Amaç: Süregen günlük baş ağrısında az araştırılmış bir konu olan psikiyatrik komorbiditenin yaygı... more Amaç: Süregen günlük baş ağrısında az araştırılmış bir konu olan psikiyatrik komorbiditenin yaygınlığını araştırmayı amaçladık. Yöntem: Süregen günlük baş ağrılı 115 hasta çalışmaya alındı. Psikiyatrik değerlendirme DSM-IV eksen I bozuklukları için yapılandırılmış klinik görüşme kılavuzuna ...
Journal of the Turkish-German Gynecological Association, 2009
Most patients with drug-induced hyponatraemia are asymptomatic and the diagnosis is made incident... more Most patients with drug-induced hyponatraemia are asymptomatic and the diagnosis is made incidentally following routine blood tests. Mild cases may be managed either by stopping the drug or by careful observation if the drug is considered essential. Severe hyponatremia (serum sodium levels less than 120 mmol/l) is associated with increased morbidity and mortality (confusion, convulsions, coma, congestive heart failure e.g.). We present a case of severe water intoxication with convulsion and prolonged coma, following the use of a high dose syntocinon infusion. A 22-year-old female who has intrauterine anencephalic fetus was refered to our hospital. Intravenous oxytocin was used to induce first-trimester abortion, eight hours later generalized tonic-clonic seizures occured and coma followed. Hyponatremia was found as the cause and treated by intravenous infusion of hypertonic 3% NaCl. The patient recovered and no seizure observed on follow-up. The central nervous system manifestations...
Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2004
OBJECTIVE Systemic lupus erythematosus (SLE) with leptomeningeal involvement is a rare condition.... more OBJECTIVE Systemic lupus erythematosus (SLE) with leptomeningeal involvement is a rare condition. We report a case in a 17-year-old woman. CLINICAL PRESENTATION AND INTERVENTION The patient was admitted to hospital with the complaints of vertigo, nausea, vomiting, headache, diplopia, ptosis on the left and weakness of the left leg. A diagnosis of SLE was established, with diffuse leptomeningeal involvement demonstrated by cranial magnetic resonance imaging. When treated with steroids, the clinical problems resolved almost completely. CONCLUSIONS Although rare, leptomeningeal involvement can complicate SLE. Cranial magnetic imaging can demonstrate tissue involvement. The condition responds to steroid therapy.
INTRODUCTION Epilepsy is a chronic neurological disorder that is treated with multiple medication... more INTRODUCTION Epilepsy is a chronic neurological disorder that is treated with multiple medications that can have significant side effects. This study investigated the potential effects of antiepileptic drugs on thyroid function. METHODS The participants in this study were epileptic adults who had been consistently monitored in follow-up care. The effects of antiepileptic drugs on the serum levels of the thyroid stimulating hormone (TSH), free T3 (fT3), and free T4 (fT4) of these patients were investigated retrospectively by comparing laboratory recordings in three defined periods: prior to antiepileptic drug treatment, between 6 months and 1 year of treatment (early stage), and after 1 year of treatment (late stage). RESULTS A total of 300 epileptic patients (F/M: 175/125) were included in the study. Significant differences in TSH and fT4 serum levels in the late stage compared to the pre-treatment stage (p = 0.006 and p = 0.0005, respectively) were found. TSH values in the late stage of treatment were abnormally high in one case and low in five cases; all six of these cases had normal pre-treatment and early-stage TSH values. Patients who received monotherapy with valproic acid, levetiracetam or carbamazepine were evaluated separately and there was no statistically significant difference in TSH and fT3 levels, while fT4 levels were significantly increased during treatment in each treatment group. CONCLUSIONS A significant increase in TSH levels was found in epileptic patients on polytherapy. Our results give us the opportunity to highlight the potential unique or cumulative effect of antiepileptic drugs on thyroid hormone levels.
The authors report a patient who was diagnosed with idiopathic orbital myositis based on the find... more The authors report a patient who was diagnosed with idiopathic orbital myositis based on the findings of diplopia, worse on right gaze, globe retraction on adduction and injection at the lateral muscle tendon insertion of the left eye. Although orbital myositis as a cause of acquired retraction of the eye is rare, they wish to emphasize the importance of globe retraction with injection over the recti as an important clue for the diagnosis of orbital myositis.
Les comites d’ethique sont-ils suffisants ? resultats d’une etude pilote en TurquieLa situation a... more Les comites d’ethique sont-ils suffisants ? resultats d’une etude pilote en TurquieLa situation actuelle de 49 comites d’ethique en Turquie a ete etudiee. Un questionnaire mis au point par le Conseil Europeen en 1997 a ete traduit et utilise pour la collecte de donnees. Ces donnees sont discutees sous leurs aspects structurels et fonctionnels. Les constatations indiquent qu’il existe des differences majeures entre les comites d’ethique.
BACKGROUND Iron accumulation in substantia nigra pars compacta (SNpc) and related intensity and v... more BACKGROUND Iron accumulation in substantia nigra pars compacta (SNpc) and related intensity and volumetric changes in patients with idiopathic Parkinson's disease (PD) has been reported previously. There are only a few studies evaluating the relation between neuroradiological findings and clinical scores, with contradictory results. AIMS In this study we aimed to measure the iron-rich brain areas of PD patients and healthy subjects with T2-weighted magnetic resonance imaging (MRI) and to evaluate the relation between the clinical scores of PD patients and these imaging results. METHODS AND MATERIALS T2-weighted MRI findings were studied in 20 patients with PD and 16 healthy controls. The width of SNpc, putamen volume, and the intensity of the basal ganglia were measured. Unified Parkinson's Disease Rating Scale (UPDRS) was used for evaluating the clinical status. STATISTICAL ANALYSES Mann Whitney U test for group comparisons, Wilcoxon sign rank test for comparisons within th...
Les comites d’ethique sont-ils suffisants ? resultats d’une etude pilote en TurquieLa situation a... more Les comites d’ethique sont-ils suffisants ? resultats d’une etude pilote en TurquieLa situation actuelle de 49 comites d’ethique en Turquie a ete etudiee. Un questionnaire mis au point par le Conseil Europeen en 1997 a ete traduit et utilise pour la collecte de donnees. Ces donnees sont discutees sous leurs aspects structurels et fonctionnels. Les constatations indiquent qu’il existe des differences majeures entre les comites d’ethique.
We aimed to evaluate nerve conduction studies and gastrocnemius H reflex responses in rheumatoid ... more We aimed to evaluate nerve conduction studies and gastrocnemius H reflex responses in rheumatoid arthritis (RA) patients and compared to the healthy adult subjects. Twenty-six RA patients and twenty-two healthy adult subjects were included in the study. The nerve conduction study (NCS) findings and bilateral gastrocnemius H reflex responses were evaluated in all the groups. Age, gender, subcutaneous nodules, joint deformities, laboratory parameters, duration of disease, anti-rheumatic drug and steroid usage were recorded. Activity of disease was assessed using a 28-joint disease activity score (DAS28).The functional status was measured using the health assessment questionnaire (HAQ), pain intensity measured using a visual analog scale (VAS). The rate of electroneuromyographic (ENMG) abnormalities was 73% in RA patients. The most common diagnosis was carpal tunnel syndrome (61.4%). There were no significant correlations between ENMG findings and clinical and laboratory features evalu...
Amaç: Süregen günlük baş ağrısında az araştırılmış bir konu olan psikiyatrik komorbiditenin yaygı... more Amaç: Süregen günlük baş ağrısında az araştırılmış bir konu olan psikiyatrik komorbiditenin yaygınlığını araştırmayı amaçladık. Yöntem: Süregen günlük baş ağrılı 115 hasta çalışmaya alındı. Psikiyatrik değerlendirme DSM-IV eksen I bozuklukları için yapılandırılmış klinik görüşme kılavuzuna ...
Journal of the Turkish-German Gynecological Association, 2009
Most patients with drug-induced hyponatraemia are asymptomatic and the diagnosis is made incident... more Most patients with drug-induced hyponatraemia are asymptomatic and the diagnosis is made incidentally following routine blood tests. Mild cases may be managed either by stopping the drug or by careful observation if the drug is considered essential. Severe hyponatremia (serum sodium levels less than 120 mmol/l) is associated with increased morbidity and mortality (confusion, convulsions, coma, congestive heart failure e.g.). We present a case of severe water intoxication with convulsion and prolonged coma, following the use of a high dose syntocinon infusion. A 22-year-old female who has intrauterine anencephalic fetus was refered to our hospital. Intravenous oxytocin was used to induce first-trimester abortion, eight hours later generalized tonic-clonic seizures occured and coma followed. Hyponatremia was found as the cause and treated by intravenous infusion of hypertonic 3% NaCl. The patient recovered and no seizure observed on follow-up. The central nervous system manifestations...
Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2004
OBJECTIVE Systemic lupus erythematosus (SLE) with leptomeningeal involvement is a rare condition.... more OBJECTIVE Systemic lupus erythematosus (SLE) with leptomeningeal involvement is a rare condition. We report a case in a 17-year-old woman. CLINICAL PRESENTATION AND INTERVENTION The patient was admitted to hospital with the complaints of vertigo, nausea, vomiting, headache, diplopia, ptosis on the left and weakness of the left leg. A diagnosis of SLE was established, with diffuse leptomeningeal involvement demonstrated by cranial magnetic resonance imaging. When treated with steroids, the clinical problems resolved almost completely. CONCLUSIONS Although rare, leptomeningeal involvement can complicate SLE. Cranial magnetic imaging can demonstrate tissue involvement. The condition responds to steroid therapy.
INTRODUCTION Epilepsy is a chronic neurological disorder that is treated with multiple medication... more INTRODUCTION Epilepsy is a chronic neurological disorder that is treated with multiple medications that can have significant side effects. This study investigated the potential effects of antiepileptic drugs on thyroid function. METHODS The participants in this study were epileptic adults who had been consistently monitored in follow-up care. The effects of antiepileptic drugs on the serum levels of the thyroid stimulating hormone (TSH), free T3 (fT3), and free T4 (fT4) of these patients were investigated retrospectively by comparing laboratory recordings in three defined periods: prior to antiepileptic drug treatment, between 6 months and 1 year of treatment (early stage), and after 1 year of treatment (late stage). RESULTS A total of 300 epileptic patients (F/M: 175/125) were included in the study. Significant differences in TSH and fT4 serum levels in the late stage compared to the pre-treatment stage (p = 0.006 and p = 0.0005, respectively) were found. TSH values in the late stage of treatment were abnormally high in one case and low in five cases; all six of these cases had normal pre-treatment and early-stage TSH values. Patients who received monotherapy with valproic acid, levetiracetam or carbamazepine were evaluated separately and there was no statistically significant difference in TSH and fT3 levels, while fT4 levels were significantly increased during treatment in each treatment group. CONCLUSIONS A significant increase in TSH levels was found in epileptic patients on polytherapy. Our results give us the opportunity to highlight the potential unique or cumulative effect of antiepileptic drugs on thyroid hormone levels.
The authors report a patient who was diagnosed with idiopathic orbital myositis based on the find... more The authors report a patient who was diagnosed with idiopathic orbital myositis based on the findings of diplopia, worse on right gaze, globe retraction on adduction and injection at the lateral muscle tendon insertion of the left eye. Although orbital myositis as a cause of acquired retraction of the eye is rare, they wish to emphasize the importance of globe retraction with injection over the recti as an important clue for the diagnosis of orbital myositis.
Les comites d’ethique sont-ils suffisants ? resultats d’une etude pilote en TurquieLa situation a... more Les comites d’ethique sont-ils suffisants ? resultats d’une etude pilote en TurquieLa situation actuelle de 49 comites d’ethique en Turquie a ete etudiee. Un questionnaire mis au point par le Conseil Europeen en 1997 a ete traduit et utilise pour la collecte de donnees. Ces donnees sont discutees sous leurs aspects structurels et fonctionnels. Les constatations indiquent qu’il existe des differences majeures entre les comites d’ethique.
BACKGROUND Iron accumulation in substantia nigra pars compacta (SNpc) and related intensity and v... more BACKGROUND Iron accumulation in substantia nigra pars compacta (SNpc) and related intensity and volumetric changes in patients with idiopathic Parkinson's disease (PD) has been reported previously. There are only a few studies evaluating the relation between neuroradiological findings and clinical scores, with contradictory results. AIMS In this study we aimed to measure the iron-rich brain areas of PD patients and healthy subjects with T2-weighted magnetic resonance imaging (MRI) and to evaluate the relation between the clinical scores of PD patients and these imaging results. METHODS AND MATERIALS T2-weighted MRI findings were studied in 20 patients with PD and 16 healthy controls. The width of SNpc, putamen volume, and the intensity of the basal ganglia were measured. Unified Parkinson's Disease Rating Scale (UPDRS) was used for evaluating the clinical status. STATISTICAL ANALYSES Mann Whitney U test for group comparisons, Wilcoxon sign rank test for comparisons within th...
Les comites d’ethique sont-ils suffisants ? resultats d’une etude pilote en TurquieLa situation a... more Les comites d’ethique sont-ils suffisants ? resultats d’une etude pilote en TurquieLa situation actuelle de 49 comites d’ethique en Turquie a ete etudiee. Un questionnaire mis au point par le Conseil Europeen en 1997 a ete traduit et utilise pour la collecte de donnees. Ces donnees sont discutees sous leurs aspects structurels et fonctionnels. Les constatations indiquent qu’il existe des differences majeures entre les comites d’ethique.
We aimed to evaluate nerve conduction studies and gastrocnemius H reflex responses in rheumatoid ... more We aimed to evaluate nerve conduction studies and gastrocnemius H reflex responses in rheumatoid arthritis (RA) patients and compared to the healthy adult subjects. Twenty-six RA patients and twenty-two healthy adult subjects were included in the study. The nerve conduction study (NCS) findings and bilateral gastrocnemius H reflex responses were evaluated in all the groups. Age, gender, subcutaneous nodules, joint deformities, laboratory parameters, duration of disease, anti-rheumatic drug and steroid usage were recorded. Activity of disease was assessed using a 28-joint disease activity score (DAS28).The functional status was measured using the health assessment questionnaire (HAQ), pain intensity measured using a visual analog scale (VAS). The rate of electroneuromyographic (ENMG) abnormalities was 73% in RA patients. The most common diagnosis was carpal tunnel syndrome (61.4%). There were no significant correlations between ENMG findings and clinical and laboratory features evalu...
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