Background: PHC was adopted by the SA ministry of health in 1981. Around 2100 PHC centers are dis... more Background: PHC was adopted by the SA ministry of health in 1981. Around 2100 PHC centers are distributed throughout the Kingdom. Only 3 nationally-endorsed CPGs are available for use. Aim: In order to reduce the variation in care and to realize the national and international accreditation standards,[for full text, please go to the a.m. URL]
This report is a systematic review of the published literature on the effectiveness of school bas... more This report is a systematic review of the published literature on the effectiveness of school based interventions that aim to promote mental wellbeing amongst children in primary education and that both take a universal approach and are primarily focussed on the prevention of violence or bullying. It reports data from 17 studies outside the United Kingdom. The following definitions of mental wellbeing, bullying and violence are used: •Mental wellbeing encompasses emotional, psychological and social wellbeing •Bullying is a form of aggression in which one or more children repeatedly and intentionally intimidate, harass or physically harm a victim who cannot easily defend him or herself •Violence is an act of aggression directed to another person or persons, or to property. It covers individual acts such as homicide and infliction of non-fatal injury. It may include the carrying of weapons. It usually implies physical aggression
Parallel Session 3.3: Oral presentations A new approach to CPG adaptation in Saudi Arabia: Adapta... more Parallel Session 3.3: Oral presentations A new approach to CPG adaptation in Saudi Arabia: Adaptation of practice guidelines to a country-specific context using the GRADE/ DECIDE evidence to decision framework Zulfa AL RAYESS1, Amena MUNSHI1, Yaser ADI1, Wojtek WIERCIOCH2, http://www.g-i-n.net/document-store/g-i-n-conferences/melbourne-2014/gin-2014-abstract-book 1 Ministry of Health, Saudi Arabia 2 McMaster University, Canada Background: Adaptation of clinical practice guidelines (CPGs) is the systematic approach to the use and/or modification of a guideline produced in one setting for application in a different context.In an initiative between the Ministry of Health of the Kingdom of Saudi Arabia (KSA) and McMaster University, we developed an approach to adapt multiple CPGs to the local healthcare setting based on the GRADE/DECIDE evidence to decision (EtD) framework. Objectives: To establish methodology for a program of rigorous adaptation of CPGs and local capacity building thro...
Background: Acromegaly, an orphan disease usually caused by a benign pituitary tumour, is charact... more Background: Acromegaly, an orphan disease usually caused by a benign pituitary tumour, is characterised by hyper-secretion of growth hormone (GH) and insulin-like growth factor I (IGF1). It is associated with reduced life expectancy, cardiovascular problems, a variety of insidiously progressing detrimental symptoms and metabolic malfunction. Treatments include surgery, radiotherapy and pharmacotherapy. Pegvisomant (PEG) is a genetically engineered GH analogue licensed as a third or fourth line option when other treatments have failed to normalise IGF-1 levels. Methods: Evidence about effectiveness and cost-effectiveness of PEG was systematically reviewed. Data were extracted from published studies and used for a narrative synthesis of evidence. A decision analytical economic model was identified and modified to assess the cost-effectiveness of PEG. Results: One RCT and 17 non-randomised studies were reviewed for effectiveness. PEG substantially reduced and rapidly normalised IGF-1 l...
Searching MEDLINE, EMBASE, ERIC, CINAHL, ASSIA, DARE, the Cochrane CENTRAL Register, SIGLE, Socio... more Searching MEDLINE, EMBASE, ERIC, CINAHL, ASSIA, DARE, the Cochrane CENTRAL Register, SIGLE, Sociological Abstracts, PsycINFO and the Cochrane Database of Systematic Reviews were searched from 1990 to June 2007 for papers published in English. Five websites were also searched: CASEL, EPPI centre, Community Guide Guide to community preventive services, Search Institute and the Joseph Rowntree Trust. The bibliographies of reviews and other studies were checked for additional studies.
Whilst accepting a lack of robust data for many of the relevant variables, the basecase analysis ... more Whilst accepting a lack of robust data for many of the relevant variables, the basecase analysis undertaken by Connock et al represents an exceedingly conservative estimate of the cost-effectiveness of pegvisomant. In particular: • Dosing of pegvisomant. The cost-effectiveness results obtained by Connock et al. are particularly sensitive to the cost of pegvisomant therapy. The authors assumed a pegvisomant dose of 20 mg/day/patient (hence an annual cost of £36,500 per patient). However, an analysis of all patients in the UK receiving pegvisomant shows an average daily dose of 16 mg per patient (equivalent to £29,200 per patient per year). This dosing data is very similar to that reported in the one RCT that has investigated pegvisomant in its licenced indication. This clinical study showed the average daily use to be 15 mg. Pfizer have provided the clinical practice dosing information to the authors. • Treating co-morbidites. As well as reduced life expectancy, uncontrolled acromega...
Background: PHC was adopted by the SA ministry of health in 1981. Around 2100 PHC centers are dis... more Background: PHC was adopted by the SA ministry of health in 1981. Around 2100 PHC centers are distributed throughout the Kingdom. Only 3 nationally-endorsed CPGs are available for use. Aim: In order to reduce the variation in care and to realize the national and international accreditation standards,[for full text, please go to the a.m. URL]
This report is a systematic review of the published literature on the effectiveness of school bas... more This report is a systematic review of the published literature on the effectiveness of school based interventions that aim to promote mental wellbeing amongst children in primary education and that both take a universal approach and are primarily focussed on the prevention of violence or bullying. It reports data from 17 studies outside the United Kingdom. The following definitions of mental wellbeing, bullying and violence are used: •Mental wellbeing encompasses emotional, psychological and social wellbeing •Bullying is a form of aggression in which one or more children repeatedly and intentionally intimidate, harass or physically harm a victim who cannot easily defend him or herself •Violence is an act of aggression directed to another person or persons, or to property. It covers individual acts such as homicide and infliction of non-fatal injury. It may include the carrying of weapons. It usually implies physical aggression
Parallel Session 3.3: Oral presentations A new approach to CPG adaptation in Saudi Arabia: Adapta... more Parallel Session 3.3: Oral presentations A new approach to CPG adaptation in Saudi Arabia: Adaptation of practice guidelines to a country-specific context using the GRADE/ DECIDE evidence to decision framework Zulfa AL RAYESS1, Amena MUNSHI1, Yaser ADI1, Wojtek WIERCIOCH2, http://www.g-i-n.net/document-store/g-i-n-conferences/melbourne-2014/gin-2014-abstract-book 1 Ministry of Health, Saudi Arabia 2 McMaster University, Canada Background: Adaptation of clinical practice guidelines (CPGs) is the systematic approach to the use and/or modification of a guideline produced in one setting for application in a different context.In an initiative between the Ministry of Health of the Kingdom of Saudi Arabia (KSA) and McMaster University, we developed an approach to adapt multiple CPGs to the local healthcare setting based on the GRADE/DECIDE evidence to decision (EtD) framework. Objectives: To establish methodology for a program of rigorous adaptation of CPGs and local capacity building thro...
Background: Acromegaly, an orphan disease usually caused by a benign pituitary tumour, is charact... more Background: Acromegaly, an orphan disease usually caused by a benign pituitary tumour, is characterised by hyper-secretion of growth hormone (GH) and insulin-like growth factor I (IGF1). It is associated with reduced life expectancy, cardiovascular problems, a variety of insidiously progressing detrimental symptoms and metabolic malfunction. Treatments include surgery, radiotherapy and pharmacotherapy. Pegvisomant (PEG) is a genetically engineered GH analogue licensed as a third or fourth line option when other treatments have failed to normalise IGF-1 levels. Methods: Evidence about effectiveness and cost-effectiveness of PEG was systematically reviewed. Data were extracted from published studies and used for a narrative synthesis of evidence. A decision analytical economic model was identified and modified to assess the cost-effectiveness of PEG. Results: One RCT and 17 non-randomised studies were reviewed for effectiveness. PEG substantially reduced and rapidly normalised IGF-1 l...
Searching MEDLINE, EMBASE, ERIC, CINAHL, ASSIA, DARE, the Cochrane CENTRAL Register, SIGLE, Socio... more Searching MEDLINE, EMBASE, ERIC, CINAHL, ASSIA, DARE, the Cochrane CENTRAL Register, SIGLE, Sociological Abstracts, PsycINFO and the Cochrane Database of Systematic Reviews were searched from 1990 to June 2007 for papers published in English. Five websites were also searched: CASEL, EPPI centre, Community Guide Guide to community preventive services, Search Institute and the Joseph Rowntree Trust. The bibliographies of reviews and other studies were checked for additional studies.
Whilst accepting a lack of robust data for many of the relevant variables, the basecase analysis ... more Whilst accepting a lack of robust data for many of the relevant variables, the basecase analysis undertaken by Connock et al represents an exceedingly conservative estimate of the cost-effectiveness of pegvisomant. In particular: • Dosing of pegvisomant. The cost-effectiveness results obtained by Connock et al. are particularly sensitive to the cost of pegvisomant therapy. The authors assumed a pegvisomant dose of 20 mg/day/patient (hence an annual cost of £36,500 per patient). However, an analysis of all patients in the UK receiving pegvisomant shows an average daily dose of 16 mg per patient (equivalent to £29,200 per patient per year). This dosing data is very similar to that reported in the one RCT that has investigated pegvisomant in its licenced indication. This clinical study showed the average daily use to be 15 mg. Pfizer have provided the clinical practice dosing information to the authors. • Treating co-morbidites. As well as reduced life expectancy, uncontrolled acromega...
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