The effect of chronic administration of gabapentin, carbamazepine or a gabapentin-carbamazepine c... more The effect of chronic administration of gabapentin, carbamazepine or a gabapentin-carbamazepine combination on testicular function in male rats was investigated to determine the effect of combining reduced doses of anti-epileptic drugs on the management of seizures, particularly with respect to the testis sequellae of chronic anti-epileptic administration. Male rats were randomized into four groups (n=10). Each group received daily intraperitoneal (i.p.) injections for 28days as follows: Group I, normal saline 0.1mL/day; Group II, gabapentin (GBP) 16mg/kg/day; Group III, carbamazepine (CBZ) 20mg/kg/day; and Group IV, sub-therapeutic doses of both GBP (8mg/kg) and CBZ (10mg/kg)/day. Twenty-four hours after the last treatment, five rats from each group were sacrificed and the remaining rats were allowed to recover for another four weeks. Sperm characteristics, serum testosterone, and histological integrity of the testis was assessed 24h after treatment and after 28days of drug withdrawal. GBP, CBZ, and GBP-CBZ combination significantly reduced the absolute weight of the testis, epididymis, and seminal vesicle (p<0.05). Moreover, epididymal sperm count and morphology were significantly decreased (p<0.05) in GBP, CBZ, and GBP-CBZ groups. Reduction in serum levels of testosterone for all of the treated groups was statistically significant (p<0.05). The cytoarchitecture of the testicular tissue in the testis of CBZ and GBP-CBZ groups showed disorganization. The altered testicular function were almost restored in GBP treated rats. CBZ and GBP-CBZ combination have delayed but reversible antifertility in the rats. Hence, chronic administration of GBP, CBZ, and GBP-CBZ combination reversibly reduced testicular function in male rats.
... SI Ola and GN Egbunike*. ... In the restricted suckling groups apron linen was tied round the... more ... SI Ola and GN Egbunike*. ... In the restricted suckling groups apron linen was tied round the belly, including the udder, of the doe to prevent access to the teats by the kids during the hours of suckling restriction. Data collection and analysis. ...
The need for accurate selection of the best oocytes for in vitro fertilization protocols and thus... more The need for accurate selection of the best oocytes for in vitro fertilization protocols and thus, production of embryos has driven the search for oocyte quality markers from morphological criteria to biochemical parameters. Current studies are focused on the biochemical constituents of the follicular fluid and gene expression profiling of the cumulus cells. These parameters are, however, affected by factors that must be considered before making a judgment of the oocyte's quality. These includes factors such as the type of hormonal stimulation protocol, age of oocyte donor and heat stress on the donor, all of which have been reported to influence the concentrations of many hormones, apolipoproteins, metabolites, fatty acids and growth factors in the follicular fluid and the expression of several genes in the cumulus cells. Another important point to note is species variation in the response to these extraneous influences, which thus calls for species targeted investigations. As ...
43 Summary The physiological responses in terms of respiration rate (RR) and rectal temperature (... more 43 Summary The physiological responses in terms of respiration rate (RR) and rectal temperature (RT) of 30 West Afri-can Dwarf (WAD) does were monitored after a single im injection of different doses of progestagens meant for synchronising oestrus. The treatments involved im ...
The behavioural and morphological changes associated with oestrus were studied in 28 West African... more The behavioural and morphological changes associated with oestrus were studied in 28 West African Dwarf does grouped into 3 parity groups or under natural or synchronised cycle in the humid tropical climate of Ile-Ife, Nigeria. Behavioural changes which were diagnostic of ...
... 1937; Ola et al., 2005). We may use this to explain the preponderance of parabasal cells in t... more ... 1937; Ola et al., 2005). We may use this to explain the preponderance of parabasal cells in the smear of NO-COT (no contact with male) animals as been in a state of anoestrus. Since parabasal cells occurrence was highest in and also dominate the smears from does isolated ...
The effect of chronic administration of gabapentin, carbamazepine or a gabapentin-carbamazepine c... more The effect of chronic administration of gabapentin, carbamazepine or a gabapentin-carbamazepine combination on testicular function in male rats was investigated to determine the effect of combining reduced doses of anti-epileptic drugs on the management of seizures, particularly with respect to the testis sequellae of chronic anti-epileptic administration. Male rats were randomized into four groups (n=10). Each group received daily intraperitoneal (i.p.) injections for 28days as follows: Group I, normal saline 0.1mL/day; Group II, gabapentin (GBP) 16mg/kg/day; Group III, carbamazepine (CBZ) 20mg/kg/day; and Group IV, sub-therapeutic doses of both GBP (8mg/kg) and CBZ (10mg/kg)/day. Twenty-four hours after the last treatment, five rats from each group were sacrificed and the remaining rats were allowed to recover for another four weeks. Sperm characteristics, serum testosterone, and histological integrity of the testis was assessed 24h after treatment and after 28days of drug withdrawal. GBP, CBZ, and GBP-CBZ combination significantly reduced the absolute weight of the testis, epididymis, and seminal vesicle (p<0.05). Moreover, epididymal sperm count and morphology were significantly decreased (p<0.05) in GBP, CBZ, and GBP-CBZ groups. Reduction in serum levels of testosterone for all of the treated groups was statistically significant (p<0.05). The cytoarchitecture of the testicular tissue in the testis of CBZ and GBP-CBZ groups showed disorganization. The altered testicular function were almost restored in GBP treated rats. CBZ and GBP-CBZ combination have delayed but reversible antifertility in the rats. Hence, chronic administration of GBP, CBZ, and GBP-CBZ combination reversibly reduced testicular function in male rats.
... SI Ola and GN Egbunike*. ... In the restricted suckling groups apron linen was tied round the... more ... SI Ola and GN Egbunike*. ... In the restricted suckling groups apron linen was tied round the belly, including the udder, of the doe to prevent access to the teats by the kids during the hours of suckling restriction. Data collection and analysis. ...
The need for accurate selection of the best oocytes for in vitro fertilization protocols and thus... more The need for accurate selection of the best oocytes for in vitro fertilization protocols and thus, production of embryos has driven the search for oocyte quality markers from morphological criteria to biochemical parameters. Current studies are focused on the biochemical constituents of the follicular fluid and gene expression profiling of the cumulus cells. These parameters are, however, affected by factors that must be considered before making a judgment of the oocyte's quality. These includes factors such as the type of hormonal stimulation protocol, age of oocyte donor and heat stress on the donor, all of which have been reported to influence the concentrations of many hormones, apolipoproteins, metabolites, fatty acids and growth factors in the follicular fluid and the expression of several genes in the cumulus cells. Another important point to note is species variation in the response to these extraneous influences, which thus calls for species targeted investigations. As ...
43 Summary The physiological responses in terms of respiration rate (RR) and rectal temperature (... more 43 Summary The physiological responses in terms of respiration rate (RR) and rectal temperature (RT) of 30 West Afri-can Dwarf (WAD) does were monitored after a single im injection of different doses of progestagens meant for synchronising oestrus. The treatments involved im ...
The behavioural and morphological changes associated with oestrus were studied in 28 West African... more The behavioural and morphological changes associated with oestrus were studied in 28 West African Dwarf does grouped into 3 parity groups or under natural or synchronised cycle in the humid tropical climate of Ile-Ife, Nigeria. Behavioural changes which were diagnostic of ...
... 1937; Ola et al., 2005). We may use this to explain the preponderance of parabasal cells in t... more ... 1937; Ola et al., 2005). We may use this to explain the preponderance of parabasal cells in the smear of NO-COT (no contact with male) animals as been in a state of anoestrus. Since parabasal cells occurrence was highest in and also dominate the smears from does isolated ...
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