Hyperhomocysteinemia is a risk factor for thrombosis, and methylenetetrahydrofolate reductase (MT... more Hyperhomocysteinemia is a risk factor for thrombosis, and methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) polymorphisms, folate, and B12 levels could contribute to plasma homocysteine (Hcy) variation. Although well established in adults, few studies have been performed in childhood. In this study, we investigated association of polymorphisms C677T and A1298C in the MTHFR gene and A66G in the MTRR gene with Hcy levels in children. These polymorphisms, as well as Hcy, folate, and vitamin B12 levels were investigated in 220 normal children with ages ranging from 1 to 8 years. Plasma Hcy, folate, and vitamin B12 levels were normal in all children. None of the polymorphisms could be considered an independent risk factor for hyperhomocysteinemia during childhood. The median Hcy levels in 37 children (17%) doubly heterozygous for C677T and A1298C mutations in the MTHFR gene were not different from the other genotypes. However, the association of the different genotypes with Hcy, folate, and vitamin B12 levels demonstrated significant P-values. The folate levels demonstrated a statistically significant decrease (P = 0.0477) from the C677T mutation in the MTHFR gene (TT genotype) when compared to the other groups. Folate was the only independent risk factor for hyperhomocysteinemia. Thus, monitoring the concentrations of folate would be more helpful for evaluating hyperhomocysteinemia and for preventing cardiovascular disease.
The efficient movement of users and goods is the primary purpose of the surface transportation sy... more The efficient movement of users and goods is the primary purpose of the surface transportation system. Roadway traffic crashes have devastating impacts on quality of life of the users as well as health of the system. While researchers are utilizing advanced computing and communication tools to reduce number of crashes on the roadways, there is still an absence of appropriate method to evaluate the safety performances of these advanced technologies in the planning stage. Development of crash modification factors (CMFs) is a standard method to evaluate the safety effect of proposed countermeasures. Though, the current practices of developing CMFs are not efficient and cost-effective in case of addressing impacts of Intelligent Transportation System (ITS) countermeasures. This study demonstrated a proof of concept of simulation-based framework for determining CMFs for ITS countermeasures. The proposed framework includes the application of traffic microsimulation model and Surrogate Saf...
No-notice evacuations of metropolitan areas can place significant demands on transportation infra... more No-notice evacuations of metropolitan areas can place significant demands on transportation infrastructure. Connected vehicle (CV) technology, with real-time vehicle to vehicle and vehicle to infrastructure communications, can help emergency managers to develop efficient and cost-effective traffic management plans for such events. The objectives of this research were to evaluate the impacts of CVs on no-notice evacuations using a case study of a downtown metropolitan area. The microsimulation software VISSIM was used to model the roadway network and the evacuation traffic. The model was built, calibrated, and validated for studying the performance of traffic during the evacuation. The researchers evaluated system performance with different CV penetration rates (from 0 to 30 percent CVs) and measured average speed, average delays, and total delays. The findings suggest significant reductions in total delays when CVs reached a penetration rate of 30 percent, albeit increases in delays...
Hyperhomocysteinemia is a risk factor for thrombosis, and methylenetetrahydrofolate reductase (MT... more Hyperhomocysteinemia is a risk factor for thrombosis, and methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) polymorphisms, folate, and B12 levels could contribute to plasma homocysteine (Hcy) variation. Although well established in adults, few studies have been performed in childhood. In this study, we investigated association of polymorphisms C677T and A1298C in the MTHFR gene and A66G in the MTRR gene with Hcy levels in children. These polymorphisms, as well as Hcy, folate, and vitamin B12 levels were investigated in 220 normal children with ages ranging from 1 to 8 years. Plasma Hcy, folate, and vitamin B12 levels were normal in all children. None of the polymorphisms could be considered an independent risk factor for hyperhomocysteinemia during childhood. The median Hcy levels in 37 children (17%) doubly heterozygous for C677T and A1298C mutations in the MTHFR gene were not different from the other genotypes. However, the association of the different genotypes with Hcy, folate, and vitamin B12 levels demonstrated significant P-values. The folate levels demonstrated a statistically significant decrease (P = 0.0477) from the C677T mutation in the MTHFR gene (TT genotype) when compared to the other groups. Folate was the only independent risk factor for hyperhomocysteinemia. Thus, monitoring the concentrations of folate would be more helpful for evaluating hyperhomocysteinemia and for preventing cardiovascular disease.
The efficient movement of users and goods is the primary purpose of the surface transportation sy... more The efficient movement of users and goods is the primary purpose of the surface transportation system. Roadway traffic crashes have devastating impacts on quality of life of the users as well as health of the system. While researchers are utilizing advanced computing and communication tools to reduce number of crashes on the roadways, there is still an absence of appropriate method to evaluate the safety performances of these advanced technologies in the planning stage. Development of crash modification factors (CMFs) is a standard method to evaluate the safety effect of proposed countermeasures. Though, the current practices of developing CMFs are not efficient and cost-effective in case of addressing impacts of Intelligent Transportation System (ITS) countermeasures. This study demonstrated a proof of concept of simulation-based framework for determining CMFs for ITS countermeasures. The proposed framework includes the application of traffic microsimulation model and Surrogate Saf...
No-notice evacuations of metropolitan areas can place significant demands on transportation infra... more No-notice evacuations of metropolitan areas can place significant demands on transportation infrastructure. Connected vehicle (CV) technology, with real-time vehicle to vehicle and vehicle to infrastructure communications, can help emergency managers to develop efficient and cost-effective traffic management plans for such events. The objectives of this research were to evaluate the impacts of CVs on no-notice evacuations using a case study of a downtown metropolitan area. The microsimulation software VISSIM was used to model the roadway network and the evacuation traffic. The model was built, calibrated, and validated for studying the performance of traffic during the evacuation. The researchers evaluated system performance with different CV penetration rates (from 0 to 30 percent CVs) and measured average speed, average delays, and total delays. The findings suggest significant reductions in total delays when CVs reached a penetration rate of 30 percent, albeit increases in delays...
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