Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a gen... more Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study (GWAS) followed by replication in a combined total of 10,503 PACG cases and 29,567 controls drawn from 24 countries across Asia, Australia, Europe, North America, and South America. We observed significant evidence of disease association at five new genetic loci upon meta-analysis of all patient collections. These loci are at EPDR1 rs3816415 (odds ratio (OR) = 1.24, P = 5.94 × 10(-15)), CHAT rs1258267 (OR = 1.22, P = 2.85 × 10(-16)), GLIS3 rs736893 (OR = 1.18, P = 1.43 × 10(-14)), FERMT2 rs7494379 (OR = 1.14, P = 3.43 × 10(-11)), and DPM2-FAM102A rs3739821 (OR = 1.15, P = 8.32 × 10(-12)). We also confirmed significant association at three previously described loci (P…
2010 12th International Conference on Frontiers in Handwriting Recognition, 2010
... Digital Image Process-ing and Analysis. Prentiece Hall of India, New Delhi, 2005. [3] K. Fran... more ... Digital Image Process-ing and Analysis. Prentiece Hall of India, New Delhi, 2005. [3] K. Franke and M. Koppen. A computer-based system to support forensic studies on handwritten documents. Pattern Recognition, 33(1):133148, 2000. [4] RA Huber and AM Headrick. ...
Abstract : In the present study measurement of radon and its progeny concentration has been under... more Abstract : In the present study measurement of radon and its progeny concentration has been undertaken in the buildings constructed in the surroundings of National Hydroelectric Power Corporation (NHPC). LR-115 Type-II solid state nuclear track detectors fixed on a thick flat ...
Molecular and cellular endocrinology, Jan 14, 2010
The role of the newly discovered estrogen receptor GPR30 in islet physiology and pathophysiology ... more The role of the newly discovered estrogen receptor GPR30 in islet physiology and pathophysiology is unclear. We examined GPR30 expression in relation to hormone secretion and possible anti-apoptotic effects in isolated mouse islets using the synthetic GPR30 ligand G-1. The mRNA and protein expression of GPR30 was analyzed by qPCR, Western blot and confocal microscopy. Hormone secretion and cAMP content were determined with RIA and apoptosis in islet cells with the Annexin-V method. GPR30 mRNA and protein expression was markedly higher in islets from females compared to male. This gender difference was not found for the genomic estrogen receptors ER alpha and ER beta, the ER alpha expression being 10-fold higher than ER beta in both genders. Confocal microscopy revealed abounden GPR30 expression in insulin, glucagon and somatostatin cells. Dose-response studies of G-1 vs 17beta-estradiol in isolated islets at 1 or 12 mM glucose showed an almost identical pattern in that both compound...
Studies suggest that the experiences of unmarried young women seeking abortion in India differ fr... more Studies suggest that the experiences of unmarried young women seeking abortion in India differ from those of their married counterparts, but the evidence is limited. Research was undertaken among nulliparous young women aged 15-24 who had abortions at the clinics of a leading NGO in Bihar and Jharkhand. Over a 14-month period in 2007-08, 246 married and 549 unmarried young abortion seekers were surveyed and 26 who were unmarried were interviewed in depth. Those who were unmarried were far more likely to report non-consensual sexual relations. As many as 25% of unmarried young women, compared to only 9% of married young women, had had a second trimester abortion. The unmarried were far more likely to report non-consensual sexual relations leading to pregnancy. They were also more likely to report such obstacles to timely abortion as failure to recognise the pregnancy promptly, exclusion from abortion-related decision-making, seeking confidentiality as paramount in selection of aborti...
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2010
Polytetrafluoroethylene (PTFE) films were irradiated under vacuum and at room temperature with 15... more Polytetrafluoroethylene (PTFE) films were irradiated under vacuum and at room temperature with 150MeV Ni11+ ions and fluences ranging from 5× 1010 to 5× 1012ions/cm2. Ion induced modifications in optical, chemical and structural properties were studied by ...
Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a gen... more Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study (GWAS) followed by replication in a combined total of 10,503 PACG cases and 29,567 controls drawn from 24 countries across Asia, Australia, Europe, North America, and South America. We observed significant evidence of disease association at five new genetic loci upon meta-analysis of all patient collections. These loci are at EPDR1 rs3816415 (odds ratio (OR) = 1.24, P = 5.94 × 10(-15)), CHAT rs1258267 (OR = 1.22, P = 2.85 × 10(-16)), GLIS3 rs736893 (OR = 1.18, P = 1.43 × 10(-14)), FERMT2 rs7494379 (OR = 1.14, P = 3.43 × 10(-11)), and DPM2-FAM102A rs3739821 (OR = 1.15, P = 8.32 × 10(-12)). We also confirmed significant association at three previously described loci (P…
2010 12th International Conference on Frontiers in Handwriting Recognition, 2010
... Digital Image Process-ing and Analysis. Prentiece Hall of India, New Delhi, 2005. [3] K. Fran... more ... Digital Image Process-ing and Analysis. Prentiece Hall of India, New Delhi, 2005. [3] K. Franke and M. Koppen. A computer-based system to support forensic studies on handwritten documents. Pattern Recognition, 33(1):133148, 2000. [4] RA Huber and AM Headrick. ...
Abstract : In the present study measurement of radon and its progeny concentration has been under... more Abstract : In the present study measurement of radon and its progeny concentration has been undertaken in the buildings constructed in the surroundings of National Hydroelectric Power Corporation (NHPC). LR-115 Type-II solid state nuclear track detectors fixed on a thick flat ...
Molecular and cellular endocrinology, Jan 14, 2010
The role of the newly discovered estrogen receptor GPR30 in islet physiology and pathophysiology ... more The role of the newly discovered estrogen receptor GPR30 in islet physiology and pathophysiology is unclear. We examined GPR30 expression in relation to hormone secretion and possible anti-apoptotic effects in isolated mouse islets using the synthetic GPR30 ligand G-1. The mRNA and protein expression of GPR30 was analyzed by qPCR, Western blot and confocal microscopy. Hormone secretion and cAMP content were determined with RIA and apoptosis in islet cells with the Annexin-V method. GPR30 mRNA and protein expression was markedly higher in islets from females compared to male. This gender difference was not found for the genomic estrogen receptors ER alpha and ER beta, the ER alpha expression being 10-fold higher than ER beta in both genders. Confocal microscopy revealed abounden GPR30 expression in insulin, glucagon and somatostatin cells. Dose-response studies of G-1 vs 17beta-estradiol in isolated islets at 1 or 12 mM glucose showed an almost identical pattern in that both compound...
Studies suggest that the experiences of unmarried young women seeking abortion in India differ fr... more Studies suggest that the experiences of unmarried young women seeking abortion in India differ from those of their married counterparts, but the evidence is limited. Research was undertaken among nulliparous young women aged 15-24 who had abortions at the clinics of a leading NGO in Bihar and Jharkhand. Over a 14-month period in 2007-08, 246 married and 549 unmarried young abortion seekers were surveyed and 26 who were unmarried were interviewed in depth. Those who were unmarried were far more likely to report non-consensual sexual relations. As many as 25% of unmarried young women, compared to only 9% of married young women, had had a second trimester abortion. The unmarried were far more likely to report non-consensual sexual relations leading to pregnancy. They were also more likely to report such obstacles to timely abortion as failure to recognise the pregnancy promptly, exclusion from abortion-related decision-making, seeking confidentiality as paramount in selection of aborti...
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2010
Polytetrafluoroethylene (PTFE) films were irradiated under vacuum and at room temperature with 15... more Polytetrafluoroethylene (PTFE) films were irradiated under vacuum and at room temperature with 150MeV Ni11+ ions and fluences ranging from 5× 1010 to 5× 1012ions/cm2. Ion induced modifications in optical, chemical and structural properties were studied by ...
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