A new model, vetted by experiments on lung cancer cells, may help to explain how cancer and other diseases accumulate drug-resistance mutations that can compromise the effectiveness of treatments.

Proteins at the interfaces of two immiscible condensates can act as biological switches, regulating the formation of complex architectures with shared stable interfaces.

Large and slow eukaryotic cells favor spatial over temporal comparison for chemotaxis; this study supports this heuristic notion using information theory, accounting for physical limits of sensing.

Incorporating chain rigidification, desolvation, and sticker pair formation into a dynamic aging simulation explains the formation of solid shells around condensate surfaces, as observed in recent experiments.

Interactions between drug-resistant mutants and their evolutionary ancestors in the absence of treatment can significantly impact treatment efficacy. This explains pre-existing drug resistance in non-small cell lung cancer, providing new insights for treatment strategies.

A new model, vetted by experiments on lung cancer cells, may help to explain how cancer and other diseases accumulate drug-resistance mutations that can compromise the effectiveness of treatments.

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Jeff Maltas et al.
PRX Life 2, 023010 (2024)

PRX Life would like to welcome Josh Shaevitz, Professor of Physics and Genomics at Princeton University, to the editorial team. Josh’s research explores how life emerges from collections of molecules, cells, and organisms, focusing on bacterial growth, cellular pattern formation, and discrete animal behaviors.

Social norms—the rules by which people assess others and adopt behaviors—are classified in a society where people gossip and make judgment errors independently. Key strategies that maximize cooperation and are robust against defectors are identified.

When determining the authorship list for your next paper, be generous yet disciplined.

A phenomenological renormalization group analysis of 3-hour spiking data from the visual cortices of urethane-anesthetized rats shows that scale invariance is intermittent, with a broad range of cortical states corresponding to small deviations around a critical point.

Even when the underlying model for a neuron is unknown, relevant information on ion channels can still be inferred by utilizing recursive piecewise assimilation of electrophysiological data, and model error can be quantified.

APS has selected 156 Outstanding Referees for 2024 who have demonstrated exceptional work in the assessment of manuscripts published in the Physical Review journals. A full list of the Outstanding Referees is available online.

PRX Life’s Special Collection on Machine Learning and Structural Biology showcases cutting-edge research where machine learning intersects with structural biology. The collection is open to everyone and PRX Life is waiving article publication charges for all accepted manuscripts.

Manuscripts will be considered and published on a rolling basis.

The editors of PRX Life introduce the journal’s first issue and discuss their vision for serving the research communities working at the intersection of physics and the living world.