Background It is suggested that vitamin D may have a beneficial role in male reproduction. The ma... more Background It is suggested that vitamin D may have a beneficial role in male reproduction. The male reproductive system is a target tissue for vitamin D. This study will aim to evaluate the effects of vitamin D supplementation on sperm parameters, seminal and serum levels of oxidative stress and serum endocrine factors in asthenospermia infertile men. Methods/design This randomized, triple-blind, placebo-controlled clinical trial will be conducted on 86 infertile men with idiopathic asthenozoospermia (the mobility of sperm < 40% and rapid progressive sperm motility < 32%), with serum levels of vitamin D less than 30 ng / ml in the “Infertility Clinic of Ahvaz Jahad daneshgahi”, Iran. Main outcomes measure (s) Demographic data, dietary intake, physical activity, sun exposure, anthropometric indices, serum and seminal levels of MDA (Malondialdehyde), 8-hydroxy-2- Dioxy Guanosine (8-OHDG), Total Antioxidant Capacity (TAC) and calcium, sperm DNA fragmentation index (DFI), serum 25...
BACKGROUND AND OBJECTIVES Coronary artery disease (CAD) is a major cause of death worldwide. Chro... more BACKGROUND AND OBJECTIVES Coronary artery disease (CAD) is a major cause of death worldwide. Chronic stable angina (CSA) is the primary sign of CAD. Oxidative stress and inflammation play a substantial role in pathogenesis and progression of CAD. The aim of this study was to investigate the effects of oral administration of powdered Melissa officinalis (MO) on biomarkers of oxidative stress, inflammation, and lipid profile in patients with CSA. METHODS AND STUDY DESIGN A randomized, double-blind, placebo-controlled clinical trial was performed in 80 patients with CSA. The subjects were randomly assigned to obtaineither oral MO 3 g/d (n=40) or placebo (n=40) for eight weeks. Anthropometric indices, biomarkers of oxidative stress, inflammation, and lipid profile were evaluated at baseline and post-intervention. RESULTS The mean serum concentrations of triglycerides, total-cholesterol, LDL-cholesterol, and malondialdehyde (MDA), and high sensitive C-Reactive Protein (hs-CRP) were lower...
Background: Brain microstructural changes in white matter (WM) and gray matter (GM) of type 2 dia... more Background: Brain microstructural changes in white matter (WM) and gray matter (GM) of type 2 diabetes mellitus (T2DM) patients can be explained using Diffusion Tensor Imaging (DTI) method. Increased oxidative stress has been recognized the key factor in T2DM induce neural damage. Rutin flavonoid plays protective roles in several oxidative stress-mediated neurodegenerative disorders. So, the effects of rutin on WM and GM continuous changes in T2DM patients requires to be more investigated.Method: We will conduct a 3 months, double-blind, randomized controlled clinical trial to examine the effects of rutin supplementation on WM and GM changes in 26 T2DM cases. The intervention group (n=13) and the control group (n=13) will receive one tablet of 1 g rutin/day and one tablet of 1 g placebo/day after meals, respectively. Before and after the intervention, DTI will perform at 1.5 Tesla, followed by an analysis employing tract-based spatial statistics (TBSS) to explore the changes in frac...
Iron deficiency anemia is one of the most common nutritional problems during pregnancy. The aim o... more Iron deficiency anemia is one of the most common nutritional problems during pregnancy. The aim of this study was to evaluate the effect of education based on health belief model to promote preventive behaviors against iron deficiency anemia among pregnant women. The study was performed on 80 pregnant women that were randomized equally into the experimental and control groups. A self-administered questionnaire based on health belief model constructs was applied to gather data. The experimental group received two educational sessions. The mean age of women was 27.96±5.6 years and mean gestational age was 16.6±1 weeks. Before the intervention, no significant differences in terms of demographic characteristics and health belief model constructs were found between the groups, while after the intervention, the scores of health belief model were different significantly between the control and experimental groups . Since the results of the study indicated the applicability of health belief...
This paper should be cited as: Zare Javid A, Niknejad N, Shahbazian H, Latifi SM, Niknejad B, Hor... more This paper should be cited as: Zare Javid A, Niknejad N, Shahbazian H, Latifi SM, Niknejad B, Hormoznejad R. The Relationship between Snacking and Risk of Individual Components of Metabolic Syndrome in Normal-weight Adults: A Cross-sectional Study. Journal of Nutrition and Food Security (JNFS), 2017; 2 (4): 265-278. The Relationship between Snacking and Risk of Individual Components of Metabolic Syndrome in Normal-weight Adults: A Cross-sectional Study
Dental caries is the most prevalent disease worldwide. The goal of the study was to determine the... more Dental caries is the most prevalent disease worldwide. The goal of the study was to determine the effect of curcumin on the acidogenicity, viable bacteria and biomass in an experimental biofilm caries model on human enamel. A validated caries model with Streptococcus mutans ATCC 3568 biofilms was used. Biofilms were formed on enamel slabs during five days. To copycariogenic challenges, slabs were exposed three times per day for five minutes to 10 sucrose followed by five additional minutes of exposure to different dilutions of curcumin(5, 10 and 20 mg/ml) in dimethyl sulfoxide. Slabs were exposed to 10 sucrose followed by 0.9 NaCl served as caries-positive control. The acidogenicity of medium was measured twice per day by a pH meter. After the experimental phase, biofilms were recovered andthe biomass and viable bacteria were determined. Significant differences were observed in the number of viable bacterial cells and in the biomass (P < 0.05). Our findings suggest that curcumin ...
Background Obesity can increase the risk of diabetes mellitus and complications associated with i... more Background Obesity can increase the risk of diabetes mellitus and complications associated with it. Objectives The aim of this study was to estimate the associations between new and old anthropometric indices and the risk of type 2 diabetes mellitus (T2DM) and its metabolic complications. Methods In this cross-sectional analytical study, 110 T2DM subjects and 110 healthy controls were selected by convenience sampling. Metabolic factors were evaluated including the atherogenic index of plasma (AIP), glycemic status, lipid profile, blood pressure, kidney indices, new anthropometric indices (abdominal volume index [AVI], body shape index [ABSI], lipid accumulation product [LAP], body adiposity index [BAI], and conicity index [CI]), and old anthropometric indices (weight, body mass index [BMI], and waist and hip circumference [WC and HC]). Results Significant positive correlations were observed between AVI, LAP, and BAI and fasting blood glucose and HbA1c in the T2DM group (p < 0.001...
Fasting-mimicking diet (FMD) has been recently promoted to achieve similar metabolic changes of f... more Fasting-mimicking diet (FMD) has been recently promoted to achieve similar metabolic changes of fasting. The purpose of our study was to compare the effect of FMD versus continuous energy restriction (CER) on anthropometric measurements, body composition, glucose metabolism, and serum levels of leptin, neuropeptide Y (NPY), and total ghrelin. A randomized controlled trial (RCT) was conducted on 60 women with obesity aged 18–55 years. Subjects received either a 5-day FMD (low in energy, sugars, and proteins, but high in unsaturated fats) or a CER (an average daily energy deficit of 500 kcal) for 2 months. Anthropometric and biochemical factors were measured at baseline and the end of the study. Serum levels of leptin, total ghrelin, and NPY were tested with an ELISA kit. Physical activity and dietary intakes were also recorded. There was no significant difference in weight loss between the two groups: mean weight change for CER was − 2.29 (standard deviation [SD], 1.95) kg compared to − 1.13 (2.27) kg for FMD (p = 0.06). There was more reduction in the basal metabolic rate (BMR) in the CER group (p = 0.045). Favorable effects on fat mass and muscle mass were only seen in the FMD group. Although insulin resistance was reduced in the FMD group compared to the CER group, results were not significant after adjustment. After controlling for potential confounders, there was a significant increase in serum levels of total ghrelin (p = 0.048) and NPY (p = 0.041) following CER; however, results for circulating leptin were not statistically significant (p = 0.48). There was no significant difference in weight loss following FMD and CER. However, FMD was more effective at reducing insulin resistance and regulating appetite-regulating hormones as well as preserving muscle mass and BMR. This trial was registered at the Iranian Clinical Trial Registry (https://www.irct.ir/trial/40881) with the IRCT identification number IRCT20190717044244N1.
Background: Diabetes mellitus is a common chronic disease. Dyslipidemia and hypertension are two ... more Background: Diabetes mellitus is a common chronic disease. Dyslipidemia and hypertension are two complications that may develop in diabetic patients if hyperglycemia, insulin resistance, and weight gain are not controlled. This study investigated the effects of melatonin supplementation on some cardiovascular disease risk factors and anthropometric indices in patients with type 2 diabetes mellitus (T2DM).Materials and Methods: In this double-blind, randomized, placebo-controlled trial, 50 T2DM patients were randomly allocated to intervention and control groups which received two tablets of either melatonin or placebo (250 mg) once a day for eight weeks. Mean arterial pressure (MAP), pulse pressure (PP), the atherogenic index of plasma (AIP), weight, body mass index (BMI), waist and hip circumference (WC, HC), body shape index (ABSI), abdominal volume index (AVI), body adiposity index (BAI), lipid accumulation product (LAP), conicity index, and waist-to-height ratio (WHR) were evalua...
BackgroundDiabetes mellitus (DM) and periodontitis are two common chronic diseases with bidirecti... more BackgroundDiabetes mellitus (DM) and periodontitis are two common chronic diseases with bidirectional relationship. Oxidative stress plays a key role in the pathogenesis of these two diseases. The aim of this study was to investigate the effects of melatonin supplementation in adjunct with non-surgical periodontal therapy on periodontal status, serum melatonin and inflammatory markers in type 2 DM patients with chronic periodontitis (CP).Materials and methodsIn this double-blind clinical trial study, 50 type 2 DM patients with CP were randomly allocated to the intervention and control groups. The intervention and control groups received either 6 mg melatonin or placebo (2 tablets) once a day. Serum levels of melatonin, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), hs-C-reactive protein (hs-CRP), clinical attachment loss (CAL), pocket depth (PD), bleeding on probing (BOP) and plaque index were evaluated in all subjects pre- and post-intervention.ResultsMelatonin supplementation significantly increased the mean serum levels of melatonin after intervention. The mean changes of melatonin were significantly higher in intervention group compared with control group. IL-6 and hs-CRP levels were significantly (p = 0.008 and p = 0.017, respectively) reduced in the intervention group. The mean changes of IL-6 were significantly lower in the intervention group compared with the control group (p = 0.04). In the intervention group, PD and CAL were significantly decreased after intervention (p < 0.001). There were significant differences in the mean change of PD and CAL between the intervention and control groups after intervention (p < 0.001).ConclusionsMelatonin supplementation in adjunct with non-surgical periodontal therapy might improve inflammatory and periodontal status in T2DM with CP.
Background It is suggested that vitamin D may have a beneficial role in male reproduction. The ma... more Background It is suggested that vitamin D may have a beneficial role in male reproduction. The male reproductive system is a target tissue for vitamin D. This study will aim to evaluate the effects of vitamin D supplementation on sperm parameters, seminal and serum levels of oxidative stress and serum endocrine factors in asthenospermia infertile men. Methods/design This randomized, triple-blind, placebo-controlled clinical trial will be conducted on 86 infertile men with idiopathic asthenozoospermia (the mobility of sperm < 40% and rapid progressive sperm motility < 32%), with serum levels of vitamin D less than 30 ng / ml in the “Infertility Clinic of Ahvaz Jahad daneshgahi”, Iran. Main outcomes measure (s) Demographic data, dietary intake, physical activity, sun exposure, anthropometric indices, serum and seminal levels of MDA (Malondialdehyde), 8-hydroxy-2- Dioxy Guanosine (8-OHDG), Total Antioxidant Capacity (TAC) and calcium, sperm DNA fragmentation index (DFI), serum 25...
BACKGROUND AND OBJECTIVES Coronary artery disease (CAD) is a major cause of death worldwide. Chro... more BACKGROUND AND OBJECTIVES Coronary artery disease (CAD) is a major cause of death worldwide. Chronic stable angina (CSA) is the primary sign of CAD. Oxidative stress and inflammation play a substantial role in pathogenesis and progression of CAD. The aim of this study was to investigate the effects of oral administration of powdered Melissa officinalis (MO) on biomarkers of oxidative stress, inflammation, and lipid profile in patients with CSA. METHODS AND STUDY DESIGN A randomized, double-blind, placebo-controlled clinical trial was performed in 80 patients with CSA. The subjects were randomly assigned to obtaineither oral MO 3 g/d (n=40) or placebo (n=40) for eight weeks. Anthropometric indices, biomarkers of oxidative stress, inflammation, and lipid profile were evaluated at baseline and post-intervention. RESULTS The mean serum concentrations of triglycerides, total-cholesterol, LDL-cholesterol, and malondialdehyde (MDA), and high sensitive C-Reactive Protein (hs-CRP) were lower...
Background: Brain microstructural changes in white matter (WM) and gray matter (GM) of type 2 dia... more Background: Brain microstructural changes in white matter (WM) and gray matter (GM) of type 2 diabetes mellitus (T2DM) patients can be explained using Diffusion Tensor Imaging (DTI) method. Increased oxidative stress has been recognized the key factor in T2DM induce neural damage. Rutin flavonoid plays protective roles in several oxidative stress-mediated neurodegenerative disorders. So, the effects of rutin on WM and GM continuous changes in T2DM patients requires to be more investigated.Method: We will conduct a 3 months, double-blind, randomized controlled clinical trial to examine the effects of rutin supplementation on WM and GM changes in 26 T2DM cases. The intervention group (n=13) and the control group (n=13) will receive one tablet of 1 g rutin/day and one tablet of 1 g placebo/day after meals, respectively. Before and after the intervention, DTI will perform at 1.5 Tesla, followed by an analysis employing tract-based spatial statistics (TBSS) to explore the changes in frac...
Iron deficiency anemia is one of the most common nutritional problems during pregnancy. The aim o... more Iron deficiency anemia is one of the most common nutritional problems during pregnancy. The aim of this study was to evaluate the effect of education based on health belief model to promote preventive behaviors against iron deficiency anemia among pregnant women. The study was performed on 80 pregnant women that were randomized equally into the experimental and control groups. A self-administered questionnaire based on health belief model constructs was applied to gather data. The experimental group received two educational sessions. The mean age of women was 27.96±5.6 years and mean gestational age was 16.6±1 weeks. Before the intervention, no significant differences in terms of demographic characteristics and health belief model constructs were found between the groups, while after the intervention, the scores of health belief model were different significantly between the control and experimental groups . Since the results of the study indicated the applicability of health belief...
This paper should be cited as: Zare Javid A, Niknejad N, Shahbazian H, Latifi SM, Niknejad B, Hor... more This paper should be cited as: Zare Javid A, Niknejad N, Shahbazian H, Latifi SM, Niknejad B, Hormoznejad R. The Relationship between Snacking and Risk of Individual Components of Metabolic Syndrome in Normal-weight Adults: A Cross-sectional Study. Journal of Nutrition and Food Security (JNFS), 2017; 2 (4): 265-278. The Relationship between Snacking and Risk of Individual Components of Metabolic Syndrome in Normal-weight Adults: A Cross-sectional Study
Dental caries is the most prevalent disease worldwide. The goal of the study was to determine the... more Dental caries is the most prevalent disease worldwide. The goal of the study was to determine the effect of curcumin on the acidogenicity, viable bacteria and biomass in an experimental biofilm caries model on human enamel. A validated caries model with Streptococcus mutans ATCC 3568 biofilms was used. Biofilms were formed on enamel slabs during five days. To copycariogenic challenges, slabs were exposed three times per day for five minutes to 10 sucrose followed by five additional minutes of exposure to different dilutions of curcumin(5, 10 and 20 mg/ml) in dimethyl sulfoxide. Slabs were exposed to 10 sucrose followed by 0.9 NaCl served as caries-positive control. The acidogenicity of medium was measured twice per day by a pH meter. After the experimental phase, biofilms were recovered andthe biomass and viable bacteria were determined. Significant differences were observed in the number of viable bacterial cells and in the biomass (P < 0.05). Our findings suggest that curcumin ...
Background Obesity can increase the risk of diabetes mellitus and complications associated with i... more Background Obesity can increase the risk of diabetes mellitus and complications associated with it. Objectives The aim of this study was to estimate the associations between new and old anthropometric indices and the risk of type 2 diabetes mellitus (T2DM) and its metabolic complications. Methods In this cross-sectional analytical study, 110 T2DM subjects and 110 healthy controls were selected by convenience sampling. Metabolic factors were evaluated including the atherogenic index of plasma (AIP), glycemic status, lipid profile, blood pressure, kidney indices, new anthropometric indices (abdominal volume index [AVI], body shape index [ABSI], lipid accumulation product [LAP], body adiposity index [BAI], and conicity index [CI]), and old anthropometric indices (weight, body mass index [BMI], and waist and hip circumference [WC and HC]). Results Significant positive correlations were observed between AVI, LAP, and BAI and fasting blood glucose and HbA1c in the T2DM group (p < 0.001...
Fasting-mimicking diet (FMD) has been recently promoted to achieve similar metabolic changes of f... more Fasting-mimicking diet (FMD) has been recently promoted to achieve similar metabolic changes of fasting. The purpose of our study was to compare the effect of FMD versus continuous energy restriction (CER) on anthropometric measurements, body composition, glucose metabolism, and serum levels of leptin, neuropeptide Y (NPY), and total ghrelin. A randomized controlled trial (RCT) was conducted on 60 women with obesity aged 18–55 years. Subjects received either a 5-day FMD (low in energy, sugars, and proteins, but high in unsaturated fats) or a CER (an average daily energy deficit of 500 kcal) for 2 months. Anthropometric and biochemical factors were measured at baseline and the end of the study. Serum levels of leptin, total ghrelin, and NPY were tested with an ELISA kit. Physical activity and dietary intakes were also recorded. There was no significant difference in weight loss between the two groups: mean weight change for CER was − 2.29 (standard deviation [SD], 1.95) kg compared to − 1.13 (2.27) kg for FMD (p = 0.06). There was more reduction in the basal metabolic rate (BMR) in the CER group (p = 0.045). Favorable effects on fat mass and muscle mass were only seen in the FMD group. Although insulin resistance was reduced in the FMD group compared to the CER group, results were not significant after adjustment. After controlling for potential confounders, there was a significant increase in serum levels of total ghrelin (p = 0.048) and NPY (p = 0.041) following CER; however, results for circulating leptin were not statistically significant (p = 0.48). There was no significant difference in weight loss following FMD and CER. However, FMD was more effective at reducing insulin resistance and regulating appetite-regulating hormones as well as preserving muscle mass and BMR. This trial was registered at the Iranian Clinical Trial Registry (https://www.irct.ir/trial/40881) with the IRCT identification number IRCT20190717044244N1.
Background: Diabetes mellitus is a common chronic disease. Dyslipidemia and hypertension are two ... more Background: Diabetes mellitus is a common chronic disease. Dyslipidemia and hypertension are two complications that may develop in diabetic patients if hyperglycemia, insulin resistance, and weight gain are not controlled. This study investigated the effects of melatonin supplementation on some cardiovascular disease risk factors and anthropometric indices in patients with type 2 diabetes mellitus (T2DM).Materials and Methods: In this double-blind, randomized, placebo-controlled trial, 50 T2DM patients were randomly allocated to intervention and control groups which received two tablets of either melatonin or placebo (250 mg) once a day for eight weeks. Mean arterial pressure (MAP), pulse pressure (PP), the atherogenic index of plasma (AIP), weight, body mass index (BMI), waist and hip circumference (WC, HC), body shape index (ABSI), abdominal volume index (AVI), body adiposity index (BAI), lipid accumulation product (LAP), conicity index, and waist-to-height ratio (WHR) were evalua...
BackgroundDiabetes mellitus (DM) and periodontitis are two common chronic diseases with bidirecti... more BackgroundDiabetes mellitus (DM) and periodontitis are two common chronic diseases with bidirectional relationship. Oxidative stress plays a key role in the pathogenesis of these two diseases. The aim of this study was to investigate the effects of melatonin supplementation in adjunct with non-surgical periodontal therapy on periodontal status, serum melatonin and inflammatory markers in type 2 DM patients with chronic periodontitis (CP).Materials and methodsIn this double-blind clinical trial study, 50 type 2 DM patients with CP were randomly allocated to the intervention and control groups. The intervention and control groups received either 6 mg melatonin or placebo (2 tablets) once a day. Serum levels of melatonin, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), hs-C-reactive protein (hs-CRP), clinical attachment loss (CAL), pocket depth (PD), bleeding on probing (BOP) and plaque index were evaluated in all subjects pre- and post-intervention.ResultsMelatonin supplementation significantly increased the mean serum levels of melatonin after intervention. The mean changes of melatonin were significantly higher in intervention group compared with control group. IL-6 and hs-CRP levels were significantly (p = 0.008 and p = 0.017, respectively) reduced in the intervention group. The mean changes of IL-6 were significantly lower in the intervention group compared with the control group (p = 0.04). In the intervention group, PD and CAL were significantly decreased after intervention (p < 0.001). There were significant differences in the mean change of PD and CAL between the intervention and control groups after intervention (p < 0.001).ConclusionsMelatonin supplementation in adjunct with non-surgical periodontal therapy might improve inflammatory and periodontal status in T2DM with CP.
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