ABSTRACT The systemic pressure response technic was applied in 4 patients undergoing diagnostic c... more ABSTRACT The systemic pressure response technic was applied in 4 patients undergoing diagnostic catheterization. Injections were made alternately into the pulmonary artery and the ascending aorta and the systemic arterial pressor responses to each of these two routes of administration were compared. In 2 subjects, the pressor potency of angiotensin II given by way of the pulmonary artery was identical to that resulting from aortic injections, thus indicating the absence of pulmonary extraction of the octapeptide. In 2 other patients, angiotensin I was twice as potent by the pulmonary than by the aortic route; this could have resulted only from the marked conversion of the inactive decapeptide under the influence of pulmonary converting-enzyme activity.
ABSTRACT The systemic pressure response technic was applied in 4 patients undergoing diagnostic c... more ABSTRACT The systemic pressure response technic was applied in 4 patients undergoing diagnostic catheterization. Injections were made alternately into the pulmonary artery and the ascending aorta and the systemic arterial pressor responses to each of these two routes of administration were compared. In 2 subjects, the pressor potency of angiotensin II given by way of the pulmonary artery was identical to that resulting from aortic injections, thus indicating the absence of pulmonary extraction of the octapeptide. In 2 other patients, angiotensin I was twice as potent by the pulmonary than by the aortic route; this could have resulted only from the marked conversion of the inactive decapeptide under the influence of pulmonary converting-enzyme activity.
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