OBJECTIVE To report a case of acute myopathy after concomitant use of colchicine and pravastatin.... more OBJECTIVE To report a case of acute myopathy after concomitant use of colchicine and pravastatin. CASE SUMMARY A 65-year-old woman was admitted to the hospital with an acute episode of gout. She had been taking pravastatin 20 mg once daily for 6 years. On admission, blood urea nitrogen and serum creatinine levels were 48 mg/dL and 1.3 mg/dL, respectively. Colchicine 1.5 mg/day was added to the treatment regimen, but 20 days after the initiation of colchicine therapy, symmetrical proximal muscle weakness developed in the woman's legs. Physical examination, laboratory findings, and electromyelogram findings suggested myopathy. The Naranjo probability scale indicated a probable relationship between myopathy and combined therapy. Seven days after discontinuation of colchicine and pravastatin, the patient's weakness improved and enzyme levels returned to normal. Colchicine was restarted at 1.0 mg/day 5 days later; no myopathy occurred. DISCUSSION Hydroxymethylglutaryl coenzyme A ...
Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi
Objectives: To compare elderly-onset rheumatoid arthritis(EORA) patients with younger-onset rheum... more Objectives: To compare elderly-onset rheumatoid arthritis(EORA) patients with younger-onset rheumatoid arthritis(YORA) patients in terms of sociodemographic, clinical and radiological features, and treatment responses. Materials and Methods: 422 rheumatoid arthritis(RA) patients were evaluated retrospectively. Patients with the age of onset of disease symptoms ≥60 were considered EORA,and those 0.05). Conclusion:There is no difference in many clinical and laboratory findings,especially disease activity scores and radiographic scores,in patients with EORA and YORA.
Background: Social support is defined as a helpful resource that can meet an individual’s urgent ... more Background: Social support is defined as a helpful resource that can meet an individual’s urgent needs and is provided by a network of others, such as family members, friends, colleagues and other communities. Perceived social support (PSS) is the subjective support that individuals may experience, emphasizing the individual’s self-understanding, experience and feelings of social support from different sources. Social support directly exerts beneficial effects on the health-related quality of life in rheumatoid arthritis and fibromyalgia patients. Objectives: The aim of this study is to compare the effect of perceived social support on quality of life of rheumatoid arthritis and fibromyalgia patients. The effect of social support from family, friends and significant others are examined separately. Methods: Fifty-eight patients with rheumatoid arthritis, fifty patients with fibromyalgia and fifty healhy controls were enrolled in the study. Short form 36 (SF-36) was used to determine ...
Objective. To investigate ovarian reserves in attack-free familial Mediterranean fever (AF-FMF) p... more Objective. To investigate ovarian reserves in attack-free familial Mediterranean fever (AF-FMF) patients at the reproductive age by anti-Müllerian hormone (AMH), antral follicle count (AFC), ovarian volume, and hormonal parameters.Methods. Thirty-three AF-FMF patients aging 18–45 years and 34 healthy women were enrolled and FSH, LH, E2, PRL, and AMH levels were measured in the morning blood samples at 2nd–4th days of menstruation by ELISA. Concomitant pelvic ultrasonography was performed to calculate AFC and ovarian volumes.Results. In FMF patient group, median AMH levels were statistically significantly lower in the M69V mutation positive group than in the negative ones (P=0.018). There was no statistically significant difference in median AMH levels between E148Q mutation positive patients and the negative ones (P=0.920). There was also no statistically significant difference in median AMH levels between M680I mutation positive patients and the negative ones (P=0.868). No statisti...
OBJECTIVE To report a case of acute myopathy after concomitant use of colchicine and pravastatin.... more OBJECTIVE To report a case of acute myopathy after concomitant use of colchicine and pravastatin. CASE SUMMARY A 65-year-old woman was admitted to the hospital with an acute episode of gout. She had been taking pravastatin 20 mg once daily for 6 years. On admission, blood urea nitrogen and serum creatinine levels were 48 mg/dL and 1.3 mg/dL, respectively. Colchicine 1.5 mg/day was added to the treatment regimen, but 20 days after the initiation of colchicine therapy, symmetrical proximal muscle weakness developed in the woman's legs. Physical examination, laboratory findings, and electromyelogram findings suggested myopathy. The Naranjo probability scale indicated a probable relationship between myopathy and combined therapy. Seven days after discontinuation of colchicine and pravastatin, the patient's weakness improved and enzyme levels returned to normal. Colchicine was restarted at 1.0 mg/day 5 days later; no myopathy occurred. DISCUSSION Hydroxymethylglutaryl coenzyme A ...
Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi
Objectives: To compare elderly-onset rheumatoid arthritis(EORA) patients with younger-onset rheum... more Objectives: To compare elderly-onset rheumatoid arthritis(EORA) patients with younger-onset rheumatoid arthritis(YORA) patients in terms of sociodemographic, clinical and radiological features, and treatment responses. Materials and Methods: 422 rheumatoid arthritis(RA) patients were evaluated retrospectively. Patients with the age of onset of disease symptoms ≥60 were considered EORA,and those 0.05). Conclusion:There is no difference in many clinical and laboratory findings,especially disease activity scores and radiographic scores,in patients with EORA and YORA.
Background: Social support is defined as a helpful resource that can meet an individual’s urgent ... more Background: Social support is defined as a helpful resource that can meet an individual’s urgent needs and is provided by a network of others, such as family members, friends, colleagues and other communities. Perceived social support (PSS) is the subjective support that individuals may experience, emphasizing the individual’s self-understanding, experience and feelings of social support from different sources. Social support directly exerts beneficial effects on the health-related quality of life in rheumatoid arthritis and fibromyalgia patients. Objectives: The aim of this study is to compare the effect of perceived social support on quality of life of rheumatoid arthritis and fibromyalgia patients. The effect of social support from family, friends and significant others are examined separately. Methods: Fifty-eight patients with rheumatoid arthritis, fifty patients with fibromyalgia and fifty healhy controls were enrolled in the study. Short form 36 (SF-36) was used to determine ...
Objective. To investigate ovarian reserves in attack-free familial Mediterranean fever (AF-FMF) p... more Objective. To investigate ovarian reserves in attack-free familial Mediterranean fever (AF-FMF) patients at the reproductive age by anti-Müllerian hormone (AMH), antral follicle count (AFC), ovarian volume, and hormonal parameters.Methods. Thirty-three AF-FMF patients aging 18–45 years and 34 healthy women were enrolled and FSH, LH, E2, PRL, and AMH levels were measured in the morning blood samples at 2nd–4th days of menstruation by ELISA. Concomitant pelvic ultrasonography was performed to calculate AFC and ovarian volumes.Results. In FMF patient group, median AMH levels were statistically significantly lower in the M69V mutation positive group than in the negative ones (P=0.018). There was no statistically significant difference in median AMH levels between E148Q mutation positive patients and the negative ones (P=0.920). There was also no statistically significant difference in median AMH levels between M680I mutation positive patients and the negative ones (P=0.868). No statisti...
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