A field experiment was conducted during rabi season of 2010-2011 and 2011-12 at Pantnagar in tara... more A field experiment was conducted during rabi season of 2010-2011 and 2011-12 at Pantnagar in tarai soil of Uttarakhand to study the effect of different herbicides on plant growth, weed dynamics, nutrient uptake and yield of dwarf fieldpea. Results revealed that uncontrolled weeds caused 27.3 and 39.4 per cent reduction in grain yield of dwarf fieldpea during first and second year, respectively as compared to two hand weedings done at 20 and 40 days after sowing (DAS). Among the chemical treatments, minimum nutrient removal of 3.0 kg N,0.5 kg P and 3.3 kg K ha-1by weeds was recorded under pendimethalin 1.0kg ha-1 (PE)+ imazethapyr 0.05 kg ha-1 (POE,30 DAS) as against 11.4 kg N, 1.96 kg P and 12.6 kg K ha-1, respectively in weedy check Two hand weedings done at 20 and 40 DAS, which remained at par with pendimethalin1.0 kg ha-1 (PE) + imazethapyr 0.05 kg ha-1 (POE, 30 DAS) and pendimethalin 1.0kg ha-1(PE) + quizalofop ethyl 0.05kg ha-1(POE, 30 DAS) caused significant reduction in weed ...
Comparative gross and radiographic anatomical study of dental arches of adult Bakarwali goat, loc... more Comparative gross and radiographic anatomical study of dental arches of adult Bakarwali goat, local shecp of Jammu region and sambar deer revealed that incisors were deeply and firmly placed in lower jaw having shovel shaped incisor in goat and sheep, whereas hocky stick like shaped incisors in sambar deer. The length of root was almost twice that of crown of respective incisor. In deer, the root of incisor was curved in central pair and strainght in corner pair, whereas the pattern Was reverse in sheep and goat. The 6 cheek teeth on either side of each jaw were placed deep but loose in deer, firmly anchored in sheep. however, in goats they were loosely and shallowly placed. Further the occlusal surface of premolars and molars showed horizontal and vertical lines of dentine in deer which has not been described in any ruminant. Radiographically it was revealed that cheek teeth occupy whole of body of horizontal ramus of mandible. The caudal alveoli for cheek teeth were present even ...
Journal of Evolution of medical and Dental Sciences, 2014
PURPOSE: The purpose of the study was to assess the awareness of physicians in rural Kolar distri... more PURPOSE: The purpose of the study was to assess the awareness of physicians in rural Kolar district towards diabetes and diabetic retinopathy. MATERIALS AND METHODS: A cross sectional survey was conducted in rural Kolar district during May 2013. The study participants were 38 physicians and 2 general practitioners who had special training in diabetes. The data were collected by means of filling up of pre-tested specially designed questionnaires focused on awareness towards Diabetes Mellitus and Diabetic retinopathy. The assessment was done by total score as satisfactory (Diabetic retinopathy awareness index >12), moderately satisfactory (DRAI 9-11) or unsatisfactory if index 12) was attained by only 55% (22/40) practitioners. Nearly 62.5% of physicians refer the diabetics to ophthalmologists only when they develop significant vision problems. CONCLUSION: This survey highlighted some of the lacunae in the knowledge about referral system of the general physicians and identified the...
Comparative gross anatomical study was made on adult skulls of Bakarwali goat (6) and local sheep... more Comparative gross anatomical study was made on adult skulls of Bakarwali goat (6) and local sheep of Jammu region (6) for their gross anatomical comparison. The frontal eminence was well developed in goat, whereas it was slightly evaginated in sheep. The frontal suture was serrated, the fronto nasal suture was 'V' shaped, the external occipital protuberance was sharp and pointed and, the intercondyloid cleft formed a deep 'U' shaped notch in Bakarwali goat. In the maxilla just cranial to the infraorbital foranien, a deep fossa was recorded only in goat whereas, in sheep a shallow lacrimal fossa was recorded just behind the orbito-facial crest. The external surface of the tympanic bullae was smooth and glistening in goat. However, in sheep it was rough with the presence of a low ridge. The body of the basisphenoid bone formed a sharp ridge in sheep in comparison to smooth in goat. The palatine process of maxillary area was elongated in sheep as compared to that in goa...
Fibroma is a common soft tissue lesion of the oral cavity, however, the origin of broma in a pal... more Fibroma is a common soft tissue lesion of the oral cavity, however, the origin of broma in a palatal region is rare. It may arise as a hyperplastic inammatory reaction in response to a local inciting agent, inammatory source, or chronic traumatic injury. These masses represent hyperplasia instead of true neoplasm. We present a case of broma present on the palatal region in an 8- year-old child diagnosed based on clinical, radiological, and histological features.
A major obstacle in Alzheimer’s disease (AD) research is the lack of predictive and translatable ... more A major obstacle in Alzheimer’s disease (AD) research is the lack of predictive and translatable animal models that reflect disease progression and drug efficacy. Transgenic mice overexpressing amyloid precursor protein (App) gene manifest non-physiological and ectopic expression of APP and its fragments in the brain, which is not observed in AD patients. The App knock-in mice circumvented some of these problems, but they do not exhibit tau pathology and neuronal death. We have generated a rat model, with three familiar App mutations and humanized Aβ sequence knocked into the rat App gene. Without altering the levels of full-length APP and other APP fragments, this model exhibits pathologies and disease progression resembling those in human patients: deposit of Aβ plaques in relevant brain regions, microglia activation and gliosis, progressive synaptic degeneration and AD-relevant cognitive deficits. Interestingly, we have observed tau pathology, neuronal apoptosis and necroptosis a...
A study was undertaken to evaluate the effect of different level of citric acid and packaging mat... more A study was undertaken to evaluate the effect of different level of citric acid and packaging material on physico chemical quality, sensory quality and shelf life of developed papaya fruit bar .The study revealed that the moisture content (19.06% to 16.95% in PET jars – 19.06% to 17.06% in glass jars), TSS (64.17 to 69.30°Brix in PETjars and 64.17 to 69.46°Brix in glass jars), Vitamin- C (55.30 to 45.80 mg/100mg in PET jars and 55.30 to 46.75 mg/100mg in glass jars) and total plate count decreased with increasing the level of citric acid from 0.5 to 1.0% after 90 days of storage in. During storage there was a reduction in moisture content, pH and vitamin-C, where as TSS (total soluble solids), optical density and total plate count increased during storage. No microbial detection in developed fresh fruit bar was found. The organoleptic score of the bar samples in glass jars at 0.75% citric acid level was found to be higher followed by samples packed in PET jars and the developed ...
The Indian Journal of Animal Sciences, Mar 18, 2005
A 6-week feeding trial was conducted in a factorial design format on 144, day-old broiler chicks ... more A 6-week feeding trial was conducted in a factorial design format on 144, day-old broiler chicks to determine the effects of phytase supplementation in the diets containing different Levels of non-phytate phosphorus (NPP). There were 4 dietary NPP levels (0.18, 0.29, 0.40 and 0.52%) and 2 phytase levels (0 and 500 U/kg diet). Observation on growth performance, blood biochemicals and bone mineralization were recorded. Lower dietary NPP levels decreased feed intake and weight gain (135.2 ± 18.8Og) and increased mortality, whereas dietary phytase increased feed intake and weight gain (1477.50 ± 18.80g) significantly (P&lt0.01) and increased the mortality from 28.22 to 13.89%. The serum concentrations of Ca and inorganic P were significantly (P&ltO.O1) increased by phytase supplementation from 6.33 to 7.41 mg/dl respectively. Ash and mineral contents of tibia were linearly decreased as dietary NPP levels reduced but dietary phytase improved the bone mineralization. The improved chick performance was related to an improved utilization of dietrvy P, as confirmed by significantly elevated serum concentration of inorganic P and increased tibia ash cent in birds receiving phytase treated diets. It was concluded that dairy phytase improved the performance, P utilization and bone mineralization of broilers.
A glioma is the most common type of brain tumor that accounts for nearly 80 % of brain cancers. V... more A glioma is the most common type of brain tumor that accounts for nearly 80 % of brain cancers. Vascular endothelial growth factor (VEGF) and its receptor, the kinase insert domain receptor (KDR), are involved in the angiogenesis of cancers. In this study, we investigate whether the polymorphisms of VEGF and KDR are associated with a glioma risk. Blood samples were collected from 477 glioma patients and 477 healthy controls. Five tag-single nucleotide polymorphisms (SNPs) of KDR were obtained from the HapMap database, and eight tag-SNPs of VEGF were selected based on previous studies. After extraction of genomic DNAs by a Qiagen DNA blood kit, the SNPs of VEGF and KDR were genotyped with a Sequenom MassArray iPLEX platform and further analyzed with matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry. The odds ratios and their 95 % confidence interval (95 % CI) were used to assess the association between VEGF, KDR polymorphisms, and glioma risks w...
Alzheimer’s disease (AD) is characterized by impaired protein homeostasis leading to amyloid-beta... more Alzheimer’s disease (AD) is characterized by impaired protein homeostasis leading to amyloid-beta (Aβ) amyloidosis. Here, we show that autophagy is similarly inhibited in AD brains and App knock-in AD mouse models. To determine how pathologies translate to cerebrospinal fluid (CSF), label-free mass spectrometry of mouse CSF was used. This identified autophagy-related extracellular matrix (ECM) protein decorin as significantly and similarly increased in App knock-in mice and cognitively normal human subjects with abnormal CSF-amyloid. Notably, a switch from negative to positive correlation of CSF-decorin and CSF-amyloid occurs in cognitively normal subjects when CSF-amyloid becomes abnormal, indicating an early change in CSF-decorin induced by Aβ amyloidosis. In App knock-in mice increased CSF-decorin correlated with accentuated decorin expression in choroid plexus and decreased interneuronal decorin. Furthermore, decorin activates neuronal autophagy-lysosomal system by enhancing lys...
A field experiment was conducted during rabi season of 2010-2011 and 2011-12 at Pantnagar in tara... more A field experiment was conducted during rabi season of 2010-2011 and 2011-12 at Pantnagar in tarai soil of Uttarakhand to study the effect of different herbicides on plant growth, weed dynamics, nutrient uptake and yield of dwarf fieldpea. Results revealed that uncontrolled weeds caused 27.3 and 39.4 per cent reduction in grain yield of dwarf fieldpea during first and second year, respectively as compared to two hand weedings done at 20 and 40 days after sowing (DAS). Among the chemical treatments, minimum nutrient removal of 3.0 kg N,0.5 kg P and 3.3 kg K ha-1by weeds was recorded under pendimethalin 1.0kg ha-1 (PE)+ imazethapyr 0.05 kg ha-1 (POE,30 DAS) as against 11.4 kg N, 1.96 kg P and 12.6 kg K ha-1, respectively in weedy check Two hand weedings done at 20 and 40 DAS, which remained at par with pendimethalin1.0 kg ha-1 (PE) + imazethapyr 0.05 kg ha-1 (POE, 30 DAS) and pendimethalin 1.0kg ha-1(PE) + quizalofop ethyl 0.05kg ha-1(POE, 30 DAS) caused significant reduction in weed ...
Comparative gross and radiographic anatomical study of dental arches of adult Bakarwali goat, loc... more Comparative gross and radiographic anatomical study of dental arches of adult Bakarwali goat, local shecp of Jammu region and sambar deer revealed that incisors were deeply and firmly placed in lower jaw having shovel shaped incisor in goat and sheep, whereas hocky stick like shaped incisors in sambar deer. The length of root was almost twice that of crown of respective incisor. In deer, the root of incisor was curved in central pair and strainght in corner pair, whereas the pattern Was reverse in sheep and goat. The 6 cheek teeth on either side of each jaw were placed deep but loose in deer, firmly anchored in sheep. however, in goats they were loosely and shallowly placed. Further the occlusal surface of premolars and molars showed horizontal and vertical lines of dentine in deer which has not been described in any ruminant. Radiographically it was revealed that cheek teeth occupy whole of body of horizontal ramus of mandible. The caudal alveoli for cheek teeth were present even ...
Journal of Evolution of medical and Dental Sciences, 2014
PURPOSE: The purpose of the study was to assess the awareness of physicians in rural Kolar distri... more PURPOSE: The purpose of the study was to assess the awareness of physicians in rural Kolar district towards diabetes and diabetic retinopathy. MATERIALS AND METHODS: A cross sectional survey was conducted in rural Kolar district during May 2013. The study participants were 38 physicians and 2 general practitioners who had special training in diabetes. The data were collected by means of filling up of pre-tested specially designed questionnaires focused on awareness towards Diabetes Mellitus and Diabetic retinopathy. The assessment was done by total score as satisfactory (Diabetic retinopathy awareness index >12), moderately satisfactory (DRAI 9-11) or unsatisfactory if index 12) was attained by only 55% (22/40) practitioners. Nearly 62.5% of physicians refer the diabetics to ophthalmologists only when they develop significant vision problems. CONCLUSION: This survey highlighted some of the lacunae in the knowledge about referral system of the general physicians and identified the...
Comparative gross anatomical study was made on adult skulls of Bakarwali goat (6) and local sheep... more Comparative gross anatomical study was made on adult skulls of Bakarwali goat (6) and local sheep of Jammu region (6) for their gross anatomical comparison. The frontal eminence was well developed in goat, whereas it was slightly evaginated in sheep. The frontal suture was serrated, the fronto nasal suture was 'V' shaped, the external occipital protuberance was sharp and pointed and, the intercondyloid cleft formed a deep 'U' shaped notch in Bakarwali goat. In the maxilla just cranial to the infraorbital foranien, a deep fossa was recorded only in goat whereas, in sheep a shallow lacrimal fossa was recorded just behind the orbito-facial crest. The external surface of the tympanic bullae was smooth and glistening in goat. However, in sheep it was rough with the presence of a low ridge. The body of the basisphenoid bone formed a sharp ridge in sheep in comparison to smooth in goat. The palatine process of maxillary area was elongated in sheep as compared to that in goa...
Fibroma is a common soft tissue lesion of the oral cavity, however, the origin of broma in a pal... more Fibroma is a common soft tissue lesion of the oral cavity, however, the origin of broma in a palatal region is rare. It may arise as a hyperplastic inammatory reaction in response to a local inciting agent, inammatory source, or chronic traumatic injury. These masses represent hyperplasia instead of true neoplasm. We present a case of broma present on the palatal region in an 8- year-old child diagnosed based on clinical, radiological, and histological features.
A major obstacle in Alzheimer’s disease (AD) research is the lack of predictive and translatable ... more A major obstacle in Alzheimer’s disease (AD) research is the lack of predictive and translatable animal models that reflect disease progression and drug efficacy. Transgenic mice overexpressing amyloid precursor protein (App) gene manifest non-physiological and ectopic expression of APP and its fragments in the brain, which is not observed in AD patients. The App knock-in mice circumvented some of these problems, but they do not exhibit tau pathology and neuronal death. We have generated a rat model, with three familiar App mutations and humanized Aβ sequence knocked into the rat App gene. Without altering the levels of full-length APP and other APP fragments, this model exhibits pathologies and disease progression resembling those in human patients: deposit of Aβ plaques in relevant brain regions, microglia activation and gliosis, progressive synaptic degeneration and AD-relevant cognitive deficits. Interestingly, we have observed tau pathology, neuronal apoptosis and necroptosis a...
A study was undertaken to evaluate the effect of different level of citric acid and packaging mat... more A study was undertaken to evaluate the effect of different level of citric acid and packaging material on physico chemical quality, sensory quality and shelf life of developed papaya fruit bar .The study revealed that the moisture content (19.06% to 16.95% in PET jars – 19.06% to 17.06% in glass jars), TSS (64.17 to 69.30°Brix in PETjars and 64.17 to 69.46°Brix in glass jars), Vitamin- C (55.30 to 45.80 mg/100mg in PET jars and 55.30 to 46.75 mg/100mg in glass jars) and total plate count decreased with increasing the level of citric acid from 0.5 to 1.0% after 90 days of storage in. During storage there was a reduction in moisture content, pH and vitamin-C, where as TSS (total soluble solids), optical density and total plate count increased during storage. No microbial detection in developed fresh fruit bar was found. The organoleptic score of the bar samples in glass jars at 0.75% citric acid level was found to be higher followed by samples packed in PET jars and the developed ...
The Indian Journal of Animal Sciences, Mar 18, 2005
A 6-week feeding trial was conducted in a factorial design format on 144, day-old broiler chicks ... more A 6-week feeding trial was conducted in a factorial design format on 144, day-old broiler chicks to determine the effects of phytase supplementation in the diets containing different Levels of non-phytate phosphorus (NPP). There were 4 dietary NPP levels (0.18, 0.29, 0.40 and 0.52%) and 2 phytase levels (0 and 500 U/kg diet). Observation on growth performance, blood biochemicals and bone mineralization were recorded. Lower dietary NPP levels decreased feed intake and weight gain (135.2 ± 18.8Og) and increased mortality, whereas dietary phytase increased feed intake and weight gain (1477.50 ± 18.80g) significantly (P&lt0.01) and increased the mortality from 28.22 to 13.89%. The serum concentrations of Ca and inorganic P were significantly (P&ltO.O1) increased by phytase supplementation from 6.33 to 7.41 mg/dl respectively. Ash and mineral contents of tibia were linearly decreased as dietary NPP levels reduced but dietary phytase improved the bone mineralization. The improved chick performance was related to an improved utilization of dietrvy P, as confirmed by significantly elevated serum concentration of inorganic P and increased tibia ash cent in birds receiving phytase treated diets. It was concluded that dairy phytase improved the performance, P utilization and bone mineralization of broilers.
A glioma is the most common type of brain tumor that accounts for nearly 80 % of brain cancers. V... more A glioma is the most common type of brain tumor that accounts for nearly 80 % of brain cancers. Vascular endothelial growth factor (VEGF) and its receptor, the kinase insert domain receptor (KDR), are involved in the angiogenesis of cancers. In this study, we investigate whether the polymorphisms of VEGF and KDR are associated with a glioma risk. Blood samples were collected from 477 glioma patients and 477 healthy controls. Five tag-single nucleotide polymorphisms (SNPs) of KDR were obtained from the HapMap database, and eight tag-SNPs of VEGF were selected based on previous studies. After extraction of genomic DNAs by a Qiagen DNA blood kit, the SNPs of VEGF and KDR were genotyped with a Sequenom MassArray iPLEX platform and further analyzed with matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry. The odds ratios and their 95 % confidence interval (95 % CI) were used to assess the association between VEGF, KDR polymorphisms, and glioma risks w...
Alzheimer’s disease (AD) is characterized by impaired protein homeostasis leading to amyloid-beta... more Alzheimer’s disease (AD) is characterized by impaired protein homeostasis leading to amyloid-beta (Aβ) amyloidosis. Here, we show that autophagy is similarly inhibited in AD brains and App knock-in AD mouse models. To determine how pathologies translate to cerebrospinal fluid (CSF), label-free mass spectrometry of mouse CSF was used. This identified autophagy-related extracellular matrix (ECM) protein decorin as significantly and similarly increased in App knock-in mice and cognitively normal human subjects with abnormal CSF-amyloid. Notably, a switch from negative to positive correlation of CSF-decorin and CSF-amyloid occurs in cognitively normal subjects when CSF-amyloid becomes abnormal, indicating an early change in CSF-decorin induced by Aβ amyloidosis. In App knock-in mice increased CSF-decorin correlated with accentuated decorin expression in choroid plexus and decreased interneuronal decorin. Furthermore, decorin activates neuronal autophagy-lysosomal system by enhancing lys...
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