Coccinia grandis L. Voigt, commonly called the ivy gourd, is a perennial herb or a vine found ext... more Coccinia grandis L. Voigt, commonly called the ivy gourd, is a perennial herb or a vine found extensively from Africa to Asia. It is also known as Coccinia indica. The leaves of this plant were used to treat diabetes. The studies showed that the leaves of the plant possess antioxidant properties and produce analgesic, anti-pyretic and antiinflammatory effect in rats. In the methodology, hydroethanolic extract of the dried leaves of Coccinia grandis L. i.e. was prepared and evaluated for solubility and phytochemical studies and finally in-vitro haemolytic, anti arthritic & anti inflammatory activity was carried on.
The present research work involve the development of a bilayer tablet of ciprofloxacin hydrochlor... more The present research work involve the development of a bilayer tablet of ciprofloxacin hydrochloride using a superdisintegranting agent (sodium starch glycolate) for the fast releasing layer and hydrophobic polymers like ethyl cellulose, acrycoat L100 and acrycoat S100 for the delayed releasing layer. Ciprofloxacin was used as a model drug. Tablets were prepared by wet granulation method. The prepared bilayer tablets were evaluated for angle of repose, bulk density, tapped density, Carr’s index, Hausner’s ratio at the precompression stage and thickness variation, weight variation, hardness, friability, drug content, disintegration time, in vitro drug release study at the post compression stage.. In vitro dissolution studies were carried out in a USP 24 apparatus I. In vitro dissolution kinetics followed the Higuchi model via a non-Fickian diffusion controlled release mechanism after the initial burst release. FT-IR studies revealed that there was no interaction between the drug and...
Coccinia grandis L. Voigt, commonly called the ivy gourd, is a perennial herb or a vine found ext... more Coccinia grandis L. Voigt, commonly called the ivy gourd, is a perennial herb or a vine found extensively from Africa to Asia. It is also known as Coccinia indica. The leaves of this plant were used to treat diabetes. The studies showed that the leaves of the plant possess antioxidant properties and produce analgesic, anti-pyretic and antiinflammatory effect in rats. In the methodology, hydroethanolic extract of the dried leaves of Coccinia grandis L. i.e. was prepared and evaluated for solubility and phytochemical studies and finally in-vitro haemolytic, anti arthritic & anti inflammatory activity was carried on.
The present research work involve the development of a bilayer tablet of ciprofloxacin hydrochlor... more The present research work involve the development of a bilayer tablet of ciprofloxacin hydrochloride using a superdisintegranting agent (sodium starch glycolate) for the fast releasing layer and hydrophobic polymers like ethyl cellulose, acrycoat L100 and acrycoat S100 for the delayed releasing layer. Ciprofloxacin was used as a model drug. Tablets were prepared by wet granulation method. The prepared bilayer tablets were evaluated for angle of repose, bulk density, tapped density, Carr’s index, Hausner’s ratio at the precompression stage and thickness variation, weight variation, hardness, friability, drug content, disintegration time, in vitro drug release study at the post compression stage.. In vitro dissolution studies were carried out in a USP 24 apparatus I. In vitro dissolution kinetics followed the Higuchi model via a non-Fickian diffusion controlled release mechanism after the initial burst release. FT-IR studies revealed that there was no interaction between the drug and...
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