PurposeAcute and chronic obstructive pulmonary disease (COPD) is a common and progressive lung di... more PurposeAcute and chronic obstructive pulmonary disease (COPD) is a common and progressive lung disease that makes breathing difficult over time and can even lead to death. Despite this, there is no definitive treatment for it yet. This study aims to evaluate the studies on single and combined herbal interventions affecting COPD.Design/methodology/approachIn this study, all articles published in English up to 2020 were extracted from the Web of Science (WoS) database and collected using Boolean tools based on keywords, titles and abstracts. Finally, the data required for bibliographic analysis, such as the author(s), publication year, academic journal, institution, country of origin, institution, financial institution and keywords were extracted from the database.FindingsA total of 573 articles were analyzed. The number of papers in the lung disease field showed an upward trend from 1984 to 2021, and there was a surge in paper publications in 2013. China, Korea and Brazil published t...
Clinical, Biological and Molecular Aspects of COVID-19, 2021
AIM We aimed to describe the epidemiological and clinical characteristics of Iranian patients wit... more AIM We aimed to describe the epidemiological and clinical characteristics of Iranian patients with COVID-19. METHODS In this single-center and retrospective study, patients with confirmed COVID-19 infections were enrolled. Univariate and multivariate logistic regression methods were used to explore the risk factors associated with outcomes. RESULTS Of 179 patients with confirmed COVID-19 infection, 12 remained hospitalized at the end of the study and 167 were included in the final analysis. Of these, 153 (91.6%) were discharged and 14 (8.38%) died in hospital. Approximately half (50.9%) of patients suffered from a comorbidity, with diabetes or coronary heart disease being the most common in 20 patients. The most common symptoms on admission were fever, dyspnea, and cough. The mean durations from first symptoms to hospital admission was 8.64 ± 4.14 days, whereas the mean hospitalization time to discharge or death was 5.19 ± 2.42 and 4.35 ± 2.70 days, respectively. There was a significantly higher age in non-survivor patients compared with survivor patients. Multivariate regression showed increasing odds ratio (OR) of in-hospital death associated with respiratory rates >20 breaths/min (OR: 5.14, 95% CI: 1.19-22.15, p = 0.028) and blood urea nitrogen (BUN) >19 mg/dL (OR: 4.54, 95% CI: 1.30-15.85, p = 0.017) on admission. In addition, higher respiratory rate was associated with continuous fever (OR: 4.08, 95% CI: 1.18-14.08, p = 0.026) and other clinical symptoms (OR: 3.52, 95% CI: 1.05-11.87, p = 0.04). CONCLUSION The potential risk factors including high respiratory rate and BUN levels could help to identify COVID-19 patients with poor prognosis at an early stage in the Iranian population.
Background Cancer is one of the critical issues of the global health system with a high mortality... more Background Cancer is one of the critical issues of the global health system with a high mortality rate even with the available therapies, so using novel therapeutic approaches to reduce the mortality rate and increase the quality of life is sensed more than ever. Main body CAR-T cell therapy and oncolytic viruses are innovative cancer therapeutic approaches with fewer complications than common treatments such as chemotherapy and radiotherapy and significantly improve the quality of life. Oncolytic viruses can selectively proliferate in the cancer cells and destroy them. The specificity of oncolytic viruses potentially maintains the normal cells and tissues intact. T-cells are genetically manipulated and armed against the specific antigens of the tumor cells in CAR-T cell therapy. Eventually, they are returned to the body and act against the tumor cells. Nowadays, virology and oncology researchers intend to improve the efficacy of immunotherapy by utilizing CAR-T cells in combination...
Identification of Biomarkers, New Treatments, and Vaccines for COVID-19, 2021
The exaggerated host response to Sars-CoV-2 plays an important role in COVID-19 pathology but pro... more The exaggerated host response to Sars-CoV-2 plays an important role in COVID-19 pathology but provides a therapeutic opportunity until definitive virus targeted therapies and vaccines become available. Given a central role of endothelial dysfunction and systemic inflammation, repurposing ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), statins, and aspirin has been of interest. In this retrospective, single-center study, we evaluated the primary outcomes of mortality and ICU admission in 587 hospitalized patients with documented COVID-19 with or without ACEIs, ARBs, statins, and aspirin. Atorvastatin was associated with reduced mortality, which persisted after adjusting for age, lockdown status, and other medications (OR: 0.18. 95% CI: 0.06-0.49, P = 0.001). ACEIs were also associated with reduced mortality in the crude model (OR: 0.20, CI: 0.06-0.66, P = 0.008), as ACEIs and ARBs were combined as a single group (OR: 0.35, CI: 0.16-0.75, P = 0.007), although ARBs alone did not reach statistical significance. There was no association between any medications and risk of ICU admission. Aspirin only achieved a significant association of reduced mortality in a subgroup of patients with diabetes in the crude model (OR: 0.17, CI: 0.04-0.80, P = 0.02). The reduced mortality observed with atorvastatin is consistent with other literature, and consideration should be given to atorvastatin as a COVID-19 treatment. While there was suggested benefit of ACEIs and ARBs in the present study, other studies are varied and further studies are warranted to recommend employing these medications as a treatment strategy. Nevertheless, this study combined with others continues to give credibility that ACEIs and ARBs are safe to continue in the setting of COVID-19.
Clinical, Biological and Molecular Aspects of COVID-19, 2021
There is data from individual clinical trials suggesting that procalcitonin (PCT) may be a progno... more There is data from individual clinical trials suggesting that procalcitonin (PCT) may be a prognostic factor in the severity of COVID-19 disease. Therefore, this systematic review and meta-analysis was performed to investigate PCT levels in severe COVID-19 patients. We searched Embase, ProQuest, MEDLINE/PubMed, Scopus, and ISI/Web of Science for studies that reported the level of PCT of patient with severe COVID-19. We included all studies regardless of design that reported the level of PCT in patients with severe COVID-19. We excluded articles not regarding COVID-19 or not reporting PCT level, studies not in severe patients, review articles, editorials or letters, expert opinions, comments, and animal studies. Nine studies were included in the analysis. The odds of having more severe COVID-19 disease was higher in subjects with elevated PCT (≥0.05 ng/mL) compared with those having low procalcitonin (<0.05 ng/mL) [n = 6, OR(95% CI) = 2.91(1.14, 7.42), p = 0.025). After estimating the mean and standard deviation values from the sample size, median, and interquartile range, a pooled effect analysis indicated higher serum PCT concentrations in patients with severe versus less severe disease [n = 6, SMD(95% CI) = 0.64(0.02, 1.26), p = 0.042]. The results of this study showed that PCT is increased in patients with severe COVID-19 infection.
Background and Aim: More than 100,000 Iranian veterans suffer from chemical damage caused by must... more Background and Aim: More than 100,000 Iranian veterans suffer from chemical damage caused by mustard gas. The aim of this study was to determine the body composition status of chemical warfare veterans with chronic obstructive pulmonary disease (COPD). Methods: This is a cross-sectional study. 97 chemical warfare veterans with COPD in Karaj, Iran were included in the study. The Patients were divided into two groups low and medium to high disease severity according to spirometry parameters. The body composition parameters were evaluated using the Bioelectrical Impedance Analysis method. Results: Mean age, height and weight of patients were 49.19±3.86, 171.85±6.11, 79.24±11.09, respectively. 65.6 % of them were overweight or obese. According to spirometry indexes, 55.7% (n=54) of veterans had low disease severity and 44.3% (n=43) had moderate to high disease severity. There was a significant difference between chemical veterans with low severity of COPD and moderate to high severity o...
International Journal of Fertility & Sterility, 2021
Background: Recent studies have indicated that epigenetic alterations are critical for normal fun... more Background: Recent studies have indicated that epigenetic alterations are critical for normal function and development of spermatozoa during fertilization process. This review will focus on the latest advances in epigenome profiling of the chromatin modifications during sperm development, as well as the potential roles of epigenetic mechanisms in the context of male infertility. Methods: We performed a review of published studies considering the effect of epigenetic abnormalities on human spermatogenesis, sperm parameters quality, fertilization process, embryo development and live births. PubMed was searched for all experimental and clinical studies using the Keywords “epigenetic modifications”, “male infertility”, “spermatogenesis”, “embryo development” and “reproductive function”. Results: Post-translational modifications of histone, DNA methylations, chromatin remodeling or rearrangement, and expression patterns of different non-coding RNAs (ncRNAs) are the most important types o...
International Journal of Fertility & Sterility, 2019
Calcium (Ca) is a significant element that acts as an intracellular second messenger. It is neces... more Calcium (Ca) is a significant element that acts as an intracellular second messenger. It is necessary for many physi- ological processes in spermatozoa including spermatogenesis, sperm motility, capacitation, acrosome reaction and fertilization. Although influences of Ca deficiency on sperm function and male infertility have been widely studied, mechanisms for these abnormalities are not well considered. Poor sperm motility, impairment of chemotaxis, capaci- tation, acrosome reaction and steroidogenesis are the major mechanisms by which Ca deficiency induces male infertil- ity. Therefore, an optimal seminal Ca concentration is required to strengthen sperm function and all steps leading to successful fertilization. Furthermore, identification of these mechanisms provides valuable information regarding the mechanisms of Ca deficiency on male reproductive system and the way for developing a better clinical approach. In this review, we aim to discuss the proposed cellular and molecular ...
Iranian Journal of Pharmacology and Therapeutics, 2018
Sulfur mustard (SM) is a mutagenic compound that causes oxidative stress, antioxidant depletion e... more Sulfur mustard (SM) is a mutagenic compound that causes oxidative stress, antioxidant depletion even several years after exposure. Melatonin is an alternative medication that has antioxidant peroperties. The aim of this study was to investigate the effect of melatonin treatment on serum levels of several mineral elements, total antioxidant (TAC) and total oxidant status (TOS) in sulfur mustard-exposed patients. Victims with lung and sleep disorders was divided randomly to placebo and melatonin groups. They received melatonin or placebo for 56 days. Blood samples were taken before and after drug usage. The concentrations of serum trace elements (manganese, zinc, copper, and iron) and one other essential element (magnesium) were determined by graphite furnace and flame atomic absorption spectroscopy. TAC and TOS in serum were determined colorimetrically. Results showed that melatonin administration increases the magnesium and TAC concentrations. After the drug usage, placebo and melat...
Introduction: Vincristine (VCR) is potential anti-cancer drug that is highly toxic for renal tiss... more Introduction: Vincristine (VCR) is potential anti-cancer drug that is highly toxic for renal tissue. This study aimed to evaluate the protective effect of alcoholic extract of saffron stigma against vincristine renal toxicity in male rats. Methods: A total number of 50 rats were randomly divided into 10 groups. Different doses of VCR (0.25, 0.5 and 0.75mg/kg) and saffron (0.5 and 1mg/kg) were used to treat vincristine-induced renal toxicity in rats. Serum level of renal biomarkers, creatinine (Cr), uric acid and blood urea nitrogen (BUN) were measured using specific kits at the end of the experimental period. Serum total antioxidant capacity (TAC) and malondialdehyde (MDA) values were measured using Ferric reducing antioxidant of power (FRAP) and Thiobarbituric acid reaction (TBAR) methods, respectively. Results: Administration of VCR to the experimental rats caused severe renal injury with significant increase in the levels of creatinine (Cr), uric acid and blood urea nitrogen (BUN...
Vincristine (VCR) is an important anti-cancer drug, which is highly toxic for the liver. This stu... more Vincristine (VCR) is an important anti-cancer drug, which is highly toxic for the liver. This study aimed at evaluating the protective effect of alcoholic extract of saffron stigma against vincristine hepatotoxicity in the rat. A total number of 50 rats were randomly divided into 10 groups, including controls, rats receiving 0.25 mg/kg (A group), 0.5 mg/kg (B group), 0.75 mg/kg (C group) VCR, 0.25 mg/kg VCR + 0.5 mg/kg saffron (D group), 0.5 mg/kg VCR + 0.5 mg/kg saffron (E group), 0.75 mg/kg VCR + 0.5 mg/kg saffron (F group), 0.25 mg/kg VCR + 1mg/kg saffron (G group), 0.5 mg/kg VCR + 1 mg/kg saffron (H group), and 0.75 mg/kg VCR + 1 mg/kg saffron (I group) groups. Serum level of liver enzymes, including aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and bilirubin were measured using specific kits at the end of the experimental period. Serum total antioxidant capacity (TAC) and malondialdehyde (MDA) values were measured using ferric reducing an...
Disaster Medicine and Public Health Preparedness, 2020
ABSTRACTCoronavirus disease 2019 (COVID-19) is an infectious disease caused by the severe acute r... more ABSTRACTCoronavirus disease 2019 (COVID-19) is an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged as a health problem worldwide. It seems that COVID-19 is more lethal for Iranian veterans with a history of exposure to mustard gas. There are some similarities in the pathogenesis of SARS-CoV-2 and mustard gas in immune system disruption and pulmonary infection. SARS-CoV-2 and mustard gas inducing oxidative stress, immune system dysregulation, cytokine storm, and overexpression of angiotensin-converting enzyme II (ACE2) receptor in lungs that act as functional entry receptors for SARS-CoV-2. Moreover, Iranian survivors of mustard gas exposure are more susceptible and vulnerable to COVID-19. It is suggested that the principles of COVID-19 infection prevention and control be adhered to more stringently in Iranian survivors of mustard gas exposure than others who have not been exposed to mustard gas. Therefore, in this review, we ...
Some heavy metals are nutritionally essential elements playing key roles in different physiologic... more Some heavy metals are nutritionally essential elements playing key roles in different physiological and biological processes, like: iron, cobalt, zinc, copper, chromium, molybdenum, selenium and manganese, while some others are considered as the potentially toxic elements in high amounts or certain chemical forms. Nowadays, various usage of heavy metals in industry, agriculture, medicine and technology has led to a widespread distribution in nature raising concerns about their effects on human health and environment. Metallic ions may interact with cellular components such as DNA and nuclear proteins leading to apoptosis and carcinogenesis arising from DNA damage and structural changes. As a result, exposure to heavy metals through ingestion, inhalation and dermal contact causes several health problems such as, cardiovascular diseases, neurological and neurobehavioral abnormalities, diabetes, blood abnormalities and various types of cancer. Due to extensive damage caused by heavy me...
PurposeAcute and chronic obstructive pulmonary disease (COPD) is a common and progressive lung di... more PurposeAcute and chronic obstructive pulmonary disease (COPD) is a common and progressive lung disease that makes breathing difficult over time and can even lead to death. Despite this, there is no definitive treatment for it yet. This study aims to evaluate the studies on single and combined herbal interventions affecting COPD.Design/methodology/approachIn this study, all articles published in English up to 2020 were extracted from the Web of Science (WoS) database and collected using Boolean tools based on keywords, titles and abstracts. Finally, the data required for bibliographic analysis, such as the author(s), publication year, academic journal, institution, country of origin, institution, financial institution and keywords were extracted from the database.FindingsA total of 573 articles were analyzed. The number of papers in the lung disease field showed an upward trend from 1984 to 2021, and there was a surge in paper publications in 2013. China, Korea and Brazil published t...
Clinical, Biological and Molecular Aspects of COVID-19, 2021
AIM We aimed to describe the epidemiological and clinical characteristics of Iranian patients wit... more AIM We aimed to describe the epidemiological and clinical characteristics of Iranian patients with COVID-19. METHODS In this single-center and retrospective study, patients with confirmed COVID-19 infections were enrolled. Univariate and multivariate logistic regression methods were used to explore the risk factors associated with outcomes. RESULTS Of 179 patients with confirmed COVID-19 infection, 12 remained hospitalized at the end of the study and 167 were included in the final analysis. Of these, 153 (91.6%) were discharged and 14 (8.38%) died in hospital. Approximately half (50.9%) of patients suffered from a comorbidity, with diabetes or coronary heart disease being the most common in 20 patients. The most common symptoms on admission were fever, dyspnea, and cough. The mean durations from first symptoms to hospital admission was 8.64 ± 4.14 days, whereas the mean hospitalization time to discharge or death was 5.19 ± 2.42 and 4.35 ± 2.70 days, respectively. There was a significantly higher age in non-survivor patients compared with survivor patients. Multivariate regression showed increasing odds ratio (OR) of in-hospital death associated with respiratory rates >20 breaths/min (OR: 5.14, 95% CI: 1.19-22.15, p = 0.028) and blood urea nitrogen (BUN) >19 mg/dL (OR: 4.54, 95% CI: 1.30-15.85, p = 0.017) on admission. In addition, higher respiratory rate was associated with continuous fever (OR: 4.08, 95% CI: 1.18-14.08, p = 0.026) and other clinical symptoms (OR: 3.52, 95% CI: 1.05-11.87, p = 0.04). CONCLUSION The potential risk factors including high respiratory rate and BUN levels could help to identify COVID-19 patients with poor prognosis at an early stage in the Iranian population.
Background Cancer is one of the critical issues of the global health system with a high mortality... more Background Cancer is one of the critical issues of the global health system with a high mortality rate even with the available therapies, so using novel therapeutic approaches to reduce the mortality rate and increase the quality of life is sensed more than ever. Main body CAR-T cell therapy and oncolytic viruses are innovative cancer therapeutic approaches with fewer complications than common treatments such as chemotherapy and radiotherapy and significantly improve the quality of life. Oncolytic viruses can selectively proliferate in the cancer cells and destroy them. The specificity of oncolytic viruses potentially maintains the normal cells and tissues intact. T-cells are genetically manipulated and armed against the specific antigens of the tumor cells in CAR-T cell therapy. Eventually, they are returned to the body and act against the tumor cells. Nowadays, virology and oncology researchers intend to improve the efficacy of immunotherapy by utilizing CAR-T cells in combination...
Identification of Biomarkers, New Treatments, and Vaccines for COVID-19, 2021
The exaggerated host response to Sars-CoV-2 plays an important role in COVID-19 pathology but pro... more The exaggerated host response to Sars-CoV-2 plays an important role in COVID-19 pathology but provides a therapeutic opportunity until definitive virus targeted therapies and vaccines become available. Given a central role of endothelial dysfunction and systemic inflammation, repurposing ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), statins, and aspirin has been of interest. In this retrospective, single-center study, we evaluated the primary outcomes of mortality and ICU admission in 587 hospitalized patients with documented COVID-19 with or without ACEIs, ARBs, statins, and aspirin. Atorvastatin was associated with reduced mortality, which persisted after adjusting for age, lockdown status, and other medications (OR: 0.18. 95% CI: 0.06-0.49, P = 0.001). ACEIs were also associated with reduced mortality in the crude model (OR: 0.20, CI: 0.06-0.66, P = 0.008), as ACEIs and ARBs were combined as a single group (OR: 0.35, CI: 0.16-0.75, P = 0.007), although ARBs alone did not reach statistical significance. There was no association between any medications and risk of ICU admission. Aspirin only achieved a significant association of reduced mortality in a subgroup of patients with diabetes in the crude model (OR: 0.17, CI: 0.04-0.80, P = 0.02). The reduced mortality observed with atorvastatin is consistent with other literature, and consideration should be given to atorvastatin as a COVID-19 treatment. While there was suggested benefit of ACEIs and ARBs in the present study, other studies are varied and further studies are warranted to recommend employing these medications as a treatment strategy. Nevertheless, this study combined with others continues to give credibility that ACEIs and ARBs are safe to continue in the setting of COVID-19.
Clinical, Biological and Molecular Aspects of COVID-19, 2021
There is data from individual clinical trials suggesting that procalcitonin (PCT) may be a progno... more There is data from individual clinical trials suggesting that procalcitonin (PCT) may be a prognostic factor in the severity of COVID-19 disease. Therefore, this systematic review and meta-analysis was performed to investigate PCT levels in severe COVID-19 patients. We searched Embase, ProQuest, MEDLINE/PubMed, Scopus, and ISI/Web of Science for studies that reported the level of PCT of patient with severe COVID-19. We included all studies regardless of design that reported the level of PCT in patients with severe COVID-19. We excluded articles not regarding COVID-19 or not reporting PCT level, studies not in severe patients, review articles, editorials or letters, expert opinions, comments, and animal studies. Nine studies were included in the analysis. The odds of having more severe COVID-19 disease was higher in subjects with elevated PCT (≥0.05 ng/mL) compared with those having low procalcitonin (<0.05 ng/mL) [n = 6, OR(95% CI) = 2.91(1.14, 7.42), p = 0.025). After estimating the mean and standard deviation values from the sample size, median, and interquartile range, a pooled effect analysis indicated higher serum PCT concentrations in patients with severe versus less severe disease [n = 6, SMD(95% CI) = 0.64(0.02, 1.26), p = 0.042]. The results of this study showed that PCT is increased in patients with severe COVID-19 infection.
Background and Aim: More than 100,000 Iranian veterans suffer from chemical damage caused by must... more Background and Aim: More than 100,000 Iranian veterans suffer from chemical damage caused by mustard gas. The aim of this study was to determine the body composition status of chemical warfare veterans with chronic obstructive pulmonary disease (COPD). Methods: This is a cross-sectional study. 97 chemical warfare veterans with COPD in Karaj, Iran were included in the study. The Patients were divided into two groups low and medium to high disease severity according to spirometry parameters. The body composition parameters were evaluated using the Bioelectrical Impedance Analysis method. Results: Mean age, height and weight of patients were 49.19±3.86, 171.85±6.11, 79.24±11.09, respectively. 65.6 % of them were overweight or obese. According to spirometry indexes, 55.7% (n=54) of veterans had low disease severity and 44.3% (n=43) had moderate to high disease severity. There was a significant difference between chemical veterans with low severity of COPD and moderate to high severity o...
International Journal of Fertility & Sterility, 2021
Background: Recent studies have indicated that epigenetic alterations are critical for normal fun... more Background: Recent studies have indicated that epigenetic alterations are critical for normal function and development of spermatozoa during fertilization process. This review will focus on the latest advances in epigenome profiling of the chromatin modifications during sperm development, as well as the potential roles of epigenetic mechanisms in the context of male infertility. Methods: We performed a review of published studies considering the effect of epigenetic abnormalities on human spermatogenesis, sperm parameters quality, fertilization process, embryo development and live births. PubMed was searched for all experimental and clinical studies using the Keywords “epigenetic modifications”, “male infertility”, “spermatogenesis”, “embryo development” and “reproductive function”. Results: Post-translational modifications of histone, DNA methylations, chromatin remodeling or rearrangement, and expression patterns of different non-coding RNAs (ncRNAs) are the most important types o...
International Journal of Fertility & Sterility, 2019
Calcium (Ca) is a significant element that acts as an intracellular second messenger. It is neces... more Calcium (Ca) is a significant element that acts as an intracellular second messenger. It is necessary for many physi- ological processes in spermatozoa including spermatogenesis, sperm motility, capacitation, acrosome reaction and fertilization. Although influences of Ca deficiency on sperm function and male infertility have been widely studied, mechanisms for these abnormalities are not well considered. Poor sperm motility, impairment of chemotaxis, capaci- tation, acrosome reaction and steroidogenesis are the major mechanisms by which Ca deficiency induces male infertil- ity. Therefore, an optimal seminal Ca concentration is required to strengthen sperm function and all steps leading to successful fertilization. Furthermore, identification of these mechanisms provides valuable information regarding the mechanisms of Ca deficiency on male reproductive system and the way for developing a better clinical approach. In this review, we aim to discuss the proposed cellular and molecular ...
Iranian Journal of Pharmacology and Therapeutics, 2018
Sulfur mustard (SM) is a mutagenic compound that causes oxidative stress, antioxidant depletion e... more Sulfur mustard (SM) is a mutagenic compound that causes oxidative stress, antioxidant depletion even several years after exposure. Melatonin is an alternative medication that has antioxidant peroperties. The aim of this study was to investigate the effect of melatonin treatment on serum levels of several mineral elements, total antioxidant (TAC) and total oxidant status (TOS) in sulfur mustard-exposed patients. Victims with lung and sleep disorders was divided randomly to placebo and melatonin groups. They received melatonin or placebo for 56 days. Blood samples were taken before and after drug usage. The concentrations of serum trace elements (manganese, zinc, copper, and iron) and one other essential element (magnesium) were determined by graphite furnace and flame atomic absorption spectroscopy. TAC and TOS in serum were determined colorimetrically. Results showed that melatonin administration increases the magnesium and TAC concentrations. After the drug usage, placebo and melat...
Introduction: Vincristine (VCR) is potential anti-cancer drug that is highly toxic for renal tiss... more Introduction: Vincristine (VCR) is potential anti-cancer drug that is highly toxic for renal tissue. This study aimed to evaluate the protective effect of alcoholic extract of saffron stigma against vincristine renal toxicity in male rats. Methods: A total number of 50 rats were randomly divided into 10 groups. Different doses of VCR (0.25, 0.5 and 0.75mg/kg) and saffron (0.5 and 1mg/kg) were used to treat vincristine-induced renal toxicity in rats. Serum level of renal biomarkers, creatinine (Cr), uric acid and blood urea nitrogen (BUN) were measured using specific kits at the end of the experimental period. Serum total antioxidant capacity (TAC) and malondialdehyde (MDA) values were measured using Ferric reducing antioxidant of power (FRAP) and Thiobarbituric acid reaction (TBAR) methods, respectively. Results: Administration of VCR to the experimental rats caused severe renal injury with significant increase in the levels of creatinine (Cr), uric acid and blood urea nitrogen (BUN...
Vincristine (VCR) is an important anti-cancer drug, which is highly toxic for the liver. This stu... more Vincristine (VCR) is an important anti-cancer drug, which is highly toxic for the liver. This study aimed at evaluating the protective effect of alcoholic extract of saffron stigma against vincristine hepatotoxicity in the rat. A total number of 50 rats were randomly divided into 10 groups, including controls, rats receiving 0.25 mg/kg (A group), 0.5 mg/kg (B group), 0.75 mg/kg (C group) VCR, 0.25 mg/kg VCR + 0.5 mg/kg saffron (D group), 0.5 mg/kg VCR + 0.5 mg/kg saffron (E group), 0.75 mg/kg VCR + 0.5 mg/kg saffron (F group), 0.25 mg/kg VCR + 1mg/kg saffron (G group), 0.5 mg/kg VCR + 1 mg/kg saffron (H group), and 0.75 mg/kg VCR + 1 mg/kg saffron (I group) groups. Serum level of liver enzymes, including aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and bilirubin were measured using specific kits at the end of the experimental period. Serum total antioxidant capacity (TAC) and malondialdehyde (MDA) values were measured using ferric reducing an...
Disaster Medicine and Public Health Preparedness, 2020
ABSTRACTCoronavirus disease 2019 (COVID-19) is an infectious disease caused by the severe acute r... more ABSTRACTCoronavirus disease 2019 (COVID-19) is an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged as a health problem worldwide. It seems that COVID-19 is more lethal for Iranian veterans with a history of exposure to mustard gas. There are some similarities in the pathogenesis of SARS-CoV-2 and mustard gas in immune system disruption and pulmonary infection. SARS-CoV-2 and mustard gas inducing oxidative stress, immune system dysregulation, cytokine storm, and overexpression of angiotensin-converting enzyme II (ACE2) receptor in lungs that act as functional entry receptors for SARS-CoV-2. Moreover, Iranian survivors of mustard gas exposure are more susceptible and vulnerable to COVID-19. It is suggested that the principles of COVID-19 infection prevention and control be adhered to more stringently in Iranian survivors of mustard gas exposure than others who have not been exposed to mustard gas. Therefore, in this review, we ...
Some heavy metals are nutritionally essential elements playing key roles in different physiologic... more Some heavy metals are nutritionally essential elements playing key roles in different physiological and biological processes, like: iron, cobalt, zinc, copper, chromium, molybdenum, selenium and manganese, while some others are considered as the potentially toxic elements in high amounts or certain chemical forms. Nowadays, various usage of heavy metals in industry, agriculture, medicine and technology has led to a widespread distribution in nature raising concerns about their effects on human health and environment. Metallic ions may interact with cellular components such as DNA and nuclear proteins leading to apoptosis and carcinogenesis arising from DNA damage and structural changes. As a result, exposure to heavy metals through ingestion, inhalation and dermal contact causes several health problems such as, cardiovascular diseases, neurological and neurobehavioral abnormalities, diabetes, blood abnormalities and various types of cancer. Due to extensive damage caused by heavy me...
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Papers by alireza shahriary