A variety of quinoxalines were synthesized via tandem one-pot procedure for the first time in wate... more A variety of quinoxalines were synthesized via tandem one-pot procedure for the first time in water medium. The key strategy was the in situ preparation of a-halo-b-keto esters by the reaction of N-bromo succinimide with b-keto esters and further condensation with phenylene diamines. This novel eco-friendly approach offers an easy, efficient, and mild synthesis of highly substituted quinoxalines in good yields.
β‐Cyclodextrin catalyzed synthesis of indole derivatives from indole, aldehyde and N‐methylanilin... more β‐Cyclodextrin catalyzed synthesis of indole derivatives from indole, aldehyde and N‐methylaniline is reported.The β‐cyclodextrin can be recovered and reused without significant loss of catalytic activity, and it is inexpensive, readily available when compared to other cyclodextrins (α, γ).
A simple and efficient, ligand-free C–N cross-coupling of aryl halides/benzyl bromides with trans-... more A simple and efficient, ligand-free C–N cross-coupling of aryl halides/benzyl bromides with trans-4hydroxyL-proline has been developed to produce aromatized N-substituted pyrroles, using a catalytic amount of magnetically separable and recyclable CuFe2O4 nanoparticles, in the presence of Cs2CO3 in DMSO at 100 C.
A simple and highly practical method for the synthesis of 2-N-substituted benzothiazoles has been... more A simple and highly practical method for the synthesis of 2-N-substituted benzothiazoles has been developed by using nano copper ferrite as a magnetically separable, recyclable catalyst. The present tandem process allows to get access to a wide range of 2-N-substituted benzothiazoles in good to excellent yields by the reaction of benzothiazole with nitrogen nucleophiles in the presence of Cs2CO3 as a base. The nano CuFe2O4 could be recovered and reused with no significant loss of catalytic activity.
A ligand free Ru/C-catalyzed amination of 2-halo azoles with a broad scope of aminating reagents ... more A ligand free Ru/C-catalyzed amination of 2-halo azoles with a broad scope of aminating reagents has been developed. A variety of 2-aminoazole derivatives were synthesized in moderate to good yields by utilizing this protocol. The methodology is operationally simple and not sensitive to air and moisture. It provides potentially useful products by using an inexpensive and recyclable catalytic system under ligand free conditions without significant loss of its catalytic activity up to four cycles.
2-Phenyl-2,3-dihydroquinazolin-4(1H)-one derivatives were synthesized for the first time in water ... more 2-Phenyl-2,3-dihydroquinazolin-4(1H)-one derivatives were synthesized for the first time in water under neutral conditions by the reaction of aldehyde, and anthranilamide mediated by b-cyclodextrin in high yields. b-Cyclodextrin can be recovered and reused with a small loss of catalytic activity.
The first ever tandem one-pot synthetic protocol for the synthesis of thiazoles/selenazoles from a... more The first ever tandem one-pot synthetic protocol for the synthesis of thiazoles/selenazoles from alkynes via the formation of 2,2-dibromo-1-phenylethanone is reported. The reaction is catalyzed by b-cyclodextrin in aqueous medium and resulted in good yields.
Efficient synthesis of diverse quinazolines from readily available starting materials was... more Efficient synthesis of diverse quinazolines from readily available starting materials was achieved in aqueous medium via one‐pot protocol. A number of 2,4‐disubstituted quinazolines were prepared in moderate to good yields under mild and catalyst‐free conditions. Neutral reaction conditions, easy work‐up procedures with wide substrate scope and atom economy are the remarkable features of this method.
Recyclable copper oxide nanoparticles catalyzed simple and highly efficient protocol for the synth... more Recyclable copper oxide nanoparticles catalyzed simple and highly efficient protocol for the synthesis of symmetrical aryl sulfides was developed by the cross-coupling of aromatic halides with inexpensive and commercially available thiourea which was used as an effective sulfur surrogate. The present cross-coupling protocol of thiourea, via cascade reaction with various substituted aryl halides, producing desired aryl sulfides, has an added advantage of avoiding foul-smelling thiols.
The recyclable Ru/C catalyzed oxidative a-cyanation of tertiary amines with ethyl cyanoformate by... more The recyclable Ru/C catalyzed oxidative a-cyanation of tertiary amines with ethyl cyanoformate by using TBHP as an oxidant under ambient conditions has been developed. Utilizing this protocol, a-aminonitrile derivatives were synthesized in good to excellent yields with high selectivity. The cyanide source (ethyl cyanoformate) employed herein was relatively cheap and less toxic, which would be beneficial. The catalyst was also inexpensive and commercially available as well as recyclable up to four cycles, without significant loss of its catalytic activity.
A novel one pot synthesis of b-hydroxy-1,4-disubstituted-1,2,3-triazoles has been developed by us... more A novel one pot synthesis of b-hydroxy-1,4-disubstituted-1,2,3-triazoles has been developed by using CuFe2O4 magnetic nanoparticles. This methodology involves additive free, easily recyclable catalyst in water medium and avoids the handling of organic azides as they are generated in situ.
The synthesis of 1,4-disubstituted 1,2,3-triazoles is attempted using magnetically separable and ... more The synthesis of 1,4-disubstituted 1,2,3-triazoles is attempted using magnetically separable and reusable copper ferrite nano particles in a one pot reaction, in tap water.
A variety of quinoxalines were synthesized via tandem one-pot procedure for the first time in wate... more A variety of quinoxalines were synthesized via tandem one-pot procedure for the first time in water medium. The key strategy was the in situ preparation of a-halo-b-keto esters by the reaction of N-bromo succinimide with b-keto esters and further condensation with phenylene diamines. This novel eco-friendly approach offers an easy, efficient, and mild synthesis of highly substituted quinoxalines in good yields.
β‐Cyclodextrin catalyzed synthesis of indole derivatives from indole, aldehyde and N‐methylanilin... more β‐Cyclodextrin catalyzed synthesis of indole derivatives from indole, aldehyde and N‐methylaniline is reported.The β‐cyclodextrin can be recovered and reused without significant loss of catalytic activity, and it is inexpensive, readily available when compared to other cyclodextrins (α, γ).
A simple and efficient, ligand-free C–N cross-coupling of aryl halides/benzyl bromides with trans-... more A simple and efficient, ligand-free C–N cross-coupling of aryl halides/benzyl bromides with trans-4hydroxyL-proline has been developed to produce aromatized N-substituted pyrroles, using a catalytic amount of magnetically separable and recyclable CuFe2O4 nanoparticles, in the presence of Cs2CO3 in DMSO at 100 C.
A simple and highly practical method for the synthesis of 2-N-substituted benzothiazoles has been... more A simple and highly practical method for the synthesis of 2-N-substituted benzothiazoles has been developed by using nano copper ferrite as a magnetically separable, recyclable catalyst. The present tandem process allows to get access to a wide range of 2-N-substituted benzothiazoles in good to excellent yields by the reaction of benzothiazole with nitrogen nucleophiles in the presence of Cs2CO3 as a base. The nano CuFe2O4 could be recovered and reused with no significant loss of catalytic activity.
A ligand free Ru/C-catalyzed amination of 2-halo azoles with a broad scope of aminating reagents ... more A ligand free Ru/C-catalyzed amination of 2-halo azoles with a broad scope of aminating reagents has been developed. A variety of 2-aminoazole derivatives were synthesized in moderate to good yields by utilizing this protocol. The methodology is operationally simple and not sensitive to air and moisture. It provides potentially useful products by using an inexpensive and recyclable catalytic system under ligand free conditions without significant loss of its catalytic activity up to four cycles.
2-Phenyl-2,3-dihydroquinazolin-4(1H)-one derivatives were synthesized for the first time in water ... more 2-Phenyl-2,3-dihydroquinazolin-4(1H)-one derivatives were synthesized for the first time in water under neutral conditions by the reaction of aldehyde, and anthranilamide mediated by b-cyclodextrin in high yields. b-Cyclodextrin can be recovered and reused with a small loss of catalytic activity.
The first ever tandem one-pot synthetic protocol for the synthesis of thiazoles/selenazoles from a... more The first ever tandem one-pot synthetic protocol for the synthesis of thiazoles/selenazoles from alkynes via the formation of 2,2-dibromo-1-phenylethanone is reported. The reaction is catalyzed by b-cyclodextrin in aqueous medium and resulted in good yields.
Efficient synthesis of diverse quinazolines from readily available starting materials was... more Efficient synthesis of diverse quinazolines from readily available starting materials was achieved in aqueous medium via one‐pot protocol. A number of 2,4‐disubstituted quinazolines were prepared in moderate to good yields under mild and catalyst‐free conditions. Neutral reaction conditions, easy work‐up procedures with wide substrate scope and atom economy are the remarkable features of this method.
Recyclable copper oxide nanoparticles catalyzed simple and highly efficient protocol for the synth... more Recyclable copper oxide nanoparticles catalyzed simple and highly efficient protocol for the synthesis of symmetrical aryl sulfides was developed by the cross-coupling of aromatic halides with inexpensive and commercially available thiourea which was used as an effective sulfur surrogate. The present cross-coupling protocol of thiourea, via cascade reaction with various substituted aryl halides, producing desired aryl sulfides, has an added advantage of avoiding foul-smelling thiols.
The recyclable Ru/C catalyzed oxidative a-cyanation of tertiary amines with ethyl cyanoformate by... more The recyclable Ru/C catalyzed oxidative a-cyanation of tertiary amines with ethyl cyanoformate by using TBHP as an oxidant under ambient conditions has been developed. Utilizing this protocol, a-aminonitrile derivatives were synthesized in good to excellent yields with high selectivity. The cyanide source (ethyl cyanoformate) employed herein was relatively cheap and less toxic, which would be beneficial. The catalyst was also inexpensive and commercially available as well as recyclable up to four cycles, without significant loss of its catalytic activity.
A novel one pot synthesis of b-hydroxy-1,4-disubstituted-1,2,3-triazoles has been developed by us... more A novel one pot synthesis of b-hydroxy-1,4-disubstituted-1,2,3-triazoles has been developed by using CuFe2O4 magnetic nanoparticles. This methodology involves additive free, easily recyclable catalyst in water medium and avoids the handling of organic azides as they are generated in situ.
The synthesis of 1,4-disubstituted 1,2,3-triazoles is attempted using magnetically separable and ... more The synthesis of 1,4-disubstituted 1,2,3-triazoles is attempted using magnetically separable and reusable copper ferrite nano particles in a one pot reaction, in tap water.
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approach offers an easy, efficient, and mild synthesis of highly substituted quinoxalines in good yields.
loss of catalytic activity, and it is inexpensive, readily available when compared to other cyclodextrins (α, γ).
excellent yields by the reaction of benzothiazole with nitrogen nucleophiles in the presence of Cs2CO3 as a base. The nano CuFe2O4 could be recovered and reused with no significant loss of catalytic activity.
are the remarkable features of this method.
approach offers an easy, efficient, and mild synthesis of highly substituted quinoxalines in good yields.
loss of catalytic activity, and it is inexpensive, readily available when compared to other cyclodextrins (α, γ).
excellent yields by the reaction of benzothiazole with nitrogen nucleophiles in the presence of Cs2CO3 as a base. The nano CuFe2O4 could be recovered and reused with no significant loss of catalytic activity.
are the remarkable features of this method.