ACM Transactions on Architecture and Code Optimization
The maturity level of RISC-V and the availability of domain-specific instruction set extensions, ... more The maturity level of RISC-V and the availability of domain-specific instruction set extensions, like vector processing, make RISC-V a good candidate for supporting the integration of specialized hardware in processor cores for the High Performance Computing (HPC) application domain. In this paper, we present Vitruvius+, the vector processing acceleration engine which represents the core of vector instruction execution in the HPC challenge that comes within the EuroHPC initiative. It implements the RISC-V vector extension (RVV) 0.7.1 and can be easily connected to a scalar core using the Open Vector Interface (OVI) standard. Vitruvius+ natively supports long vectors: 256 Double Precision (DP) floating-point elements in a single vector register. It is composed of a set of identical vector pipelines (lanes), each containing a slice of the Vector Register File (VRF) and functional units (one integer, one floating-point). The vector instruction execution scheme is hybrid in-order/out-of...
Borges defines the text as an encounter with the reader, several times throughout his work. He do... more Borges defines the text as an encounter with the reader, several times throughout his work. He does not describe it as an object, a thing among other things, but as an event, as a dialog. This article explores the implications of such a definition of the text. It connects what Borges says in his essays with his own practice of reading and writing, and with the numerous encounters that take place in his stories. It also explores some contact points between Borges and another philosopher of the encounter, Louis Althusser.
Background Asthma is one of the conditions that contributes to the global burden of respiratory d... more Background Asthma is one of the conditions that contributes to the global burden of respiratory diseases and has been previously associated with diet intake. The goal of this study was to determine the relationship between diet, assessed by a developed score, and asthma in Peruvian children. Methods This study was a cross sectional analysis nested within an unmatched case-control study of children in two peri-urban communities of Lima, Peru. We evaluated 767 children and adolescents (573 with asthma, 194 controls) between 9 and 19 years. Diet was assessed using a food frequency questionnaire (FFQ), with food groups classified as “healthy” or “unhealthy”. Asthma control, Lung function and atopy were assessed by Asthma Control Test, Spirometry and InmunoCAP 250 test, respectively. Results Mean age of participants was 13.8 years (SD 2.6). Mean diet score was 5 (SD 1.23; range 2–8). Healthy Diet Score was associated with asthma status [OR 0.83, 95% CI (0.72, 0.95), p = 0.009] in adjuste...
Background: Asthma prevalence is increasing in many countries and diet is one of several factors ... more Background: Asthma prevalence is increasing in many countries and diet is one of several factors contributing to this trend. However, this relationship has rarely been investigated in Peruvian children. Objective: Determine the relationship between diet quality and asthma in a population of Peruvian children. Methods: We evaluated 768 children (574 asthmatics-194 controls) in two peri-urban districts in Lima, Peru. Asthma was defined as a history of doctor-diagnosed asthma, report of wheeze or asthma medication use in 12 months. Control subjects had no history of asthma or wheeze and had normal lung function. Diet was assessed using food frequency questionnaires with eleven food groups classified as healthy or unhealthy according to the Alternative Healthy Eating Index. Diet quality score was created by dividing frequencies into quartiles (1-4) for healthy and unhealthy food groups and summing these quartile scores to create a final score; a higher score indicates a healthier diet. Multivariable logistic regression was used to determine the relationship between diet score and asthma status adjusting for confounders including SES, residence site, age, sex and BMI. Results: Mean age of participants was 13.8 years. Mean diet score was 5 (±1.23; range 2-8). Continuous diet score was associated with asthma status with a one-unit increase in diet score associated with a 17% lower odds of asthma (p=0.009). Participants in the highest quartile of diet score had 60% reduced odds of having asthma (p=0.002) when compared to the lowest. Conclusions: Higher diet quality was associated with lower odds of having asthma. Diet modification in this population may be a potential intervention to prevent the increasing prevalence of asthma.
2009 IEEE/WIC/ACM International Joint Conference on Web Intelligence and Intelligent Agent Technology, 2009
We present a generic framework to evaluate patterns obtained from transactional web data streams ... more We present a generic framework to evaluate patterns obtained from transactional web data streams whose underlying distribution changes with time. The evolving nature of the data makes it very difficult to determine whether there is structure in the data stream, and whether this structure is being learned. This challenge arises in applications such as mining online store transactions, summarizing dynamic
ABSTRACT Many system-level studies involve the simulation of power systems with growing penetrati... more ABSTRACT Many system-level studies involve the simulation of power systems with growing penetration of power electronic devices and loads at distribution level. This gives rise to the need for fast models of static switching converters and efficient simulation tools. The so-called dynamic average-value models (AVMs), which use averaging techniques by neglecting switching, are widely used and appear to be very promising for the system-level transient studies of power-electronic loads. However, considering converter losses and predicting the energy efficiency remains challenging. This paper presents a methodology to include converter losses in AVMs of medium power active front-end (AFE) rectifier loads. The proposed new method is applied to a two-level voltage source converter (VSC) operating under direct power control (DPC). The conducted simulation results demonstrate the new methodology and confirm its accuracy in predicting conduction and switching losses and efficiency, while providing significant computational savings compared to the detailed switching model.
El presente ensayo intenta reconstruir las lineas principales del modelo de historia cultural que... more El presente ensayo intenta reconstruir las lineas principales del modelo de historia cultural que el microhistoriador italiano Carlo Ginzburg ha venido desarrollando desde hace ya casi cuatro decadas, y que se han plasmado de una manera ejemplar en su hoy ya celebre libro EL QUESO Y LOS GUSANOS. Asi, tratando de reconstruir tanto las versiones de historia cultural que este libro y este modelo ginzburguianos tratan de criticar y de superar, como tambien las filiaciones de los autores y perspectivas que este modelo pretende prolongar y asumir como antecedentes, el ensayo trata de dar cuenta de la singular originalidad especifica de esta propuesta de historia cultural de Carlo Ginzburg, caracterizada en parte por tratar de rescatar los problemas desde "la perspectiva misma de las victimas" de los procesos historicos estudiados.
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes nigrostriatal dopaminergic neurotoxici... more 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes nigrostriatal dopaminergic neurotoxicity and behavioral impairment in rodents similar to Parkinson's disease. The MPTP mouse model is widely used to evaluate new protective agents. EGb 761 is a well-defined mixture of active compounds extracted from Ginkgo biloba leaves according to a standardized procedure. We have shown that EGb 761 attenuates the loss of striatal dopamine levels and prevents the neurodegeneration of the nigrostriatal pathway induced by MPTP. This finding shows that neuroprotective effects of EGb 761 act, in part, on the dopamine system. Therefore, this study investigates whether EGb 761 exerts dopaminergic neuroprotection through the regulation of dopamine-related gene expression in MPTP-induced Parkinsonism. Male C57BL/6J mice were injected with MPTP (30 mg/kg, i.p.) for 5 days and later with EGb 761 (40 mg/kg, i.p.) daily for 18 days. The expression of selected genes was evaluated in the striatum and midbrain by quantitative PCR. The genes for tyrosine hydroxylase (Th), vesicular monoamine transporter 2 (Vmat2), dopamine transporter (Dat), dopamine D2 receptor (Da-d2r), and transcription factors (Pitx3 and Nurr1) related to dopamine neurotransmission were selected for the analysis. EGb 761 administration to MPTP-treated mice protected Th (41%), Vmat2 (15%), Dat (102%), Da-d2r (46%), Pitx3 (63%), and Nurr1 (148%) mRNA levels in the midbrain, all of which were up-regulated. However, EGb 761 partially reversed the MPTP effect exclusively for Th (48%) and Nurr1 (96%) mRNA in the striatum. Only Th and Nurr1 mRNA and protein levels were regulated by EGb 761 in both regions of the nigrostriatal pathway. This result could be related to the regulation of their transcription. Our results suggest that EGb 761-associated neuroprotection against MPTP neurotoxicity is related to the regulation of the dopamine genes. Moreover, this neuroprotection also involves the regulation of transcription factors such as Nurr1 that are important for the functional maintenance of dopaminergic neurons.
ACM Transactions on Architecture and Code Optimization
The maturity level of RISC-V and the availability of domain-specific instruction set extensions, ... more The maturity level of RISC-V and the availability of domain-specific instruction set extensions, like vector processing, make RISC-V a good candidate for supporting the integration of specialized hardware in processor cores for the High Performance Computing (HPC) application domain. In this paper, we present Vitruvius+, the vector processing acceleration engine which represents the core of vector instruction execution in the HPC challenge that comes within the EuroHPC initiative. It implements the RISC-V vector extension (RVV) 0.7.1 and can be easily connected to a scalar core using the Open Vector Interface (OVI) standard. Vitruvius+ natively supports long vectors: 256 Double Precision (DP) floating-point elements in a single vector register. It is composed of a set of identical vector pipelines (lanes), each containing a slice of the Vector Register File (VRF) and functional units (one integer, one floating-point). The vector instruction execution scheme is hybrid in-order/out-of...
Borges defines the text as an encounter with the reader, several times throughout his work. He do... more Borges defines the text as an encounter with the reader, several times throughout his work. He does not describe it as an object, a thing among other things, but as an event, as a dialog. This article explores the implications of such a definition of the text. It connects what Borges says in his essays with his own practice of reading and writing, and with the numerous encounters that take place in his stories. It also explores some contact points between Borges and another philosopher of the encounter, Louis Althusser.
Background Asthma is one of the conditions that contributes to the global burden of respiratory d... more Background Asthma is one of the conditions that contributes to the global burden of respiratory diseases and has been previously associated with diet intake. The goal of this study was to determine the relationship between diet, assessed by a developed score, and asthma in Peruvian children. Methods This study was a cross sectional analysis nested within an unmatched case-control study of children in two peri-urban communities of Lima, Peru. We evaluated 767 children and adolescents (573 with asthma, 194 controls) between 9 and 19 years. Diet was assessed using a food frequency questionnaire (FFQ), with food groups classified as “healthy” or “unhealthy”. Asthma control, Lung function and atopy were assessed by Asthma Control Test, Spirometry and InmunoCAP 250 test, respectively. Results Mean age of participants was 13.8 years (SD 2.6). Mean diet score was 5 (SD 1.23; range 2–8). Healthy Diet Score was associated with asthma status [OR 0.83, 95% CI (0.72, 0.95), p = 0.009] in adjuste...
Background: Asthma prevalence is increasing in many countries and diet is one of several factors ... more Background: Asthma prevalence is increasing in many countries and diet is one of several factors contributing to this trend. However, this relationship has rarely been investigated in Peruvian children. Objective: Determine the relationship between diet quality and asthma in a population of Peruvian children. Methods: We evaluated 768 children (574 asthmatics-194 controls) in two peri-urban districts in Lima, Peru. Asthma was defined as a history of doctor-diagnosed asthma, report of wheeze or asthma medication use in 12 months. Control subjects had no history of asthma or wheeze and had normal lung function. Diet was assessed using food frequency questionnaires with eleven food groups classified as healthy or unhealthy according to the Alternative Healthy Eating Index. Diet quality score was created by dividing frequencies into quartiles (1-4) for healthy and unhealthy food groups and summing these quartile scores to create a final score; a higher score indicates a healthier diet. Multivariable logistic regression was used to determine the relationship between diet score and asthma status adjusting for confounders including SES, residence site, age, sex and BMI. Results: Mean age of participants was 13.8 years. Mean diet score was 5 (±1.23; range 2-8). Continuous diet score was associated with asthma status with a one-unit increase in diet score associated with a 17% lower odds of asthma (p=0.009). Participants in the highest quartile of diet score had 60% reduced odds of having asthma (p=0.002) when compared to the lowest. Conclusions: Higher diet quality was associated with lower odds of having asthma. Diet modification in this population may be a potential intervention to prevent the increasing prevalence of asthma.
2009 IEEE/WIC/ACM International Joint Conference on Web Intelligence and Intelligent Agent Technology, 2009
We present a generic framework to evaluate patterns obtained from transactional web data streams ... more We present a generic framework to evaluate patterns obtained from transactional web data streams whose underlying distribution changes with time. The evolving nature of the data makes it very difficult to determine whether there is structure in the data stream, and whether this structure is being learned. This challenge arises in applications such as mining online store transactions, summarizing dynamic
ABSTRACT Many system-level studies involve the simulation of power systems with growing penetrati... more ABSTRACT Many system-level studies involve the simulation of power systems with growing penetration of power electronic devices and loads at distribution level. This gives rise to the need for fast models of static switching converters and efficient simulation tools. The so-called dynamic average-value models (AVMs), which use averaging techniques by neglecting switching, are widely used and appear to be very promising for the system-level transient studies of power-electronic loads. However, considering converter losses and predicting the energy efficiency remains challenging. This paper presents a methodology to include converter losses in AVMs of medium power active front-end (AFE) rectifier loads. The proposed new method is applied to a two-level voltage source converter (VSC) operating under direct power control (DPC). The conducted simulation results demonstrate the new methodology and confirm its accuracy in predicting conduction and switching losses and efficiency, while providing significant computational savings compared to the detailed switching model.
El presente ensayo intenta reconstruir las lineas principales del modelo de historia cultural que... more El presente ensayo intenta reconstruir las lineas principales del modelo de historia cultural que el microhistoriador italiano Carlo Ginzburg ha venido desarrollando desde hace ya casi cuatro decadas, y que se han plasmado de una manera ejemplar en su hoy ya celebre libro EL QUESO Y LOS GUSANOS. Asi, tratando de reconstruir tanto las versiones de historia cultural que este libro y este modelo ginzburguianos tratan de criticar y de superar, como tambien las filiaciones de los autores y perspectivas que este modelo pretende prolongar y asumir como antecedentes, el ensayo trata de dar cuenta de la singular originalidad especifica de esta propuesta de historia cultural de Carlo Ginzburg, caracterizada en parte por tratar de rescatar los problemas desde "la perspectiva misma de las victimas" de los procesos historicos estudiados.
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes nigrostriatal dopaminergic neurotoxici... more 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes nigrostriatal dopaminergic neurotoxicity and behavioral impairment in rodents similar to Parkinson's disease. The MPTP mouse model is widely used to evaluate new protective agents. EGb 761 is a well-defined mixture of active compounds extracted from Ginkgo biloba leaves according to a standardized procedure. We have shown that EGb 761 attenuates the loss of striatal dopamine levels and prevents the neurodegeneration of the nigrostriatal pathway induced by MPTP. This finding shows that neuroprotective effects of EGb 761 act, in part, on the dopamine system. Therefore, this study investigates whether EGb 761 exerts dopaminergic neuroprotection through the regulation of dopamine-related gene expression in MPTP-induced Parkinsonism. Male C57BL/6J mice were injected with MPTP (30 mg/kg, i.p.) for 5 days and later with EGb 761 (40 mg/kg, i.p.) daily for 18 days. The expression of selected genes was evaluated in the striatum and midbrain by quantitative PCR. The genes for tyrosine hydroxylase (Th), vesicular monoamine transporter 2 (Vmat2), dopamine transporter (Dat), dopamine D2 receptor (Da-d2r), and transcription factors (Pitx3 and Nurr1) related to dopamine neurotransmission were selected for the analysis. EGb 761 administration to MPTP-treated mice protected Th (41%), Vmat2 (15%), Dat (102%), Da-d2r (46%), Pitx3 (63%), and Nurr1 (148%) mRNA levels in the midbrain, all of which were up-regulated. However, EGb 761 partially reversed the MPTP effect exclusively for Th (48%) and Nurr1 (96%) mRNA in the striatum. Only Th and Nurr1 mRNA and protein levels were regulated by EGb 761 in both regions of the nigrostriatal pathway. This result could be related to the regulation of their transcription. Our results suggest that EGb 761-associated neuroprotection against MPTP neurotoxicity is related to the regulation of the dopamine genes. Moreover, this neuroprotection also involves the regulation of transcription factors such as Nurr1 that are important for the functional maintenance of dopaminergic neurons.
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