BACKGROUND Pakistanis belong to the South Asian population, which has the highest identified rate... more BACKGROUND Pakistanis belong to the South Asian population, which has the highest identified rate of cardio vascular diseases. Hypertension (HTN) or high blood pressure is a chronic medical condition in which the systemic arterial blood pressure is elevated. It is a mutagenic trait and so is affected by mutations and polymorphisms of numerous genes. As multiple genes are involved so personalized medicine on the basis of genetic makeup would be of great help. OBJECTIVE The present study is focused to perceive the possible association of MTHFR_C677T, ACE I/D polymorphism and FTO genes, with hypertension in Pakistani population. METHODOLOGY For this study 5ml venous blood sample from patients and age, sex matched control individuals were collected randomly with informed consents from a primary health care hospitals. All the patients were clinically evaluated for CAD, Diabetes mellitus, IHD, Hypertension, and Obesity. DNA was isolated from the collected blood samples.MTHFR_C677T, ACE I/...
Exploring healing power in plants emerged in prehistory of human civilization. Sustaining good he... more Exploring healing power in plants emerged in prehistory of human civilization. Sustaining good health has been achieved over the millions of years by use of plant products in various traditional sockets. A major contribution of medicinal plants to health care systems is their limitless possession of bioactive components that stimulate explicit physiological actions. Luckily Pakistan is blessed with huge reservoir of plants with medicinal potential and some of them; we focused in this study for their medicinal importance.In this study we checked the antibacterial activity inherent in Ricinus communis, Solanum nigrum, Dodonaea viscose and Berberis lyceum extracts for multidrug resistance bacterial strains Klebsiella pneumonae, E. coli and methyciline resistant Staphylococcus aureus. MRSA showed sensitivity for Ricinus communis. Multidrug resistant Klebsiella pneumonae was sensitive with Pine roxburgii and Ricinus communis but weakly susceptible for Solanum nigrum. Multidrug resistant ...
Multiple factors such as genetic and environmental, are involved in causing hearing impairment (H... more Multiple factors such as genetic and environmental, are involved in causing hearing impairment (HI). Severe or profound hearing loss affects approximately one in 1000 children worldwide and half of these cases are due to genetic factors. In case of hereditary nonsyndromic HI, approximately 75–80% of cases are involved in autosomal recessive inheritance and 15% of cases involve autosomal dominant inheritance. HI represents extreme genetic heterogeneity. In nonsyndromic deafness, 135 loci have been mapped till now including 77 autosomal recessive genes of which only 29 corresponding nuclear genes have been cloned. This study was designed to apply bioinformatic approach for reducing large number of candidate genes responsible for deafness to a handy number for their mutation analysis. Databases of expressed mouse inner ear genes and the expressed human cochlear genes were used to cross-reference all genes present in particular locus predicting candidate genes for phenotypes of nonsyndr...
Multiple factors such as genetic and environmental, are involved in causing hearing impairment (H... more Multiple factors such as genetic and environmental, are involved in causing hearing impairment (HI). Severe or profound hearing loss affects approximately one in 1000 children worldwide and half of these cases are due to genetic factors. In case of hereditary nonsyndromic HI, approximately 75–80% of cases are involved in autosomal recessive inheritance and 15% of cases involve autosomal dominant inheritance. HI represents extreme genetic heterogeneity. In nonsyndromic deafness, 135 loci have been mapped till now including 77 autosomal recessive genes of which only 29 corresponding nuclear genes have been cloned. This study was designed to apply bioinformatic approach for reducing large number of candidate genes responsible for deafness to a handy number for their mutation analysis. Databases of expressed mouse inner ear genes and the expressed human cochlear genes were used to cross-reference all genes present in particular locus predicting candidate genes for phenotypes of nonsyndr...
Refurbishing conventional buildings into green buildings can increase campus sustainability along... more Refurbishing conventional buildings into green buildings can increase campus sustainability alongside building new sustainable buildings. However, refurbishing all campus' buildings is impractical, uneconomical and involves thorough planning and prioritisation. Unlike other concepts of assessment, assessing the green potential of a conventional building is rarely discussed in past literature. Therefore, this paper presents the development of a conceptual framework for prioritising buildings that can be refurbished by assessing their green potentials. Through this paper, this concept will be discussed in depth by reviewing relevant literature on existing assessment tools. The review focuses on identifying methods and indicators that can be adopted for the assessment of green potential. The study discovers that while literature on green potential assessment is limited, the frameworks of other types of assessments concerning green buildings are still viable. It is found that the mo...
Assessment of the green potentials in a conventional building is rarely discussed in past literat... more Assessment of the green potentials in a conventional building is rarely discussed in past literature unlike other types of assessments, such as a building's current performance and qualities. 'Green potential' is the capacity of a conventional building to be refurbished into a green building. This paper presents the development of a rating tool to assess green potentials of existing conventional buildings. The development process involves reviewing relevant literature on the existing assessment tools. The review focuses on identifying methods and indicators that can be adopted for the assessment of green potentials. It is discovered that while literature on green potential assessment is limited, the frameworks of other types of assessments concerning green buildings are still suitable to be adopted. Additionally, with some modifications, commercial green building rating tools provide the most suitable indicators to assess green potentials. Apart from filling the knowledg...
Background: Primary microcephaly is a rare autosomal recessive neurological disorder characterize... more Background: Primary microcephaly is a rare autosomal recessive neurological disorder characterized by head circumference >3 SD (Standard Deviations) below the population age and sex-related mean which is a consequence of decreased size of cereberal cortex. Although MCPH patients have single clinical phenotype, genetic heterogeneity has been observed with this disease. Seven loci have been reported in the literature frequently, with an addition of three new loci recently. Six of these loci have been ascertained in the Pakistani families (MCPH1, MCPH2, MCPH3 MCPH5, MCPH6 and MCHPH8), with three of them remaining exclusive for this region (MCPH1, MCPH3 and MCPH8). Objective: In the present study, exclusion studies in two Pakistani families for MCPH locus MCPH1, MCPH2, MCPH4, MCPH5, MCPH6 and MCPH8 were done. Materials and Methods: Two families from Punjab area of Pakistan with two affected individuals with autosomal recessive primary microcephaly were ascertained. Both the families ...
Lipoid proteinosis (LP) is rare autosomal recessive skin disorder, with varying severity of clini... more Lipoid proteinosis (LP) is rare autosomal recessive skin disorder, with varying severity of clinical manifestations. Common clinical appearances of LP are weak cry and early infancy with hoarseness, widespread scarring and infiltrated plaques on mucosal surfaces and skin, especially at the sites of minor trauma and on sun-exposed areas. Lipoid proteinosis is the consequences from pathogenetic loss-of-function mutations in the gene encoding extracellular matrix protein1 (ECM1), mapped to a locus on chromosome 1q21. Forty six ECM1 gene mutations have been described to date in discrete patients affected with lipoid proteinosis. The mutations in LP include predominantly 19 insertions/deletions, 8 missense, 15 nonsense, and 4 splice site mutations and mostly are present on exon 6 and 7. The present study was undertaken with a view to model ECM1 of full-length and its domains. Therefore, increased quality model of the ECM1 protein through threading modeling approach and its domains throug...
Current pharmaceutical biotechnology, Jan 31, 2015
Data obtained through high-throughput technologies have gradually revealed that a unique stratifi... more Data obtained through high-throughput technologies have gradually revealed that a unique stratified epithelial architecture of human skin along with the antioxidant-response pathways provided vital defensive mechanisms against UV radiation. However, it is noteworthy that skin is a major target for toxic insult by UV radiations that can alter its structure and function. Substantial fraction of information has been added into the existing pool of knowledge related to natural products mediated biological effects in UV exposed skin cells. Accumulating evidence has started to shed light on the potential of these bioactive ingredients as protective natural products in cosmetics against UV photodamage by exerting biological effects mainly through wide ranging intracellular signalling cascades of oxidative stress and modulation of miRNAs. In this review, we have summarized recently emerging scientific evidences addressing underlying mechanisms of UV induced oxidative stress and deregulation...
Prior research has demonstrated how the endoplasmic reticulum (ER) functions as a multifunctional... more Prior research has demonstrated how the endoplasmic reticulum (ER) functions as a multifunctional organelle and as a well-orchestrated protein-folding unit. It consists of sensors which detect stress-induced unfolded/misfolded proteins and it is the place where protein folding is catalyzed with chaperones. During this folding process, an immaculate disulfide bond formation requires an oxidized environment provided by the ER. Protein folding and the generation of reactive oxygen species (ROS) as a protein oxidative byproduct in ER are crosslinked. An ER stress-induced response also mediates the expression of the apoptosis-associated gene C/EBP-homologous protein (CHOP) and death receptor 5 (DR5). ER stress induces the upregulation of tumor necrosis factor-related apoptosis inducing ligand (TRAIL) receptor and opening new horizons for therapeutic research. These findings can be used to maximize TRAIL-induced apoptosis in xenografted mice. This review summarizes the current understanding of the interplay between ER stress and ROS. We also discuss how damage-associated molecular patterns (DAMPs) function as modulators of immunogenic cell death and how natural products and drugs have shown potential in regulating ER stress and ROS in different cancer cell lines. Drugs as inducers and inhibitors of ROS modulation may respectively exert inducible and inhibitory effects on ER stress and unfolded protein response (UPR). Reconceptualization of the molecular crosstalk among ROS modulating effectors, ER stress, and DAMPs will lead to advances in anticancer therapy.
This paper presents two novel epileptic seizure onset detectors. The detectors rely on a common s... more This paper presents two novel epileptic seizure onset detectors. The detectors rely on a common spatial pattern (CSP)-based feature enhancement stage that increases the variance between seizure and nonseizure scalp electroencephalography (EEG). The proposed feature enhancement stage enables better discrimination between seizure and nonseizure features. The first detector adopts a conventional classification stage using a support vector machine (SVM) that feeds the energy features extracted from different subbands to an SVM for seizure onset detection. The second detector uses logical operators to pool SVM seizure onset detections made independently across different EEG spectral bands. The proposed detectors exhibit an improved performance, with respect to sensitivity and detection latency, compared with the state-of-the-art detectors. Experimental results have demonstrated that the first detector achieves a sensitivity of 95.2%, detection latency of 6.43s, and false alarm rate of 0....
Archivum Immunologiae et Therapiae Experimentalis, 2015
Double-stranded breaks (DSBs) are cytotoxic DNA lesions caused by oxygen radicals, ionizing radia... more Double-stranded breaks (DSBs) are cytotoxic DNA lesions caused by oxygen radicals, ionizing radiation, and radiomimetic chemicals. Increasing understanding of DNA damage signaling has provided an ever-expanding list of modulators reported to orchestrate DNA damage repair and ataxia telangiectasia mutated (ATM) is the master regulator and main transducer of the DSB response. Increasingly, it is being realized that DNA damage response is a synchronized and branched network that functionalizes different molecular cascades to activate special checkpoints, thus temporarily arresting progression of the cell cycle while damage is being assessed and processed. It is noteworthy that both nutrigenetics and nutrigenomics have revolutionized the field of molecular biology and rapidly accumulating experimental evidence has started to shed light on biological activities of a wide range of phytochemicals reported to modulate cell cycle, DNA repair, cell growth, differentiation and apoptosis as evidenced by cell-based studies. In this review, we have attempted to provide an overview of DNA damage signaling, how ATM signaling regulates tumor necrosis factors-related apoptosis inducing ligand (TRAIL)-induced intracellular network. We also illuminate on how resveratrol, epigallocatechin gallate, curcumin, jaceosidin, cucurbitacin, apigenin, genistein, and others trigger activation of ATM in different cancer cells as well as agents for ATM inactivation. Understanding the interplay of TRAIL-induced intracellular signaling and ATM modulation of downstream effectors is very important. This holds particularly for a reconceptualization of the apparently paradoxical roles and therapeutically targetable for enhancing the response to DNA damage-inducing therapy.
Background: 49,XXXXY Syndrome is a rare aneuploidic sex chromosomal abnormality; its frequency is... more Background: 49,XXXXY Syndrome is a rare aneuploidic sex chromosomal abnormality; its frequency is approximately 1 out of in 85,000 to 100,000 males. It was originally described by Fraccaro and colleagues in 1960. Over 100 such cases have been reported so far in the world. Objective: The case we report here, to the best of our knowledge, is the first such case reported from Pakistan. Case Report: A 12 year old boy was presented with classical features of the mental age of six years old child, normal Apgar score at birth, moderately low IQ, receptive expressive communication and behavioural problems. History of delayed milestones, fits leading to collapse, hypertelorism, short neck, narrow shoulder, round face in infancy, flat foot, moderately hyper extensible joints, hypotonia, generalised muscle wasting, hypogonadism, both testes were smaller around 60% (3.2×1.9 Cm) of normal size, i.e., (5×3 Cm) and penis was like 5 years old child but ambiguity of genitalia was not observed in our...
Research concerning the epigenome over the years has systematically and sequentially shown substa... more Research concerning the epigenome over the years has systematically and sequentially shown substantial development and we have moved from global inhibition of modifications of the epigenome toward identification and targeted therapy against tumor-specific epigenetic mechanisms. In accordance with this approach, several drugs with epigenetically modulating activity have received considerable attention and appreciation, and recently emerging scientific evidence is uncovering details of their mode of action. High-throughput technologies have considerably improved our existing understanding of tumor suppressors, oncogenes, and signaling pathways that are key drivers of cancer. In this review, we summarize the general epigenetic mechanisms in cancer, including: the post-translational modification of DNA methyltransferase and its mediated inactivation of Ras association domain family 1 isoform A, Sonic hedgehog signaling, Wnt signaling, Notch signaling, transforming growth factor signalin...
Proceedings of the 4th International Conference on Wireless Mobile Communication and Healthcare - "Transforming healthcare through innovations in mobile and wireless technologies", 2014
2005 13th IEEE International Conference on Networks Jointly held with the 2005 IEEE 7th Malaysia International Conf on Communic, 2005
Page 1. Performance of Uplink Power Control During Soft Handover in WCDMA System Jamil S. Abdulaz... more Page 1. Performance of Uplink Power Control During Soft Handover in WCDMA System Jamil S. Abdulaziz Dept. of Computer Engineering Sana'a Community College Sana'a, Republic ofYemen e-mail: jameeI730@ hotmail .com M. Ismail, AM Hasbi Fac. ...
It is becoming increasingly understood that tumor cells may have different mutations and dependen... more It is becoming increasingly understood that tumor cells may have different mutations and dependencies on diverse intracellular signaling cascades for survival or metastatic potential. Overexpression of oncogenes, inactivation of tumor suppressor genes, genetic/epigenetic mutations, genomic instability, and loss of apoptotic cell death are some of the mechanisms that have been widely investigated in molecular oncology. We partition this multicomponent review into the most recent evidence on the anticancer activity of fungal substances obtained from in vitro and xenografted models, and these fungal substances modulate expression of oncogenic and tumor suppressor miRNAs. There are some outstanding questions regarding fungus-derived chemical-induced modulation of intracellular signaling networks in different cancer cell lines and preclinical models. Certain hints have emerged, emphasizing mechanisms via which apoptosis can be restored in TRAIL-resistant cancer cells. Reconceptualization...
Hernia : the journal of hernias and abdominal wall surgery, 2004
Late complications of mesh repair are commonly due to mesh migration and erosion into neighbourin... more Late complications of mesh repair are commonly due to mesh migration and erosion into neighbouring visceri. We report the first case of a mesh repair of a lower midline laprotomy incisional hernia complicated by erosion of the mesh into the bladder which presented as haematuria.
BACKGROUND Pakistanis belong to the South Asian population, which has the highest identified rate... more BACKGROUND Pakistanis belong to the South Asian population, which has the highest identified rate of cardio vascular diseases. Hypertension (HTN) or high blood pressure is a chronic medical condition in which the systemic arterial blood pressure is elevated. It is a mutagenic trait and so is affected by mutations and polymorphisms of numerous genes. As multiple genes are involved so personalized medicine on the basis of genetic makeup would be of great help. OBJECTIVE The present study is focused to perceive the possible association of MTHFR_C677T, ACE I/D polymorphism and FTO genes, with hypertension in Pakistani population. METHODOLOGY For this study 5ml venous blood sample from patients and age, sex matched control individuals were collected randomly with informed consents from a primary health care hospitals. All the patients were clinically evaluated for CAD, Diabetes mellitus, IHD, Hypertension, and Obesity. DNA was isolated from the collected blood samples.MTHFR_C677T, ACE I/...
Exploring healing power in plants emerged in prehistory of human civilization. Sustaining good he... more Exploring healing power in plants emerged in prehistory of human civilization. Sustaining good health has been achieved over the millions of years by use of plant products in various traditional sockets. A major contribution of medicinal plants to health care systems is their limitless possession of bioactive components that stimulate explicit physiological actions. Luckily Pakistan is blessed with huge reservoir of plants with medicinal potential and some of them; we focused in this study for their medicinal importance.In this study we checked the antibacterial activity inherent in Ricinus communis, Solanum nigrum, Dodonaea viscose and Berberis lyceum extracts for multidrug resistance bacterial strains Klebsiella pneumonae, E. coli and methyciline resistant Staphylococcus aureus. MRSA showed sensitivity for Ricinus communis. Multidrug resistant Klebsiella pneumonae was sensitive with Pine roxburgii and Ricinus communis but weakly susceptible for Solanum nigrum. Multidrug resistant ...
Multiple factors such as genetic and environmental, are involved in causing hearing impairment (H... more Multiple factors such as genetic and environmental, are involved in causing hearing impairment (HI). Severe or profound hearing loss affects approximately one in 1000 children worldwide and half of these cases are due to genetic factors. In case of hereditary nonsyndromic HI, approximately 75–80% of cases are involved in autosomal recessive inheritance and 15% of cases involve autosomal dominant inheritance. HI represents extreme genetic heterogeneity. In nonsyndromic deafness, 135 loci have been mapped till now including 77 autosomal recessive genes of which only 29 corresponding nuclear genes have been cloned. This study was designed to apply bioinformatic approach for reducing large number of candidate genes responsible for deafness to a handy number for their mutation analysis. Databases of expressed mouse inner ear genes and the expressed human cochlear genes were used to cross-reference all genes present in particular locus predicting candidate genes for phenotypes of nonsyndr...
Multiple factors such as genetic and environmental, are involved in causing hearing impairment (H... more Multiple factors such as genetic and environmental, are involved in causing hearing impairment (HI). Severe or profound hearing loss affects approximately one in 1000 children worldwide and half of these cases are due to genetic factors. In case of hereditary nonsyndromic HI, approximately 75–80% of cases are involved in autosomal recessive inheritance and 15% of cases involve autosomal dominant inheritance. HI represents extreme genetic heterogeneity. In nonsyndromic deafness, 135 loci have been mapped till now including 77 autosomal recessive genes of which only 29 corresponding nuclear genes have been cloned. This study was designed to apply bioinformatic approach for reducing large number of candidate genes responsible for deafness to a handy number for their mutation analysis. Databases of expressed mouse inner ear genes and the expressed human cochlear genes were used to cross-reference all genes present in particular locus predicting candidate genes for phenotypes of nonsyndr...
Refurbishing conventional buildings into green buildings can increase campus sustainability along... more Refurbishing conventional buildings into green buildings can increase campus sustainability alongside building new sustainable buildings. However, refurbishing all campus' buildings is impractical, uneconomical and involves thorough planning and prioritisation. Unlike other concepts of assessment, assessing the green potential of a conventional building is rarely discussed in past literature. Therefore, this paper presents the development of a conceptual framework for prioritising buildings that can be refurbished by assessing their green potentials. Through this paper, this concept will be discussed in depth by reviewing relevant literature on existing assessment tools. The review focuses on identifying methods and indicators that can be adopted for the assessment of green potential. The study discovers that while literature on green potential assessment is limited, the frameworks of other types of assessments concerning green buildings are still viable. It is found that the mo...
Assessment of the green potentials in a conventional building is rarely discussed in past literat... more Assessment of the green potentials in a conventional building is rarely discussed in past literature unlike other types of assessments, such as a building's current performance and qualities. 'Green potential' is the capacity of a conventional building to be refurbished into a green building. This paper presents the development of a rating tool to assess green potentials of existing conventional buildings. The development process involves reviewing relevant literature on the existing assessment tools. The review focuses on identifying methods and indicators that can be adopted for the assessment of green potentials. It is discovered that while literature on green potential assessment is limited, the frameworks of other types of assessments concerning green buildings are still suitable to be adopted. Additionally, with some modifications, commercial green building rating tools provide the most suitable indicators to assess green potentials. Apart from filling the knowledg...
Background: Primary microcephaly is a rare autosomal recessive neurological disorder characterize... more Background: Primary microcephaly is a rare autosomal recessive neurological disorder characterized by head circumference >3 SD (Standard Deviations) below the population age and sex-related mean which is a consequence of decreased size of cereberal cortex. Although MCPH patients have single clinical phenotype, genetic heterogeneity has been observed with this disease. Seven loci have been reported in the literature frequently, with an addition of three new loci recently. Six of these loci have been ascertained in the Pakistani families (MCPH1, MCPH2, MCPH3 MCPH5, MCPH6 and MCHPH8), with three of them remaining exclusive for this region (MCPH1, MCPH3 and MCPH8). Objective: In the present study, exclusion studies in two Pakistani families for MCPH locus MCPH1, MCPH2, MCPH4, MCPH5, MCPH6 and MCPH8 were done. Materials and Methods: Two families from Punjab area of Pakistan with two affected individuals with autosomal recessive primary microcephaly were ascertained. Both the families ...
Lipoid proteinosis (LP) is rare autosomal recessive skin disorder, with varying severity of clini... more Lipoid proteinosis (LP) is rare autosomal recessive skin disorder, with varying severity of clinical manifestations. Common clinical appearances of LP are weak cry and early infancy with hoarseness, widespread scarring and infiltrated plaques on mucosal surfaces and skin, especially at the sites of minor trauma and on sun-exposed areas. Lipoid proteinosis is the consequences from pathogenetic loss-of-function mutations in the gene encoding extracellular matrix protein1 (ECM1), mapped to a locus on chromosome 1q21. Forty six ECM1 gene mutations have been described to date in discrete patients affected with lipoid proteinosis. The mutations in LP include predominantly 19 insertions/deletions, 8 missense, 15 nonsense, and 4 splice site mutations and mostly are present on exon 6 and 7. The present study was undertaken with a view to model ECM1 of full-length and its domains. Therefore, increased quality model of the ECM1 protein through threading modeling approach and its domains throug...
Current pharmaceutical biotechnology, Jan 31, 2015
Data obtained through high-throughput technologies have gradually revealed that a unique stratifi... more Data obtained through high-throughput technologies have gradually revealed that a unique stratified epithelial architecture of human skin along with the antioxidant-response pathways provided vital defensive mechanisms against UV radiation. However, it is noteworthy that skin is a major target for toxic insult by UV radiations that can alter its structure and function. Substantial fraction of information has been added into the existing pool of knowledge related to natural products mediated biological effects in UV exposed skin cells. Accumulating evidence has started to shed light on the potential of these bioactive ingredients as protective natural products in cosmetics against UV photodamage by exerting biological effects mainly through wide ranging intracellular signalling cascades of oxidative stress and modulation of miRNAs. In this review, we have summarized recently emerging scientific evidences addressing underlying mechanisms of UV induced oxidative stress and deregulation...
Prior research has demonstrated how the endoplasmic reticulum (ER) functions as a multifunctional... more Prior research has demonstrated how the endoplasmic reticulum (ER) functions as a multifunctional organelle and as a well-orchestrated protein-folding unit. It consists of sensors which detect stress-induced unfolded/misfolded proteins and it is the place where protein folding is catalyzed with chaperones. During this folding process, an immaculate disulfide bond formation requires an oxidized environment provided by the ER. Protein folding and the generation of reactive oxygen species (ROS) as a protein oxidative byproduct in ER are crosslinked. An ER stress-induced response also mediates the expression of the apoptosis-associated gene C/EBP-homologous protein (CHOP) and death receptor 5 (DR5). ER stress induces the upregulation of tumor necrosis factor-related apoptosis inducing ligand (TRAIL) receptor and opening new horizons for therapeutic research. These findings can be used to maximize TRAIL-induced apoptosis in xenografted mice. This review summarizes the current understanding of the interplay between ER stress and ROS. We also discuss how damage-associated molecular patterns (DAMPs) function as modulators of immunogenic cell death and how natural products and drugs have shown potential in regulating ER stress and ROS in different cancer cell lines. Drugs as inducers and inhibitors of ROS modulation may respectively exert inducible and inhibitory effects on ER stress and unfolded protein response (UPR). Reconceptualization of the molecular crosstalk among ROS modulating effectors, ER stress, and DAMPs will lead to advances in anticancer therapy.
This paper presents two novel epileptic seizure onset detectors. The detectors rely on a common s... more This paper presents two novel epileptic seizure onset detectors. The detectors rely on a common spatial pattern (CSP)-based feature enhancement stage that increases the variance between seizure and nonseizure scalp electroencephalography (EEG). The proposed feature enhancement stage enables better discrimination between seizure and nonseizure features. The first detector adopts a conventional classification stage using a support vector machine (SVM) that feeds the energy features extracted from different subbands to an SVM for seizure onset detection. The second detector uses logical operators to pool SVM seizure onset detections made independently across different EEG spectral bands. The proposed detectors exhibit an improved performance, with respect to sensitivity and detection latency, compared with the state-of-the-art detectors. Experimental results have demonstrated that the first detector achieves a sensitivity of 95.2%, detection latency of 6.43s, and false alarm rate of 0....
Archivum Immunologiae et Therapiae Experimentalis, 2015
Double-stranded breaks (DSBs) are cytotoxic DNA lesions caused by oxygen radicals, ionizing radia... more Double-stranded breaks (DSBs) are cytotoxic DNA lesions caused by oxygen radicals, ionizing radiation, and radiomimetic chemicals. Increasing understanding of DNA damage signaling has provided an ever-expanding list of modulators reported to orchestrate DNA damage repair and ataxia telangiectasia mutated (ATM) is the master regulator and main transducer of the DSB response. Increasingly, it is being realized that DNA damage response is a synchronized and branched network that functionalizes different molecular cascades to activate special checkpoints, thus temporarily arresting progression of the cell cycle while damage is being assessed and processed. It is noteworthy that both nutrigenetics and nutrigenomics have revolutionized the field of molecular biology and rapidly accumulating experimental evidence has started to shed light on biological activities of a wide range of phytochemicals reported to modulate cell cycle, DNA repair, cell growth, differentiation and apoptosis as evidenced by cell-based studies. In this review, we have attempted to provide an overview of DNA damage signaling, how ATM signaling regulates tumor necrosis factors-related apoptosis inducing ligand (TRAIL)-induced intracellular network. We also illuminate on how resveratrol, epigallocatechin gallate, curcumin, jaceosidin, cucurbitacin, apigenin, genistein, and others trigger activation of ATM in different cancer cells as well as agents for ATM inactivation. Understanding the interplay of TRAIL-induced intracellular signaling and ATM modulation of downstream effectors is very important. This holds particularly for a reconceptualization of the apparently paradoxical roles and therapeutically targetable for enhancing the response to DNA damage-inducing therapy.
Background: 49,XXXXY Syndrome is a rare aneuploidic sex chromosomal abnormality; its frequency is... more Background: 49,XXXXY Syndrome is a rare aneuploidic sex chromosomal abnormality; its frequency is approximately 1 out of in 85,000 to 100,000 males. It was originally described by Fraccaro and colleagues in 1960. Over 100 such cases have been reported so far in the world. Objective: The case we report here, to the best of our knowledge, is the first such case reported from Pakistan. Case Report: A 12 year old boy was presented with classical features of the mental age of six years old child, normal Apgar score at birth, moderately low IQ, receptive expressive communication and behavioural problems. History of delayed milestones, fits leading to collapse, hypertelorism, short neck, narrow shoulder, round face in infancy, flat foot, moderately hyper extensible joints, hypotonia, generalised muscle wasting, hypogonadism, both testes were smaller around 60% (3.2×1.9 Cm) of normal size, i.e., (5×3 Cm) and penis was like 5 years old child but ambiguity of genitalia was not observed in our...
Research concerning the epigenome over the years has systematically and sequentially shown substa... more Research concerning the epigenome over the years has systematically and sequentially shown substantial development and we have moved from global inhibition of modifications of the epigenome toward identification and targeted therapy against tumor-specific epigenetic mechanisms. In accordance with this approach, several drugs with epigenetically modulating activity have received considerable attention and appreciation, and recently emerging scientific evidence is uncovering details of their mode of action. High-throughput technologies have considerably improved our existing understanding of tumor suppressors, oncogenes, and signaling pathways that are key drivers of cancer. In this review, we summarize the general epigenetic mechanisms in cancer, including: the post-translational modification of DNA methyltransferase and its mediated inactivation of Ras association domain family 1 isoform A, Sonic hedgehog signaling, Wnt signaling, Notch signaling, transforming growth factor signalin...
Proceedings of the 4th International Conference on Wireless Mobile Communication and Healthcare - "Transforming healthcare through innovations in mobile and wireless technologies", 2014
2005 13th IEEE International Conference on Networks Jointly held with the 2005 IEEE 7th Malaysia International Conf on Communic, 2005
Page 1. Performance of Uplink Power Control During Soft Handover in WCDMA System Jamil S. Abdulaz... more Page 1. Performance of Uplink Power Control During Soft Handover in WCDMA System Jamil S. Abdulaziz Dept. of Computer Engineering Sana'a Community College Sana'a, Republic ofYemen e-mail: jameeI730@ hotmail .com M. Ismail, AM Hasbi Fac. ...
It is becoming increasingly understood that tumor cells may have different mutations and dependen... more It is becoming increasingly understood that tumor cells may have different mutations and dependencies on diverse intracellular signaling cascades for survival or metastatic potential. Overexpression of oncogenes, inactivation of tumor suppressor genes, genetic/epigenetic mutations, genomic instability, and loss of apoptotic cell death are some of the mechanisms that have been widely investigated in molecular oncology. We partition this multicomponent review into the most recent evidence on the anticancer activity of fungal substances obtained from in vitro and xenografted models, and these fungal substances modulate expression of oncogenic and tumor suppressor miRNAs. There are some outstanding questions regarding fungus-derived chemical-induced modulation of intracellular signaling networks in different cancer cell lines and preclinical models. Certain hints have emerged, emphasizing mechanisms via which apoptosis can be restored in TRAIL-resistant cancer cells. Reconceptualization...
Hernia : the journal of hernias and abdominal wall surgery, 2004
Late complications of mesh repair are commonly due to mesh migration and erosion into neighbourin... more Late complications of mesh repair are commonly due to mesh migration and erosion into neighbouring visceri. We report the first case of a mesh repair of a lower midline laprotomy incisional hernia complicated by erosion of the mesh into the bladder which presented as haematuria.
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