Previously Research Fellow at Stanford University & NASA Ames Research Center, USA, and Newcastle University, UK. Founding member and technical lead at e-Therapeutics plc, a network pharmacology & drug discovery company. Currently CEO at Hexis Lab Limited, UK Address: Newcastle, England, United Kingdom
Human skin is a stratified organ frequently exposed to sun-generated ultraviolet radiation (UVR),... more Human skin is a stratified organ frequently exposed to sun-generated ultraviolet radiation (UVR), which is considered one of the major factors responsible for DNA damage. Such damage can be direct, through interactions of DNA with UV photons, or indirect, mainly through enhanced production of reactive oxygen species that introduce oxidative changes to the DNA. Oxidative stress and DNA damage also associate with profound changes at the cellular and molecular level involving several cell cycle and signal transduction factors responsible for DNA repair or irreversible changes linked to ageing. Crucially, some of these factors constitute part of the signalling known for the induction of biological changes in non-irradiated, neighbouring cells and defined as the bystander effect. Network interactions with a number of natural compounds, based on their known activity towards these biomarkers in the skin, reveal the capacity to inhibit both the bystander signalling and cell cycle/DNA damage...
Clinical, cosmetic and investigational dermatology, 2018
Individual responses of human skin to the environmental stress are determined by differences in t... more Individual responses of human skin to the environmental stress are determined by differences in the anatomy and physiology that are closely linked to the genetic characteristics such as pigmentation. Ethnic skin phenotypes can be distinguished based on defined genotypic traits, structural organization and compartmentalized sensitivity to distinct extrinsic aging factors. These differences are not only responsible for the variation in skin performance after exposure to damaging conditions, but can also affect the mechanisms of drug absorption, sensitization and other longer term effects. The unique characteristics of the individual skin function and, particularly, of the ethnic skin type are currently considered to shape the future of clinical and pharmacologic interventions as a basis for personalized skincare. Individual approaches to skincare render a novel and actively growing area with a range of biomedical and commercial applications within cosmetics industry. In this review, w...
Clinical, cosmetic and investigational dermatology, 2018
Human skin is a stratified endocrine organ with primary roles in protection against detrimental b... more Human skin is a stratified endocrine organ with primary roles in protection against detrimental biochemical and biophysical factors in the environment. Environmental stress causes gradual accumulation of the macromolecular damage and clinical manifestations consistent with chronic inflammatory conditions and premature aging of the skin. Structural proteins of cell nucleus, the nuclear lamins and lamina-associated proteins, play an important role in the regulation of a number of signal transduction pathways associated with stress. The nuclear lamina proteins have been implicated in a number of degenerative disorders with frequent clinical manifestations of the skin conditions related to premature aging. Analysis of the molecular signatures in response of the skin to a range of damaging factors not only points at the likely involvement of the nuclear lamina in transmission of the signals between the environment and cell nucleus but also defines skin's sensitivity to stress, and th...
Proceedings. 2004 IEEE Computational Systems Bioinformatics Conference, 2004. CSB 2004.
Abstract Identifying functionally important proteins that are essential to the survival of a bact... more Abstract Identifying functionally important proteins that are essential to the survival of a bacterial cell is of considerable interest in the development of new antimicrobial agents. Recent studies have shown that functionally important components in protein interaction ...
Fault tolerance is a key aspect of the dependability of complex computer-based systems. Fault tol... more Fault tolerance is a key aspect of the dependability of complex computer-based systems. Fault toler- ance may be difficult to measure directly in complex real world systems, and we propose here to measure it in terms of integrity preservation of the system under the assumption of a particular fault occurrence distribution. We measure the integrity preservation ability of the system by measuring the change of structural integrity of the graph representing the system while it is exposed to random node removal according to the assumed fault distribution. We show how to use such measures to measure the integrity reservation of computer-based systems and in this way indirectly their fault tolerance. We discuss the application of the proposed method in the context of a real world exam- ple, the Linux operating system. The results indicate that integrity preservation metrics can serve as an appropriate measure of fault tolerance of complex computer-based systems.
The skin is considered to be the largest organ in the human body and is the first line of defense... more The skin is considered to be the largest organ in the human body and is the first line of defense against the external environment such as ultraviolet radiation (UVR), chemicals, and pathogenic microorganisms. Research suggests that skin aging has both an intrinsic and extrinsic aspect. Intrinsic aging is genetically determined and is thought to be a result of mitochondrial ROS production as a natural by-product of oxidative phosphorylation within cells. On the other hand, extrinsic aging can be controlled and occurs as a result of exposure to damaging environmental stressors such as UVR and pollution which have been shown to generate ROS in levels which saturate the skin’s natural defense mechanisms.
Correct and efficient text classification is a major challenge in today’s world of rapidly increa... more Correct and efficient text classification is a major challenge in today’s world of rapidly increasing amount of accessible electronic text data. Kohonen networks have been applied to document classification with comparable success to other document clustering methods. An important challenge is to devise text similarity metrics that can improve the performance of text classification Kohonen networks by integrating more semantic information into the metric. Here we propose an augmented metric for text similarity that is based on the comparison of word consecutiveness graphs of documents. We show that using the proposed augmented similarity metric Kohonen networks perform better than Kohonen networks using usual Euclidean distance metric comparison of word frequency vectors. Our results indicate that word consecutiveness graph comparison includes more semantic information into the text similarity measure improving text classification performance.
Helium II at temperatures below Tλ can be described as a superposition of two interacting fluids.... more Helium II at temperatures below Tλ can be described as a superposition of two interacting fluids. A normal-fluid which has non-zero viscosity, and an inviscid superfluid in which vorticity is confined to quantised vortex filaments. These two fluids are coupled together by ...
Human skin is a stratified organ frequently exposed to sun-generated ultraviolet radiation (UVR),... more Human skin is a stratified organ frequently exposed to sun-generated ultraviolet radiation (UVR), which is considered one of the major factors responsible for DNA damage. Such damage can be direct, through interactions of DNA with UV photons, or indirect, mainly through enhanced production of reactive oxygen species that introduce oxidative changes to the DNA. Oxidative stress and DNA damage also associate with profound changes at the cellular and molecular level involving several cell cycle and signal transduction factors responsible for DNA repair or irreversible changes linked to ageing. Crucially, some of these factors constitute part of the signalling known for the induction of biological changes in non-irradiated, neighbouring cells and defined as the bystander effect. Network interactions with a number of natural compounds, based on their known activity towards these biomarkers in the skin, reveal the capacity to inhibit both the bystander signalling and cell cycle/DNA damage...
Clinical, cosmetic and investigational dermatology, 2018
Individual responses of human skin to the environmental stress are determined by differences in t... more Individual responses of human skin to the environmental stress are determined by differences in the anatomy and physiology that are closely linked to the genetic characteristics such as pigmentation. Ethnic skin phenotypes can be distinguished based on defined genotypic traits, structural organization and compartmentalized sensitivity to distinct extrinsic aging factors. These differences are not only responsible for the variation in skin performance after exposure to damaging conditions, but can also affect the mechanisms of drug absorption, sensitization and other longer term effects. The unique characteristics of the individual skin function and, particularly, of the ethnic skin type are currently considered to shape the future of clinical and pharmacologic interventions as a basis for personalized skincare. Individual approaches to skincare render a novel and actively growing area with a range of biomedical and commercial applications within cosmetics industry. In this review, w...
Clinical, cosmetic and investigational dermatology, 2018
Human skin is a stratified endocrine organ with primary roles in protection against detrimental b... more Human skin is a stratified endocrine organ with primary roles in protection against detrimental biochemical and biophysical factors in the environment. Environmental stress causes gradual accumulation of the macromolecular damage and clinical manifestations consistent with chronic inflammatory conditions and premature aging of the skin. Structural proteins of cell nucleus, the nuclear lamins and lamina-associated proteins, play an important role in the regulation of a number of signal transduction pathways associated with stress. The nuclear lamina proteins have been implicated in a number of degenerative disorders with frequent clinical manifestations of the skin conditions related to premature aging. Analysis of the molecular signatures in response of the skin to a range of damaging factors not only points at the likely involvement of the nuclear lamina in transmission of the signals between the environment and cell nucleus but also defines skin's sensitivity to stress, and th...
Proceedings. 2004 IEEE Computational Systems Bioinformatics Conference, 2004. CSB 2004.
Abstract Identifying functionally important proteins that are essential to the survival of a bact... more Abstract Identifying functionally important proteins that are essential to the survival of a bacterial cell is of considerable interest in the development of new antimicrobial agents. Recent studies have shown that functionally important components in protein interaction ...
Fault tolerance is a key aspect of the dependability of complex computer-based systems. Fault tol... more Fault tolerance is a key aspect of the dependability of complex computer-based systems. Fault toler- ance may be difficult to measure directly in complex real world systems, and we propose here to measure it in terms of integrity preservation of the system under the assumption of a particular fault occurrence distribution. We measure the integrity preservation ability of the system by measuring the change of structural integrity of the graph representing the system while it is exposed to random node removal according to the assumed fault distribution. We show how to use such measures to measure the integrity reservation of computer-based systems and in this way indirectly their fault tolerance. We discuss the application of the proposed method in the context of a real world exam- ple, the Linux operating system. The results indicate that integrity preservation metrics can serve as an appropriate measure of fault tolerance of complex computer-based systems.
The skin is considered to be the largest organ in the human body and is the first line of defense... more The skin is considered to be the largest organ in the human body and is the first line of defense against the external environment such as ultraviolet radiation (UVR), chemicals, and pathogenic microorganisms. Research suggests that skin aging has both an intrinsic and extrinsic aspect. Intrinsic aging is genetically determined and is thought to be a result of mitochondrial ROS production as a natural by-product of oxidative phosphorylation within cells. On the other hand, extrinsic aging can be controlled and occurs as a result of exposure to damaging environmental stressors such as UVR and pollution which have been shown to generate ROS in levels which saturate the skin’s natural defense mechanisms.
Correct and efficient text classification is a major challenge in today’s world of rapidly increa... more Correct and efficient text classification is a major challenge in today’s world of rapidly increasing amount of accessible electronic text data. Kohonen networks have been applied to document classification with comparable success to other document clustering methods. An important challenge is to devise text similarity metrics that can improve the performance of text classification Kohonen networks by integrating more semantic information into the metric. Here we propose an augmented metric for text similarity that is based on the comparison of word consecutiveness graphs of documents. We show that using the proposed augmented similarity metric Kohonen networks perform better than Kohonen networks using usual Euclidean distance metric comparison of word frequency vectors. Our results indicate that word consecutiveness graph comparison includes more semantic information into the text similarity measure improving text classification performance.
Helium II at temperatures below Tλ can be described as a superposition of two interacting fluids.... more Helium II at temperatures below Tλ can be described as a superposition of two interacting fluids. A normal-fluid which has non-zero viscosity, and an inviscid superfluid in which vorticity is confined to quantised vortex filaments. These two fluids are coupled together by ...
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