The present study is designed to develop Type-3 diabetes mellitus characterized by insulin resist... more The present study is designed to develop Type-3 diabetes mellitus characterized by insulin resistance, mainly at the brain level. The experimental rats in group-1: received vehicle (5 ml/kg, i.p.) for 28 days, group-2-4: received aluminium chloride (AlCl3) (12.5, 25, and 50 mg/kg, i.p.) daily for 28 days, group-5: received single dose of STZ (45 mg/kg, i.p.), and group-6-8: received STZ and AlCl3 (12.5, 25, and 50 mg/kg, i.p. daily for 28 days) from the third day of STZ administration. The behavioral analysis was initiated on the 29th day, estimating locomotor activity using an open field test, learning and memory-related functions using elevated plus maze (EPM) and morris water maze (MWM) tests. Afterwards, the rats were sacrificed, and brain and blood were collected for whole-brain neurochemical and plasma biochemical assays, including glucose, insulin, nitrite, MDA and amyloid-beta levels. The brain tissues were sectioned, followed by H&E and congo red staining for histopathologi...
Neuropathic pain is caused by functional abnormalities of structural lesions in the peripheral or... more Neuropathic pain is caused by functional abnormalities of structural lesions in the peripheral or central nervous system. Various diseases, such as postherpetic neuralgia, trigeminal neuralgia, diabetic neuropathy, spinal cord injury, cancer, stroke, and degenerative neurological diseases are responsible for producing neuropathic pain. Its symptoms include spontaneous and stimulus evoked painful sensations such as mechanical hyperalgesia, thermal and cold allodynia. Several maladaptive mechanisms underlying these symptoms have been identified in recent years which include peripheral sensitization of nociception, abnormal excitability of afferent neurons, central sensitization comprising pronociceptive facilitation, dis-inhibition of nociception, central reorganization processes, alterations in various ion channels. This review focuses on these pathophysiological principles, focussing on specific cellular and molecular changes that affect membrane excitability and are responsible for...
Quality Control of Cellular Protein in Neurodegenerative Disorders, 2020
Mitophagy is a selective autophagy process in which damaged or surplus mitochondria are removed t... more Mitophagy is a selective autophagy process in which damaged or surplus mitochondria are removed to sustain normal homeostasis. The efficient removal of damaged or stressed mitochondria is crucial for cellular health. Recent literature emphasizes the role of PINK1-Parkin pathways in the pathogenesis process of various neurodegenerative disorders. Further, mitophagy has shown potential therapeutic activity in treating neurodegenerative diseases. Thus, mitophagy might be important in the field of pharmacotherapeutics. In the present chapter, the authors explain mitophagy, mitophagy signaling pathways, as well as mechanisms and roles of mitophagy in various neurodegenerative disorders.
Quality Control of Cellular Protein in Neurodegenerative Disorders, 2020
Autophagy is a normal physiological process characterized by the degradation of complex cellular ... more Autophagy is a normal physiological process characterized by the degradation of complex cellular contents into a simpler one and reutilized them in biosynthetic pathways. Lysosomes are the cell organelle that participates in the process of autophagy. The brain is the most vulnerable organ in most lysosome disorders because neurons are inefficient in removing impaired organelles and waste materials. In the brain, autophagy suppresses the accumulation of ubiquitinated proteins that results in further damage to the neurons responsible for neurodegeneration. Autophagy mediates protective effects in age-related diseases. In the chapter, the authors describe the process of autophagy, the mechanism involved, and the implication of the autophagic pathways in the various neurodegenerative disorders.
In view of the pathologic basis for the treatment of diabetic neuropathy, it is important to enha... more In view of the pathologic basis for the treatment of diabetic neuropathy, it is important to enhance nerve regeneration as well as prevent nerve degeneration. So, in the present study, we have investigated the effect of S‐Methylisothiourea Sulfate (selective iNOS inhibitor) and Citicoline, alone and in combination, on Type II diabetes mellitus induced neuropathic pain in wistar rats. Type II diabetes was induced by providing high fat diet and low dose of Streptozotocin for 35 days in rats. Type II diabetes mellitus was assessed in terms of increased glucose, triglycerides, cholesterol, LDL levels, glucose tolerance and decrease in HDL levels. Neuropathy as the complication of type II diabetes was assessed in terms of decreased nerve conduction velocity, mechanical and thermal hyperalgesia and cold allodynia. Oxidative stress was assessed in sciatic nerve and showed increase in LPO and nitrite levels whereas decrease was shown in GSH and catalase activity. Axonal degeneration marked ...
The present study is designed to develop Type-3 diabetes mellitus characterized by insulin resist... more The present study is designed to develop Type-3 diabetes mellitus characterized by insulin resistance, mainly at the brain level. The experimental rats in group-1: received vehicle (5 ml/kg, i.p.) for 28 days, group-2-4: received aluminium chloride (AlCl3) (12.5, 25, and 50 mg/kg, i.p.) daily for 28 days, group-5: received single dose of STZ (45 mg/kg, i.p.), and group-6-8: received STZ and AlCl3 (12.5, 25, and 50 mg/kg, i.p. daily for 28 days) from the third day of STZ administration. The behavioral analysis was initiated on the 29th day, estimating locomotor activity using an open field test, learning and memory-related functions using elevated plus maze (EPM) and morris water maze (MWM) tests. Afterwards, the rats were sacrificed, and brain and blood were collected for whole-brain neurochemical and plasma biochemical assays, including glucose, insulin, nitrite, MDA and amyloid-beta levels. The brain tissues were sectioned, followed by H&E and congo red staining for histopathologi...
Neuropathic pain is caused by functional abnormalities of structural lesions in the peripheral or... more Neuropathic pain is caused by functional abnormalities of structural lesions in the peripheral or central nervous system. Various diseases, such as postherpetic neuralgia, trigeminal neuralgia, diabetic neuropathy, spinal cord injury, cancer, stroke, and degenerative neurological diseases are responsible for producing neuropathic pain. Its symptoms include spontaneous and stimulus evoked painful sensations such as mechanical hyperalgesia, thermal and cold allodynia. Several maladaptive mechanisms underlying these symptoms have been identified in recent years which include peripheral sensitization of nociception, abnormal excitability of afferent neurons, central sensitization comprising pronociceptive facilitation, dis-inhibition of nociception, central reorganization processes, alterations in various ion channels. This review focuses on these pathophysiological principles, focussing on specific cellular and molecular changes that affect membrane excitability and are responsible for...
Quality Control of Cellular Protein in Neurodegenerative Disorders, 2020
Mitophagy is a selective autophagy process in which damaged or surplus mitochondria are removed t... more Mitophagy is a selective autophagy process in which damaged or surplus mitochondria are removed to sustain normal homeostasis. The efficient removal of damaged or stressed mitochondria is crucial for cellular health. Recent literature emphasizes the role of PINK1-Parkin pathways in the pathogenesis process of various neurodegenerative disorders. Further, mitophagy has shown potential therapeutic activity in treating neurodegenerative diseases. Thus, mitophagy might be important in the field of pharmacotherapeutics. In the present chapter, the authors explain mitophagy, mitophagy signaling pathways, as well as mechanisms and roles of mitophagy in various neurodegenerative disorders.
Quality Control of Cellular Protein in Neurodegenerative Disorders, 2020
Autophagy is a normal physiological process characterized by the degradation of complex cellular ... more Autophagy is a normal physiological process characterized by the degradation of complex cellular contents into a simpler one and reutilized them in biosynthetic pathways. Lysosomes are the cell organelle that participates in the process of autophagy. The brain is the most vulnerable organ in most lysosome disorders because neurons are inefficient in removing impaired organelles and waste materials. In the brain, autophagy suppresses the accumulation of ubiquitinated proteins that results in further damage to the neurons responsible for neurodegeneration. Autophagy mediates protective effects in age-related diseases. In the chapter, the authors describe the process of autophagy, the mechanism involved, and the implication of the autophagic pathways in the various neurodegenerative disorders.
In view of the pathologic basis for the treatment of diabetic neuropathy, it is important to enha... more In view of the pathologic basis for the treatment of diabetic neuropathy, it is important to enhance nerve regeneration as well as prevent nerve degeneration. So, in the present study, we have investigated the effect of S‐Methylisothiourea Sulfate (selective iNOS inhibitor) and Citicoline, alone and in combination, on Type II diabetes mellitus induced neuropathic pain in wistar rats. Type II diabetes was induced by providing high fat diet and low dose of Streptozotocin for 35 days in rats. Type II diabetes mellitus was assessed in terms of increased glucose, triglycerides, cholesterol, LDL levels, glucose tolerance and decrease in HDL levels. Neuropathy as the complication of type II diabetes was assessed in terms of decreased nerve conduction velocity, mechanical and thermal hyperalgesia and cold allodynia. Oxidative stress was assessed in sciatic nerve and showed increase in LPO and nitrite levels whereas decrease was shown in GSH and catalase activity. Axonal degeneration marked ...
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Papers by abhilasha ahlawat