OBJECTIVES To determine the efficacy and safety of brolucizumab therapy administered on a pro re ... more OBJECTIVES To determine the efficacy and safety of brolucizumab therapy administered on a pro re nata (PRN) basis without loading dose in treatment naïve patients with diabetic macular edema (DME) for 1 year follow-up. METHODS Patients with recent DME (< 6 months) received a mandatory brolucizumab injection at inclusion and other injections could be given on a PRN basis with an 8-week interval (between injections) at minimum. Rescue therapy with other anti-VEGF was possible in case of incomplete DME resolution after the second brolucizumab and with a minimum of 1-month treatment free interval between 2 injections. The primary outcome measure was the change in best-corrected visual acuity (BCVA) at 12 months. Secondary outcome measures included the change in central subfield thickness (CST), the change in hard exudate surface area and microaneurysms at 1 year. RESULTS A total of 53 patients were included. At 12 months, the mean (SD) number of injections was 2.6 (0.8) in addition t...
A 22-year-old male patient presented with gradual outward deviation of the right eye following co... more A 22-year-old male patient presented with gradual outward deviation of the right eye following corneal tear repair in that eye 8 years prior. He was asymptomatic in the left eye. On examination, his best corrected visual acuity was counting fingers at 2 m in the right eye and 20/80 in the left eye. The left eye showed a large macular hole, 2845 µm in diameter, with a retinal detachment at the posterior pole. The patient underwent pars plana vitrectomy, internal limiting membrane (ILM) peeling with inverted ILM flap technique and silicone oil injection. At the 1-week follow-up visit, there was growth of retinal tissue under the ILM flap. At 2-month follow-up, there was a complete closure of the macular hole and visual acuity was 20/100. At this time, the patient underwent removal of the silicone oil, following which visual acuity was maintained at 20/100.
Purpose: The aim was to study choroidal thickness (CT) and its profile based on location in healt... more Purpose: The aim was to study choroidal thickness (CT) and its profile based on location in healthy Indian subjects using Cirrus high definition (HD) optical coherence tomography. Materials and Methods: A total of 211 eyes of 115 healthy subjects with no retinal or choroidal disease were consecutively scanned using Cirrus HD 1 line raster scan mode without pupillary dilation. Eyes with any ocular disease or axial length (AXL) >24 mm or <20 mm were excluded. Experienced technician measured CT from the lower border of the retinal pigment epithelium (RPE) to the lower border of choroid. CT was measured from the posterior edge of the RPE to the choroid/sclera junction at 500-μm intervals up to 3000 μm temporal and nasal to the fovea. Generalized estimating equations were used to evaluate the correlation between CT at various locations and age, AXL, spherical equivalent, and macular thickness. Results: Mean age was 42.8 ± 13.6 years. Mean AXL was 22.84 ± 0.78 mm. Median spherical e...
OBJECTIVES To determine the efficacy and safety of brolucizumab therapy administered on a pro re ... more OBJECTIVES To determine the efficacy and safety of brolucizumab therapy administered on a pro re nata (PRN) basis without loading dose in treatment naïve patients with diabetic macular edema (DME) for 1 year follow-up. METHODS Patients with recent DME (< 6 months) received a mandatory brolucizumab injection at inclusion and other injections could be given on a PRN basis with an 8-week interval (between injections) at minimum. Rescue therapy with other anti-VEGF was possible in case of incomplete DME resolution after the second brolucizumab and with a minimum of 1-month treatment free interval between 2 injections. The primary outcome measure was the change in best-corrected visual acuity (BCVA) at 12 months. Secondary outcome measures included the change in central subfield thickness (CST), the change in hard exudate surface area and microaneurysms at 1 year. RESULTS A total of 53 patients were included. At 12 months, the mean (SD) number of injections was 2.6 (0.8) in addition t...
A 22-year-old male patient presented with gradual outward deviation of the right eye following co... more A 22-year-old male patient presented with gradual outward deviation of the right eye following corneal tear repair in that eye 8 years prior. He was asymptomatic in the left eye. On examination, his best corrected visual acuity was counting fingers at 2 m in the right eye and 20/80 in the left eye. The left eye showed a large macular hole, 2845 µm in diameter, with a retinal detachment at the posterior pole. The patient underwent pars plana vitrectomy, internal limiting membrane (ILM) peeling with inverted ILM flap technique and silicone oil injection. At the 1-week follow-up visit, there was growth of retinal tissue under the ILM flap. At 2-month follow-up, there was a complete closure of the macular hole and visual acuity was 20/100. At this time, the patient underwent removal of the silicone oil, following which visual acuity was maintained at 20/100.
Purpose: The aim was to study choroidal thickness (CT) and its profile based on location in healt... more Purpose: The aim was to study choroidal thickness (CT) and its profile based on location in healthy Indian subjects using Cirrus high definition (HD) optical coherence tomography. Materials and Methods: A total of 211 eyes of 115 healthy subjects with no retinal or choroidal disease were consecutively scanned using Cirrus HD 1 line raster scan mode without pupillary dilation. Eyes with any ocular disease or axial length (AXL) >24 mm or <20 mm were excluded. Experienced technician measured CT from the lower border of the retinal pigment epithelium (RPE) to the lower border of choroid. CT was measured from the posterior edge of the RPE to the choroid/sclera junction at 500-μm intervals up to 3000 μm temporal and nasal to the fovea. Generalized estimating equations were used to evaluate the correlation between CT at various locations and age, AXL, spherical equivalent, and macular thickness. Results: Mean age was 42.8 ± 13.6 years. Mean AXL was 22.84 ± 0.78 mm. Median spherical e...
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Papers by riddhima deshpande