Mikania cordata is a fast growing perennial vine that is pantropic in distribution and is commonl... more Mikania cordata is a fast growing perennial vine that is pantropic in distribution and is commonly found everywhere. Different organs of the plant were documented used traditionally for healing open wounds on animal bites and other forms of lacerations. Its wound healing property is often ascribed to its believed ability to cleanse or disinfect wounds, to inhibit inflammation, and to stop bleeding. The floral organ, however, is poorly documented to date, which is why this study was conducted to determine the phytochemical constituents of its inflorescence and its cytotoxicity, anti-inflammatory and thrombolytic properties. Thin Layer Chromatography revealed that the flower of M. cordata has essential oils, sterols, phenols, anthraquinones, coumarins, anthrones, flavonoids, tannins, and alkaloids. The Brine Shrimp Lethality Assay yielded an LC50 at 24 hours of 5961ppm, which is considered non-toxic because it is way above the critical concentration for toxicity that is 1000ppm. The Human Red Blood Cell Membrane Stabilization Assay resulted to a % lysis inhibition of 39.45% at 500ppm, which is much lower than that of the diclofenac (66.44%): the % inhibition of lysis however appears to be dose-dependent. The in vitro thrombolytic activity assay showed that the clot lysis percentage of M. cordata extract (22.65%) is comparable to that of Aspirin (24.6%) at 10000ppm. Generally, the ethanolic extract of the flower of M. cordata has a wide array of secondary metabolites, it is non-toxic, it has little anti-inflammatory property, and it has mild thrombolytic activity.
Mikania cordata is a fast growing perennial vine that is pantropic in distribution and is commonl... more Mikania cordata is a fast growing perennial vine that is pantropic in distribution and is commonly found everywhere. Different organs of the plant were documented used traditionally for healing open wounds on animal bites and other forms of lacerations. Its wound healing property is often ascribed to its believed ability to cleanse or disinfect wounds, to inhibit inflammation, and to stop bleeding. The floral organ, however, is poorly documented to date, which is why this study was conducted to determine the phytochemical constituents of its inflorescence and its cytotoxicity, anti-inflammatory and thrombolytic properties. Thin Layer Chromatography revealed that the flower of M. cordata has essential oils, sterols, phenols, anthraquinones, coumarins, anthrones, flavonoids, tannins, and alkaloids. The Brine Shrimp Lethality Assay yielded an LC50 at 24 hours of 5961ppm, which is considered non-toxic because it is way above the critical concentration for toxicity that is 1000ppm. The Human Red Blood Cell Membrane Stabilization Assay resulted to a % lysis inhibition of 39.45% at 500ppm, which is much lower than that of the diclofenac (66.44%): the % inhibition of lysis however appears to be dose-dependent. The in vitro thrombolytic activity assay showed that the clot lysis percentage of M. cordata extract (22.65%) is comparable to that of Aspirin (24.6%) at 10000ppm. Generally, the ethanolic extract of the flower of M. cordata has a wide array of secondary metabolites, it is non-toxic, it has little anti-inflammatory property, and it has mild thrombolytic activity.
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