... The large majority of the skin cancers were basal cell carcinomas, consistent with findings f... more ... The large majority of the skin cancers were basal cell carcinomas, consistent with findings from Lobo et al. [15]. ... Lobo DV,; Chu P,; Grekin RC,; Berger TG. . Nonmelanoma skin cancers and infection with the human immunodeficiency virus. ...
The median duration of highly active antiretroviral therapy (HAART) regimens was reported to be 1... more The median duration of highly active antiretroviral therapy (HAART) regimens was reported to be 11.8 months in one US study, but that study included both treatment-experienced and treatment-naive patients. The duration of initial HAART regimens for treatment-naive patients alone has not been reported. We selected 405 antiretroviral-naive patients who were seen at the University of Alabama at Birmingham HIV Outpatient Clinic from 1 January 1996 through 9 October 2001, and we assessed the duration of initial and successive HAART regimens in this group. Any antiretroviral medication change, excluding dosage changes, that lasted >or=14 days was considered to indicate the start of a new regimen. The median duration of regimens was determined by Kaplan-Meier analysis, and proportional hazards regression was used to identify factors associated with shorter duration of initial regimen. The median duration of initial regimens was 1.6 years, and medication toxicity-associated events were the cause of one-half of discontinuations. Only a history of opportunistic infection and injection drug use were significantly associated with shorter regimen duration.
... The large majority of the skin cancers were basal cell carcinomas, consistent with findings f... more ... The large majority of the skin cancers were basal cell carcinomas, consistent with findings from Lobo et al. [15]. ... Lobo DV,; Chu P,; Grekin RC,; Berger TG. . Nonmelanoma skin cancers and infection with the human immunodeficiency virus. ...
The median duration of highly active antiretroviral therapy (HAART) regimens was reported to be 1... more The median duration of highly active antiretroviral therapy (HAART) regimens was reported to be 11.8 months in one US study, but that study included both treatment-experienced and treatment-naive patients. The duration of initial HAART regimens for treatment-naive patients alone has not been reported. We selected 405 antiretroviral-naive patients who were seen at the University of Alabama at Birmingham HIV Outpatient Clinic from 1 January 1996 through 9 October 2001, and we assessed the duration of initial and successive HAART regimens in this group. Any antiretroviral medication change, excluding dosage changes, that lasted >or=14 days was considered to indicate the start of a new regimen. The median duration of regimens was determined by Kaplan-Meier analysis, and proportional hazards regression was used to identify factors associated with shorter duration of initial regimen. The median duration of initial regimens was 1.6 years, and medication toxicity-associated events were the cause of one-half of discontinuations. Only a history of opportunistic infection and injection drug use were significantly associated with shorter regimen duration.
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