Notice is hereby given that on Tuesday, November 6 th , 2012 a General Election will be held at t... more Notice is hereby given that on Tuesday, November 6 th , 2012 a General Election will be held at the usual polling places in the election precincts of Buffalo County, Nebraska. The polls will open at 8 a.m. and close at 8 p.m. Said election will be for electing candidates to various offices and for such issues as stated. Some races will not appear on your General Election ballot as the candidates are elected by specific subdivisions, districts or wards. The Secretary of State will publish a true copy of the title and text of any amendment or referendums once a week for three consecutive weeks preceding the election. Dated this 17 th day of September, 2012 Lisa Poff Buffalo County Election Commissioner’s Office ____________________________________________________________________________________________________________ PARTISAN TICKET
We conduct the first empirical investigation of common-pool resource users ’ dynamic and strategi... more We conduct the first empirical investigation of common-pool resource users ’ dynamic and strategic behavior at the micro level using real-world data. Fishermen’s strategies in a fully dynamic game account for latent resource dynamics and other players ’ actions, revealing the profit structure of the fishery. We compare the fishermen’s actual and socially optimal exploitation paths under a time-specific vessel alloca-tion policy and find a sizable dynamic externality. Individual fishermen respond to other users by exerting effort above the optimal level early in the season. Congestion is costly instantaneously but is beneficial in the long run because it partially offsets dynamic inefficiencies.
As robotic systems are deployed into everyday situations, the need for abstract reasoning becomes... more As robotic systems are deployed into everyday situations, the need for abstract reasoning becomes more pronounced. The ideal robotic assistant should be able to understand verbal commands and work independently to fulfill human-prescribed goals, even if instructions are ambiguous or circumstances change. This paper presents a new algorithm for high-level reasoning based on Euclidean representations of words and their meanings. Rather than using ontologies or knowledge graphs, we model information about the world as a learned geometry of the contexts in which human beings tend to use each idea. Building on the analogy algorithms utilized by Mikolov et al. [1], we perform mathematical operations on the vector space to infer responses to previously unseen problems, and apply our method to a sequence of semantic reasoning tasks in order to answer questions such as ‘Where can I find a dustpan?’, ‘Where do the crayons belong?’, and ‘What transportation method will bring me to the airport?...
This research aimed to uncover key factors in how college students select a favorite sports team.... more This research aimed to uncover key factors in how college students select a favorite sports team. An important issue in today’s sport industry is recognizing fans motives for supporting their favorite sport teams. Sport managers need to better understand fan’s motives in order to address the team's needs and increase the fan base. Also, the team needs to cultivate a relationship for fan involvement to garner economic benefits. The subjects for this study were college students at St. John Fisher College. Using an online survey, the results of this uncovered that team factors were the most important in someone supporting their favorite sports team. Document Type Undergraduate Project Professor's Name Emily Dane-Staples
Freshwater flooding has been shown to be the leading cause of death in tropical cyclones (TCs) ac... more Freshwater flooding has been shown to be the leading cause of death in tropical cyclones (TCs) accounting for over half of the TC related deaths in the United States between 1970 and 1999 (Rappaport 2000). Recently, a greater understanding of the extratropical transition process (ET) has lead to better forecasts of TC flooding events. Comprehensive research on ET by Evans and Hart (2003), Hart and Evans (2001), Hart (2003), Klein et al. (2000, 2002), Harr and Elsberry (2000), Atallah and Bosart (2003, 2007) and numerous others has allowed forecasters to apply their understanding of quasi-geostrophic (QG) theory to more accurately predict where heavy rainfall will occur. However, rainfall forecasts have remained problematic for storms that do not undergo ET or remain too small for QG theory to apply. This study will use Hurricane Gaston (2004) to investigate the dynamics that drive heavy precipitation in these ―nontraditional‖ storms.
Importing necessary metabolites into the mitochondrial matrix is a crucial step of fuel choice du... more Importing necessary metabolites into the mitochondrial matrix is a crucial step of fuel choice during stress adaptation. Branched chain-amino acids (BCAA) are essential amino acids needed for anabolic processes, but they are also imported into the mitochondria for catabolic reactions. What controls the distinct subcellular BCAA utilization during stress adaptation is insufficiently understood. The present study reports the role of SLC25A44, a recently identified mitochondrial BCAA carrier (MBC), in the regulation of mitochondrial BCAA catabolism and adaptive response to fever in rodents. We found that mitochondrial BCAA oxidation in brown adipose tissue (BAT) is significantly enhanced during fever in response to the pyrogenic mediator prostaglandin E2 (PGE2) and psychological stress in mice and rats. Genetic deletion of MBC in a BAT-specific manner blunts mitochondrial BCAA oxidation and non-shivering thermogenesis following intracerebroventricular PGE2 administration. At a cellular...
ABSTRACT: Hydrogel thin films (HTFs), which have multiple functions including hemocompatibility a... more ABSTRACT: Hydrogel thin films (HTFs), which have multiple functions including hemocompatibility and enhancing growth of endothelia cell (EC) while suppressing proliferation of smooth muscle cell (SMC), have garnered intense scientific interest due to their potential applications in the field of blood-contact materials. In the present study, we developed stable, multifunctional HTFs containing multiple functional groups (-SO3Na, -COONa, -OH, -NH2) by layer-by-layer (LbL) self-assembly of a modified sulfonated sodium alginate (SSA) and chitosan (CS), followed by ascidian-inspired post-crosslinking. The prepared HTFs, with a 3D porous structure, as revealed by scanning electron microscope (SEM), maintained outstanding long-term stability. The results of protein adsorption, platelet adhesion and activation, and clotting time confirmed that the hemocompatibility of the HTFs was significantly enhanced compared with the matrix. From the cytocompatibility test, the multiple functional groups at the HTF surface le...
Ce chapitre de conclusion analyse un certain nombre de questions communes aux domaines thematique... more Ce chapitre de conclusion analyse un certain nombre de questions communes aux domaines thematiques examines dans l’enquete (energie, transport, eau, alimentation et dechets) et leur evolution dans le temps. Il permet de constater que le consentement a payer varie d’un bien environnemental a l’autre (par exemple pour les voitures electriques, l’electricite « verte » et les aliments biologiques), et ce qui motive les menages a economiser l’energie et l’eau. En outre, le chapitre propose, sur certaines questions, une comparaison entre les six pays ayant participe aux deux editions de l’Enquete sur la politique de l’environnement et le comportement individuel (EPIC).
Ce chapitre passe en revue quelques-unes des principales mesures destinees a influencer le compor... more Ce chapitre passe en revue quelques-unes des principales mesures destinees a influencer le comportement des menages dans cinq domaines differents : la consommation d’energie, la consommation d’eau, la production et le recyclage des dechets, l’alimentation et le choix du mode de transport personnel. Il presente la facon dont les personnes interrogees percoivent les politiques en place, et dresse par ailleurs un etat des lieux des mesures adoptees dans les onze pays etudies. S’agissant des services environnementaux, le recours aux instruments de marche et aux incitations de prix est examine pour la collecte des dechets et la consommation d’eau et d’electricite. Les differences relevees entre les pays concernent leurs systemes de tarification, l’octroi de subventions pour encourager les menages a investir dans des equipements respectueux de l’environnement, le recours a l’eco-etiquetage et l’acces a des services de collecte des materiaux recyclables ou aux transports publics.
Hepatocellular carcinoma (HCC) is a major health problem worldwide with increasing incidence rate... more Hepatocellular carcinoma (HCC) is a major health problem worldwide with increasing incidence rates. As HCC traditionally occurs in chronically inflamed livers, this inflammation aids to drive oncogenesis and often renders these lesions to be immunogenic and therefore potential targets for immunotherapy. As patients with HCC generally have underlying liver dysfunction, we sought to determine if immune checkpoint inhibitors were safe to use in patients with HCC as compared to melanoma and non-small cell lung cancer (NSCLC) in terms of the gastrointestinal side effects of elevation of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and diarrhea as well as patients who drop out of the study due to drug toxicity and death secondary to drug toxicity. A literature review was performed for clinical trials that have been completed with single agent immune checkpoint inhibitors for patients with HCC, melanoma, and NSCLC. Gastrointestinal related adverse events including elev...
Hepatocellular carcinoma (HCC) is a common cause of cancer-related death worldwide. As obesity an... more Hepatocellular carcinoma (HCC) is a common cause of cancer-related death worldwide. As obesity and diabetes become more prevalent, the contribution of non-alcoholic fatty liver disease (NAFLD) to HCC is rising. Recently, we reported intrahepatic CD4 T cells are critical for anti-tumor surveillance in NAFLD. Lipid accumulation in the liver is the hallmark of NAFLD, which may perturb T cell function. We sought to investigate how the lipid-rich liver environment influences CD4 T cells by focusing on carnitine palmitoyltransferase (CPT) family members, which control the mitochondrial β-oxidation of fatty acids and act as key molecules in lipid catabolism. Linoleic acid (C18:2) co-localized within the mitochondria along with a corresponding increase in CPT gene upregulation. This CPT upregulation can be recapitulated by feeding mice with a high-C18:2 diet or the NAFLD promoting methionine-choline-deficient (MCD) diet. Using an agonist and antagonist, the induction of CPT genes was found ...
Resistance to insecticides and herbicides has cost billions of U.S. dollars in the agricultural s... more Resistance to insecticides and herbicides has cost billions of U.S. dollars in the agricultural sector and could result in millions of lives lost to insect-vectored diseases. We mostly continue to use pesticides as if resistance is a temporary issue that will be addressed by commercialization of new pesticides with novel modes of action. However, current evidence suggests that insect and weed evolution may outstrip our ability to replace outmoded chemicals and other control mechanisms. To avoid this outcome, we must address the mix of ecological, genetic, economic, and sociopolitical factors that prevent implementation of sustainable pest management practices. We offer an ambitious proposition.
Journal of geriatric physical therapy (2001), Jan 28, 2017
We sought to evaluate the Balance Outcome Measure for Elder Rehabilitation (BOOMER) in community-... more We sought to evaluate the Balance Outcome Measure for Elder Rehabilitation (BOOMER) in community-dwelling women 65 years and older with vertebral fracture and to describe score distributions and potential ceiling and floor effects. This was a secondary data analysis of baseline data from the Build Better Bones with Exercise randomized controlled trial using the BOOMER. A total of 141 women with osteoporosis and radiographically confirmed vertebral fracture were included. Concurrent validity and internal consistency were assessed in comparison to the Short Physical Performance Battery (SPPB). Normality and ceiling/floor effects of total BOOMER scores and component test items were also assessed. Exploratory analyses of assistive aid use and falls history were performed. Tests for concurrent validity demonstrated moderate correlation between total BOOMER and SPPB scores. The BOOMER component tests showed modest internal consistency. Substantial ceiling effect and nonnormal score distri...
Nature structural & molecular biology, Jan 23, 2017
Many studies have revealed pathways of epigenetic gene silencing by Polycomb repressive complex 2... more Many studies have revealed pathways of epigenetic gene silencing by Polycomb repressive complex 2 (PRC2) in vivo, but understanding the underlying molecular mechanisms requires biochemistry. Here we analyze interactions of reconstituted human PRC2 with nucleosome complexes. Histone modifications, the H3K27M cancer mutation, and inclusion of JARID2 or EZH1 in the PRC2 complex have unexpectedly minor effects on PRC2-nucleosome binding. Instead, protein-free linker DNA dominates the PRC2-nucleosome interaction. Specificity for CG-rich sequences is consistent with PRC2 occupying CG-rich DNA in vivo. PRC2 preferentially binds methylated DNA regulated by its AEBP2 subunit, suggesting how DNA and histone methylation collaborate to repress chromatin. We find that RNA, known to inhibit PRC2 activity, is not a methyltransferase inhibitor per se. Instead, RNA sequesters PRC2 from nucleosome substrates, because PRC2 binding requires linker DNA, and RNA and DNA binding are mutually exclusive. To...
Risk analysis : an official publication of the Society for Risk Analysis, Jan 23, 2016
Decision analysis tools and mathematical modeling are increasingly emphasized in malaria control ... more Decision analysis tools and mathematical modeling are increasingly emphasized in malaria control programs worldwide to improve resource allocation and address ongoing challenges with sustainability. However, such tools require substantial scientific evidence, which is costly to acquire. The value of information (VOI) has been proposed as a metric for gauging the value of reduced model uncertainty. We apply this concept to an evidenced-based Malaria Decision Analysis Support Tool (MDAST) designed for application in East Africa. In developing MDAST, substantial gaps in the scientific evidence base were identified regarding insecticide resistance in malaria vector control and the effectiveness of alternative mosquito control approaches, including larviciding. We identify four entomological parameters in the model (two for insecticide resistance and two for larviciding) that involve high levels of uncertainty and to which outputs in MDAST are sensitive. We estimate and compare a VOI for...
Notice is hereby given that on Tuesday, November 6 th , 2012 a General Election will be held at t... more Notice is hereby given that on Tuesday, November 6 th , 2012 a General Election will be held at the usual polling places in the election precincts of Buffalo County, Nebraska. The polls will open at 8 a.m. and close at 8 p.m. Said election will be for electing candidates to various offices and for such issues as stated. Some races will not appear on your General Election ballot as the candidates are elected by specific subdivisions, districts or wards. The Secretary of State will publish a true copy of the title and text of any amendment or referendums once a week for three consecutive weeks preceding the election. Dated this 17 th day of September, 2012 Lisa Poff Buffalo County Election Commissioner’s Office ____________________________________________________________________________________________________________ PARTISAN TICKET
We conduct the first empirical investigation of common-pool resource users ’ dynamic and strategi... more We conduct the first empirical investigation of common-pool resource users ’ dynamic and strategic behavior at the micro level using real-world data. Fishermen’s strategies in a fully dynamic game account for latent resource dynamics and other players ’ actions, revealing the profit structure of the fishery. We compare the fishermen’s actual and socially optimal exploitation paths under a time-specific vessel alloca-tion policy and find a sizable dynamic externality. Individual fishermen respond to other users by exerting effort above the optimal level early in the season. Congestion is costly instantaneously but is beneficial in the long run because it partially offsets dynamic inefficiencies.
As robotic systems are deployed into everyday situations, the need for abstract reasoning becomes... more As robotic systems are deployed into everyday situations, the need for abstract reasoning becomes more pronounced. The ideal robotic assistant should be able to understand verbal commands and work independently to fulfill human-prescribed goals, even if instructions are ambiguous or circumstances change. This paper presents a new algorithm for high-level reasoning based on Euclidean representations of words and their meanings. Rather than using ontologies or knowledge graphs, we model information about the world as a learned geometry of the contexts in which human beings tend to use each idea. Building on the analogy algorithms utilized by Mikolov et al. [1], we perform mathematical operations on the vector space to infer responses to previously unseen problems, and apply our method to a sequence of semantic reasoning tasks in order to answer questions such as ‘Where can I find a dustpan?’, ‘Where do the crayons belong?’, and ‘What transportation method will bring me to the airport?...
This research aimed to uncover key factors in how college students select a favorite sports team.... more This research aimed to uncover key factors in how college students select a favorite sports team. An important issue in today’s sport industry is recognizing fans motives for supporting their favorite sport teams. Sport managers need to better understand fan’s motives in order to address the team's needs and increase the fan base. Also, the team needs to cultivate a relationship for fan involvement to garner economic benefits. The subjects for this study were college students at St. John Fisher College. Using an online survey, the results of this uncovered that team factors were the most important in someone supporting their favorite sports team. Document Type Undergraduate Project Professor's Name Emily Dane-Staples
Freshwater flooding has been shown to be the leading cause of death in tropical cyclones (TCs) ac... more Freshwater flooding has been shown to be the leading cause of death in tropical cyclones (TCs) accounting for over half of the TC related deaths in the United States between 1970 and 1999 (Rappaport 2000). Recently, a greater understanding of the extratropical transition process (ET) has lead to better forecasts of TC flooding events. Comprehensive research on ET by Evans and Hart (2003), Hart and Evans (2001), Hart (2003), Klein et al. (2000, 2002), Harr and Elsberry (2000), Atallah and Bosart (2003, 2007) and numerous others has allowed forecasters to apply their understanding of quasi-geostrophic (QG) theory to more accurately predict where heavy rainfall will occur. However, rainfall forecasts have remained problematic for storms that do not undergo ET or remain too small for QG theory to apply. This study will use Hurricane Gaston (2004) to investigate the dynamics that drive heavy precipitation in these ―nontraditional‖ storms.
Importing necessary metabolites into the mitochondrial matrix is a crucial step of fuel choice du... more Importing necessary metabolites into the mitochondrial matrix is a crucial step of fuel choice during stress adaptation. Branched chain-amino acids (BCAA) are essential amino acids needed for anabolic processes, but they are also imported into the mitochondria for catabolic reactions. What controls the distinct subcellular BCAA utilization during stress adaptation is insufficiently understood. The present study reports the role of SLC25A44, a recently identified mitochondrial BCAA carrier (MBC), in the regulation of mitochondrial BCAA catabolism and adaptive response to fever in rodents. We found that mitochondrial BCAA oxidation in brown adipose tissue (BAT) is significantly enhanced during fever in response to the pyrogenic mediator prostaglandin E2 (PGE2) and psychological stress in mice and rats. Genetic deletion of MBC in a BAT-specific manner blunts mitochondrial BCAA oxidation and non-shivering thermogenesis following intracerebroventricular PGE2 administration. At a cellular...
ABSTRACT: Hydrogel thin films (HTFs), which have multiple functions including hemocompatibility a... more ABSTRACT: Hydrogel thin films (HTFs), which have multiple functions including hemocompatibility and enhancing growth of endothelia cell (EC) while suppressing proliferation of smooth muscle cell (SMC), have garnered intense scientific interest due to their potential applications in the field of blood-contact materials. In the present study, we developed stable, multifunctional HTFs containing multiple functional groups (-SO3Na, -COONa, -OH, -NH2) by layer-by-layer (LbL) self-assembly of a modified sulfonated sodium alginate (SSA) and chitosan (CS), followed by ascidian-inspired post-crosslinking. The prepared HTFs, with a 3D porous structure, as revealed by scanning electron microscope (SEM), maintained outstanding long-term stability. The results of protein adsorption, platelet adhesion and activation, and clotting time confirmed that the hemocompatibility of the HTFs was significantly enhanced compared with the matrix. From the cytocompatibility test, the multiple functional groups at the HTF surface le...
Ce chapitre de conclusion analyse un certain nombre de questions communes aux domaines thematique... more Ce chapitre de conclusion analyse un certain nombre de questions communes aux domaines thematiques examines dans l’enquete (energie, transport, eau, alimentation et dechets) et leur evolution dans le temps. Il permet de constater que le consentement a payer varie d’un bien environnemental a l’autre (par exemple pour les voitures electriques, l’electricite « verte » et les aliments biologiques), et ce qui motive les menages a economiser l’energie et l’eau. En outre, le chapitre propose, sur certaines questions, une comparaison entre les six pays ayant participe aux deux editions de l’Enquete sur la politique de l’environnement et le comportement individuel (EPIC).
Ce chapitre passe en revue quelques-unes des principales mesures destinees a influencer le compor... more Ce chapitre passe en revue quelques-unes des principales mesures destinees a influencer le comportement des menages dans cinq domaines differents : la consommation d’energie, la consommation d’eau, la production et le recyclage des dechets, l’alimentation et le choix du mode de transport personnel. Il presente la facon dont les personnes interrogees percoivent les politiques en place, et dresse par ailleurs un etat des lieux des mesures adoptees dans les onze pays etudies. S’agissant des services environnementaux, le recours aux instruments de marche et aux incitations de prix est examine pour la collecte des dechets et la consommation d’eau et d’electricite. Les differences relevees entre les pays concernent leurs systemes de tarification, l’octroi de subventions pour encourager les menages a investir dans des equipements respectueux de l’environnement, le recours a l’eco-etiquetage et l’acces a des services de collecte des materiaux recyclables ou aux transports publics.
Hepatocellular carcinoma (HCC) is a major health problem worldwide with increasing incidence rate... more Hepatocellular carcinoma (HCC) is a major health problem worldwide with increasing incidence rates. As HCC traditionally occurs in chronically inflamed livers, this inflammation aids to drive oncogenesis and often renders these lesions to be immunogenic and therefore potential targets for immunotherapy. As patients with HCC generally have underlying liver dysfunction, we sought to determine if immune checkpoint inhibitors were safe to use in patients with HCC as compared to melanoma and non-small cell lung cancer (NSCLC) in terms of the gastrointestinal side effects of elevation of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and diarrhea as well as patients who drop out of the study due to drug toxicity and death secondary to drug toxicity. A literature review was performed for clinical trials that have been completed with single agent immune checkpoint inhibitors for patients with HCC, melanoma, and NSCLC. Gastrointestinal related adverse events including elev...
Hepatocellular carcinoma (HCC) is a common cause of cancer-related death worldwide. As obesity an... more Hepatocellular carcinoma (HCC) is a common cause of cancer-related death worldwide. As obesity and diabetes become more prevalent, the contribution of non-alcoholic fatty liver disease (NAFLD) to HCC is rising. Recently, we reported intrahepatic CD4 T cells are critical for anti-tumor surveillance in NAFLD. Lipid accumulation in the liver is the hallmark of NAFLD, which may perturb T cell function. We sought to investigate how the lipid-rich liver environment influences CD4 T cells by focusing on carnitine palmitoyltransferase (CPT) family members, which control the mitochondrial β-oxidation of fatty acids and act as key molecules in lipid catabolism. Linoleic acid (C18:2) co-localized within the mitochondria along with a corresponding increase in CPT gene upregulation. This CPT upregulation can be recapitulated by feeding mice with a high-C18:2 diet or the NAFLD promoting methionine-choline-deficient (MCD) diet. Using an agonist and antagonist, the induction of CPT genes was found ...
Resistance to insecticides and herbicides has cost billions of U.S. dollars in the agricultural s... more Resistance to insecticides and herbicides has cost billions of U.S. dollars in the agricultural sector and could result in millions of lives lost to insect-vectored diseases. We mostly continue to use pesticides as if resistance is a temporary issue that will be addressed by commercialization of new pesticides with novel modes of action. However, current evidence suggests that insect and weed evolution may outstrip our ability to replace outmoded chemicals and other control mechanisms. To avoid this outcome, we must address the mix of ecological, genetic, economic, and sociopolitical factors that prevent implementation of sustainable pest management practices. We offer an ambitious proposition.
Journal of geriatric physical therapy (2001), Jan 28, 2017
We sought to evaluate the Balance Outcome Measure for Elder Rehabilitation (BOOMER) in community-... more We sought to evaluate the Balance Outcome Measure for Elder Rehabilitation (BOOMER) in community-dwelling women 65 years and older with vertebral fracture and to describe score distributions and potential ceiling and floor effects. This was a secondary data analysis of baseline data from the Build Better Bones with Exercise randomized controlled trial using the BOOMER. A total of 141 women with osteoporosis and radiographically confirmed vertebral fracture were included. Concurrent validity and internal consistency were assessed in comparison to the Short Physical Performance Battery (SPPB). Normality and ceiling/floor effects of total BOOMER scores and component test items were also assessed. Exploratory analyses of assistive aid use and falls history were performed. Tests for concurrent validity demonstrated moderate correlation between total BOOMER and SPPB scores. The BOOMER component tests showed modest internal consistency. Substantial ceiling effect and nonnormal score distri...
Nature structural & molecular biology, Jan 23, 2017
Many studies have revealed pathways of epigenetic gene silencing by Polycomb repressive complex 2... more Many studies have revealed pathways of epigenetic gene silencing by Polycomb repressive complex 2 (PRC2) in vivo, but understanding the underlying molecular mechanisms requires biochemistry. Here we analyze interactions of reconstituted human PRC2 with nucleosome complexes. Histone modifications, the H3K27M cancer mutation, and inclusion of JARID2 or EZH1 in the PRC2 complex have unexpectedly minor effects on PRC2-nucleosome binding. Instead, protein-free linker DNA dominates the PRC2-nucleosome interaction. Specificity for CG-rich sequences is consistent with PRC2 occupying CG-rich DNA in vivo. PRC2 preferentially binds methylated DNA regulated by its AEBP2 subunit, suggesting how DNA and histone methylation collaborate to repress chromatin. We find that RNA, known to inhibit PRC2 activity, is not a methyltransferase inhibitor per se. Instead, RNA sequesters PRC2 from nucleosome substrates, because PRC2 binding requires linker DNA, and RNA and DNA binding are mutually exclusive. To...
Risk analysis : an official publication of the Society for Risk Analysis, Jan 23, 2016
Decision analysis tools and mathematical modeling are increasingly emphasized in malaria control ... more Decision analysis tools and mathematical modeling are increasingly emphasized in malaria control programs worldwide to improve resource allocation and address ongoing challenges with sustainability. However, such tools require substantial scientific evidence, which is costly to acquire. The value of information (VOI) has been proposed as a metric for gauging the value of reduced model uncertainty. We apply this concept to an evidenced-based Malaria Decision Analysis Support Tool (MDAST) designed for application in East Africa. In developing MDAST, substantial gaps in the scientific evidence base were identified regarding insecticide resistance in malaria vector control and the effectiveness of alternative mosquito control approaches, including larviciding. We identify four entomological parameters in the model (two for insecticide resistance and two for larviciding) that involve high levels of uncertainty and to which outputs in MDAST are sensitive. We estimate and compare a VOI for...
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