The medications may enhance the recovery after nerve paralysis. We aimed to evaluate the effects ... more The medications may enhance the recovery after nerve paralysis. We aimed to evaluate the effects of aminoguanidine (AG), melatonin, and methylprednisolone on peripheral facial nerve neurorrhaphy. The buccal branch of the facial nerve was transected and autografted in 32 New Zealand rabbits. Subjects were divided into 4 groups equally (AG, melatonin, methylprednisolone, and control). After the medical treatment latency and amplitude were measured with nerve conduction study at 3, 6, and 10 weeks. Then, coapted segments of nerve were examined microscopically. The groups were compared with each other. The latent period was shortened, and the amplitudes were increased in the AG group; the latent period was shortened, and the amplitudes did not show significant change in the melatonin group with the time. There were no significant differences between the amplitudes at 3 to 6 and 3 to 10 weeks in the methylprednisolone group, and the latent period was shortened. There was no significant difference between the amplitude values at 3, 6, and 10 weeks in the control group. In the histological examination, AG had the best influence on preventing myelin degeneration and reducing the accumulation of myelin debris. Considering the increase in collagen fibers, the best results were achieved in the melatonin group. The degree of myelin-axonal degeneration was higher in the methylprednisolone group. The degree of collagen fiber increase, axonal degeneration, myelin degeneration, and the accumulation of myelin debris were detected quite high in the control group. Aminoguanidine and melatonin alone achieved an increase in regeneration after peripheral facial nerve neurorrhaphy, but methylprednisolone did not. The best healing was determined in the AG group.
Angiotensin II, the effector peptide of the renin angiotensin system, regulates cellular growth i... more Angiotensin II, the effector peptide of the renin angiotensin system, regulates cellular growth in response to developmental, physiological, and pathological processes. It is well established that Angiotensin II has an important role in regulating cardiovascular hemodynamics and structure. Multiple lines of evidence have suggested the existence of at least two distinct Angiotensin II receptor subtypes, as AT1 and AT2 receptors. Most of the known effects of Angiotensin II in cardiovascular tissues are attributable to the AT1 receptor, but less is known about the AT2 receptor. AT1 and AT2 receptors may exert opposite effects in terms of cell growth and blood pressure regulation. Herein, we will discuss the role of the AT2 receptor in the cardiovascular system. Key Words: Renin, Angiotensin II, AT2 Receptor, Cardiovascular System
Objectives: We investigated the incidence and etiologic factors of pharyngocutaneous fistulas occ... more Objectives: We investigated the incidence and etiologic factors of pharyngocutaneous fistulas occurring after total laryngectomy. Patients and methods: The study included 53 patients (46 males, 7 females; mean age 59 years; range 34 to 84 years) who underwent total laryngectomy for epidermoid carcinoma. Risk factors for pharyngocutaneous fistula, its incidence and time of occurrence, treatment approaches, and length of hospital stay were evaluated. Results: Pharyngocutaneous fistula developed in 19 patients (35.9%) within a mean of 7.4 days postoperatively. Age, smoking, the presence of chronic systemic disease; T1-T2 stage, localization, and differentiation of tumor, concomitant bilateral neck dissection, T/Y shaped pharyngeal closure, and high fever in the first postoperative 48 hours did not show any significant relationship with the formation of fistula. Factors significantly associated with fistula formation were T4 stage, alcohol consumption, postoperative anemia, and hypoproteinemia. The mean hospital stay was 40.5 days in patients with pharyngocutaneous fistula compared with 15.3 days in patients without fistula. Conclusion: Postoperative anemia, hypoproteinemia, alcohol consumption, and T4 stage are significant risk factors for pharyngocutaneous fistula formation.
Purpose: Conventional cold curettage adenoidectomy(CCA) is the most used method for Adenoidectomy... more Purpose: Conventional cold curettage adenoidectomy(CCA) is the most used method for Adenoidectomy. With the advances in surgical instruments, endoscopy assisted less invasive techniques are coming into use. Herein we compared CCA with endoscopic microdebrider adenoidectomy(EMA) in terms of safety and recurrence.Methods: Patients who underwent adenoidectomy in our clinic between 2009-2021 years were included into the study. Study performed retrospectively. Patients operated with CCA accepted as GroupA and EMA as GroupB. Two groups compared for the recurrence rate and post-operative complications. Results: We studied 833 children aged between 3-12 years (mean 4,2 years old), had adenoidectomy, including 482 male(57.86%) and 351 female(42.14%). There were 473 patients in GroupA, and 360 patients in GroupB. Seventeen patients(%3.59) in GroupA had reoperation for the recurrence of adenoid tissue. There was no recurrence in GroupB. Residual tissue, recurrent hypertrophy, and postoperative...
La cartilagine rappresenta una delle opzioni più interessanti per il confezionamento dell'inn... more La cartilagine rappresenta una delle opzioni più interessanti per il confezionamento dell'innesto nella timpanoplastica (TPL). Col presente studio presentiamo i nostri risultati audiologici e il rate di attecchimento nei casi di TPL trattati con innesto di cartilagine con pericondrio (PACIT). Sono stati analizzati, in termini di tipo di chirurgia effettuata, attecchimento dell'innesto e risultati audiologici, 194 orecchi di 191 pazienti (108 maschi, 83 donne). Sono state effettuate 127 (65,46%) TPL tipo I, 45 (23,20%) tipo II e 22 (11,34%) tipo III. Il gap medio fra via aerea e via ossea all'audiometria tonale preoperatoria è stato rispettivamente 33,74 ± 9,60, 52,58 ± 9,07, e 56,58 ± 10,27 dB HL; i valori nel postoperatorio sono stai invece 18,55 ± 9,25, 31,21 ± 4,36, and 44,84 ± 12,45 dB HL. Nel postoperatorio di è registrato un miglioramento della soglia (≥ 10dB) nel 76,81% degli orecchi valutati, con un recupero medio di 20 dB HL (range 10-40 dB). Tuttavia il 19,07% ...
Mulberry hypertrophy occasionally coexists with sinonasal pathologies. There are very few reports... more Mulberry hypertrophy occasionally coexists with sinonasal pathologies. There are very few reports in the literature on this clinical entity. We conducted a retrospective study to draw attention to this condition in the context of accompanying sinonasal pathologies. Our study group was made up of 68 patients—51 males and 17 females, aged 13 to 57 years (mean: 34.9)—who had been diagnosed with mulberry hypertrophy and at least one accompanying sinonasal pathology. All patients had a long-standing chronic discharge. Forty-nine of these patients (72.1%) had unilateral mulberry hypertrophy. The most common concomitant pathologies were chronic rhinosinusitis and ostiomeatal complex disease; others included septal deviation, nasal polyposis, allergic rhinitis, and concha bullosa. Thirty-six patients (52.9%) with varying degrees of choanal/nasal obstruction were operated on with endoscopic excision to treat the mulberry hypertrophy. In all, most patients underwent some sort of surgery to tr...
Angiotensin II, the effector peptide of the renin angiotensin system, regulates cellular growth i... more Angiotensin II, the effector peptide of the renin angiotensin system, regulates cellular growth in response to developmental, physiological, and pathological processes. It is well established that Angiotensin II has an important role in regulating cardiovascular hemodynamics and structure. Multiple lines of evidence have suggested the existence of at least two distinct Angiotensin II receptor subtypes, as AT1 and AT2 receptors. Most of the known effects of Angiotensin II in cardiovascular tissues are attributable to the AT1 receptor, but less is known about the AT2 receptor. AT1 and AT2 receptors may exert opposite effects in terms of cell growth and blood pressure regulation. Herein, we will discuss the role of the AT2 receptor in the cardiovascular system. Key Words: Renin, Angiotensin II, AT2 Receptor, Cardiovascular System
Objectives: During inhalation through the nose, the weakness of lateral cartilage may cause the c... more Objectives: During inhalation through the nose, the weakness of lateral cartilage may cause the collapse of nasal vestibule and sidewall, causing the complaint of difficult breathing through the nose. We aimed to support the lateral cartilage with a square edged strut to resolve this problem. Methods: We described a technique in 8 cases (5 males, 3 females). In this technique the lateral cartilage is semi wrapped from the underside to a square edged strut, and arched to outside with an open approach rhinoplasty. As it was only a physical support and did not create a new canting up through the skin, we named this maneuver as pseudodome technique. Results: All patients experienced relief of symptoms and no complications observed. The reinforcement effect of the strut was effective in preventing collapse of the nasal alar sidewall as well as did not cause contour irregularities. Conclusions: Pseudodome technique can be performed for acquired or congenital nasal sidewall collapse caused...
Objectives: To make a contribution to the ossicle reconstruction in chronic supurative otitis med... more Objectives: To make a contribution to the ossicle reconstruction in chronic supurative otitis media surgery preoperatively by assessing the presence of colesteatoma and ossicle destructions by comparing preoperative temporal bone high resolution computed tomography(HRCT) and intraoperative findings. Patients and Methods: Ninety five (57 males, 38 females; mean age 35.2 years; range 7 to 67 years) with ossicular chain destruction were included in this retrospective clinical study. Every patient had an axial and coronal plain HRCT with 1 mm consecutive slices, interpreted by the same radiologist. The preoperative HRCT and intraoperative findings compared to evaluate the colesteatoma and the ossicle destructions. Results: All of the patients had a simple or modified radical or radical mastoidectomy with tympanoplasty operation. The rates of preoperative HRCT and intraoperation findings for the colesteatoma were 62.11% and 70.52%, the soft tissue in the middle ear and/or mastoid cavity ...
The medications may enhance the recovery after nerve paralysis. We aimed to evaluate the effects ... more The medications may enhance the recovery after nerve paralysis. We aimed to evaluate the effects of aminoguanidine (AG), melatonin, and methylprednisolone on peripheral facial nerve neurorrhaphy. The buccal branch of the facial nerve was transected and autografted in 32 New Zealand rabbits. Subjects were divided into 4 groups equally (AG, melatonin, methylprednisolone, and control). After the medical treatment latency and amplitude were measured with nerve conduction study at 3, 6, and 10 weeks. Then, coapted segments of nerve were examined microscopically. The groups were compared with each other. The latent period was shortened, and the amplitudes were increased in the AG group; the latent period was shortened, and the amplitudes did not show significant change in the melatonin group with the time. There were no significant differences between the amplitudes at 3 to 6 and 3 to 10 weeks in the methylprednisolone group, and the latent period was shortened. There was no significant difference between the amplitude values at 3, 6, and 10 weeks in the control group. In the histological examination, AG had the best influence on preventing myelin degeneration and reducing the accumulation of myelin debris. Considering the increase in collagen fibers, the best results were achieved in the melatonin group. The degree of myelin-axonal degeneration was higher in the methylprednisolone group. The degree of collagen fiber increase, axonal degeneration, myelin degeneration, and the accumulation of myelin debris were detected quite high in the control group. Aminoguanidine and melatonin alone achieved an increase in regeneration after peripheral facial nerve neurorrhaphy, but methylprednisolone did not. The best healing was determined in the AG group.
Surgery for nasal obstruction is performed to give a subjective benefit. We aimed to evaluate the... more Surgery for nasal obstruction is performed to give a subjective benefit. We aimed to evaluate the surgical management of the nasal obstruction in the patient`s perception. The study was performed prospectively with 134 patients over the age of 18. They were allotted to three groups according to the level of nasal obstruction by clinical examination. The G1 group had only a deviated nasal septum (DNS), G2 had DNS and hypertrophy of inferior turbinates, and G3 had nasal valve problems in conjunction with DNS. All the patients had surgery focused on obstructive pathologies. The study was conducted using three different scoring systems to determine the patients` evaluation of the surgical procedures. The study included more man than woman, with a mean age around 28 (wide range). Twenty six patients were in G1, 73 patients in G2 and 35 patients in G3. Total and general Glasgow Benefit Inventory (GBI) scores for each group showed improvement postoperatively. There was a significant differ...
The medications may enhance the recovery after nerve paralysis. We aimed to evaluate the effects ... more The medications may enhance the recovery after nerve paralysis. We aimed to evaluate the effects of aminoguanidine (AG), melatonin, and methylprednisolone on peripheral facial nerve neurorrhaphy. The buccal branch of the facial nerve was transected and autografted in 32 New Zealand rabbits. Subjects were divided into 4 groups equally (AG, melatonin, methylprednisolone, and control). After the medical treatment latency and amplitude were measured with nerve conduction study at 3, 6, and 10 weeks. Then, coapted segments of nerve were examined microscopically. The groups were compared with each other. The latent period was shortened, and the amplitudes were increased in the AG group; the latent period was shortened, and the amplitudes did not show significant change in the melatonin group with the time. There were no significant differences between the amplitudes at 3 to 6 and 3 to 10 weeks in the methylprednisolone group, and the latent period was shortened. There was no significant difference between the amplitude values at 3, 6, and 10 weeks in the control group. In the histological examination, AG had the best influence on preventing myelin degeneration and reducing the accumulation of myelin debris. Considering the increase in collagen fibers, the best results were achieved in the melatonin group. The degree of myelin-axonal degeneration was higher in the methylprednisolone group. The degree of collagen fiber increase, axonal degeneration, myelin degeneration, and the accumulation of myelin debris were detected quite high in the control group. Aminoguanidine and melatonin alone achieved an increase in regeneration after peripheral facial nerve neurorrhaphy, but methylprednisolone did not. The best healing was determined in the AG group.
Angiotensin II, the effector peptide of the renin angiotensin system, regulates cellular growth i... more Angiotensin II, the effector peptide of the renin angiotensin system, regulates cellular growth in response to developmental, physiological, and pathological processes. It is well established that Angiotensin II has an important role in regulating cardiovascular hemodynamics and structure. Multiple lines of evidence have suggested the existence of at least two distinct Angiotensin II receptor subtypes, as AT1 and AT2 receptors. Most of the known effects of Angiotensin II in cardiovascular tissues are attributable to the AT1 receptor, but less is known about the AT2 receptor. AT1 and AT2 receptors may exert opposite effects in terms of cell growth and blood pressure regulation. Herein, we will discuss the role of the AT2 receptor in the cardiovascular system. Key Words: Renin, Angiotensin II, AT2 Receptor, Cardiovascular System
Objectives: We investigated the incidence and etiologic factors of pharyngocutaneous fistulas occ... more Objectives: We investigated the incidence and etiologic factors of pharyngocutaneous fistulas occurring after total laryngectomy. Patients and methods: The study included 53 patients (46 males, 7 females; mean age 59 years; range 34 to 84 years) who underwent total laryngectomy for epidermoid carcinoma. Risk factors for pharyngocutaneous fistula, its incidence and time of occurrence, treatment approaches, and length of hospital stay were evaluated. Results: Pharyngocutaneous fistula developed in 19 patients (35.9%) within a mean of 7.4 days postoperatively. Age, smoking, the presence of chronic systemic disease; T1-T2 stage, localization, and differentiation of tumor, concomitant bilateral neck dissection, T/Y shaped pharyngeal closure, and high fever in the first postoperative 48 hours did not show any significant relationship with the formation of fistula. Factors significantly associated with fistula formation were T4 stage, alcohol consumption, postoperative anemia, and hypoproteinemia. The mean hospital stay was 40.5 days in patients with pharyngocutaneous fistula compared with 15.3 days in patients without fistula. Conclusion: Postoperative anemia, hypoproteinemia, alcohol consumption, and T4 stage are significant risk factors for pharyngocutaneous fistula formation.
Purpose: Conventional cold curettage adenoidectomy(CCA) is the most used method for Adenoidectomy... more Purpose: Conventional cold curettage adenoidectomy(CCA) is the most used method for Adenoidectomy. With the advances in surgical instruments, endoscopy assisted less invasive techniques are coming into use. Herein we compared CCA with endoscopic microdebrider adenoidectomy(EMA) in terms of safety and recurrence.Methods: Patients who underwent adenoidectomy in our clinic between 2009-2021 years were included into the study. Study performed retrospectively. Patients operated with CCA accepted as GroupA and EMA as GroupB. Two groups compared for the recurrence rate and post-operative complications. Results: We studied 833 children aged between 3-12 years (mean 4,2 years old), had adenoidectomy, including 482 male(57.86%) and 351 female(42.14%). There were 473 patients in GroupA, and 360 patients in GroupB. Seventeen patients(%3.59) in GroupA had reoperation for the recurrence of adenoid tissue. There was no recurrence in GroupB. Residual tissue, recurrent hypertrophy, and postoperative...
La cartilagine rappresenta una delle opzioni più interessanti per il confezionamento dell'inn... more La cartilagine rappresenta una delle opzioni più interessanti per il confezionamento dell'innesto nella timpanoplastica (TPL). Col presente studio presentiamo i nostri risultati audiologici e il rate di attecchimento nei casi di TPL trattati con innesto di cartilagine con pericondrio (PACIT). Sono stati analizzati, in termini di tipo di chirurgia effettuata, attecchimento dell'innesto e risultati audiologici, 194 orecchi di 191 pazienti (108 maschi, 83 donne). Sono state effettuate 127 (65,46%) TPL tipo I, 45 (23,20%) tipo II e 22 (11,34%) tipo III. Il gap medio fra via aerea e via ossea all'audiometria tonale preoperatoria è stato rispettivamente 33,74 ± 9,60, 52,58 ± 9,07, e 56,58 ± 10,27 dB HL; i valori nel postoperatorio sono stai invece 18,55 ± 9,25, 31,21 ± 4,36, and 44,84 ± 12,45 dB HL. Nel postoperatorio di è registrato un miglioramento della soglia (≥ 10dB) nel 76,81% degli orecchi valutati, con un recupero medio di 20 dB HL (range 10-40 dB). Tuttavia il 19,07% ...
Mulberry hypertrophy occasionally coexists with sinonasal pathologies. There are very few reports... more Mulberry hypertrophy occasionally coexists with sinonasal pathologies. There are very few reports in the literature on this clinical entity. We conducted a retrospective study to draw attention to this condition in the context of accompanying sinonasal pathologies. Our study group was made up of 68 patients—51 males and 17 females, aged 13 to 57 years (mean: 34.9)—who had been diagnosed with mulberry hypertrophy and at least one accompanying sinonasal pathology. All patients had a long-standing chronic discharge. Forty-nine of these patients (72.1%) had unilateral mulberry hypertrophy. The most common concomitant pathologies were chronic rhinosinusitis and ostiomeatal complex disease; others included septal deviation, nasal polyposis, allergic rhinitis, and concha bullosa. Thirty-six patients (52.9%) with varying degrees of choanal/nasal obstruction were operated on with endoscopic excision to treat the mulberry hypertrophy. In all, most patients underwent some sort of surgery to tr...
Angiotensin II, the effector peptide of the renin angiotensin system, regulates cellular growth i... more Angiotensin II, the effector peptide of the renin angiotensin system, regulates cellular growth in response to developmental, physiological, and pathological processes. It is well established that Angiotensin II has an important role in regulating cardiovascular hemodynamics and structure. Multiple lines of evidence have suggested the existence of at least two distinct Angiotensin II receptor subtypes, as AT1 and AT2 receptors. Most of the known effects of Angiotensin II in cardiovascular tissues are attributable to the AT1 receptor, but less is known about the AT2 receptor. AT1 and AT2 receptors may exert opposite effects in terms of cell growth and blood pressure regulation. Herein, we will discuss the role of the AT2 receptor in the cardiovascular system. Key Words: Renin, Angiotensin II, AT2 Receptor, Cardiovascular System
Objectives: During inhalation through the nose, the weakness of lateral cartilage may cause the c... more Objectives: During inhalation through the nose, the weakness of lateral cartilage may cause the collapse of nasal vestibule and sidewall, causing the complaint of difficult breathing through the nose. We aimed to support the lateral cartilage with a square edged strut to resolve this problem. Methods: We described a technique in 8 cases (5 males, 3 females). In this technique the lateral cartilage is semi wrapped from the underside to a square edged strut, and arched to outside with an open approach rhinoplasty. As it was only a physical support and did not create a new canting up through the skin, we named this maneuver as pseudodome technique. Results: All patients experienced relief of symptoms and no complications observed. The reinforcement effect of the strut was effective in preventing collapse of the nasal alar sidewall as well as did not cause contour irregularities. Conclusions: Pseudodome technique can be performed for acquired or congenital nasal sidewall collapse caused...
Objectives: To make a contribution to the ossicle reconstruction in chronic supurative otitis med... more Objectives: To make a contribution to the ossicle reconstruction in chronic supurative otitis media surgery preoperatively by assessing the presence of colesteatoma and ossicle destructions by comparing preoperative temporal bone high resolution computed tomography(HRCT) and intraoperative findings. Patients and Methods: Ninety five (57 males, 38 females; mean age 35.2 years; range 7 to 67 years) with ossicular chain destruction were included in this retrospective clinical study. Every patient had an axial and coronal plain HRCT with 1 mm consecutive slices, interpreted by the same radiologist. The preoperative HRCT and intraoperative findings compared to evaluate the colesteatoma and the ossicle destructions. Results: All of the patients had a simple or modified radical or radical mastoidectomy with tympanoplasty operation. The rates of preoperative HRCT and intraoperation findings for the colesteatoma were 62.11% and 70.52%, the soft tissue in the middle ear and/or mastoid cavity ...
The medications may enhance the recovery after nerve paralysis. We aimed to evaluate the effects ... more The medications may enhance the recovery after nerve paralysis. We aimed to evaluate the effects of aminoguanidine (AG), melatonin, and methylprednisolone on peripheral facial nerve neurorrhaphy. The buccal branch of the facial nerve was transected and autografted in 32 New Zealand rabbits. Subjects were divided into 4 groups equally (AG, melatonin, methylprednisolone, and control). After the medical treatment latency and amplitude were measured with nerve conduction study at 3, 6, and 10 weeks. Then, coapted segments of nerve were examined microscopically. The groups were compared with each other. The latent period was shortened, and the amplitudes were increased in the AG group; the latent period was shortened, and the amplitudes did not show significant change in the melatonin group with the time. There were no significant differences between the amplitudes at 3 to 6 and 3 to 10 weeks in the methylprednisolone group, and the latent period was shortened. There was no significant difference between the amplitude values at 3, 6, and 10 weeks in the control group. In the histological examination, AG had the best influence on preventing myelin degeneration and reducing the accumulation of myelin debris. Considering the increase in collagen fibers, the best results were achieved in the melatonin group. The degree of myelin-axonal degeneration was higher in the methylprednisolone group. The degree of collagen fiber increase, axonal degeneration, myelin degeneration, and the accumulation of myelin debris were detected quite high in the control group. Aminoguanidine and melatonin alone achieved an increase in regeneration after peripheral facial nerve neurorrhaphy, but methylprednisolone did not. The best healing was determined in the AG group.
Surgery for nasal obstruction is performed to give a subjective benefit. We aimed to evaluate the... more Surgery for nasal obstruction is performed to give a subjective benefit. We aimed to evaluate the surgical management of the nasal obstruction in the patient`s perception. The study was performed prospectively with 134 patients over the age of 18. They were allotted to three groups according to the level of nasal obstruction by clinical examination. The G1 group had only a deviated nasal septum (DNS), G2 had DNS and hypertrophy of inferior turbinates, and G3 had nasal valve problems in conjunction with DNS. All the patients had surgery focused on obstructive pathologies. The study was conducted using three different scoring systems to determine the patients` evaluation of the surgical procedures. The study included more man than woman, with a mean age around 28 (wide range). Twenty six patients were in G1, 73 patients in G2 and 35 patients in G3. Total and general Glasgow Benefit Inventory (GBI) scores for each group showed improvement postoperatively. There was a significant differ...
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