Abstract A survey of published data for 33 proteins from rat liver confirms earlier claims that w... more Abstract A survey of published data for 33 proteins from rat liver confirms earlier claims that within cells large polypeptides tend to be degraded more rapidly than small ones. The rate of degradation of protein multimers correlates primarily with the molecular weight of the subunits rather than with that of the multimer. Because of the many exceptions to this correlation, especially among proteins with short half-lives, molecular size appears to be but one factor influencing a protein's rate of catabolism.
Abstract A survey of published data for 33 proteins from rat liver confirms earlier claims that w... more Abstract A survey of published data for 33 proteins from rat liver confirms earlier claims that within cells large polypeptides tend to be degraded more rapidly than small ones. The rate of degradation of protein multimers correlates primarily with the molecular weight of the subunits rather than with that of the multimer. Because of the many exceptions to this correlation, especially among proteins with short half-lives, molecular size appears to be but one factor influencing a protein's rate of catabolism.
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