This study aims to modify alginate with sodium dodecyl sulfate (SDS) to reduce the release of ora... more This study aims to modify alginate with sodium dodecyl sulfate (SDS) to reduce the release of oral protein in the acidic stomach environment and transport it to the colon medium. Bovine serum albumin (BSA), which was chosen as a model protein, was loaded into surfactant modified calcium alginate beads (SDS/Ca-Alg). The encapsulation efficiency of BSA in SDS/Ca-Alg beads was found significantly higher (96.3%) compared to that of beads without SDS. The most remarkable result is that protein release from the modified gel in the stomach environment was significantly reduced compared to protein release from the plain alginate gel. At the same time, the release time of the whole drug in the intestinal environment was significantly prolonged. The SDS-modified alginate beads are proposed as suitable carriers for the passage of orally taken protein-type drugs into the colon medium by preventing their degradation in acidic gastric fluid.
ABSTRACT A capillary zone electrophoresis (CZE) method for the simultaneous assay of bromide, iod... more ABSTRACT A capillary zone electrophoresis (CZE) method for the simultaneous assay of bromide, iodide, nitrite, nitrate, and thiocyanate using direct UV detection is reported. The method is based on the separation of anions in a capillary coated with a cationic polymer, polyethyleneimine (PEI). The minimum detection limits, reproducibility of peak areas, and migration times were determined at the optimal condition. The method was applied to the analysis of tap water and human urine. The changes in separation selectivity of the anions resulting from addition of the cationic polymer to the buffer were investigated.
Journal of Bioactive and Compatible Polymers, 2015
This work describes the in vitro release of a small drug, riboflavin, from novel calcium and bari... more This work describes the in vitro release of a small drug, riboflavin, from novel calcium and barium crosslinked alginate–montmorillonite composite beads via oral route. Effect of crosslinking cation, concentration of montmorillonite and media on encapsulation efficiencies, and release profiles of riboflavin were studied. Beads were characterized using gravimetric swelling ability study, Fourier transform infrared spectroscopy, and scanning electron microscopy. Results indicate that addition of montmorillonite increases the encapsulation efficiencies and slows down the release rates significantly.
International journal of biological macromolecules, Jan 2, 2016
This paper addresses the controlled variation of the mechanical properties of alginate gel beads ... more This paper addresses the controlled variation of the mechanical properties of alginate gel beads by changing the alginate concentration or by adding different surfactants or cross-linking cations. Alginate beads containing nonionic Brij 35 or anionic sodium dodecyl sulfate (SDS) surfactants were prepared with two different types of cations (Ca(2+), Ba(2+)) as crosslinkers. Compression measurements were performed to investigate the effect of the surfactant and cation types and their concentrations on the Young's modulus of alginate beads. The Young's modulus was determined by using Hertz theory. For all types of alginate gel beads the Young's modulus showed an increasing value for increasing alginate contents. Addition of the anionic surfactant SDS increases the Young's modulus of the alginate beads while the addition of non-ionic surfactant Brij 35 leads to a decrease in Young's modulus. This opposite behavior is related to the contrary effect of both surfactants...
Journal of agricultural and food chemistry, Jan 26, 2015
The aim of this study was to investigate the effect of solid-state fermentation (SSF) by Aspergil... more The aim of this study was to investigate the effect of solid-state fermentation (SSF) by Aspergillus niger on phenolic contents and antioxidant activity in Sambucus nigra L. and Sambucus ebulus L. berry pomaces. The effect of fermentation time on the total fats and major lipid classes (neutral and polar) was also investigated. During the SSF, the extractable phenolics increased with 18.82% for S. ebulus L. and 11.11% for S. nigra L. The levels of antioxidant activity of methanolic extracts were also significantly enhanced. The HPLC-MS analysis indicated that the cyanidin 3-sambubioside-5-glucoside is the major phenolic compound in both fermented Sambucus fruit residues. In the early stages of fungal growth, the extracted oils (with TAGs as major lipid fraction) increased with 12% for S. nigra L. and 10.50% for S. ebulus L. The GC-MS analysis showed that the SSF resulted in a slight increase of the linoleic and oleic acids level.
We report in the present paper the result of our potentiometric studies on the complexation tende... more We report in the present paper the result of our potentiometric studies on the complexation tendency of phenolate anion with divalent manganese, cobalt, nickel, and copper ions in aqueous sodium pperchlorate solutions of 0.1 M ionic strenght at 25.0°
ABSTRACT The use of polyethyleneimine-coated capillaries for the capillary electrophoretic separa... more ABSTRACT The use of polyethyleneimine-coated capillaries for the capillary electrophoretic separation of substituted phenols has been demonstrated. Efficient separation of phenols has been achieved in the coated capillaries.
This study aims to modify alginate with sodium dodecyl sulfate (SDS) to reduce the release of ora... more This study aims to modify alginate with sodium dodecyl sulfate (SDS) to reduce the release of oral protein in the acidic stomach environment and transport it to the colon medium. Bovine serum albumin (BSA), which was chosen as a model protein, was loaded into surfactant modified calcium alginate beads (SDS/Ca-Alg). The encapsulation efficiency of BSA in SDS/Ca-Alg beads was found significantly higher (96.3%) compared to that of beads without SDS. The most remarkable result is that protein release from the modified gel in the stomach environment was significantly reduced compared to protein release from the plain alginate gel. At the same time, the release time of the whole drug in the intestinal environment was significantly prolonged. The SDS-modified alginate beads are proposed as suitable carriers for the passage of orally taken protein-type drugs into the colon medium by preventing their degradation in acidic gastric fluid.
ABSTRACT A capillary zone electrophoresis (CZE) method for the simultaneous assay of bromide, iod... more ABSTRACT A capillary zone electrophoresis (CZE) method for the simultaneous assay of bromide, iodide, nitrite, nitrate, and thiocyanate using direct UV detection is reported. The method is based on the separation of anions in a capillary coated with a cationic polymer, polyethyleneimine (PEI). The minimum detection limits, reproducibility of peak areas, and migration times were determined at the optimal condition. The method was applied to the analysis of tap water and human urine. The changes in separation selectivity of the anions resulting from addition of the cationic polymer to the buffer were investigated.
Journal of Bioactive and Compatible Polymers, 2015
This work describes the in vitro release of a small drug, riboflavin, from novel calcium and bari... more This work describes the in vitro release of a small drug, riboflavin, from novel calcium and barium crosslinked alginate–montmorillonite composite beads via oral route. Effect of crosslinking cation, concentration of montmorillonite and media on encapsulation efficiencies, and release profiles of riboflavin were studied. Beads were characterized using gravimetric swelling ability study, Fourier transform infrared spectroscopy, and scanning electron microscopy. Results indicate that addition of montmorillonite increases the encapsulation efficiencies and slows down the release rates significantly.
International journal of biological macromolecules, Jan 2, 2016
This paper addresses the controlled variation of the mechanical properties of alginate gel beads ... more This paper addresses the controlled variation of the mechanical properties of alginate gel beads by changing the alginate concentration or by adding different surfactants or cross-linking cations. Alginate beads containing nonionic Brij 35 or anionic sodium dodecyl sulfate (SDS) surfactants were prepared with two different types of cations (Ca(2+), Ba(2+)) as crosslinkers. Compression measurements were performed to investigate the effect of the surfactant and cation types and their concentrations on the Young's modulus of alginate beads. The Young's modulus was determined by using Hertz theory. For all types of alginate gel beads the Young's modulus showed an increasing value for increasing alginate contents. Addition of the anionic surfactant SDS increases the Young's modulus of the alginate beads while the addition of non-ionic surfactant Brij 35 leads to a decrease in Young's modulus. This opposite behavior is related to the contrary effect of both surfactants...
Journal of agricultural and food chemistry, Jan 26, 2015
The aim of this study was to investigate the effect of solid-state fermentation (SSF) by Aspergil... more The aim of this study was to investigate the effect of solid-state fermentation (SSF) by Aspergillus niger on phenolic contents and antioxidant activity in Sambucus nigra L. and Sambucus ebulus L. berry pomaces. The effect of fermentation time on the total fats and major lipid classes (neutral and polar) was also investigated. During the SSF, the extractable phenolics increased with 18.82% for S. ebulus L. and 11.11% for S. nigra L. The levels of antioxidant activity of methanolic extracts were also significantly enhanced. The HPLC-MS analysis indicated that the cyanidin 3-sambubioside-5-glucoside is the major phenolic compound in both fermented Sambucus fruit residues. In the early stages of fungal growth, the extracted oils (with TAGs as major lipid fraction) increased with 12% for S. nigra L. and 10.50% for S. ebulus L. The GC-MS analysis showed that the SSF resulted in a slight increase of the linoleic and oleic acids level.
We report in the present paper the result of our potentiometric studies on the complexation tende... more We report in the present paper the result of our potentiometric studies on the complexation tendency of phenolate anion with divalent manganese, cobalt, nickel, and copper ions in aqueous sodium pperchlorate solutions of 0.1 M ionic strenght at 25.0°
ABSTRACT The use of polyethyleneimine-coated capillaries for the capillary electrophoretic separa... more ABSTRACT The use of polyethyleneimine-coated capillaries for the capillary electrophoretic separation of substituted phenols has been demonstrated. Efficient separation of phenols has been achieved in the coated capillaries.
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