Aim To estimate and compare plasma lycopene levels in patients with clinically/ histopathological... more Aim To estimate and compare plasma lycopene levels in patients with clinically/ histopathologically proven leukoplakia with that of control group (smokers/non-smokers) Materials and MethodsTotal of 90 individuals were included in the study with two main groups namely cases and controls: clinically/ histopathologically proven cases of oral leukoplakia (30) and age and sex matched control group divided into two categories non-smokers (30) and smokers without leukoplakia (30). Diagnosis of oral leukoplakia was first made on the basis of history and clinical features. Determination of lycopene in blood plasma by high performance liquid chromatography. ResultsThe age of the patients varied between 32-65 years. In the study group out of 30 patients of leukoplakia 16 patients were with clinically homogenous variety of leukoplakia and 14 with the speckled variety. Histopathologically out of 30 patients 13 had mild dysplasia and 17 with moderate dysplasia. The mean plasma lycopene level valu...
The COVID-19 pandemic that started in China's Wuhan city in December, 2019, hasspread to all ... more The COVID-19 pandemic that started in China's Wuhan city in December, 2019, hasspread to all over the world. It is not only affecting personnel health but also the Indian economyas well as the world economy. Its severity depends on longevity of lockdown period, health crisisand resumption of economic activities in phased manner. In this paper we want to analysis anddevelop a framework to resumption of micro, small and medium enterprises (MSME) activitieswhich one of the most vulnerable and vital segment of the economy. We divide MSMEs intothree segment namely high, moderate and low risk entities on the basis of physical interactionbetween employees of the entity and infection risk involved. We also study measures taken bythe government so far and advises measure may taken by the government to revive the sector
The selection of this title was deliberate. We chose 'coming together' to signify the imp... more The selection of this title was deliberate. We chose 'coming together' to signify the importance of community within rural, remote and northern areas. This report is grounded within the importance of context and the solutions needed to sustain the nursing workforce are dependent upon partnership with: each other, government, and associations. We chose 'moving forward' as a reflection of the resilience of rural, remote and northern communities and the nursing workforce in these areas. While it is easy to dwell on deficiencies and what is not working, we have prepared this report to build on successes and focus on solutions. Lastly, 'building the next chapter' speaks to the important role rural, remote and northern communities have played in the development of the province of Ontario and Canada as a whole. The next chapter for Ontario's rural, remote and northern nursing workforce can be vibrant with the implementation of the proposed recommendations in thi...
Single cell RNA sequencing (scRNA-seq) has been a transformative technology in many research fiel... more Single cell RNA sequencing (scRNA-seq) has been a transformative technology in many research fields. Dimensional reduction techniques such as UMAP and tSNE are used to visualize scRNA-seq data in two or three dimensions in order for cells to be clustered in biologically meaningful ways. Subsequently, gene expression is frequently mapped onto these plots to show the distribution of gene expression across the plots, for instance to distinguish cell types. However, plotting each cell with only one color leads to repetitive and unintuitive representations. Here, we present Pie Party, which allows scRNA-seq data to be plotted such that every cell is represented as a pie chart, and every slice in the pie charts corresponds to the gene expression of individual genes. This allows for the simultaneous visualization of the expression of multiple genes and gene networks. The resulting figures are information dense, space efficient and highly intuitive. PieParty is publicly available on GitHub ...
Pseudomonas aeruginosa and Aspergillus fumigatus are the leading bacterial and fungal pathogens i... more Pseudomonas aeruginosa and Aspergillus fumigatus are the leading bacterial and fungal pathogens in cystic fibrosis (CF). We have shown that Af biofilms are susceptible to Pseudomonas, particularly CF phenotypes. Those studies were performed with a reference virulent non-CF Aspergillus. Pseudomonas resident in CF airways undergo profound genetic and phenotypic adaptations to the abnormal environment. Studies have also indicated Aspergillus from CF patients have unexpected profiles of antifungal susceptibility. This would suggest that Aspergillus isolates from CF patients may be different or altered from other clinical isolates. It is important to know whether Aspergillus may also be altered, as a result of that CF environment, in susceptibility to Pseudomonas. CF Aspergillus proved not different in that susceptibility.
The study assessed the knowledge, attitudes and practices of cholera prevention and preparedness ... more The study assessed the knowledge, attitudes and practices of cholera prevention and preparedness in Ga-Mampuru village (Limpopo, South Africa). Interviewers collected data using a two-pronged method, namely a household questionnaire (open- and closed-ended questions) to assess knowledge and attitudes about cholera and observations to assess practices in the prevention and management of the disease. Additionally, interviewers took pictures with the respondents’ permission. Ninety-six respondents were interviewed. Most respondents (86%) indicated they knew how cholera was contracted with 84% indicating contaminated water as a source. Ninety percent of the respondents indicated they knew how to prevent contracting cholera. All respondents generally knew that cholera could be treated with medicine received at a health-care facility or worker. Fewer respondents (58%) had specific knowledge such as the use of rehydration solutions. The respondents’ high level of prevention practices could...
Dentinal hypersensitivity and unesthetic appearance are common findings after excision of an epul... more Dentinal hypersensitivity and unesthetic appearance are common findings after excision of an epulis due to exposure of root and underlying bone. The simultaneous placement of subepithelial connective tissue grafting after excision of the lesion seems to be viable surgical option in such cases. Furthermore, this will avoid second surgical procedure for the management of the residual gingival defect.
Aim To estimate and compare plasma lycopene levels in patients with clinically/ histopathological... more Aim To estimate and compare plasma lycopene levels in patients with clinically/ histopathologically proven leukoplakia with that of control group (smokers/non-smokers) Materials and MethodsTotal of 90 individuals were included in the study with two main groups namely cases and controls: clinically/ histopathologically proven cases of oral leukoplakia (30) and age and sex matched control group divided into two categories non-smokers (30) and smokers without leukoplakia (30). Diagnosis of oral leukoplakia was first made on the basis of history and clinical features. Determination of lycopene in blood plasma by high performance liquid chromatography. ResultsThe age of the patients varied between 32-65 years. In the study group out of 30 patients of leukoplakia 16 patients were with clinically homogenous variety of leukoplakia and 14 with the speckled variety. Histopathologically out of 30 patients 13 had mild dysplasia and 17 with moderate dysplasia. The mean plasma lycopene level valu...
The COVID-19 pandemic that started in China's Wuhan city in December, 2019, hasspread to all ... more The COVID-19 pandemic that started in China's Wuhan city in December, 2019, hasspread to all over the world. It is not only affecting personnel health but also the Indian economyas well as the world economy. Its severity depends on longevity of lockdown period, health crisisand resumption of economic activities in phased manner. In this paper we want to analysis anddevelop a framework to resumption of micro, small and medium enterprises (MSME) activitieswhich one of the most vulnerable and vital segment of the economy. We divide MSMEs intothree segment namely high, moderate and low risk entities on the basis of physical interactionbetween employees of the entity and infection risk involved. We also study measures taken bythe government so far and advises measure may taken by the government to revive the sector
The selection of this title was deliberate. We chose 'coming together' to signify the imp... more The selection of this title was deliberate. We chose 'coming together' to signify the importance of community within rural, remote and northern areas. This report is grounded within the importance of context and the solutions needed to sustain the nursing workforce are dependent upon partnership with: each other, government, and associations. We chose 'moving forward' as a reflection of the resilience of rural, remote and northern communities and the nursing workforce in these areas. While it is easy to dwell on deficiencies and what is not working, we have prepared this report to build on successes and focus on solutions. Lastly, 'building the next chapter' speaks to the important role rural, remote and northern communities have played in the development of the province of Ontario and Canada as a whole. The next chapter for Ontario's rural, remote and northern nursing workforce can be vibrant with the implementation of the proposed recommendations in thi...
Single cell RNA sequencing (scRNA-seq) has been a transformative technology in many research fiel... more Single cell RNA sequencing (scRNA-seq) has been a transformative technology in many research fields. Dimensional reduction techniques such as UMAP and tSNE are used to visualize scRNA-seq data in two or three dimensions in order for cells to be clustered in biologically meaningful ways. Subsequently, gene expression is frequently mapped onto these plots to show the distribution of gene expression across the plots, for instance to distinguish cell types. However, plotting each cell with only one color leads to repetitive and unintuitive representations. Here, we present Pie Party, which allows scRNA-seq data to be plotted such that every cell is represented as a pie chart, and every slice in the pie charts corresponds to the gene expression of individual genes. This allows for the simultaneous visualization of the expression of multiple genes and gene networks. The resulting figures are information dense, space efficient and highly intuitive. PieParty is publicly available on GitHub ...
Pseudomonas aeruginosa and Aspergillus fumigatus are the leading bacterial and fungal pathogens i... more Pseudomonas aeruginosa and Aspergillus fumigatus are the leading bacterial and fungal pathogens in cystic fibrosis (CF). We have shown that Af biofilms are susceptible to Pseudomonas, particularly CF phenotypes. Those studies were performed with a reference virulent non-CF Aspergillus. Pseudomonas resident in CF airways undergo profound genetic and phenotypic adaptations to the abnormal environment. Studies have also indicated Aspergillus from CF patients have unexpected profiles of antifungal susceptibility. This would suggest that Aspergillus isolates from CF patients may be different or altered from other clinical isolates. It is important to know whether Aspergillus may also be altered, as a result of that CF environment, in susceptibility to Pseudomonas. CF Aspergillus proved not different in that susceptibility.
The study assessed the knowledge, attitudes and practices of cholera prevention and preparedness ... more The study assessed the knowledge, attitudes and practices of cholera prevention and preparedness in Ga-Mampuru village (Limpopo, South Africa). Interviewers collected data using a two-pronged method, namely a household questionnaire (open- and closed-ended questions) to assess knowledge and attitudes about cholera and observations to assess practices in the prevention and management of the disease. Additionally, interviewers took pictures with the respondents’ permission. Ninety-six respondents were interviewed. Most respondents (86%) indicated they knew how cholera was contracted with 84% indicating contaminated water as a source. Ninety percent of the respondents indicated they knew how to prevent contracting cholera. All respondents generally knew that cholera could be treated with medicine received at a health-care facility or worker. Fewer respondents (58%) had specific knowledge such as the use of rehydration solutions. The respondents’ high level of prevention practices could...
Dentinal hypersensitivity and unesthetic appearance are common findings after excision of an epul... more Dentinal hypersensitivity and unesthetic appearance are common findings after excision of an epulis due to exposure of root and underlying bone. The simultaneous placement of subepithelial connective tissue grafting after excision of the lesion seems to be viable surgical option in such cases. Furthermore, this will avoid second surgical procedure for the management of the residual gingival defect.
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