Nanotechnology has evolved as a novel multidisciplinary concept of the twenty-first century, abri... more Nanotechnology has evolved as a novel multidisciplinary concept of the twenty-first century, abridging gaps in materials science, engineering, life sciences and medicine, with tremendous applications in diverse areas of human endeavours. Nanoparticles, which form critical components of nanoscience and nanotechnology, have also played prominent roles in extending the frontiers of applications of the emerging discipline. The metallic nanoparticles, owing to their unique optical, surface, chemical, biological, catalytic, electronic, and resonance properties have formed an epicentre of research in recent times, with major focus on synthesis and novel applications. A new line of application that has emerged is in the delivery of quality healthcare, leading to the offshoot of a sub-discipline, nanomedicine. A major health problem confronting man is the blood coagulation disorder, which often leads to cardiovascular diseases, with the attendant high mortality worldwide. The use of conventional drugs in the treatment blood coagulation has been plagued with problems of high cost, short-lived action and adverse severe reactions. Hence, there is need to search for newer treatment regimes with improved outcomes, of which nanotechnology holds a promising future. In this review, we focus on the emerging applications of metallic nanoparticles in the management of blood coagulation disorders; notably in the prevention of clot formation, dissolution of blood clots, and in the combined role of therapeutic and diagnostic agents. The review presents a comprehensive overview on blood coagulation disorders, synthesis and applications of metallic nanoparticles, and the novel management of blood coagulation disorders using nanoplatform deliveries. Emphasis has been placed on the prospects of the use of metallic nanoparticles such as silver, gold and silver-gold alloy nanoparticles as anticoagulant, thrombolytic and theranostic agents, with evidences of excellent performances in the prevention of blood clot formation, dissolution of blood clots, and enhanced imaging of thrombus (blood clot) in vivo. The increasing appraisals of these nanoplatforms, potent action, improved biocompatibility cum absence of complications of excessive bleeding are good indicators of potential future integration in the clinical management of blood coagulation disorders. However, diligent studies are needed to be conducted to establish the long-term safety of applications of these nanomedical materials. The compendium seeks to bring to the fore, the continued relevance of nanotechnology in the twenty-first century, and its potential dynamic integration into medicare programmes.
The drug delivery technology landscape has become highly competitive and rapidly evolving as more... more The drug delivery technology landscape has become highly competitive and rapidly evolving as more and more developments in delivery systems are being integrated to optimize the efficacy and cost effectiveness of therapy. Currently, extensive research in the field of nanotechnology and nanomedicines is ongoing with a major focus towards manipulating materials at nanoscale; which can subsequently lead to advancements in diagnosis, imaging as well as treatment of a broad spectrum of diseases. In wake of recent findings, cyclodextrin based nanosponges comprising of hyper-crosslinked cyclodextrin polymers, are trendsetting in modern times with nanostructured three-dimensional network. Nanosponges based systems can address the issues related to solubility, absorption, penetration, bioavailability, in vivo stability, and can achieve sustained and targeted delivery with maximum therapeutic efficacy for a number of pharmaceutical entities. Molecules having molar mass between 100 and 400 Da, ...
In recent times, nanotechnology and nanomedicines have been researched with a major focus on mani... more In recent times, nanotechnology and nanomedicines have been researched with a major focus on manipulating materials at nanometer level that can bring about advances in imaging, diagnosis, as well as treatment of a broad spectrum of diseases. Cyclodextrin (CD)-based nanosponges (NSs), foreseen as modern nanosized delivery systems, are trendsetting hypercross-linked CD polymers that are nanostructured within a three-dimensional network. Nanosponge-based delivery systems inherit the potential for enhancing the solubility, absorption, penetration, bioavailability, in vivo stability, sustained and targetable delivery, and therapeutic efficiency of numerous pharmaceutical agents. The system predominantly and effectively addresses the aforementioned problems related to the existing formulations, with further advancements in the field of pharmaceutical sciences and technology. In this chapter, NSs are scrutinized as novel nanocarrier and adjuncts, with an all-inclusive focus on the characte...
The rheological behaviour of enzyme clarified Lime (Citrus aurontifolia L.) juice was studied as ... more The rheological behaviour of enzyme clarified Lime (Citrus aurontifolia L.) juice was studied as a function of the total soluble solid (TSS) content (7.3–55.7°Brix), corresponding water activity (a<sub>w</sub>) (0.985–0.831) at different temperatures (20–80<sup>o</sup>C) using co-axial controlled stress rheometer. The rheological parameter shear stress was measured up to the shear rate of 600 s<sup>–1</sup>. The investigation showed that the enzyme clarified lime juice and its concentrate behaved like a Newtonian fluid with the viscosity (η) being in the range 3.964 to 50.290 mPa s depending upon the concentration and temperature used. The temperature dependency on the viscosity of lime juice was described by Arrhenius equation (r > 0.99) and the activation energy (E<sub>a</sub>) of viscous flow was in the range 4.151 to 26.050 kJ/mol depending upon the total soluble solids content. The effect of tota...
Nanotechnology has evolved as a novel multidisciplinary concept of the twenty-first century, abri... more Nanotechnology has evolved as a novel multidisciplinary concept of the twenty-first century, abridging gaps in materials science, engineering, life sciences and medicine, with tremendous applications in diverse areas of human endeavours. Nanoparticles, which form critical components of nanoscience and nanotechnology, have also played prominent roles in extending the frontiers of applications of the emerging discipline. The metallic nanoparticles, owing to their unique optical, surface, chemical, biological, catalytic, electronic, and resonance properties have formed an epicentre of research in recent times, with major focus on synthesis and novel applications. A new line of application that has emerged is in the delivery of quality healthcare, leading to the offshoot of a sub-discipline, nanomedicine. A major health problem confronting man is the blood coagulation disorder, which often leads to cardiovascular diseases, with the attendant high mortality worldwide. The use of conventional drugs in the treatment blood coagulation has been plagued with problems of high cost, short-lived action and adverse severe reactions. Hence, there is need to search for newer treatment regimes with improved outcomes, of which nanotechnology holds a promising future. In this review, we focus on the emerging applications of metallic nanoparticles in the management of blood coagulation disorders; notably in the prevention of clot formation, dissolution of blood clots, and in the combined role of therapeutic and diagnostic agents. The review presents a comprehensive overview on blood coagulation disorders, synthesis and applications of metallic nanoparticles, and the novel management of blood coagulation disorders using nanoplatform deliveries. Emphasis has been placed on the prospects of the use of metallic nanoparticles such as silver, gold and silver-gold alloy nanoparticles as anticoagulant, thrombolytic and theranostic agents, with evidences of excellent performances in the prevention of blood clot formation, dissolution of blood clots, and enhanced imaging of thrombus (blood clot) in vivo. The increasing appraisals of these nanoplatforms, potent action, improved biocompatibility cum absence of complications of excessive bleeding are good indicators of potential future integration in the clinical management of blood coagulation disorders. However, diligent studies are needed to be conducted to establish the long-term safety of applications of these nanomedical materials. The compendium seeks to bring to the fore, the continued relevance of nanotechnology in the twenty-first century, and its potential dynamic integration into medicare programmes.
The drug delivery technology landscape has become highly competitive and rapidly evolving as more... more The drug delivery technology landscape has become highly competitive and rapidly evolving as more and more developments in delivery systems are being integrated to optimize the efficacy and cost effectiveness of therapy. Currently, extensive research in the field of nanotechnology and nanomedicines is ongoing with a major focus towards manipulating materials at nanoscale; which can subsequently lead to advancements in diagnosis, imaging as well as treatment of a broad spectrum of diseases. In wake of recent findings, cyclodextrin based nanosponges comprising of hyper-crosslinked cyclodextrin polymers, are trendsetting in modern times with nanostructured three-dimensional network. Nanosponges based systems can address the issues related to solubility, absorption, penetration, bioavailability, in vivo stability, and can achieve sustained and targeted delivery with maximum therapeutic efficacy for a number of pharmaceutical entities. Molecules having molar mass between 100 and 400 Da, ...
In recent times, nanotechnology and nanomedicines have been researched with a major focus on mani... more In recent times, nanotechnology and nanomedicines have been researched with a major focus on manipulating materials at nanometer level that can bring about advances in imaging, diagnosis, as well as treatment of a broad spectrum of diseases. Cyclodextrin (CD)-based nanosponges (NSs), foreseen as modern nanosized delivery systems, are trendsetting hypercross-linked CD polymers that are nanostructured within a three-dimensional network. Nanosponge-based delivery systems inherit the potential for enhancing the solubility, absorption, penetration, bioavailability, in vivo stability, sustained and targetable delivery, and therapeutic efficiency of numerous pharmaceutical agents. The system predominantly and effectively addresses the aforementioned problems related to the existing formulations, with further advancements in the field of pharmaceutical sciences and technology. In this chapter, NSs are scrutinized as novel nanocarrier and adjuncts, with an all-inclusive focus on the characte...
The rheological behaviour of enzyme clarified Lime (Citrus aurontifolia L.) juice was studied as ... more The rheological behaviour of enzyme clarified Lime (Citrus aurontifolia L.) juice was studied as a function of the total soluble solid (TSS) content (7.3–55.7°Brix), corresponding water activity (a<sub>w</sub>) (0.985–0.831) at different temperatures (20–80<sup>o</sup>C) using co-axial controlled stress rheometer. The rheological parameter shear stress was measured up to the shear rate of 600 s<sup>–1</sup>. The investigation showed that the enzyme clarified lime juice and its concentrate behaved like a Newtonian fluid with the viscosity (η) being in the range 3.964 to 50.290 mPa s depending upon the concentration and temperature used. The temperature dependency on the viscosity of lime juice was described by Arrhenius equation (r > 0.99) and the activation energy (E<sub>a</sub>) of viscous flow was in the range 4.151 to 26.050 kJ/mol depending upon the total soluble solids content. The effect of tota...
Uploads
Papers by shringari manjunatha