International Journal for Vitamin and Nutrition Research, 2013
This study was designed to investigate the effects of combined administration of lipoic acid and ... more This study was designed to investigate the effects of combined administration of lipoic acid and pyridoxine on albuminuria, oxidative stress, blood pressure, serum advanced glycation end-products, nitric oxide (NO), and endothelin-1 in patients with diabetic nephropathy. Thirty-four patients were randomly assigned to either a supplement group or a placebo group. The patients in the supplement group received 800 mg lipoic acid and 80 mg pyridoxine daily for 12 weeks, whereas the placebo group received corresponding placebos. Urinary albumin, serum malondialdehyde (MDA), and systolic blood pressure decreased significantly in the supplement group compared to the placebo group (p < 0.05). Serum NO increased in the supplement group compared to the placebo group (p < 0.05). Serum pentosidine and carboxymethyl lysine decreased significantly in the supplement group at the end of week 12 compared to baseline (p < 0.05). No statistically significant differences were observed between ...
Background: The aim of this study was to compare the behavior of heart rate variability at rest, ... more Background: The aim of this study was to compare the behavior of heart rate variability at rest, mid-test, immediately, 5 and 10 min of recovery following the exhaustive arm crank and cycle ergometer protocols in healthy children, middle-aged and elderly subjects. Methods: Thirty-six healthy men volunteered to participate in this study and were assigned to three groups: child (N.=12), middle-aged (N.=12) and elder (N.=12). Heart rate variability was assessed by calculation of the mean R-R interval measured by Electrocardiogram at each phases. Results: Heart rate variability significantly decreased at mid-test, immediately and significantly increased in 5 and 10 min of recovery after both the arm crank and cycle ergometer protocols among all groups, these changes were significantly higher in cycle ergometer compared with arm crank protocol among all age groups. Moreover, increase of heart rate variability was significantly higher in the middle-aged than that for children and elder subjects during 5 and 10 min of recovery after cycle ergometer protocol. Conclusions: Our results indicate a relationship between lowered heart rate variability and the age of the subjects. In addition, our findings suggest a clinically important effect of exhaustive physical activity in various ages after upper body work than lower body work.
The neuroprotective effects of prolonged exercise training on levels of lead acetate-induced brai... more The neuroprotective effects of prolonged exercise training on levels of lead acetate-induced brain-derived neurotrophic factor (BDNF) were investigated. Forty rats were randomly divided into 4 groups: (1) basic, (2) sham, (3) lead acetate + training and (4) lead acetate groups. The rats of groups 3 and 4 experienced treadmill running of 15 to 22 m/min for 25 to 64 minutes, 5 times a week for 8 weeks. Groups 1, 3 and 4 received lead acetate (20 mg/kg) and the sham group received solvent (ethyl oleat). The results showed that BDNF in lead acetate group decreased significantly, whereas in lead acetate + training group it increased. Malone dialdehyde (MDA) significantly increased in lead acetate group, while in lead acetate + training group it decreased. Finally, the levels of total antioxidant capacity (TAC) in lead acetate group significantly decreased and increased in lead acetate + training group. Data obtained suggest a lifestyle-induced protective potential in rehabilitation of le...
Abstract We have investigated responses of hippocampus Brain Derived Neurotherophic Factor (BDNF)... more Abstract We have investigated responses of hippocampus Brain Derived Neurotherophic Factor (BDNF) and oxidative biomarkers such as; Total Antioxidant Capacity (TAC) and Malondialdehyde (MDA) to acute treadmill exercise and it’s adaptations to chronic exercise in rats exposed to lead acetate. Forty rats were randomly divided into 5 groups: (1) lead acetate, (2) endurance training, (3) acute training, (4) endurance+ acute training and (5) sham groups. Groups 1 to 4 received lead acetate (20 mg/kg), while sham group received ethyl oleat (30 mg/kg), intraperitoneally. The rats in groups 2 and 4 experienced the treadmill running for 8 weeks (15-22 m/min, 25-64 min) and the subjects in groups 3 and 4 ran on the treadmill at 1.6 km/h until exhaustion, immediately before death. Lead administration decreased BDNF, insignificantly and TAC, significantly and caused a significant increased in MDA. In contrast, performing 8 weeks exercise enhanced the hippocampus BDNF and plasma TAC, significant...
Abstract Introduction: In recent years, by understanding the free radical mechanism of Adriamycin... more Abstract Introduction: In recent years, by understanding the free radical mechanism of Adriamycin(ADR)-induced cardiac stress, it has become possible to develop effective strategies to prevent or modify expected damage. Several strategies for detecting and preventing cardiac stress have been developed, including physical activity or limiting cumulative dose. The purpose of this study was to determine the preventive effect of endurance training on various doses of adriamycin induced cardiac stress in rats. Material and Methods: Forty-eight male rats were randomly assigned to nontraining (NT) and training (T) groups and three subgroups; include ADR10mg.kg -1 and ADR20mg.kg -1and saline treatment. Training program was including treadmill running between 25 to 54 min/day and 15 to 20 m/min, 5 days/wk for 6 wk. Results: ADR administration, in particularly with 20mg.kg _1, causes an imbalance in markers related to cardioprotection(HSP70, SOD) and cardiac stress (MDA, CPK-MB, CK), as compa...
The Journal of sports medicine and physical fitness, Jan 13, 2015
The aim of this study was to compare the behavior of heart rate variability at rest, midtest, imm... more The aim of this study was to compare the behavior of heart rate variability at rest, midtest, immediately, 5 and 10 min of recovery following the exhaustive arm crank and cycle ergometer protocols in healthy children, middle--aged and elderly subjects. Thirty--six healthy men volunteered to participate in this study and were assigned to three groups: child (N=12), middle--aged (N=12) and elder (N=12). Heart rate variability was assessed by calculation of the mean R--R interval measured by Electrocardiogram at each phases. Heart rate variability significantly decreased at midtest, immediately and significantly increased in 5 and 10 min of recovery after both of the arm crank and cycle ergometer protocols among all groups, these changes was significantly higher in cycle ergometer compared with arm crank protocol among all age groups. Moreover, increase of heart rate variability was significantly higher in the middle--aged than children and elder subjects during 5 and 10 min of recov...
The Journal of sports medicine and physical fitness
The purpose of this study was to determine the effects of endurance and/ or weight training in no... more The purpose of this study was to determine the effects of endurance and/ or weight training in normal and/ or moderate heat environments on heat shock protein (HSP72) response in active young females. Forty-five healthy active female (21±3 year, 61.4±10.2 kg, VO2max 37.2±5.3 mL/kg/min) were randomLy assigned into five groups; endurance training+normal heat (ET+NH), endurance training+moderate heat (ET+MH), weight training+normal heat (WT+NH), weight training+moderate heat (WT+MH) and heat group (HG). The training protocols include treadmill running to exhaustion on a treadmill at %65-75 V02max in the ET+NH and ET+MH groups and 4 sets of eccentric actions of elbow flexors (two sets with %50 and two sets with %60 1RM) in the WT+NH and WT+MH groups. Fasting blood samples were collected from non-dominant arm at three phases; consist of rest (baseline) and mid-test and 30 min after the training protocols. Endurance training and/ or weight training, in particularly, in the moderate heat a...
Background: Different training methods have been presented to reduce the side effects of doxorubi... more Background: Different training methods have been presented to reduce the side effects of doxorubicin and it seems that according to patient's condition, the time to start exercises, and the duration and stress of exercise should be considered. This study aimed to investigate the preventive effect of voluntary exercise on liver apoptosis induced by doxorubicin in aging model rats. Methods: 42 adult male Wistar rats were divided into 6 equal groups of young, aging, aging + saline, aging + doxorubicin, aging + doxorubicin + voluntary training, and aging + saline+ voluntary training. Voluntary training was performed in cages equipped with a running wheel for six weeks individually and freely. At the same time, as the end of the training, doxorubicin or saline solution was injected with a cumulative dose (1 mg/kg). 48 hours after completion of the training, liver tissue sampling was performed to assess the apoptosis via examining the expression of Bax and B-cell leukemia 2 (Bcl-2) pr...
Previous studies have confirmed the sidelong effects of Doxorubicin (DOX) on healthy tissues, but... more Previous studies have confirmed the sidelong effects of Doxorubicin (DOX) on healthy tissues, but pretreatment effect of regular Aerobic exercise in restrain of hepatotoxicity induced by various dosages of doxorubicin is not clear. The aim of this study was to determine the pretreatment effect of six weeks aerobic exercise on stress markers level and liver injury, including heat shock protein (HSP72), Catalase (CAT), Alanine aminotransferase (ALT) and Aspartate transaminase (AST) in male Wistar rats. Materials & Methods: Forty-eight Wistar male rats were randomly assigned to control and training groups with three subgroups: DOX10mg/kg, DOX20mg/kg and saline. The training protocol included treadmill running progressively between 25 to 54 min/day and 15 to 20m/min, 5 days/week for six weeks. DOX and saline injection was performed 24 h after the last exercise session, and tissue collection was done 24 h after the injections. Results: Administration of DOX20mg/kg caused a significant increase in markers related to hepatic protection (HSP72, CAT) and hepatic injury (ALT, AST) as compared to saline group. Six weeks training before DOX 20mg/kg and DOX 10mg/kg administration led to insignificant increase in HSP72, ALT, AST and a significant increase in CAT as compared to control group. In addition, there was no significant difference between DOX20mg/kg and DOX 10mg/kg, just in HSP72. Conclusion: It can be concluded that pretreatment with sub-chronic aerobic exercise, probably by upregulation the antioxidant system, reduces hepatic damage and can be an effective strategy against DOXinduced hepatotoxicity
International Journal for Vitamin and Nutrition Research, 2013
This study was designed to investigate the effects of combined administration of lipoic acid and ... more This study was designed to investigate the effects of combined administration of lipoic acid and pyridoxine on albuminuria, oxidative stress, blood pressure, serum advanced glycation end-products, nitric oxide (NO), and endothelin-1 in patients with diabetic nephropathy. Thirty-four patients were randomly assigned to either a supplement group or a placebo group. The patients in the supplement group received 800 mg lipoic acid and 80 mg pyridoxine daily for 12 weeks, whereas the placebo group received corresponding placebos. Urinary albumin, serum malondialdehyde (MDA), and systolic blood pressure decreased significantly in the supplement group compared to the placebo group (p < 0.05). Serum NO increased in the supplement group compared to the placebo group (p < 0.05). Serum pentosidine and carboxymethyl lysine decreased significantly in the supplement group at the end of week 12 compared to baseline (p < 0.05). No statistically significant differences were observed between ...
Background: The aim of this study was to compare the behavior of heart rate variability at rest, ... more Background: The aim of this study was to compare the behavior of heart rate variability at rest, mid-test, immediately, 5 and 10 min of recovery following the exhaustive arm crank and cycle ergometer protocols in healthy children, middle-aged and elderly subjects. Methods: Thirty-six healthy men volunteered to participate in this study and were assigned to three groups: child (N.=12), middle-aged (N.=12) and elder (N.=12). Heart rate variability was assessed by calculation of the mean R-R interval measured by Electrocardiogram at each phases. Results: Heart rate variability significantly decreased at mid-test, immediately and significantly increased in 5 and 10 min of recovery after both the arm crank and cycle ergometer protocols among all groups, these changes were significantly higher in cycle ergometer compared with arm crank protocol among all age groups. Moreover, increase of heart rate variability was significantly higher in the middle-aged than that for children and elder subjects during 5 and 10 min of recovery after cycle ergometer protocol. Conclusions: Our results indicate a relationship between lowered heart rate variability and the age of the subjects. In addition, our findings suggest a clinically important effect of exhaustive physical activity in various ages after upper body work than lower body work.
The neuroprotective effects of prolonged exercise training on levels of lead acetate-induced brai... more The neuroprotective effects of prolonged exercise training on levels of lead acetate-induced brain-derived neurotrophic factor (BDNF) were investigated. Forty rats were randomly divided into 4 groups: (1) basic, (2) sham, (3) lead acetate + training and (4) lead acetate groups. The rats of groups 3 and 4 experienced treadmill running of 15 to 22 m/min for 25 to 64 minutes, 5 times a week for 8 weeks. Groups 1, 3 and 4 received lead acetate (20 mg/kg) and the sham group received solvent (ethyl oleat). The results showed that BDNF in lead acetate group decreased significantly, whereas in lead acetate + training group it increased. Malone dialdehyde (MDA) significantly increased in lead acetate group, while in lead acetate + training group it decreased. Finally, the levels of total antioxidant capacity (TAC) in lead acetate group significantly decreased and increased in lead acetate + training group. Data obtained suggest a lifestyle-induced protective potential in rehabilitation of le...
Abstract We have investigated responses of hippocampus Brain Derived Neurotherophic Factor (BDNF)... more Abstract We have investigated responses of hippocampus Brain Derived Neurotherophic Factor (BDNF) and oxidative biomarkers such as; Total Antioxidant Capacity (TAC) and Malondialdehyde (MDA) to acute treadmill exercise and it’s adaptations to chronic exercise in rats exposed to lead acetate. Forty rats were randomly divided into 5 groups: (1) lead acetate, (2) endurance training, (3) acute training, (4) endurance+ acute training and (5) sham groups. Groups 1 to 4 received lead acetate (20 mg/kg), while sham group received ethyl oleat (30 mg/kg), intraperitoneally. The rats in groups 2 and 4 experienced the treadmill running for 8 weeks (15-22 m/min, 25-64 min) and the subjects in groups 3 and 4 ran on the treadmill at 1.6 km/h until exhaustion, immediately before death. Lead administration decreased BDNF, insignificantly and TAC, significantly and caused a significant increased in MDA. In contrast, performing 8 weeks exercise enhanced the hippocampus BDNF and plasma TAC, significant...
Abstract Introduction: In recent years, by understanding the free radical mechanism of Adriamycin... more Abstract Introduction: In recent years, by understanding the free radical mechanism of Adriamycin(ADR)-induced cardiac stress, it has become possible to develop effective strategies to prevent or modify expected damage. Several strategies for detecting and preventing cardiac stress have been developed, including physical activity or limiting cumulative dose. The purpose of this study was to determine the preventive effect of endurance training on various doses of adriamycin induced cardiac stress in rats. Material and Methods: Forty-eight male rats were randomly assigned to nontraining (NT) and training (T) groups and three subgroups; include ADR10mg.kg -1 and ADR20mg.kg -1and saline treatment. Training program was including treadmill running between 25 to 54 min/day and 15 to 20 m/min, 5 days/wk for 6 wk. Results: ADR administration, in particularly with 20mg.kg _1, causes an imbalance in markers related to cardioprotection(HSP70, SOD) and cardiac stress (MDA, CPK-MB, CK), as compa...
The Journal of sports medicine and physical fitness, Jan 13, 2015
The aim of this study was to compare the behavior of heart rate variability at rest, midtest, imm... more The aim of this study was to compare the behavior of heart rate variability at rest, midtest, immediately, 5 and 10 min of recovery following the exhaustive arm crank and cycle ergometer protocols in healthy children, middle--aged and elderly subjects. Thirty--six healthy men volunteered to participate in this study and were assigned to three groups: child (N=12), middle--aged (N=12) and elder (N=12). Heart rate variability was assessed by calculation of the mean R--R interval measured by Electrocardiogram at each phases. Heart rate variability significantly decreased at midtest, immediately and significantly increased in 5 and 10 min of recovery after both of the arm crank and cycle ergometer protocols among all groups, these changes was significantly higher in cycle ergometer compared with arm crank protocol among all age groups. Moreover, increase of heart rate variability was significantly higher in the middle--aged than children and elder subjects during 5 and 10 min of recov...
The Journal of sports medicine and physical fitness
The purpose of this study was to determine the effects of endurance and/ or weight training in no... more The purpose of this study was to determine the effects of endurance and/ or weight training in normal and/ or moderate heat environments on heat shock protein (HSP72) response in active young females. Forty-five healthy active female (21±3 year, 61.4±10.2 kg, VO2max 37.2±5.3 mL/kg/min) were randomLy assigned into five groups; endurance training+normal heat (ET+NH), endurance training+moderate heat (ET+MH), weight training+normal heat (WT+NH), weight training+moderate heat (WT+MH) and heat group (HG). The training protocols include treadmill running to exhaustion on a treadmill at %65-75 V02max in the ET+NH and ET+MH groups and 4 sets of eccentric actions of elbow flexors (two sets with %50 and two sets with %60 1RM) in the WT+NH and WT+MH groups. Fasting blood samples were collected from non-dominant arm at three phases; consist of rest (baseline) and mid-test and 30 min after the training protocols. Endurance training and/ or weight training, in particularly, in the moderate heat a...
Background: Different training methods have been presented to reduce the side effects of doxorubi... more Background: Different training methods have been presented to reduce the side effects of doxorubicin and it seems that according to patient's condition, the time to start exercises, and the duration and stress of exercise should be considered. This study aimed to investigate the preventive effect of voluntary exercise on liver apoptosis induced by doxorubicin in aging model rats. Methods: 42 adult male Wistar rats were divided into 6 equal groups of young, aging, aging + saline, aging + doxorubicin, aging + doxorubicin + voluntary training, and aging + saline+ voluntary training. Voluntary training was performed in cages equipped with a running wheel for six weeks individually and freely. At the same time, as the end of the training, doxorubicin or saline solution was injected with a cumulative dose (1 mg/kg). 48 hours after completion of the training, liver tissue sampling was performed to assess the apoptosis via examining the expression of Bax and B-cell leukemia 2 (Bcl-2) pr...
Previous studies have confirmed the sidelong effects of Doxorubicin (DOX) on healthy tissues, but... more Previous studies have confirmed the sidelong effects of Doxorubicin (DOX) on healthy tissues, but pretreatment effect of regular Aerobic exercise in restrain of hepatotoxicity induced by various dosages of doxorubicin is not clear. The aim of this study was to determine the pretreatment effect of six weeks aerobic exercise on stress markers level and liver injury, including heat shock protein (HSP72), Catalase (CAT), Alanine aminotransferase (ALT) and Aspartate transaminase (AST) in male Wistar rats. Materials & Methods: Forty-eight Wistar male rats were randomly assigned to control and training groups with three subgroups: DOX10mg/kg, DOX20mg/kg and saline. The training protocol included treadmill running progressively between 25 to 54 min/day and 15 to 20m/min, 5 days/week for six weeks. DOX and saline injection was performed 24 h after the last exercise session, and tissue collection was done 24 h after the injections. Results: Administration of DOX20mg/kg caused a significant increase in markers related to hepatic protection (HSP72, CAT) and hepatic injury (ALT, AST) as compared to saline group. Six weeks training before DOX 20mg/kg and DOX 10mg/kg administration led to insignificant increase in HSP72, ALT, AST and a significant increase in CAT as compared to control group. In addition, there was no significant difference between DOX20mg/kg and DOX 10mg/kg, just in HSP72. Conclusion: It can be concluded that pretreatment with sub-chronic aerobic exercise, probably by upregulation the antioxidant system, reduces hepatic damage and can be an effective strategy against DOXinduced hepatotoxicity
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