Background: The clinical course of patients with inflammatory bowel disease (IBD) is frequently c... more Background: The clinical course of patients with inflammatory bowel disease (IBD) is frequently complicated by thromboembolic events and may involve the arterial and venous systems. Although not uniformly documented, several studies document substantial alterations in markers of coagulation and fibrinolysis in patients with IBD. Methods: 45 patients with IBD (31 UC,14 CD) were included in the study. Age and sex matched 16 volunteers were used as a control group. TAFI antigen was determined using an ELISA kit VisuLiseTM for quantitative measurement. Results: Inflammatory parameters such as white blood cell, platelet levels, erythrocyte sedimentation rate, C-reactive protein were found to be significantly higher in active disease group compared to inactive patients. Coagulation parameters of prothrombin time, activated partial thromboplastin time and d-dimer levels showed no significant difference between active and inactive IBD. Fibrinogen levels were significantly higher in clinically active IBD patients. Plasma TAFI levels demonstrated no significant difference between active and control, inactive and control as well as active and inactive groups. We observed no significant changes in levels of β-TG and PF-4 between active and inactive disease group. Conclusions: We studied plasma TAFI levels in IBD. In conclusion, plasma TAFI levels does not appear to represent to be a marker of activation in IBD in contrast to literature. So further studies covering more patients with different clinic and disease activity status might improve the perspective on this issue.
Turkiye Klinikleri Journal of Gastroenterohepatology, 2012
Autoimmune hepatitis is a rare chronic liver disease of unknown etiology. The disease predominate... more Autoimmune hepatitis is a rare chronic liver disease of unknown etiology. The disease predominates among women and is characterized by hypergammaglobulinemia, characteristic autoantibodies, association with a favorable response to immunosuppressive treatment. The spectrum of presentation is wide, ranging from no symptoms to acute liver failure. In this report, we present a rare case of anti-SLA/LP antibody positive autoimmune hepatitis with acute severe hepatitis in a male patient.
DOAJ (DOAJ: Directory of Open Access Journals), Dec 1, 2011
Abs tract Objectives: The relation between non-functioning adrenal adenoma and unfavorable metabo... more Abs tract Objectives: The relation between non-functioning adrenal adenoma and unfavorable metabolic status has been a debate so far. We aimed to demonstrate the prevalence of non-alcoholic fatty liver disease (NAFLD) in subjects with silent adrenal adenomas. Materials and Methods: 130 consecutive subjects with non-functioning adrenal adenomas, 170 age-, gender- and BMI-matched individuals without adrenal gland disorders, and 20 patients with Cushing’s syndrome were included in the study. Fatty liver disease was diagnosed by ultrasonography and the severity was scored semiquantitatively. Liver function tests were performed. Cushing’s syndrome and non-functioning adrenal adenoma were diagnosed using appropriate tests of hypothalamus-pituitary-adrenal function. Results: The prevalence of NAFLD was 30.7%, 65.0% and 39.4% in adenoma group, Cushing’s syndrome group and control group, respectively. There was no significant difference in terms of Type 2 diabetes mellitus, hypertension and NAFLD prevalence between adenoma group and controls. NAFLD was not only more common in subjects with Cushing’s syndrome but was also more severe. Hypercortisolemia strongly predicted the development of metabolic syndrome (OR: 10.571, p=0.004). When age, gender, hypercortisolemia and metabolic syndrome were assessed, metabolic syndrome remained as the sole independent predictor of fatty liver development (OR: 9.162, p<0.001). Conclusion: Comparable prevalence between adenoma and control group was likely to be associated with similar rates of metabolic derangements and similar BMI. Cortisol excess seemed to be related with fatty liver development mainly through its unfavorable metabolic effects. Turk Jem 2011; 15: 116-20
Hepatic cirrhosis and hepatocellular carcinoma (HCC) are the third leading causes of death in peo... more Hepatic cirrhosis and hepatocellular carcinoma (HCC) are the third leading causes of death in people over 50 years old in Europe. This has accounted for 90% of the 5,000 liver transplantations as a result of hepatitis C virus (HCV) since the 1970s. It has been shown that neoangiogenesis and abnormal vessel architecture are related to hepatic fibrosis, cirrhosis, and HCC.[1] Hepatic fibrosis is the storage of interstitial extracellular matrix after acute or chronic hepatic damage. Independent from the etiology, cirrhosis and fibrosis are caused by degeneration of hepatic architecture and changes in microvascular Research Article
Background: The clinical course of patients with inflammatory bowel disease (IBD) is frequently c... more Background: The clinical course of patients with inflammatory bowel disease (IBD) is frequently complicated by thromboembolic events and may involve the arterial and venous systems. Although not uniformly documented, several studies document substantial alterations in markers of coagulation and fibrinolysis in patients with IBD. Methods: 45 patients with IBD (31 UC,14 CD) were included in the study. Age and sex matched 16 volunteers were used as a control group. TAFI antigen was determined using an ELISA kit VisuLiseTM for quantitative measurement. Results: Inflammatory parameters such as white blood cell, platelet levels, erythrocyte sedimentation rate, C-reactive protein were found to be significantly higher in active disease group compared to inactive patients. Coagulation parameters of prothrombin time, activated partial thromboplastin time and d-dimer levels showed no significant difference between active and inactive IBD. Fibrinogen levels were significantly higher in clinically active IBD patients. Plasma TAFI levels demonstrated no significant difference between active and control, inactive and control as well as active and inactive groups. We observed no significant changes in levels of β-TG and PF-4 between active and inactive disease group. Conclusions: We studied plasma TAFI levels in IBD. In conclusion, plasma TAFI levels does not appear to represent to be a marker of activation in IBD in contrast to literature. So further studies covering more patients with different clinic and disease activity status might improve the perspective on this issue.
Turkiye Klinikleri Journal of Gastroenterohepatology, 2012
Autoimmune hepatitis is a rare chronic liver disease of unknown etiology. The disease predominate... more Autoimmune hepatitis is a rare chronic liver disease of unknown etiology. The disease predominates among women and is characterized by hypergammaglobulinemia, characteristic autoantibodies, association with a favorable response to immunosuppressive treatment. The spectrum of presentation is wide, ranging from no symptoms to acute liver failure. In this report, we present a rare case of anti-SLA/LP antibody positive autoimmune hepatitis with acute severe hepatitis in a male patient.
DOAJ (DOAJ: Directory of Open Access Journals), Dec 1, 2011
Abs tract Objectives: The relation between non-functioning adrenal adenoma and unfavorable metabo... more Abs tract Objectives: The relation between non-functioning adrenal adenoma and unfavorable metabolic status has been a debate so far. We aimed to demonstrate the prevalence of non-alcoholic fatty liver disease (NAFLD) in subjects with silent adrenal adenomas. Materials and Methods: 130 consecutive subjects with non-functioning adrenal adenomas, 170 age-, gender- and BMI-matched individuals without adrenal gland disorders, and 20 patients with Cushing’s syndrome were included in the study. Fatty liver disease was diagnosed by ultrasonography and the severity was scored semiquantitatively. Liver function tests were performed. Cushing’s syndrome and non-functioning adrenal adenoma were diagnosed using appropriate tests of hypothalamus-pituitary-adrenal function. Results: The prevalence of NAFLD was 30.7%, 65.0% and 39.4% in adenoma group, Cushing’s syndrome group and control group, respectively. There was no significant difference in terms of Type 2 diabetes mellitus, hypertension and NAFLD prevalence between adenoma group and controls. NAFLD was not only more common in subjects with Cushing’s syndrome but was also more severe. Hypercortisolemia strongly predicted the development of metabolic syndrome (OR: 10.571, p=0.004). When age, gender, hypercortisolemia and metabolic syndrome were assessed, metabolic syndrome remained as the sole independent predictor of fatty liver development (OR: 9.162, p<0.001). Conclusion: Comparable prevalence between adenoma and control group was likely to be associated with similar rates of metabolic derangements and similar BMI. Cortisol excess seemed to be related with fatty liver development mainly through its unfavorable metabolic effects. Turk Jem 2011; 15: 116-20
Hepatic cirrhosis and hepatocellular carcinoma (HCC) are the third leading causes of death in peo... more Hepatic cirrhosis and hepatocellular carcinoma (HCC) are the third leading causes of death in people over 50 years old in Europe. This has accounted for 90% of the 5,000 liver transplantations as a result of hepatitis C virus (HCV) since the 1970s. It has been shown that neoangiogenesis and abnormal vessel architecture are related to hepatic fibrosis, cirrhosis, and HCC.[1] Hepatic fibrosis is the storage of interstitial extracellular matrix after acute or chronic hepatic damage. Independent from the etiology, cirrhosis and fibrosis are caused by degeneration of hepatic architecture and changes in microvascular Research Article
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