Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, 1996
As a result of the extensive use of new generation cephalosporins, an increase in the frequency o... more As a result of the extensive use of new generation cephalosporins, an increase in the frequency of gram negative bacteria in nosocomial infections is observed in recent years. Awareness of the rate of resistance to these agents is a requirement in order to install apropriate control measured. A study was undertaken with the participation of nine hospitals in Turkey to determine the frequency of gram negative bacteria isolated in the ICU's and compare the resistance rates to selected antibiotics. 981 bacteria were collected and antibiotic susceptibilities were determined by E-test. Pseudomonas spp. was the most prevalent organism (30%) followed by Klebsiella spp. (25%) and E. coli (18%). Imipenem, amikacin and ciprofloxacin were the most active agents in vitro with slight variations according to each center. The high rate of resistance to the new generation cephalosporins suggested the Class I and extended-broad-spectrum ß-lactamases.
The Journal of Infection in Developing Countries, 2019
Introduction: Studies indicate that adherence to hand hygiene guidelines is at suboptimal levels.... more Introduction: Studies indicate that adherence to hand hygiene guidelines is at suboptimal levels. We aimed to explore the reasons for poor hand hygiene compliance. Methodology: A qualitative study based on the Theory of Planned Behavior as a framework in explaining compliance, consisting four focus group discussions and six in-depth interviews. Results: Participants mostly practiced hand hygiene depending on the sense of "dirtiness" and "cleanliness". Some of the participants indicated that on-job training delivered by the infection control team changed their perception of "emotionally" based hand hygiene to "indication" based. Direct observations and individual feedback on one-to-one basis were the core of this training. There was low social cohesiveness and a deep polarization between the professional groups that led one group accusing the other for not being compliant. Conclusions: The infection control team should continue delivering one-t...
Drug resistance patterns of shigella strains were investigated in a prospective manner in Etimesg... more Drug resistance patterns of shigella strains were investigated in a prospective manner in Etimesgut district during a period of 1 year. Thirty strains shigella were isolated, belonged to three subgroups with preponderance of Sh. flexneri (70%), followed by Sh. sonnei (27%) and Sh. boydii (3%). The resistance was highest with streptomycin (80%), followed by trimethoprim-sulfamethoxazole (TMP-SMZ) (53%) and ampicillin (43%). Only three strains (10%) were sensitive to all eight antibiotics tested. Sixteen (53%) were resistant to three or more antibiotics. The data showed an increase in resistance to the commonly used antimicrobial agents--namely IMP-SMZ and ampicillin. IMP-SMZ is no longer the drug of choice in severe shigellosis, at least in this region of Turkey.
In this article, a case of group B streptococcal endocarditis in a diabetic patient, taking immun... more In this article, a case of group B streptococcal endocarditis in a diabetic patient, taking immunosuppressive therapy because of dermatomyositis is reported.
In an open prospective study, the efficacy of sulbactam/ampicillin (50 and 100 mg/kg, respectivel... more In an open prospective study, the efficacy of sulbactam/ampicillin (50 and 100 mg/kg, respectively, qid) was evaluated in 21 patients with intracranial abscess(es). Sixteen patients had cerebral, 3 epidural, and 2 cerebellar abscesses. Multiple lesions were found in 7 patients. Sixteen patients underwent surgical intervention, others were treated with antibiotic alone. The mean duration of antibiotic therapy (+/- SD) was 48 +/- 10 days (range 26-65 days). The mean duration of follow-up after completion of therapy (+/- SD) was 6 +/- 2.4 months. All patients had at least some reduction in size of abscess(es) within 3 weeks of the initiation of therapy as monitored by computerized tomography. Seventeen patients were cured, three patients died due to causes unrelated to their infection. One patient was reoperated since no clear improvement either clinically or radiologically was observed 18 days after the first operation. Side effects of sulbactam/ampicillin were minor and transient. Re...
Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, 1996
As a result of the extensive use of new generation cephalosporins, an increase in the frequency o... more As a result of the extensive use of new generation cephalosporins, an increase in the frequency of gram negative bacteria in nosocomial infections is observed in recent years. Awareness of the rate of resistance to these agents is a requirement in order to install apropriate control measured. A study was undertaken with the participation of nine hospitals in Turkey to determine the frequency of gram negative bacteria isolated in the ICU's and compare the resistance rates to selected antibiotics. 981 bacteria were collected and antibiotic susceptibilities were determined by E-test. Pseudomonas spp. was the most prevalent organism (30%) followed by Klebsiella spp. (25%) and E. coli (18%). Imipenem, amikacin and ciprofloxacin were the most active agents in vitro with slight variations according to each center. The high rate of resistance to the new generation cephalosporins suggested the Class I and extended-broad-spectrum ß-lactamases.
The Journal of Infection in Developing Countries, 2019
Introduction: Studies indicate that adherence to hand hygiene guidelines is at suboptimal levels.... more Introduction: Studies indicate that adherence to hand hygiene guidelines is at suboptimal levels. We aimed to explore the reasons for poor hand hygiene compliance. Methodology: A qualitative study based on the Theory of Planned Behavior as a framework in explaining compliance, consisting four focus group discussions and six in-depth interviews. Results: Participants mostly practiced hand hygiene depending on the sense of "dirtiness" and "cleanliness". Some of the participants indicated that on-job training delivered by the infection control team changed their perception of "emotionally" based hand hygiene to "indication" based. Direct observations and individual feedback on one-to-one basis were the core of this training. There was low social cohesiveness and a deep polarization between the professional groups that led one group accusing the other for not being compliant. Conclusions: The infection control team should continue delivering one-t...
Drug resistance patterns of shigella strains were investigated in a prospective manner in Etimesg... more Drug resistance patterns of shigella strains were investigated in a prospective manner in Etimesgut district during a period of 1 year. Thirty strains shigella were isolated, belonged to three subgroups with preponderance of Sh. flexneri (70%), followed by Sh. sonnei (27%) and Sh. boydii (3%). The resistance was highest with streptomycin (80%), followed by trimethoprim-sulfamethoxazole (TMP-SMZ) (53%) and ampicillin (43%). Only three strains (10%) were sensitive to all eight antibiotics tested. Sixteen (53%) were resistant to three or more antibiotics. The data showed an increase in resistance to the commonly used antimicrobial agents--namely IMP-SMZ and ampicillin. IMP-SMZ is no longer the drug of choice in severe shigellosis, at least in this region of Turkey.
In this article, a case of group B streptococcal endocarditis in a diabetic patient, taking immun... more In this article, a case of group B streptococcal endocarditis in a diabetic patient, taking immunosuppressive therapy because of dermatomyositis is reported.
In an open prospective study, the efficacy of sulbactam/ampicillin (50 and 100 mg/kg, respectivel... more In an open prospective study, the efficacy of sulbactam/ampicillin (50 and 100 mg/kg, respectively, qid) was evaluated in 21 patients with intracranial abscess(es). Sixteen patients had cerebral, 3 epidural, and 2 cerebellar abscesses. Multiple lesions were found in 7 patients. Sixteen patients underwent surgical intervention, others were treated with antibiotic alone. The mean duration of antibiotic therapy (+/- SD) was 48 +/- 10 days (range 26-65 days). The mean duration of follow-up after completion of therapy (+/- SD) was 6 +/- 2.4 months. All patients had at least some reduction in size of abscess(es) within 3 weeks of the initiation of therapy as monitored by computerized tomography. Seventeen patients were cured, three patients died due to causes unrelated to their infection. One patient was reoperated since no clear improvement either clinically or radiologically was observed 18 days after the first operation. Side effects of sulbactam/ampicillin were minor and transient. Re...
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