Three modes of the reaction for labeling of dihydropyridine compounds were studied: thermal heati... more Three modes of the reaction for labeling of dihydropyridine compounds were studied: thermal heating, microwave irradiation, and solid-state process.
DL-Phenyl alanine labeled with carbon-14 in the α-position has been synthesized from ethyl [2-C] ... more DL-Phenyl alanine labeled with carbon-14 in the α-position has been synthesized from ethyl [2-C] acetate as part of a 6-step sequence.
International journal of Advanced Biological and Biomedical Research, 2014
Objective: To evaluate the effects of bacteria and vermicompost on phenology and growth of soybea... more Objective: To evaluate the effects of bacteria and vermicompost on phenology and growth of soybean trial an experiment was conducted as split plot in a completely randomized block design with three replications. Methods: Main plots of experiment at two levels included the non-use and the use of bacteria and the subplots at three levels included the non-use of vermicompost (control), the use of 5 tons of vermicompost per acre and the use of 10 tons of vermicompost per acre. Results: The results showed that the treatment including 10 tons of vermicompost had the highest amount of the days to full maturity with the amount of 153 days and the treatment of non-use of vermicompost had the lowest amount of the days to full maturity. Also, the highest amount of SFP was obtained from the treatment including the use of vermicompost at the rate of 10 tons per acre that increasing the seed growing and filling period led to obtain the highest amount of seed yield with the amount of 1699 kg ha wh...
International journal of Advanced Biological and Biomedical Research, 2014
A B S T R A C T Objective: Investigating the microbes and interactions of the beneficial symbioti... more A B S T R A C T Objective: Investigating the microbes and interactions of the beneficial symbiotic relationships between the components of the system ecology in the food chains and life cycles is one of the modern sustainable agriculture topics. In this regard, to evaluate the effects of bacteria and vermicompost on morphological characteristics and yield of soybean an experiment was conducted as split plot in a completely randomized block design with three replications. Methods: Main plots of experiment were at two levels including the non-use and the use of bacteria and the subplots were at three levels including the non-use of vermicompost (control), the use of 5 tons of vermicompost per acre and the use of 10 tons of vermicompost per acre. Results: The results of mean comparison showed that the treatment including 10 tons of vermicompost had the highest amount of oil content (11%) and the lowest amount was obtained from the treatment including use of 5 tons with the amount of 9....
Journal of labelled compounds & radiopharmaceuticals, 2018
The importance of DHPs compounds and the need for examining the mechanism of their effect, mandat... more The importance of DHPs compounds and the need for examining the mechanism of their effect, mandated us to synthesize a number of carbon-14 labeled 1,4-dihydropyridine derivatives for pharmacological studies. Simple preparation and suitable radiochemical yield were advantages of this preparation.
N-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)thiophene-2 carboxa... more N-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)thiophene-2 carboxamide-[14C-carboxy] was prepared as part of a 6-step sequence from thiophene-2-carbonitrile -[cyano-14C] as a keysynthetic intermediate which has been synthesized from 2-iodothiophene and zinc [14C]-cyanide in thepresence of tetrakis (triphenylphosphine) palladium.
Abstract8-Chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine labeled with 14C in 11... more Abstract8-Chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine labeled with 14C in 11-position was synthesized in four steps from [carboxyl-14C]anthranilic acid using microwave irradiation with good overall radiochemical yield.
Abstract2-[2-(4-(Dibenzo[b, f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy]ethanol (Quetiapine) lab... more Abstract2-[2-(4-(Dibenzo[b, f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy]ethanol (Quetiapine) labeled with 14C in 11-position was synthesized in five steps from [carboxy-14C]anthranilic acid. The key precursor of the target product is [11-14C]dibenzothiazepin-11(10H)-one. The reaction is performed as one-pot process.
Journal of Labelled Compounds and Radiopharmaceuticals, 2017
Thioflavanones are prevalent heterocyclic structural units in pharmaceutical and biologically act... more Thioflavanones are prevalent heterocyclic structural units in pharmaceutical and biologically active compound (Scheme ). In this paper, the synthesis of 2-phenylthiochroman-4-ones and 2-phenyl-4H-1-benzothiopyran-4-one labeled with carboxyl-14 is demonstrated.
Journal of labelled compounds & radiopharmaceuticals, Jan 8, 2016
9H-Thioxanthen-9-ones are an important class of compound and are a common heterocyclic scaffold i... more 9H-Thioxanthen-9-ones are an important class of compound and are a common heterocyclic scaffold in biologically active and medicinally significant compounds. In this paper the synthesis of 1-fluoro-4-methyl-9H-thioxanthen-9-one and some amine derivatives labeled with carboxyl-14 is described.
Journal of Labelled Compounds and Radiopharmaceuticals, 2016
Olanzapine is one of the most widely used antipsychotic drugs, which acts as an antagonist for mu... more Olanzapine is one of the most widely used antipsychotic drugs, which acts as an antagonist for multiple neurotransmitter receptor sites. 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno [2,3-b][1,5] benzodiazepine (Olanzapine) labeled with carbon-14 in the four positions has been synthesized as part of a three-step sequence from 2-amino-5-methylthiophene-3-carbonitrile-[carbonitrile-(14) C].
Three modes of the reaction for labeling of dihydropyridine compounds were studied: thermal heati... more Three modes of the reaction for labeling of dihydropyridine compounds were studied: thermal heating, microwave irradiation, and solid-state process.
DL-Phenyl alanine labeled with carbon-14 in the α-position has been synthesized from ethyl [2-C] ... more DL-Phenyl alanine labeled with carbon-14 in the α-position has been synthesized from ethyl [2-C] acetate as part of a 6-step sequence.
International journal of Advanced Biological and Biomedical Research, 2014
Objective: To evaluate the effects of bacteria and vermicompost on phenology and growth of soybea... more Objective: To evaluate the effects of bacteria and vermicompost on phenology and growth of soybean trial an experiment was conducted as split plot in a completely randomized block design with three replications. Methods: Main plots of experiment at two levels included the non-use and the use of bacteria and the subplots at three levels included the non-use of vermicompost (control), the use of 5 tons of vermicompost per acre and the use of 10 tons of vermicompost per acre. Results: The results showed that the treatment including 10 tons of vermicompost had the highest amount of the days to full maturity with the amount of 153 days and the treatment of non-use of vermicompost had the lowest amount of the days to full maturity. Also, the highest amount of SFP was obtained from the treatment including the use of vermicompost at the rate of 10 tons per acre that increasing the seed growing and filling period led to obtain the highest amount of seed yield with the amount of 1699 kg ha wh...
International journal of Advanced Biological and Biomedical Research, 2014
A B S T R A C T Objective: Investigating the microbes and interactions of the beneficial symbioti... more A B S T R A C T Objective: Investigating the microbes and interactions of the beneficial symbiotic relationships between the components of the system ecology in the food chains and life cycles is one of the modern sustainable agriculture topics. In this regard, to evaluate the effects of bacteria and vermicompost on morphological characteristics and yield of soybean an experiment was conducted as split plot in a completely randomized block design with three replications. Methods: Main plots of experiment were at two levels including the non-use and the use of bacteria and the subplots were at three levels including the non-use of vermicompost (control), the use of 5 tons of vermicompost per acre and the use of 10 tons of vermicompost per acre. Results: The results of mean comparison showed that the treatment including 10 tons of vermicompost had the highest amount of oil content (11%) and the lowest amount was obtained from the treatment including use of 5 tons with the amount of 9....
Journal of labelled compounds & radiopharmaceuticals, 2018
The importance of DHPs compounds and the need for examining the mechanism of their effect, mandat... more The importance of DHPs compounds and the need for examining the mechanism of their effect, mandated us to synthesize a number of carbon-14 labeled 1,4-dihydropyridine derivatives for pharmacological studies. Simple preparation and suitable radiochemical yield were advantages of this preparation.
N-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)thiophene-2 carboxa... more N-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)thiophene-2 carboxamide-[14C-carboxy] was prepared as part of a 6-step sequence from thiophene-2-carbonitrile -[cyano-14C] as a keysynthetic intermediate which has been synthesized from 2-iodothiophene and zinc [14C]-cyanide in thepresence of tetrakis (triphenylphosphine) palladium.
Abstract8-Chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine labeled with 14C in 11... more Abstract8-Chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine labeled with 14C in 11-position was synthesized in four steps from [carboxyl-14C]anthranilic acid using microwave irradiation with good overall radiochemical yield.
Abstract2-[2-(4-(Dibenzo[b, f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy]ethanol (Quetiapine) lab... more Abstract2-[2-(4-(Dibenzo[b, f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy]ethanol (Quetiapine) labeled with 14C in 11-position was synthesized in five steps from [carboxy-14C]anthranilic acid. The key precursor of the target product is [11-14C]dibenzothiazepin-11(10H)-one. The reaction is performed as one-pot process.
Journal of Labelled Compounds and Radiopharmaceuticals, 2017
Thioflavanones are prevalent heterocyclic structural units in pharmaceutical and biologically act... more Thioflavanones are prevalent heterocyclic structural units in pharmaceutical and biologically active compound (Scheme ). In this paper, the synthesis of 2-phenylthiochroman-4-ones and 2-phenyl-4H-1-benzothiopyran-4-one labeled with carboxyl-14 is demonstrated.
Journal of labelled compounds & radiopharmaceuticals, Jan 8, 2016
9H-Thioxanthen-9-ones are an important class of compound and are a common heterocyclic scaffold i... more 9H-Thioxanthen-9-ones are an important class of compound and are a common heterocyclic scaffold in biologically active and medicinally significant compounds. In this paper the synthesis of 1-fluoro-4-methyl-9H-thioxanthen-9-one and some amine derivatives labeled with carboxyl-14 is described.
Journal of Labelled Compounds and Radiopharmaceuticals, 2016
Olanzapine is one of the most widely used antipsychotic drugs, which acts as an antagonist for mu... more Olanzapine is one of the most widely used antipsychotic drugs, which acts as an antagonist for multiple neurotransmitter receptor sites. 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno [2,3-b][1,5] benzodiazepine (Olanzapine) labeled with carbon-14 in the four positions has been synthesized as part of a three-step sequence from 2-amino-5-methylthiophene-3-carbonitrile-[carbonitrile-(14) C].
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Papers by mohsen Javaheri