Abstract. This paper presents a Dempster Shafer theory based classi-fier fusion algorithm to impr... more Abstract. This paper presents a Dempster Shafer theory based classi-fier fusion algorithm to improve the performance of fingerprint verifica-tion. The proposed fusion algorithm combines decision induced match scores of minutiae, ridge, fingercode and pore based fingerprint ...
Skull base osteomyelitis (SBO) is typically bacterial in origin and caused by Pseudomonas, althou... more Skull base osteomyelitis (SBO) is typically bacterial in origin and caused by Pseudomonas, although the fungus Aspergillus has also rarely been implicated. SBO generally arises from ear infections and infrequently complicates sinonasal infection. Rhinocerebral Mucor infection is characteristically an acute, fulminant, and deadly infection also affecting the orbits and deep face and is associated with intracranial complications. Bony involvement is uncommon because of the angioinvasive nature of the fungus. More recently, chronic invasive Mucor sinusitis has been described. We report the unusual clinical and imaging features of a patient with biopsy-proven invasive mucormycosis arising from chronic isolated sphenoid sinus disease, who presented with extensive SBO and a paucity of deep facial, orbital, or intracranial involvement.
Tropical gastroenterology : official journal of the Digestive Diseases Foundation
The hepatitis B vaccine is considered to be highly immunogenic and has a good safety profile. In ... more The hepatitis B vaccine is considered to be highly immunogenic and has a good safety profile. In adults, it has a primary non-response rate of 5%-10%. Causes of nonresponse to hepatitis B vaccine include age, sex, obesity smoking. Certain human leucocyte antigen (HLA) phenotypes have been known to be associated with responsiveness to the vaccine, and found to be different in different ethnic groups, such as Caucasians and Orientals. The study was designed to identify the HLA phenotypes that are associated with non-responsiveness to hepatitis B virus (HBV) vaccination amongst a cohort of Indian subjects who agreed to participate in the vaccination programme. The study was offered to 107 volunteers, of whom 102 were found to be negative for HBV markers (hepatitis B surface antigen [HBsAg], anti-HBc, anti-HBe, anti-HBs, hepatitis Be antigen [HBeAg]) . All 102 volunteers were offered recombinant hepatitis B vaccine (20 microg) at 0, 1, and 6 months. Anti-HBs antibody titres were tested ...
We have used two-dimensional (1)H NMR spectroscopy at 750 MHz to determine a high-resolution solu... more We have used two-dimensional (1)H NMR spectroscopy at 750 MHz to determine a high-resolution solution structure of an oligonucleotide containing restricted nucleotides with a 2'-O, 4'-C-methylene bridge (LNA) hybridized to the complementary DNA strand. The LNA:DNA duplex examined contained four thymidine LNA modifications (T(L), d(C1T(L)2G3C4T(L)5T(L)6C7T(L)8G9C10):d( G11C12A13G14A15A16G17C 18A19G20). A total relaxation matrix approach was used to obtain interproton distance bounds from NOESY cross-peak intensities. These distance bounds were used as restraints in molecular dynamics (rMD) calculations. Forty final structures were generated for the duplex from A-form and B-form DNA starting structures. The root-mean-square deviation (RMSD) of the coordinates for the 40 structures of the complex was 0.6 A. The sugar puckerings are averaged values of a dynamic interchange between N- and S-type conformation except in case of the locked nucleotides that were found to be fixed in the C3'-endo conformation. Among the other nucleotides in the modified strand, the furanose ring of C7 and G9 is predominantly in the N-type conformation whereas that of G3 is in a mixed conformation. The furanose rings of the nucleotides in the unmodified complementary strand are almost exclusively in the S-type conformation. Due to these different conformations of the sugars in the two strands, there is a structural strain between the A-type modified strand and the B-type unmodified complementary strand. This strain is relaxed by decreasing the value of rise and compensating with tip, buckle, and propeller twist. The values of twist vary along the strand but for a majority of the base pairs a value even lower than that of A-DNA is observed. The average twist over the sequence is 32+/-1 degrees. On the basis of the structure, we conclude that the high stability of LNA:DNA duplexes is caused by a local change of the phosphate backbone geometry that favors a higher degree of stacking.
Gene therapy has been recently shown as a promising tool for cancer treatment as nanotechnology-b... more Gene therapy has been recently shown as a promising tool for cancer treatment as nanotechnology-based safe and effective delivery methods are developed. Generally, genes are wrapped up in extremely tiny nanoparticles which could be taken up easily by cancer cells, not to their healthy neighboring cells. Several nanoparticle systems have been investigated primarily to address the problems involved in other methods of gene delivery and observed improved anticancer efficacy suggesting that nanomedicine provides novel opportunities to safely deliver genes, thus treat cancer. In this review, various nanoparticle types and related strategies, used in gene delivery for cancer treatment, have been discussed.
Extended release formulation of tramadol hydrochloride (TRH) based on osmotic technology was deve... more Extended release formulation of tramadol hydrochloride (TRH) based on osmotic technology was developed and evaluated. Target release profile was selected and differ- ent variables were optimized to achieve it. Formulation variables such as the level of swellable polymer, plasti- cizer and the coat thickness of semipermeable membrane (SPM) were found to markedly affect drug release. TRH release was directly proportional
Journal of Statistical Computation and Simulation, 2012
In this paper, we propose Bayes estimators of the parameter and reliability function of inverted ... more In this paper, we propose Bayes estimators of the parameter and reliability function of inverted exponential distribution under the general entropy loss function for complete, type I and type II censored samples. The proposed estimators have been compared with the corresponding maximum-likelihood estimators for their simulated risks (average loss over sample space).
In the past years global pollution and the specific situation of global warming changes have been... more In the past years global pollution and the specific situation of global warming changes have been strongly influencing public opinion and thus obliged politicians to initiate/ negotiate in-ternational agreements to control, avoid or at least reduce the impact of CO2 emissions e.g. The Kyoto Protocol (1997) and the International Copenhagen conference on Climate Change (2009). In the orbital debris area
Phylogenetic diversity analyses of archaeal 16S rRNA and ammonia monooxygenase subunit A (AamoA) ... more Phylogenetic diversity analyses of archaeal 16S rRNA and ammonia monooxygenase subunit A (AamoA) genes were carried out on sediment samples from the Mandovi and Zuari estuaries on the central west coast of India. The 16S rRNA gene libraries revealed quite high diversity of archaea in these sediments compared to previous reports from tropical and temperate estuarine sediments. Uncultured members of Crenarchaeota accounted for approximately 78% of 433 archaeal 16S rRNA gene clones from both of the estuaries. We detected archaeal 16S and amoA gene-related organisms capable of ammonia oxidation. Among Crenarchaeota, marine group I (MG I) was the most predominant. Clones matching the uncultured methanobacteria were predominant among the ribogroups of Euryarchaeota. Our results indicate that archaeal diversity in tropical estuarine sediments is influenced by the mangrove vegetation bordering the lower stretches of both estuaries. Higher diversity may be related to elevated land drainage d...
Ruthenium complexes [Ru(κ3−tpy)(AsPh3)2C1]PF6 · 0.42H2O (tpy =2,2′:6′,2′′-terpyridine) (1) and a ... more Ruthenium complexes [Ru(κ3−tpy)(AsPh3)2C1]PF6 · 0.42H2O (tpy =2,2′:6′,2′′-terpyridine) (1) and a new crystal form of [Ru(κ3−tpy)(AsPh3)2Cl]BF4(2), which crystallized without water solvate, and their comparative studies on spectral, structure and stability aspects are reported. The complexes have been characterized by elemental analyses, FAB-MS, i.r., 1H n.m.r. and electronic spectral studies. In these complexes weak C—H···Fπ and face-to-face π–π interactions lead to a single helical motif while, C—H···FX (X=F, Cl) interactions result in linear chains. Various studies on the stability of the complexes suggested that the compound containing the counter anion PF
Abstract. This paper presents a Dempster Shafer theory based classi-fier fusion algorithm to impr... more Abstract. This paper presents a Dempster Shafer theory based classi-fier fusion algorithm to improve the performance of fingerprint verifica-tion. The proposed fusion algorithm combines decision induced match scores of minutiae, ridge, fingercode and pore based fingerprint ...
Skull base osteomyelitis (SBO) is typically bacterial in origin and caused by Pseudomonas, althou... more Skull base osteomyelitis (SBO) is typically bacterial in origin and caused by Pseudomonas, although the fungus Aspergillus has also rarely been implicated. SBO generally arises from ear infections and infrequently complicates sinonasal infection. Rhinocerebral Mucor infection is characteristically an acute, fulminant, and deadly infection also affecting the orbits and deep face and is associated with intracranial complications. Bony involvement is uncommon because of the angioinvasive nature of the fungus. More recently, chronic invasive Mucor sinusitis has been described. We report the unusual clinical and imaging features of a patient with biopsy-proven invasive mucormycosis arising from chronic isolated sphenoid sinus disease, who presented with extensive SBO and a paucity of deep facial, orbital, or intracranial involvement.
Tropical gastroenterology : official journal of the Digestive Diseases Foundation
The hepatitis B vaccine is considered to be highly immunogenic and has a good safety profile. In ... more The hepatitis B vaccine is considered to be highly immunogenic and has a good safety profile. In adults, it has a primary non-response rate of 5%-10%. Causes of nonresponse to hepatitis B vaccine include age, sex, obesity smoking. Certain human leucocyte antigen (HLA) phenotypes have been known to be associated with responsiveness to the vaccine, and found to be different in different ethnic groups, such as Caucasians and Orientals. The study was designed to identify the HLA phenotypes that are associated with non-responsiveness to hepatitis B virus (HBV) vaccination amongst a cohort of Indian subjects who agreed to participate in the vaccination programme. The study was offered to 107 volunteers, of whom 102 were found to be negative for HBV markers (hepatitis B surface antigen [HBsAg], anti-HBc, anti-HBe, anti-HBs, hepatitis Be antigen [HBeAg]) . All 102 volunteers were offered recombinant hepatitis B vaccine (20 microg) at 0, 1, and 6 months. Anti-HBs antibody titres were tested ...
We have used two-dimensional (1)H NMR spectroscopy at 750 MHz to determine a high-resolution solu... more We have used two-dimensional (1)H NMR spectroscopy at 750 MHz to determine a high-resolution solution structure of an oligonucleotide containing restricted nucleotides with a 2'-O, 4'-C-methylene bridge (LNA) hybridized to the complementary DNA strand. The LNA:DNA duplex examined contained four thymidine LNA modifications (T(L), d(C1T(L)2G3C4T(L)5T(L)6C7T(L)8G9C10):d( G11C12A13G14A15A16G17C 18A19G20). A total relaxation matrix approach was used to obtain interproton distance bounds from NOESY cross-peak intensities. These distance bounds were used as restraints in molecular dynamics (rMD) calculations. Forty final structures were generated for the duplex from A-form and B-form DNA starting structures. The root-mean-square deviation (RMSD) of the coordinates for the 40 structures of the complex was 0.6 A. The sugar puckerings are averaged values of a dynamic interchange between N- and S-type conformation except in case of the locked nucleotides that were found to be fixed in the C3'-endo conformation. Among the other nucleotides in the modified strand, the furanose ring of C7 and G9 is predominantly in the N-type conformation whereas that of G3 is in a mixed conformation. The furanose rings of the nucleotides in the unmodified complementary strand are almost exclusively in the S-type conformation. Due to these different conformations of the sugars in the two strands, there is a structural strain between the A-type modified strand and the B-type unmodified complementary strand. This strain is relaxed by decreasing the value of rise and compensating with tip, buckle, and propeller twist. The values of twist vary along the strand but for a majority of the base pairs a value even lower than that of A-DNA is observed. The average twist over the sequence is 32+/-1 degrees. On the basis of the structure, we conclude that the high stability of LNA:DNA duplexes is caused by a local change of the phosphate backbone geometry that favors a higher degree of stacking.
Gene therapy has been recently shown as a promising tool for cancer treatment as nanotechnology-b... more Gene therapy has been recently shown as a promising tool for cancer treatment as nanotechnology-based safe and effective delivery methods are developed. Generally, genes are wrapped up in extremely tiny nanoparticles which could be taken up easily by cancer cells, not to their healthy neighboring cells. Several nanoparticle systems have been investigated primarily to address the problems involved in other methods of gene delivery and observed improved anticancer efficacy suggesting that nanomedicine provides novel opportunities to safely deliver genes, thus treat cancer. In this review, various nanoparticle types and related strategies, used in gene delivery for cancer treatment, have been discussed.
Extended release formulation of tramadol hydrochloride (TRH) based on osmotic technology was deve... more Extended release formulation of tramadol hydrochloride (TRH) based on osmotic technology was developed and evaluated. Target release profile was selected and differ- ent variables were optimized to achieve it. Formulation variables such as the level of swellable polymer, plasti- cizer and the coat thickness of semipermeable membrane (SPM) were found to markedly affect drug release. TRH release was directly proportional
Journal of Statistical Computation and Simulation, 2012
In this paper, we propose Bayes estimators of the parameter and reliability function of inverted ... more In this paper, we propose Bayes estimators of the parameter and reliability function of inverted exponential distribution under the general entropy loss function for complete, type I and type II censored samples. The proposed estimators have been compared with the corresponding maximum-likelihood estimators for their simulated risks (average loss over sample space).
In the past years global pollution and the specific situation of global warming changes have been... more In the past years global pollution and the specific situation of global warming changes have been strongly influencing public opinion and thus obliged politicians to initiate/ negotiate in-ternational agreements to control, avoid or at least reduce the impact of CO2 emissions e.g. The Kyoto Protocol (1997) and the International Copenhagen conference on Climate Change (2009). In the orbital debris area
Phylogenetic diversity analyses of archaeal 16S rRNA and ammonia monooxygenase subunit A (AamoA) ... more Phylogenetic diversity analyses of archaeal 16S rRNA and ammonia monooxygenase subunit A (AamoA) genes were carried out on sediment samples from the Mandovi and Zuari estuaries on the central west coast of India. The 16S rRNA gene libraries revealed quite high diversity of archaea in these sediments compared to previous reports from tropical and temperate estuarine sediments. Uncultured members of Crenarchaeota accounted for approximately 78% of 433 archaeal 16S rRNA gene clones from both of the estuaries. We detected archaeal 16S and amoA gene-related organisms capable of ammonia oxidation. Among Crenarchaeota, marine group I (MG I) was the most predominant. Clones matching the uncultured methanobacteria were predominant among the ribogroups of Euryarchaeota. Our results indicate that archaeal diversity in tropical estuarine sediments is influenced by the mangrove vegetation bordering the lower stretches of both estuaries. Higher diversity may be related to elevated land drainage d...
Ruthenium complexes [Ru(κ3−tpy)(AsPh3)2C1]PF6 · 0.42H2O (tpy =2,2′:6′,2′′-terpyridine) (1) and a ... more Ruthenium complexes [Ru(κ3−tpy)(AsPh3)2C1]PF6 · 0.42H2O (tpy =2,2′:6′,2′′-terpyridine) (1) and a new crystal form of [Ru(κ3−tpy)(AsPh3)2Cl]BF4(2), which crystallized without water solvate, and their comparative studies on spectral, structure and stability aspects are reported. The complexes have been characterized by elemental analyses, FAB-MS, i.r., 1H n.m.r. and electronic spectral studies. In these complexes weak C—H···Fπ and face-to-face π–π interactions lead to a single helical motif while, C—H···FX (X=F, Cl) interactions result in linear chains. Various studies on the stability of the complexes suggested that the compound containing the counter anion PF
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Papers by sanjay singh