Fourier transform infrared spectroscopic imaging (FTIRI) technique can be used to obtain the quan... more Fourier transform infrared spectroscopic imaging (FTIRI) technique can be used to obtain the quantitative information of content and spatial distribution of principal components in cartilage by combining with chemometrics methods. In this study, FTIRI combining with principal component analysis (PCA) and Fisher's discriminant analysis (FDA) was applied to identify the healthy and osteoarthritic (OA) articular cartilage samples. Ten 10-μm thick sections of canine cartilages were imaged at 6.25μm/pixel in FTIRI. The infrared spectra extracted from the FTIR images were imported into SPSS software for PCA and FDA. Based on the PCA result of 2 principal components, the healthy and OA cartilage samples were effectively discriminated by the FDA with high accuracy of 94% for the initial samples (training set) and cross validation, as well as 86.67% for the prediction group. The study showed that cartilage degeneration became gradually weak with the increase of the depth. FTIRI combined ...
Systemic analyses using large-scale genomic profiles have successfully identified cancer-driving ... more Systemic analyses using large-scale genomic profiles have successfully identified cancer-driving somatic copy number variations (SCNVs) loci. However, functions of vast focal SCNVs in ''protein-coding gene desert'' regions were largely unknown. The integrative analysis of long noncoding RNA (lncRNA) expression profiles with SCNVs in hepatocellular carcinoma (HCC) lead us identifying the recurrent deletion of lncRNA-PRAL (p53 regulation associated lncRNA) on chromosome 17p13.1, whose genomic alterations were significantly associated with the reduced survival of HCC patients. We found that lncRNA-PRAL could inhibit HCC growth and induce apoptosis in vivo and in vitro through p53. Subsequent investigations indicated that the three stem-loop motifs at the 5' end of lncRNA-PRAL facilitated the combination of HSP90 and p53, and thus competitively inhibited the MDM2-dependent p53 ubiquitination, resulting in the enhanced p53 stability. Additionally, in vivo lncRNA-PRAL ...
... In the following section, we will simulate the stress-strain, pore water Table 2 EVP model pa... more ... In the following section, we will simulate the stress-strain, pore water Table 2 EVP model parameters corresponding of soft rock k=V λ=V C=V εr vmo P0 mo ðkPaÞ t0 ðminÞ M 0.0204 0.1664 0.01 0 1194 60 1.75 ... Test and Analysis of Diatomaceous Soft Rock 195 Page 14. ...
ABSTRACT In recent decades, conventional electric instruments have already been widely used to mo... more ABSTRACT In recent decades, conventional electric instruments have already been widely used to monitor the performance of geotechnical structures. However, there are several inherent limitations of electric instruments for engineering including: electromagnetic interference, a large number of cables for multipoint measurement, signal loss in long distance transmission, and poor durability. Since the first Fiber Bragg Grating (FBG) sensor was fabricated in 1978, a significant progress has been made on the commercialization of optical fiber sensing technologies. In 1980s, a fully distributed sensing technology named Brillouin Optical Time Domain Analysis (BOTDA) has been proposed and developed for measuring strain and temperature. In this paper, the authors review previous studies on the development and application of fiber optic sensors. Based on the measured strains, various analysis methods were transferred to required parameters such as displacement, force and pressure which can more directly reflect the safety of geotechnical structures under complex engineering stress condition.
This paper suggests a method for obtaining closed-form solutions for a reinforced Timoshenko beam... more This paper suggests a method for obtaining closed-form solutions for a reinforced Timoshenko beam on an elastic foundation subjected to any pressure loading. A particular solution is obtained for uniform pressure loading at any location of the beam. This solution can be used to ...
... of 14th Int. Conf. on Soil Mechanic and Foundation Engineering, Hamburg, Germany: 1339-1342. ... more ... of 14th Int. Conf. on Soil Mechanic and Foundation Engineering, Hamburg, Germany: 1339-1342. Yeung, AT, Cheng, YM, Lau, CK, Mak, LM, Yu, RSM, Choi, YK, & Kim, JH (2005). An innovative Korean system of pressure-grouted soil nailing as a slope stabilization measure. ...
Fourier transform infrared spectroscopic imaging (FTIRI) technique can be used to obtain the quan... more Fourier transform infrared spectroscopic imaging (FTIRI) technique can be used to obtain the quantitative information of content and spatial distribution of principal components in cartilage by combining with chemometrics methods. In this study, FTIRI combining with principal component analysis (PCA) and Fisher's discriminant analysis (FDA) was applied to identify the healthy and osteoarthritic (OA) articular cartilage samples. Ten 10-μm thick sections of canine cartilages were imaged at 6.25μm/pixel in FTIRI. The infrared spectra extracted from the FTIR images were imported into SPSS software for PCA and FDA. Based on the PCA result of 2 principal components, the healthy and OA cartilage samples were effectively discriminated by the FDA with high accuracy of 94% for the initial samples (training set) and cross validation, as well as 86.67% for the prediction group. The study showed that cartilage degeneration became gradually weak with the increase of the depth. FTIRI combined ...
Systemic analyses using large-scale genomic profiles have successfully identified cancer-driving ... more Systemic analyses using large-scale genomic profiles have successfully identified cancer-driving somatic copy number variations (SCNVs) loci. However, functions of vast focal SCNVs in ''protein-coding gene desert'' regions were largely unknown. The integrative analysis of long noncoding RNA (lncRNA) expression profiles with SCNVs in hepatocellular carcinoma (HCC) lead us identifying the recurrent deletion of lncRNA-PRAL (p53 regulation associated lncRNA) on chromosome 17p13.1, whose genomic alterations were significantly associated with the reduced survival of HCC patients. We found that lncRNA-PRAL could inhibit HCC growth and induce apoptosis in vivo and in vitro through p53. Subsequent investigations indicated that the three stem-loop motifs at the 5' end of lncRNA-PRAL facilitated the combination of HSP90 and p53, and thus competitively inhibited the MDM2-dependent p53 ubiquitination, resulting in the enhanced p53 stability. Additionally, in vivo lncRNA-PRAL ...
... In the following section, we will simulate the stress-strain, pore water Table 2 EVP model pa... more ... In the following section, we will simulate the stress-strain, pore water Table 2 EVP model parameters corresponding of soft rock k=V λ=V C=V εr vmo P0 mo ðkPaÞ t0 ðminÞ M 0.0204 0.1664 0.01 0 1194 60 1.75 ... Test and Analysis of Diatomaceous Soft Rock 195 Page 14. ...
ABSTRACT In recent decades, conventional electric instruments have already been widely used to mo... more ABSTRACT In recent decades, conventional electric instruments have already been widely used to monitor the performance of geotechnical structures. However, there are several inherent limitations of electric instruments for engineering including: electromagnetic interference, a large number of cables for multipoint measurement, signal loss in long distance transmission, and poor durability. Since the first Fiber Bragg Grating (FBG) sensor was fabricated in 1978, a significant progress has been made on the commercialization of optical fiber sensing technologies. In 1980s, a fully distributed sensing technology named Brillouin Optical Time Domain Analysis (BOTDA) has been proposed and developed for measuring strain and temperature. In this paper, the authors review previous studies on the development and application of fiber optic sensors. Based on the measured strains, various analysis methods were transferred to required parameters such as displacement, force and pressure which can more directly reflect the safety of geotechnical structures under complex engineering stress condition.
This paper suggests a method for obtaining closed-form solutions for a reinforced Timoshenko beam... more This paper suggests a method for obtaining closed-form solutions for a reinforced Timoshenko beam on an elastic foundation subjected to any pressure loading. A particular solution is obtained for uniform pressure loading at any location of the beam. This solution can be used to ...
... of 14th Int. Conf. on Soil Mechanic and Foundation Engineering, Hamburg, Germany: 1339-1342. ... more ... of 14th Int. Conf. on Soil Mechanic and Foundation Engineering, Hamburg, Germany: 1339-1342. Yeung, AT, Cheng, YM, Lau, CK, Mak, LM, Yu, RSM, Choi, YK, & Kim, JH (2005). An innovative Korean system of pressure-grouted soil nailing as a slope stabilization measure. ...
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