The objective of this open trial was to investigate the efficacy and safety of the 3-hydroxy-3-me... more The objective of this open trial was to investigate the efficacy and safety of the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor fluvastatin in hypercholesterolemic patients already receiving probucol. All of the participants had hypercholesterolemia. i.e. serum total cholesterol > or = 220 mg/dl, despite administration of probucol, 500 mg/day, for more than 4 weeks. After this, fluvastatin, 30 mg/day, was added to probucol treatment for 12 weeks. Twenty-seven patients were recruited into this study; all were evaluated for safety, and 22 were evaluated for efficacy. The addition of fluvastatin to the probucol regimen produced a significant further reduction in serum total and low-density lipoprotein cholesterol concentrations (of 18 and 20%, respectively; p < 0.001); these effects were fully established within 4 weeks of treatment and were maintained throughout the treatment. Fluvastatin did not affect the serum high-density lipoprotein cholesterol concentration. Fluvastatin treatment decreased serum triglyceride concentrations slightly in all patients (not significant); in patients with hypertriglyceridemia, triglyceride levels were decreased significantly by 34% (p < 0.01; serum triglycerides > or = 150 mg/dl). In addition, fluvastatin significantly decreased serum apolipoprotein B, C-II, C-III and E levels, whereas serum apolipoprotein A-I and A-II levels were unaffected. One patient complained of slight abdominal discomfort during fluvastatin administration, but relationship to fluvastatin remains unclear. One patient had slight elevation of the serum alanine aminotransferase level, and another patient had an elevated gamma-glutamyl transferase level. The addition of fluvastatin to probucol treatment can be considered to be an effective and well tolerated treatment in hypercholesterolemic patients.
La Idea De America En El Pensamiento Ius Internacionalista Del Siglo Xx Estudios a Proposito De La Conmemoracion De Los Bicentenarios De Las Independencias De Las Republicas Latinoamericanas 2010 Isbn 978 84 9911 078 3 Pags 109 124, 2010
ABSTRACT Objectives Evaluate the usefulness of multilevel analysis applied to satisfaction survey... more ABSTRACT Objectives Evaluate the usefulness of multilevel analysis applied to satisfaction surveys to assess the ambulatory care offered by the Clinical Units and Medical Specialties.Methods Telephone surveys were conducted on 6,922 patients seen in outpatient visits in the Navarra Health System in order to assess 94 Clinical Units and 37 Medical Specialties. A hierarchical analysis was then performed at 3 levels (patients, Clinical Units and Medical Specialties).ResultsThe patient explained between 91.7% and 99.3% of the variability in the satisfaction survey scores. The patient perception of service quality also depends of the clinical unit, in 18 out of 20 items analysed, the variance related to the Clinical Unit was statistically significant, and ranged from 0.9% and 8.3%. The Medical Specialty explained 4.2% of the variability in only one item. Patients aged under 65 years, patients seen in first visit, and those who were seen at tertiary hospitals gave the lowest scores.Conclusions Multilevel analysis is a useful tool to analyse and compare satisfaction survey results, as it can correctly distinguish the different Clinical Units of a health service, and this is a key element in the management of these Units. Moreover, it gives the percentage of variability due to each level and which variables predict the quality of service obtained.
Page 1. 329 MODELING A PROJECT SCOPE USING A CASE-BASED REASONING APPROACH Alfredo F. Serpell, Jo... more Page 1. 329 MODELING A PROJECT SCOPE USING A CASE-BASED REASONING APPROACH Alfredo F. Serpell, José M. Rueda Department of Construction Engineering and Management, Universidad Católica de Chile, Chile ...
A probabilistic seismic hazard analysis (PSHA) for mainland Spain that takes into account recent ... more A probabilistic seismic hazard analysis (PSHA) for mainland Spain that takes into account recent new results in seismicity, seismic zoning and strong ground attenuation no considered in the previous PSHAs studies published is presented. Those new input data has been obtained by us as a three steep project carried out in order to get a new hazard map for mainland
The objective of this open trial was to investigate the efficacy and safety of the 3-hydroxy-3-me... more The objective of this open trial was to investigate the efficacy and safety of the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor fluvastatin in hypercholesterolemic patients already receiving probucol. All of the participants had hypercholesterolemia. i.e. serum total cholesterol > or = 220 mg/dl, despite administration of probucol, 500 mg/day, for more than 4 weeks. After this, fluvastatin, 30 mg/day, was added to probucol treatment for 12 weeks. Twenty-seven patients were recruited into this study; all were evaluated for safety, and 22 were evaluated for efficacy. The addition of fluvastatin to the probucol regimen produced a significant further reduction in serum total and low-density lipoprotein cholesterol concentrations (of 18 and 20%, respectively; p < 0.001); these effects were fully established within 4 weeks of treatment and were maintained throughout the treatment. Fluvastatin did not affect the serum high-density lipoprotein cholesterol concentration. Fluvastatin treatment decreased serum triglyceride concentrations slightly in all patients (not significant); in patients with hypertriglyceridemia, triglyceride levels were decreased significantly by 34% (p < 0.01; serum triglycerides > or = 150 mg/dl). In addition, fluvastatin significantly decreased serum apolipoprotein B, C-II, C-III and E levels, whereas serum apolipoprotein A-I and A-II levels were unaffected. One patient complained of slight abdominal discomfort during fluvastatin administration, but relationship to fluvastatin remains unclear. One patient had slight elevation of the serum alanine aminotransferase level, and another patient had an elevated gamma-glutamyl transferase level. The addition of fluvastatin to probucol treatment can be considered to be an effective and well tolerated treatment in hypercholesterolemic patients.
La Idea De America En El Pensamiento Ius Internacionalista Del Siglo Xx Estudios a Proposito De La Conmemoracion De Los Bicentenarios De Las Independencias De Las Republicas Latinoamericanas 2010 Isbn 978 84 9911 078 3 Pags 109 124, 2010
ABSTRACT Objectives Evaluate the usefulness of multilevel analysis applied to satisfaction survey... more ABSTRACT Objectives Evaluate the usefulness of multilevel analysis applied to satisfaction surveys to assess the ambulatory care offered by the Clinical Units and Medical Specialties.Methods Telephone surveys were conducted on 6,922 patients seen in outpatient visits in the Navarra Health System in order to assess 94 Clinical Units and 37 Medical Specialties. A hierarchical analysis was then performed at 3 levels (patients, Clinical Units and Medical Specialties).ResultsThe patient explained between 91.7% and 99.3% of the variability in the satisfaction survey scores. The patient perception of service quality also depends of the clinical unit, in 18 out of 20 items analysed, the variance related to the Clinical Unit was statistically significant, and ranged from 0.9% and 8.3%. The Medical Specialty explained 4.2% of the variability in only one item. Patients aged under 65 years, patients seen in first visit, and those who were seen at tertiary hospitals gave the lowest scores.Conclusions Multilevel analysis is a useful tool to analyse and compare satisfaction survey results, as it can correctly distinguish the different Clinical Units of a health service, and this is a key element in the management of these Units. Moreover, it gives the percentage of variability due to each level and which variables predict the quality of service obtained.
Page 1. 329 MODELING A PROJECT SCOPE USING A CASE-BASED REASONING APPROACH Alfredo F. Serpell, Jo... more Page 1. 329 MODELING A PROJECT SCOPE USING A CASE-BASED REASONING APPROACH Alfredo F. Serpell, José M. Rueda Department of Construction Engineering and Management, Universidad Católica de Chile, Chile ...
A probabilistic seismic hazard analysis (PSHA) for mainland Spain that takes into account recent ... more A probabilistic seismic hazard analysis (PSHA) for mainland Spain that takes into account recent new results in seismicity, seismic zoning and strong ground attenuation no considered in the previous PSHAs studies published is presented. Those new input data has been obtained by us as a three steep project carried out in order to get a new hazard map for mainland
MODELACION DE ACCION VIENTO Y NIEVE SOBRE ESTRUCTURAS EN CASO DE CLIMAS EXTREMOS, 2022
Se llevó a cabo una modelación de acción dinámica viento y nieve en conjunto. Tomando como base d... more Se llevó a cabo una modelación de acción dinámica viento y nieve en conjunto. Tomando como base de la modelación una estructura en la Antártida (Base Marambio). Se utilizó el software ANSYS, en especial el Fluent 2020 R2. Como resultado del modelo se puede observar que la acción de viento y nieve en conjunto no cumple con la relación lineal que establecen las normas (ASCE-7, CIRSOC), se observa a partir de los resultados de modelo que no se debe utilizar una función lineal para superponer los efectos de viento y nieve.
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