Este articulo brinda una vision general en cuanto a la simulacion de entornos tridimensionales po... more Este articulo brinda una vision general en cuanto a la simulacion de entornos tridimensionales por computadora utilizando herramientas de codigo libre. La tecnologia para simulacion ha experimentado un crecimiento acelerado en los ultimos anos gracias a las exigencias del mundo del entretenimiento, entre otras cosas. La existencia de herramientas libres para crear este tipo de entornos resulta util a la comunidad cientifica, investigadores, estudiantes y aficionados.
Based on paris-traceroutes data collected from RIPE Atlas probes (from Nov. 2013 to Apr. 2014; Ju... more Based on paris-traceroutes data collected from RIPE Atlas probes (from Nov. 2013 to Apr. 2014; June 2014 to Aug. 2014, and from Nov. 2014 to Feb. 2015), we tracked the evolution of intra-African traffic localization. We indeed looked for IXPs traversed by the AS paths, using information collected from public datasets (PeeringDB, PCHdata, IXP websites, etc.). We then evaluated the impacts of peering on the minimum RTT among ASes and compare the Quality of Service experienced by random end-users in Africa, Europe, and North America for communications between same countries. After that, we presented a web platform displaying statistics such as the IP paths between any probe source and destination, the minimum RTT heat-map between any probes pair, the discovered IXPs in the dataset, etc. Such an application would allow stakeholders and engineers to have a view of the impact of their routing policies on the QoS experienced by end-users. We aim to get feedbacks from the AFPIF community be...
La automatizacion de procesos y sistemas a traves de tecnologias avanzadas actualmente se desarro... more La automatizacion de procesos y sistemas a traves de tecnologias avanzadas actualmente se desarrolla a pasos agigantados, para el adecuado desarrollo de esto, se requiere la aplicacion del conocimiento en muchas areas de la ingenieria tales como electrica, mecanica, electronica, comunicaciones, redes, gestion, y sistemas computacionales. Todo esto conlleva la necesidad de contar con personas especializadas que hagan investigaciones basicas y aplicadas, que puedan a su vez contribuir en el avance del conocimiento y/o transfieran tecnologia directamente a la industria para solucionar los problemas que esta enfrenta.
gunnar.gruen@th-nuernberg.de www.th-nuernberg.de With the increasing demand for more energy effic... more gunnar.gruen@th-nuernberg.dewww.th-nuernberg.de With the increasing demand for more energy efficient buildings, the construction and energy service industries are faced with new challenges. Buildings are often not able to uphold the energy performance and savings predicted by the selected and applied energy efficiency measures. This so-called “performance gap” is attributed to a variety of factors. For one, the predictions tend to be unrealistically low whilst actual energy performance is usually unexpectedly high. Current modelling techniques are unable to represent realistic use and operation of buildings. Even the most detailed modelling and simulation programs still contain many simplifying assumptions, which lead to gaps between predicted and real consumption. The current simulation tools do not accurately incorporate the impact of occupant behaviour on the energy performance of buildings. Therefore, MOEEBIUS introduces a holistic energy performance optimization framework that...
Tento clanek se zabýva analýzou pravni upravy odskodňovani nemajetkove ujmy na zdravi v ceskem pr... more Tento clanek se zabýva analýzou pravni upravy odskodňovani nemajetkove ujmy na zdravi v ceskem pracovnim pravu. Autor provadi argumentaci směřujici k odpověďi na otazku, podle kterých pravidel maji subjekty po 1. 1. 2014 postupovat při výpoctu výse nahrady za nemajetkovou ujmu na zdravi. Jsou zde dvě možnosti, a ani jedna z nich neni bezproblemova. V uvahu přichazi postup dle zrusene vyhlasky c. 440/2001 Sb. nebo dle nove metodiky Nejvyssiho soudu.
espanolEn la actualidad, tanto la Ley Organica para la Mejora de la Calidad Educativa (LOMCE, 201... more espanolEn la actualidad, tanto la Ley Organica para la Mejora de la Calidad Educativa (LOMCE, 2013), como la anterior Ley Organica de Educacion (LOE, 2006), asi como los diferentes curriculos educativos que han desgranado mediante Decretos las Comunidades Autonomas, identifican el desarrollo de la competencia motriz, de forma ciclica y acumulativa, en cinco bloques de contenidos. Uno de ellos, concretamente el Bloque 3, hace referencia a las actividades adaptadas al medio (LOMCE, 2013). Este bloque, que pretende desarrollar en el alumno una actitud critica y de respeto con el medio natural, ha de llevarse a la practica dentro de la Programacion de Aula (PA) en consonancia y equilibrio con el resto de los bloques de la materia de Educacion Fisica (LOMCE, 2013). Asi pues, autores como Fernandez (2010), afirman que es necesario valorar el entorno que rodea al alumno, entre otros factores, para que la PA “atienda a las verdaderas necesidades y demandas de nuestro alumnado” (Fernandez, 2...
Mucopolysaccharidosis type IVA (MPSIVA) or Morquio A disease, a lysosomal storage disorder, is ca... more Mucopolysaccharidosis type IVA (MPSIVA) or Morquio A disease, a lysosomal storage disorder, is caused by N-acetylgalactosamine-6-sulfate sulfatase (GALNS) deficiency, resulting in keratan sulfate (KS) and chondroitin-6-sulfate accumulation. Patients develop severe skeletal dysplasia, early cartilage deterioration and life-threatening heart and tracheal complications. There is no cure and enzyme replacement therapy cannot correct skeletal abnormalities. Here, using CRISPR/Cas9 technology, we generate the first MPSIVA rat model recapitulating all skeletal and non-skeletal alterations experienced by patients. Treatment of MPSIVA rats with adeno-associated viral vector serotype 9 encoding Galns (AAV9-Galns) results in widespread transduction of bones, cartilage and peripheral tissues. This led to long-term (1 year) increase of GALNS activity and whole-body correction of KS levels, thus preventing body size reduction and severe alterations of bones, teeth, joints, trachea and heart. This...
El Comité de Nutrición de la Federación Panamericana e Ibérica de Medicina Crítica y Terapia Inte... more El Comité de Nutrición de la Federación Panamericana e Ibérica de Medicina Crítica y Terapia Intensiva presenta las Guías de Recomendaciones para los pacientes graves con COVID-19 que ameritan manejo en Cuidados Intensivos. Se realizó una revisión sistemática de la literatura por los miembros del comité de nutrición de la FEPIMCTI en las bases de literatura médica más relevantes, se realiza una selección y evaluación de la literatura disponible, relacionada de forma directa o indirecta al COVID-19, teniendo en cuenta las guías ASPEN y ESPEN. Se encontró escasa literatura específica con relación al objetivo, se construyeron las recomendaciones más relevantes con información extrapoladas del manejo diario de los pacientes graves y con ARDS.
Joule heating of Zn wires has been used to grow undoped and Sn- or Tb-doped ZnO nanowires in seco... more Joule heating of Zn wires has been used to grow undoped and Sn- or Tb-doped ZnO nanowires in seconds.
Photodiagnosis and photodynamic therapy, Jan 24, 2017
The aims of this study were to determine the spatial and temporal theoretical distribution of the... more The aims of this study were to determine the spatial and temporal theoretical distribution of the concentrations of Protoporphyrin IX, (3)O2 and doses of (1)O2. The type II mechanism and explicit dosimetry in photodynamic therapy were used. Furthermore, the mechanism of respiration and cellular metabolism acting on (3)O2 were taken into account. The dermis was considered as an absorbing and a scattering medium. An analytical solution was used for light diffusion in the skin. The photophysical, photochemical and biological effects caused by PDT with the initial irradiances of 20, 60 and 150mW/cm(2) were studied for a time of exposure of 20min. and a maximum depth of 0.5cm. We found that the initial irradiance triples its value in 0.02cm and that almost 100% of PpIX is part of the dynamics of reactions in photodynamic therapy. Additionally, with about 40μMof (3)O2 there is a balance between the consumed and supplied oxygen. Finally, we determined that with 60mW/cm(2), the highest dose...
The Journal of bone and joint surgery. American volume, Jan 15, 2017
The spasticity and increased muscle tone observed in patients with cerebral palsy can lead to hip... more The spasticity and increased muscle tone observed in patients with cerebral palsy can lead to hip degeneration, subluxation, and pain. Currently, there is hesitation to perform total hip arthroplasty in patients with cerebral palsy because of fears of early wear and dislocation. The purpose of this study was to review the outcomes of total hip arthroplasty in patients with cerebral palsy and to compare outcomes with those of matched patients with a diagnosis of osteoarthritis. Over a 24-year period, 39 patients undergoing a total hip arthroplasty with a diagnosis of cerebral palsy were identified. The cohort included 26 male patients (67%), and the mean patient age was 49 years. The mean follow-up was 7 years. Patients with cerebral palsy were matched 1:2 with a group of patients undergoing total hip arthroplasty for osteoarthritis. There was no difference in the rate of reoperation, implant survival, or complications, specifically dislocation. Prior to the surgical procedure, all p...
Este articulo brinda una vision general en cuanto a la simulacion de entornos tridimensionales po... more Este articulo brinda una vision general en cuanto a la simulacion de entornos tridimensionales por computadora utilizando herramientas de codigo libre. La tecnologia para simulacion ha experimentado un crecimiento acelerado en los ultimos anos gracias a las exigencias del mundo del entretenimiento, entre otras cosas. La existencia de herramientas libres para crear este tipo de entornos resulta util a la comunidad cientifica, investigadores, estudiantes y aficionados.
Based on paris-traceroutes data collected from RIPE Atlas probes (from Nov. 2013 to Apr. 2014; Ju... more Based on paris-traceroutes data collected from RIPE Atlas probes (from Nov. 2013 to Apr. 2014; June 2014 to Aug. 2014, and from Nov. 2014 to Feb. 2015), we tracked the evolution of intra-African traffic localization. We indeed looked for IXPs traversed by the AS paths, using information collected from public datasets (PeeringDB, PCHdata, IXP websites, etc.). We then evaluated the impacts of peering on the minimum RTT among ASes and compare the Quality of Service experienced by random end-users in Africa, Europe, and North America for communications between same countries. After that, we presented a web platform displaying statistics such as the IP paths between any probe source and destination, the minimum RTT heat-map between any probes pair, the discovered IXPs in the dataset, etc. Such an application would allow stakeholders and engineers to have a view of the impact of their routing policies on the QoS experienced by end-users. We aim to get feedbacks from the AFPIF community be...
La automatizacion de procesos y sistemas a traves de tecnologias avanzadas actualmente se desarro... more La automatizacion de procesos y sistemas a traves de tecnologias avanzadas actualmente se desarrolla a pasos agigantados, para el adecuado desarrollo de esto, se requiere la aplicacion del conocimiento en muchas areas de la ingenieria tales como electrica, mecanica, electronica, comunicaciones, redes, gestion, y sistemas computacionales. Todo esto conlleva la necesidad de contar con personas especializadas que hagan investigaciones basicas y aplicadas, que puedan a su vez contribuir en el avance del conocimiento y/o transfieran tecnologia directamente a la industria para solucionar los problemas que esta enfrenta.
gunnar.gruen@th-nuernberg.de www.th-nuernberg.de With the increasing demand for more energy effic... more gunnar.gruen@th-nuernberg.dewww.th-nuernberg.de With the increasing demand for more energy efficient buildings, the construction and energy service industries are faced with new challenges. Buildings are often not able to uphold the energy performance and savings predicted by the selected and applied energy efficiency measures. This so-called “performance gap” is attributed to a variety of factors. For one, the predictions tend to be unrealistically low whilst actual energy performance is usually unexpectedly high. Current modelling techniques are unable to represent realistic use and operation of buildings. Even the most detailed modelling and simulation programs still contain many simplifying assumptions, which lead to gaps between predicted and real consumption. The current simulation tools do not accurately incorporate the impact of occupant behaviour on the energy performance of buildings. Therefore, MOEEBIUS introduces a holistic energy performance optimization framework that...
Tento clanek se zabýva analýzou pravni upravy odskodňovani nemajetkove ujmy na zdravi v ceskem pr... more Tento clanek se zabýva analýzou pravni upravy odskodňovani nemajetkove ujmy na zdravi v ceskem pracovnim pravu. Autor provadi argumentaci směřujici k odpověďi na otazku, podle kterých pravidel maji subjekty po 1. 1. 2014 postupovat při výpoctu výse nahrady za nemajetkovou ujmu na zdravi. Jsou zde dvě možnosti, a ani jedna z nich neni bezproblemova. V uvahu přichazi postup dle zrusene vyhlasky c. 440/2001 Sb. nebo dle nove metodiky Nejvyssiho soudu.
espanolEn la actualidad, tanto la Ley Organica para la Mejora de la Calidad Educativa (LOMCE, 201... more espanolEn la actualidad, tanto la Ley Organica para la Mejora de la Calidad Educativa (LOMCE, 2013), como la anterior Ley Organica de Educacion (LOE, 2006), asi como los diferentes curriculos educativos que han desgranado mediante Decretos las Comunidades Autonomas, identifican el desarrollo de la competencia motriz, de forma ciclica y acumulativa, en cinco bloques de contenidos. Uno de ellos, concretamente el Bloque 3, hace referencia a las actividades adaptadas al medio (LOMCE, 2013). Este bloque, que pretende desarrollar en el alumno una actitud critica y de respeto con el medio natural, ha de llevarse a la practica dentro de la Programacion de Aula (PA) en consonancia y equilibrio con el resto de los bloques de la materia de Educacion Fisica (LOMCE, 2013). Asi pues, autores como Fernandez (2010), afirman que es necesario valorar el entorno que rodea al alumno, entre otros factores, para que la PA “atienda a las verdaderas necesidades y demandas de nuestro alumnado” (Fernandez, 2...
Mucopolysaccharidosis type IVA (MPSIVA) or Morquio A disease, a lysosomal storage disorder, is ca... more Mucopolysaccharidosis type IVA (MPSIVA) or Morquio A disease, a lysosomal storage disorder, is caused by N-acetylgalactosamine-6-sulfate sulfatase (GALNS) deficiency, resulting in keratan sulfate (KS) and chondroitin-6-sulfate accumulation. Patients develop severe skeletal dysplasia, early cartilage deterioration and life-threatening heart and tracheal complications. There is no cure and enzyme replacement therapy cannot correct skeletal abnormalities. Here, using CRISPR/Cas9 technology, we generate the first MPSIVA rat model recapitulating all skeletal and non-skeletal alterations experienced by patients. Treatment of MPSIVA rats with adeno-associated viral vector serotype 9 encoding Galns (AAV9-Galns) results in widespread transduction of bones, cartilage and peripheral tissues. This led to long-term (1 year) increase of GALNS activity and whole-body correction of KS levels, thus preventing body size reduction and severe alterations of bones, teeth, joints, trachea and heart. This...
El Comité de Nutrición de la Federación Panamericana e Ibérica de Medicina Crítica y Terapia Inte... more El Comité de Nutrición de la Federación Panamericana e Ibérica de Medicina Crítica y Terapia Intensiva presenta las Guías de Recomendaciones para los pacientes graves con COVID-19 que ameritan manejo en Cuidados Intensivos. Se realizó una revisión sistemática de la literatura por los miembros del comité de nutrición de la FEPIMCTI en las bases de literatura médica más relevantes, se realiza una selección y evaluación de la literatura disponible, relacionada de forma directa o indirecta al COVID-19, teniendo en cuenta las guías ASPEN y ESPEN. Se encontró escasa literatura específica con relación al objetivo, se construyeron las recomendaciones más relevantes con información extrapoladas del manejo diario de los pacientes graves y con ARDS.
Joule heating of Zn wires has been used to grow undoped and Sn- or Tb-doped ZnO nanowires in seco... more Joule heating of Zn wires has been used to grow undoped and Sn- or Tb-doped ZnO nanowires in seconds.
Photodiagnosis and photodynamic therapy, Jan 24, 2017
The aims of this study were to determine the spatial and temporal theoretical distribution of the... more The aims of this study were to determine the spatial and temporal theoretical distribution of the concentrations of Protoporphyrin IX, (3)O2 and doses of (1)O2. The type II mechanism and explicit dosimetry in photodynamic therapy were used. Furthermore, the mechanism of respiration and cellular metabolism acting on (3)O2 were taken into account. The dermis was considered as an absorbing and a scattering medium. An analytical solution was used for light diffusion in the skin. The photophysical, photochemical and biological effects caused by PDT with the initial irradiances of 20, 60 and 150mW/cm(2) were studied for a time of exposure of 20min. and a maximum depth of 0.5cm. We found that the initial irradiance triples its value in 0.02cm and that almost 100% of PpIX is part of the dynamics of reactions in photodynamic therapy. Additionally, with about 40μMof (3)O2 there is a balance between the consumed and supplied oxygen. Finally, we determined that with 60mW/cm(2), the highest dose...
The Journal of bone and joint surgery. American volume, Jan 15, 2017
The spasticity and increased muscle tone observed in patients with cerebral palsy can lead to hip... more The spasticity and increased muscle tone observed in patients with cerebral palsy can lead to hip degeneration, subluxation, and pain. Currently, there is hesitation to perform total hip arthroplasty in patients with cerebral palsy because of fears of early wear and dislocation. The purpose of this study was to review the outcomes of total hip arthroplasty in patients with cerebral palsy and to compare outcomes with those of matched patients with a diagnosis of osteoarthritis. Over a 24-year period, 39 patients undergoing a total hip arthroplasty with a diagnosis of cerebral palsy were identified. The cohort included 26 male patients (67%), and the mean patient age was 49 years. The mean follow-up was 7 years. Patients with cerebral palsy were matched 1:2 with a group of patients undergoing total hip arthroplasty for osteoarthritis. There was no difference in the rate of reoperation, implant survival, or complications, specifically dislocation. Prior to the surgical procedure, all p...
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