Background Oral contraceptives are commonly taken by women and are known to increase the risk of ... more Background Oral contraceptives are commonly taken by women and are known to increase the risk of venous thromboembolism (VTE). Objective The aim of this study was to investigate the association between oral contraceptive use and natural anticoagulants, that is, protein C (PC), protein S (PS), and antithrombin in pregnant women with deep vein thrombosis (DVT). Materials and methods This case–control study was conducted on 330 pregnant women, that is, cases 165 (who used oral contraceptives) and controls 165 (who did not use oral contraceptives). The levels of PC, PS, and antithrombin were measured and compared between the two groups. The use of different types of oral contraceptives and their association with DVT and PC and PS were also analyzed. Results The study found that women with DVT had significantly lower levels of PC and PS compared with controls (P < 0.001). However, no significant difference was found in the levels of AT. Among the different types of oral contraceptives, first-generation progestin pills including Ethynodiol Diacetate, Norethindrone Acetate, Norethynodrel, and second-generation oral contraceptives (Lynestrenol, Levonorgestrel and Norgestrel) were not found to be associated with lower levels of PC and AT while Desogestrel, Norgestimate, and Gestodene (third-generation) were associated with lower levels of PS. Conclusion This study suggests that the use of contraceptives, particularly those containing Desogestrel, Norgestimate, and Gestodene, may be associated with a higher risk of thrombosis because of the associated lower levels of PS. Monitoring anticoagulant levels is crucial in preventing DVT in this population.
TNF–α influences lymphomagenesis by upregulating proinflammatory and antiapoptotic pathways. In t... more TNF–α influences lymphomagenesis by upregulating proinflammatory and antiapoptotic pathways. In this study, we evaluated the frequency of TNF–α rs1800629 (–308 G>A) polymorphism in newly diagnosed adult patients with acute lymphoblastic leukemia (ALL) and its correlation with age at diagnosis, gender and subtype of ALL. In this case control study, a total of 330 individuals were recruited, including 165 newly diagnosed adult patients with ALL, from the Radiation and Isotope Center in Khartoum (RICK) and 165 healthy normal controls. TNF–α rs1800629 polymorphism was tested through allele-specific polymerase chain reaction (PCR) assay. The frequency of the rs1800629 GA genotype was high (70.9% vs. 60%, OR = 1.84) in the patient group as compared to healthy controls, whereas GG and AA genotypes did not exhibit any statistically significant difference between controls and patients. Based on subtype, GG and GA rs1800629 genotypes showed increased risk of B-ALL (OR 0.46 and 2.12, respec...
Venous thromboembolism (VTE) is one of the major causes of pregnancy-related mortality and morbid... more Venous thromboembolism (VTE) is one of the major causes of pregnancy-related mortality and morbidity. This study aimed to determine the frequency of factor V Leiden (FVL) and prothrombin G20210A polymorphisms and measure the plasma levels of protein C (PC), protein S (PS) and antithrombin (AT) in pregnant women with VTE and healthy pregnant women. This prospective case-control study determined the frequencies of FVL G1691A and prothrombin G20210A polymorphisms and measured the plasma levels of PC, PS and AT in 198 pregnant women with VTE and 198 healthy pregnant women. Allele-specific polymerase chain reaction (ASPCR) was used to detect the FVL G1691A polymorphisms and prothrombin G20210A gene mutations. The FVL G1691A polymorphism and prothrombin G20210A gene mutations were detected only in pregnant women with VTE, with frequencies of 4.0 and 0.5%, respectively. The highest frequency of FVL G1691A polymorphism was observed in patients with deep vein thrombosis (DVT) and positively ...
Deep vein thrombosis (DVT) is a critical condition and a potential cause of mortality and morbidi... more Deep vein thrombosis (DVT) is a critical condition and a potential cause of mortality and morbidity in Africa and worldwide with a high recurrence rate. The study was designed to assess the roles of natural anticoagulants and fibrinolytic regulatory factors in the development of DVT in Sudanese patients. A case-control study was conducted in Omdurman Teaching Hospital, Khartoum State over a period of 1 year. The study enrolled 200 patients diagnosed with DVT and 200 age-matched and gender-matched controls. Demographic data and data on acquired risk factors were collected using a semi-structured questionnaire. Protein C (PC), protein S (PS), antithrombin III (AT-III), thrombin-activable fibrinolysis inhibitor (TAFI), and plasminogen activator inhibitor-1 (PAI-1) were measured in patients and controls. Among the patients with DVT, 5.5% had PC deficiency, 8.5% had PS deficiency, and 3% had AT-III deficiency. Elevated TAFI and PAI-1 levels were demonstrated in 1.5 and 0.5% of patients, respectively. Risk factors for DVT (overweight, surgical history, and family history of DVT) were remarkably higher in patients than in controls. Among the female participants, pregnancy and usage of oral contraceptive pills were the highest associated risk factors for DVT. The findings concluded that the early assessment of risk factors, including the measurements of natural inhibitors, can predict the occurrence of DVT before it is actually detected in patients.
Background: The effective management and choice of appropriate treatment of lymphoma subtypes dep... more Background: The effective management and choice of appropriate treatment of lymphoma subtypes depend on an accurate diagnosis and differentiation, which require comprehensive haematology and pathology work. Methods: A total of 134 cases of malignant lymphoma, newly diagnosed between January 2017 to January 2020, were selected. For each patient’s samples, complete blood count, immunohistochemistry, and morphological evaluation were done. Results: Clinical data showed that 81 patients (60.4%) were males and 53 (39.6%) females. The age range was 4 to 80 years. NHL lymphoma comprised 87.3% of cases, while HL comprised 12.7% of cases. Diffuse large B cell lymphoma was the most prevalent NHL subtype, representing 39.3% of cases. Among HL subtypes, mixed cellularity was present in 41.2% of cases. B cell lymphoma constituted 93.2% of cases. All HL patients and 74.4% of NHL patients had anaemia. Conclusion: This is the first statistical report of malignant lymphoma patterns in Sudanese patie...
Background: Trace elements are well-known to affect hormones at levels of action, as well as bind... more Background: Trace elements are well-known to affect hormones at levels of action, as well as binding to the target tissue, hormone secretion, and activity. Objective: This study aimed to evaluate the serum levels of copper and zinc among hypothyroidism and hyperthyroidism Sudanese patients. Material and Methods: One hundred participants were enrolled in this cross-sectional study. Thirty-five hyperthyroidism patients, 35 hypothyroidism patients, and 30 normal healthy individuals were taken as control, with aged-matched 25 to 50 years. The automated analyzer system estimated triiodothyronine (T3), thyroxin (T4) and thyroid-stimulating hormone (TSH). Atomic Absorption Spectrophotometers estimated zinc and copper and the data were analyzed by SPSS version 19.0. Results: A significant decrease in serum zinc level among hyperthyroidism and hypothyroidism patients were found, when compared with the control group (P-value <0.05). The copper level was significantly increased among hypert...
1Clinical Laboratory Sciences Department,College of Applied Medical Sciences, Jouf University, Qu... more 1Clinical Laboratory Sciences Department,College of Applied Medical Sciences, Jouf University, Qurayyat, 77423. 2Clinical Laboratory Sciences Department, Jouf University, Qurayyat,77423. 3Clinical Chemistry Department, College of Medical Laboratory Sciences, Elrazi University, Khartoum,79371. 4Clinical Chemistry Department, College of Medical Laboratory Sciences, Sudan University of Science and Technology, Khartoum, 79371. 5Clinical Laboratory Sciences Department, Jouf University, Qurayyat, 77423. 6Clinical Laboratory Sciences Department, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh ,11543. Corresponding Author E-mail: aahamza@ju.edu.sa
1 Department of Medical Laboratory Sciences, Faculty of Applied Medical sciences, Northern Border... more 1 Department of Medical Laboratory Sciences, Faculty of Applied Medical sciences, Northern Border University, Arar, KSA 2 Department of histopathology, Faculty of Medical laboratory sciences, Al-Zaiem Al-Azhari, University, Khartoum north, Sudan 3 Department of Pathology, faculty of medicine, Al-Zaiem Al-Azhari, University, Khartoum north, Sudan 4 Department of Clinical Laboratory Sciences, College of Applied Medical sciences, Jouf University, Qurayyat, KSA 5 College of Applied Medical Science, Jouf University, Sakaka, Jouf, Saudi Arabia 6 Department of Pathology, College of Medicine, University of Hail, Kingdom of Saudi Arabia
Background Oral contraceptives are commonly taken by women and are known to increase the risk of ... more Background Oral contraceptives are commonly taken by women and are known to increase the risk of venous thromboembolism (VTE). Objective The aim of this study was to investigate the association between oral contraceptive use and natural anticoagulants, that is, protein C (PC), protein S (PS), and antithrombin in pregnant women with deep vein thrombosis (DVT). Materials and methods This case–control study was conducted on 330 pregnant women, that is, cases 165 (who used oral contraceptives) and controls 165 (who did not use oral contraceptives). The levels of PC, PS, and antithrombin were measured and compared between the two groups. The use of different types of oral contraceptives and their association with DVT and PC and PS were also analyzed. Results The study found that women with DVT had significantly lower levels of PC and PS compared with controls (P &lt; 0.001). However, no significant difference was found in the levels of AT. Among the different types of oral contraceptives, first-generation progestin pills including Ethynodiol Diacetate, Norethindrone Acetate, Norethynodrel, and second-generation oral contraceptives (Lynestrenol, Levonorgestrel and Norgestrel) were not found to be associated with lower levels of PC and AT while Desogestrel, Norgestimate, and Gestodene (third-generation) were associated with lower levels of PS. Conclusion This study suggests that the use of contraceptives, particularly those containing Desogestrel, Norgestimate, and Gestodene, may be associated with a higher risk of thrombosis because of the associated lower levels of PS. Monitoring anticoagulant levels is crucial in preventing DVT in this population.
TNF–α influences lymphomagenesis by upregulating proinflammatory and antiapoptotic pathways. In t... more TNF–α influences lymphomagenesis by upregulating proinflammatory and antiapoptotic pathways. In this study, we evaluated the frequency of TNF–α rs1800629 (–308 G>A) polymorphism in newly diagnosed adult patients with acute lymphoblastic leukemia (ALL) and its correlation with age at diagnosis, gender and subtype of ALL. In this case control study, a total of 330 individuals were recruited, including 165 newly diagnosed adult patients with ALL, from the Radiation and Isotope Center in Khartoum (RICK) and 165 healthy normal controls. TNF–α rs1800629 polymorphism was tested through allele-specific polymerase chain reaction (PCR) assay. The frequency of the rs1800629 GA genotype was high (70.9% vs. 60%, OR = 1.84) in the patient group as compared to healthy controls, whereas GG and AA genotypes did not exhibit any statistically significant difference between controls and patients. Based on subtype, GG and GA rs1800629 genotypes showed increased risk of B-ALL (OR 0.46 and 2.12, respec...
Venous thromboembolism (VTE) is one of the major causes of pregnancy-related mortality and morbid... more Venous thromboembolism (VTE) is one of the major causes of pregnancy-related mortality and morbidity. This study aimed to determine the frequency of factor V Leiden (FVL) and prothrombin G20210A polymorphisms and measure the plasma levels of protein C (PC), protein S (PS) and antithrombin (AT) in pregnant women with VTE and healthy pregnant women. This prospective case-control study determined the frequencies of FVL G1691A and prothrombin G20210A polymorphisms and measured the plasma levels of PC, PS and AT in 198 pregnant women with VTE and 198 healthy pregnant women. Allele-specific polymerase chain reaction (ASPCR) was used to detect the FVL G1691A polymorphisms and prothrombin G20210A gene mutations. The FVL G1691A polymorphism and prothrombin G20210A gene mutations were detected only in pregnant women with VTE, with frequencies of 4.0 and 0.5%, respectively. The highest frequency of FVL G1691A polymorphism was observed in patients with deep vein thrombosis (DVT) and positively ...
Deep vein thrombosis (DVT) is a critical condition and a potential cause of mortality and morbidi... more Deep vein thrombosis (DVT) is a critical condition and a potential cause of mortality and morbidity in Africa and worldwide with a high recurrence rate. The study was designed to assess the roles of natural anticoagulants and fibrinolytic regulatory factors in the development of DVT in Sudanese patients. A case-control study was conducted in Omdurman Teaching Hospital, Khartoum State over a period of 1 year. The study enrolled 200 patients diagnosed with DVT and 200 age-matched and gender-matched controls. Demographic data and data on acquired risk factors were collected using a semi-structured questionnaire. Protein C (PC), protein S (PS), antithrombin III (AT-III), thrombin-activable fibrinolysis inhibitor (TAFI), and plasminogen activator inhibitor-1 (PAI-1) were measured in patients and controls. Among the patients with DVT, 5.5% had PC deficiency, 8.5% had PS deficiency, and 3% had AT-III deficiency. Elevated TAFI and PAI-1 levels were demonstrated in 1.5 and 0.5% of patients, respectively. Risk factors for DVT (overweight, surgical history, and family history of DVT) were remarkably higher in patients than in controls. Among the female participants, pregnancy and usage of oral contraceptive pills were the highest associated risk factors for DVT. The findings concluded that the early assessment of risk factors, including the measurements of natural inhibitors, can predict the occurrence of DVT before it is actually detected in patients.
Background: The effective management and choice of appropriate treatment of lymphoma subtypes dep... more Background: The effective management and choice of appropriate treatment of lymphoma subtypes depend on an accurate diagnosis and differentiation, which require comprehensive haematology and pathology work. Methods: A total of 134 cases of malignant lymphoma, newly diagnosed between January 2017 to January 2020, were selected. For each patient’s samples, complete blood count, immunohistochemistry, and morphological evaluation were done. Results: Clinical data showed that 81 patients (60.4%) were males and 53 (39.6%) females. The age range was 4 to 80 years. NHL lymphoma comprised 87.3% of cases, while HL comprised 12.7% of cases. Diffuse large B cell lymphoma was the most prevalent NHL subtype, representing 39.3% of cases. Among HL subtypes, mixed cellularity was present in 41.2% of cases. B cell lymphoma constituted 93.2% of cases. All HL patients and 74.4% of NHL patients had anaemia. Conclusion: This is the first statistical report of malignant lymphoma patterns in Sudanese patie...
Background: Trace elements are well-known to affect hormones at levels of action, as well as bind... more Background: Trace elements are well-known to affect hormones at levels of action, as well as binding to the target tissue, hormone secretion, and activity. Objective: This study aimed to evaluate the serum levels of copper and zinc among hypothyroidism and hyperthyroidism Sudanese patients. Material and Methods: One hundred participants were enrolled in this cross-sectional study. Thirty-five hyperthyroidism patients, 35 hypothyroidism patients, and 30 normal healthy individuals were taken as control, with aged-matched 25 to 50 years. The automated analyzer system estimated triiodothyronine (T3), thyroxin (T4) and thyroid-stimulating hormone (TSH). Atomic Absorption Spectrophotometers estimated zinc and copper and the data were analyzed by SPSS version 19.0. Results: A significant decrease in serum zinc level among hyperthyroidism and hypothyroidism patients were found, when compared with the control group (P-value <0.05). The copper level was significantly increased among hypert...
1Clinical Laboratory Sciences Department,College of Applied Medical Sciences, Jouf University, Qu... more 1Clinical Laboratory Sciences Department,College of Applied Medical Sciences, Jouf University, Qurayyat, 77423. 2Clinical Laboratory Sciences Department, Jouf University, Qurayyat,77423. 3Clinical Chemistry Department, College of Medical Laboratory Sciences, Elrazi University, Khartoum,79371. 4Clinical Chemistry Department, College of Medical Laboratory Sciences, Sudan University of Science and Technology, Khartoum, 79371. 5Clinical Laboratory Sciences Department, Jouf University, Qurayyat, 77423. 6Clinical Laboratory Sciences Department, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh ,11543. Corresponding Author E-mail: aahamza@ju.edu.sa
1 Department of Medical Laboratory Sciences, Faculty of Applied Medical sciences, Northern Border... more 1 Department of Medical Laboratory Sciences, Faculty of Applied Medical sciences, Northern Border University, Arar, KSA 2 Department of histopathology, Faculty of Medical laboratory sciences, Al-Zaiem Al-Azhari, University, Khartoum north, Sudan 3 Department of Pathology, faculty of medicine, Al-Zaiem Al-Azhari, University, Khartoum north, Sudan 4 Department of Clinical Laboratory Sciences, College of Applied Medical sciences, Jouf University, Qurayyat, KSA 5 College of Applied Medical Science, Jouf University, Sakaka, Jouf, Saudi Arabia 6 Department of Pathology, College of Medicine, University of Hail, Kingdom of Saudi Arabia
Uploads
Papers by Ezeldine Abdalhabib