vehicles driven on a chassis dynamometer. The emissions measured were the regulated emissions including NO2 and the unregulated emissions such as CO2, aldehydes, olefins and polycyclic aromatic compounds (PAC). In addition the biological activity of the exhaust was tested with respect to mutagenicity according to Ames, and with a TCDD receptor affinity test system. (A) For the covering abstract see IRRD 875003.
... Sta-tistical analysis was performed by x2 test of independent distribution of number of inges... more ... Sta-tistical analysis was performed by x2 test of independent distribution of number of ingested particles per ... proposed compound methylnaphthalenecarboxaldehydec fluoren-9-one" methylfluoren-9-onec*eg unknownh dibenzofurancarboxaldehyde methylfluoren-9-oneC@-g ...
... Arrhenius Laboratory, Department of Analytical Chemistry, University of Stockholm, 106 9 1 St... more ... Arrhenius Laboratory, Department of Analytical Chemistry, University of Stockholm, 106 9 1 Stockholm, Sweden Ulf Rannug and Lars Winquist Wallenberg Laboratory, Department of Genetic and Cellular Toxicology, University of Stockholm, 106 9 1 Stockholm, Sweden ...
Abstract The impact on exhaust emissions of diesel fuel composition was studied by a comprehensiv... more Abstract The impact on exhaust emissions of diesel fuel composition was studied by a comprehensive program compiled after discussions with the oil industry, the motor vehicle manufacturers and the Swedish Environmental Protection Agency. In order to reduce the emissions from diesel fueled vehicles different possibilities have to be taken into consideration such as improvement of the engine, use of exhaust purification devices and use of diesel fuels of improved quality. The aim of this investigation was to study the connection between certain fuel parameters and exhaust emissions. Eight different diesel fuels were used in the investigation and the emission tests were carried out using a city bus and a truck, driven on a chassis dynamometer. Both regulated andunregulated emissions were measured. In addition to the emission measurements samples were taken and prepared for biological testing. The investigation showed that there is a clear correlation between certain fuel parameters and the emissions and biological activity of the exhaust. Multivariate analysis was undertaken on groups of data derived from the eight blends of fuels in order to study the correlation between the fuel and emission parameters. A least square regression analysis of the correlation between 23 fuel parameters and 43 exhaust emission parameters resulted in correlation coefficients, which were higher than 0.95 for the two vehicles tested. It was confirmed that the most important fuel parameters to be controlled are the density, boiling point range, the content of aromatics and cetane index. In addition to these parameters the content of polycyclic aromatic hydrocarbons should be controlled and limited. Sulfur is also an important parameter to be controlled especially when the fuel is going to be used for vehicles equipped with catalysts or catalytically activated particulate filters.
Proceedings of the National Academy of Sciences of the United States of America, Jan 20, 2012
Altered systemic levels of 6-formylindolo[3,2-b]carbazole (FICZ), an enigmatic endogenous ligand ... more Altered systemic levels of 6-formylindolo[3,2-b]carbazole (FICZ), an enigmatic endogenous ligand for the aryl hydrocarbon receptor (AHR), may explain adverse physiological responses evoked by small natural and anthropogenic molecules as well as by oxidative stress and light. We demonstrate here that several different chemical compounds can inhibit the metabolism of FICZ, thereby disrupting the autoregulatory feedback control of cytochrome P4501 systems and other proteins whose expression is regulated by AHR. FICZ is both the most tightly bound endogenous agonist for the AHR and an ideal substrate for cytochrome CYP1A1/1A2 and 1B1, thereby also participating in an autoregulatory loop that keeps its own steady-state concentration low. At very low concentrations FICZ influences circadian rhythms, responses to UV light, homeostasis associated with pro- and anti-inflammatory processes, and genomic stability. Here, we demonstrate that, if its metabolic clearance is compromised, femtomolar...
Uploads
Papers by Ulf Rannug