Keratinous cyst (Epidermoid cysts) is more common and frequently encountered. It is one of the co... more Keratinous cyst (Epidermoid cysts) is more common and frequently encountered. It is one of the commonest benign lesion. Malignant transformation of keratinous (epidermoid) cyst is very rare. Epidermal cyst is noted as non-malignant condition. Few cases have shown malignant transformation of keratinous cyst into Squamous Cell Carcinoma (SCC). Here, authors report a rare case of 49-year-old male who presented with long standing keratinous cyst in gluteal region which turned out as SCC 35 years after intial presentation of the leison, and here authors have discussed the clinicopathological features of this rare entity. Hence, any swelling which is long standing, showing sudden increase in size, progressing symptoms, more than 2 cm in diameter, cyst content seen as heterogenous pattern on imaging should be highly suspicious of malignancy.
Background Higher levels of the proliferation marker Ki67 at breast cancer (BC) diagnosis are inc... more Background Higher levels of the proliferation marker Ki67 at breast cancer (BC) diagnosis are increasingly recognised to indicate poorer prognosis. Change in ΔKi67 in response to endocrine treatment reflects response. The precise relationship between Ki67 and other clinico-path factors and how associations are affected by short exposure to aromatase inhibitor (AI) has been unclear. Methods POETIC was a UK-wide, phase III, randomised trial which tested perioperative use of AI (anastrozole (A), letrozole (L)) in postmenopausal women with early BC (Dowsett JNCI Monogr 2011). Ki67 was measured in a single central lab at diagnosis (B=baseline) and 2 weeks later at surgery (S) allowing in vivo assessment of AI sensitivity. POETIC recruited 4483 women from 130 UK centres. Paired biopsies were available for 96%. Relationship between Ki67 and clinico-path factors is described by summary statistics (median) and independent associations explored in multivariable linear regression models (MVM)....
International Journal of Nutrition, Pharmacology, Neurological Diseases
Background: A cerebrovascular accident or stroke is one of the leading causes of disability and d... more Background: A cerebrovascular accident or stroke is one of the leading causes of disability and death in the world. Several risk factors have been detected and extensively studied and are part of preventive strategies. Emerging risk factors for ischemic that have recently acquired interest are vitamin B-12 and homocysteine levels. A study has been conducted in a tertiary hospital in Chennai to evaluate the levels of vitamin B-12, homocysteine, and hematological variables. Aims: The objective of the study was to estimate the serum levels of homocysteine and vitamin B-12 in patients with ischemic stroke and transient ischemic attack and to analyze hematological parameters, including complete blood counts and peripheral smear and correlate with vitamin B-12. Materials and Methods: A total of 80 individuals with either ischemic stroke or transient ischemic attack were included in the study. Vitamin B-12, homocysteine, complete blood counts, and peripheral smear were analyzed for the pat...
Vijayashree Raghavan1, K Shivaprashanth2, K Ramesh Rao3 1Associate Professor, Department of Patho... more Vijayashree Raghavan1, K Shivaprashanth2, K Ramesh Rao3 1Associate Professor, Department of Pathology, Chettinad Medical College and Research Institute, Chennai, Tamil Nadu, India, 2Post-graduate Student, Department of Pathology, Chettinad Medical College and Research Institute, Chennai, Tamil Nadu, India, 3Professor and Head, Department of Pathology, Chettinad Medical College and Research Institute, Chennai, Tamil Nadu, India
Annals of Pathology and Laboratory Medicine, Jul 12, 2015
Eccrine angiokeratomatous hamartom a is a newly recognised vascular lesion of the skin, with the ... more Eccrine angiokeratomatous hamartom a is a newly recognised vascular lesion of the skin, with the first case being reported only in 2006. It has a distinctive histology with features derived from two well established vascular lesions affecting the skin: solitary angiokeratoma and eccrine angiomatous hamartoma. A 26 year old woman presented with a long standing painless warty lesion on her right ankle. Histological examination of the excised lesion showed a combination of two vascular lesions: superficial angiokeratoma and a deeper eccrine angiomatous hamartoma. Such a histological picture is consistent with the diagnosis of recently described eccrine angiokeratomatous hamartoma. Our case represents only second such case to be reported. Immunohistochemical analysis with CD34, smooth muscle actin and cytokeratin was done.
Keratinous cyst (Epidermoid cysts) is more common and frequently encountered. It is one of the co... more Keratinous cyst (Epidermoid cysts) is more common and frequently encountered. It is one of the commonest benign lesion. Malignant transformation of keratinous (epidermoid) cyst is very rare. Epidermal cyst is noted as non-malignant condition. Few cases have shown malignant transformation of keratinous cyst into Squamous Cell Carcinoma (SCC). Here, authors report a rare case of 49-year-old male who presented with long standing keratinous cyst in gluteal region which turned out as SCC 35 years after intial presentation of the leison, and here authors have discussed the clinicopathological features of this rare entity. Hence, any swelling which is long standing, showing sudden increase in size, progressing symptoms, more than 2 cm in diameter, cyst content seen as heterogenous pattern on imaging should be highly suspicious of malignancy.
Background Higher levels of the proliferation marker Ki67 at breast cancer (BC) diagnosis are inc... more Background Higher levels of the proliferation marker Ki67 at breast cancer (BC) diagnosis are increasingly recognised to indicate poorer prognosis. Change in ΔKi67 in response to endocrine treatment reflects response. The precise relationship between Ki67 and other clinico-path factors and how associations are affected by short exposure to aromatase inhibitor (AI) has been unclear. Methods POETIC was a UK-wide, phase III, randomised trial which tested perioperative use of AI (anastrozole (A), letrozole (L)) in postmenopausal women with early BC (Dowsett JNCI Monogr 2011). Ki67 was measured in a single central lab at diagnosis (B=baseline) and 2 weeks later at surgery (S) allowing in vivo assessment of AI sensitivity. POETIC recruited 4483 women from 130 UK centres. Paired biopsies were available for 96%. Relationship between Ki67 and clinico-path factors is described by summary statistics (median) and independent associations explored in multivariable linear regression models (MVM)....
International Journal of Nutrition, Pharmacology, Neurological Diseases
Background: A cerebrovascular accident or stroke is one of the leading causes of disability and d... more Background: A cerebrovascular accident or stroke is one of the leading causes of disability and death in the world. Several risk factors have been detected and extensively studied and are part of preventive strategies. Emerging risk factors for ischemic that have recently acquired interest are vitamin B-12 and homocysteine levels. A study has been conducted in a tertiary hospital in Chennai to evaluate the levels of vitamin B-12, homocysteine, and hematological variables. Aims: The objective of the study was to estimate the serum levels of homocysteine and vitamin B-12 in patients with ischemic stroke and transient ischemic attack and to analyze hematological parameters, including complete blood counts and peripheral smear and correlate with vitamin B-12. Materials and Methods: A total of 80 individuals with either ischemic stroke or transient ischemic attack were included in the study. Vitamin B-12, homocysteine, complete blood counts, and peripheral smear were analyzed for the pat...
Vijayashree Raghavan1, K Shivaprashanth2, K Ramesh Rao3 1Associate Professor, Department of Patho... more Vijayashree Raghavan1, K Shivaprashanth2, K Ramesh Rao3 1Associate Professor, Department of Pathology, Chettinad Medical College and Research Institute, Chennai, Tamil Nadu, India, 2Post-graduate Student, Department of Pathology, Chettinad Medical College and Research Institute, Chennai, Tamil Nadu, India, 3Professor and Head, Department of Pathology, Chettinad Medical College and Research Institute, Chennai, Tamil Nadu, India
Annals of Pathology and Laboratory Medicine, Jul 12, 2015
Eccrine angiokeratomatous hamartom a is a newly recognised vascular lesion of the skin, with the ... more Eccrine angiokeratomatous hamartom a is a newly recognised vascular lesion of the skin, with the first case being reported only in 2006. It has a distinctive histology with features derived from two well established vascular lesions affecting the skin: solitary angiokeratoma and eccrine angiomatous hamartoma. A 26 year old woman presented with a long standing painless warty lesion on her right ankle. Histological examination of the excised lesion showed a combination of two vascular lesions: superficial angiokeratoma and a deeper eccrine angiomatous hamartoma. Such a histological picture is consistent with the diagnosis of recently described eccrine angiokeratomatous hamartoma. Our case represents only second such case to be reported. Immunohistochemical analysis with CD34, smooth muscle actin and cytokeratin was done.
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